ES8405805A1 - Un procedimiento para preparar nuevos derivados de la c-homo-9-oxaergolina - Google Patents

Un procedimiento para preparar nuevos derivados de la c-homo-9-oxaergolina

Info

Publication number
ES8405805A1
ES8405805A1 ES525712A ES525712A ES8405805A1 ES 8405805 A1 ES8405805 A1 ES 8405805A1 ES 525712 A ES525712 A ES 525712A ES 525712 A ES525712 A ES 525712A ES 8405805 A1 ES8405805 A1 ES 8405805A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
hydrogen
group
homo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525712A
Other languages
English (en)
Other versions
ES525712A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES525712A0 publication Critical patent/ES525712A0/es
Publication of ES8405805A1 publication Critical patent/ES8405805A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE LA C-HOMO-9-OXAERGOLINA.CONSISTE EN CICLIZAR UN PRODUCTO DE FORMULA (II) PARA OBTENER UN PRODUCTO DE FORMULA (III), EL CUAL SE ESTERIFICA PARA OBTENER EL PRODUCTO DE FORMULA (IV), Y POSTERIOR TRATAMIENTO DE: SAPONIFICACION O REDUCCION, O ACCION DE UN AGENTE DE HALOGENACION O REACCION CON UNA AMINA O CLORURO DE METANO, UN ALQUILMERCAPTANO, PARA DAR COMPUESTOS DE FORMULA (I), DONDE R ES HIDROGENO O RADICAL ALQUILO CON C 1 A 4; R1 ES HIDROGENO, CLORO O BROMO; R2 ES HIDROGENO, RADICAL ALQUILO CON C 1A 4 Y OTROS; R3 ES UN RADICAL HIDROXIMETILO, Y OTROS; ALC ES UN RADICAL ALQUILO CON C 1 A 4; Y SIGNIFICANDO EL TRAZADO ONDULADO QUE EL SUSTITUYENTE ESTA EN POSICION 8-ALFA U 8-BETA.TIENE APLICACIONES FARMACEUTICAS EN EL TRATAMIENTO DE SINDROMES NEUROLOGICOS DE ORIGEN EXTRAPIRAMIDAL, COMO LA ENFERMEDAD DE PARKINSON.
ES525712A 1982-09-20 1983-09-19 Un procedimiento para preparar nuevos derivados de la c-homo-9-oxaergolina Expired ES8405805A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8215773A FR2533215A1 (fr) 1982-09-20 1982-09-20 Nouveaux derives de la c-homo 9-oxaergoline, leurs sels, procede de preparation et intermediaires de preparation, application a titre de medicaments et compositions les renfermant

Publications (2)

Publication Number Publication Date
ES525712A0 ES525712A0 (es) 1984-06-16
ES8405805A1 true ES8405805A1 (es) 1984-06-16

Family

ID=9277560

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525712A Expired ES8405805A1 (es) 1982-09-20 1983-09-19 Un procedimiento para preparar nuevos derivados de la c-homo-9-oxaergolina

Country Status (10)

Country Link
US (1) US4503053A (es)
EP (1) EP0105776B1 (es)
JP (1) JPS5973589A (es)
AT (1) ATE18227T1 (es)
CA (1) CA1208219A (es)
DE (1) DE3362323D1 (es)
ES (1) ES8405805A1 (es)
FR (1) FR2533215A1 (es)
HU (1) HU191097B (es)
ZA (1) ZA836539B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774243A (en) * 1985-12-24 1988-09-27 Merck & Co., Inc. Dopamine agonists for treating elevated intraocular pressure
FR2594828B1 (fr) * 1986-02-24 1988-07-01 Roussel Uclaf Derives du tetrahydrobenz (c,d) indole, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires
HUT69381A (en) * 1993-12-09 1995-09-28 Egyt Gyogyszervegyeszeti Gyar Process for producing (2-chloro pyridyl)-7-azabicyclo [2.2.1.]heptane
KR100789518B1 (ko) * 2002-09-24 2007-12-28 도시바 엘리베이터 가부시키가이샤 기계실을 갖지 않는 엘리베이터 시스템

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238486A (en) * 1979-11-23 1980-12-09 Merck & Co., Inc. Indolobenzoxazines
FR2476649A1 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Nouveaux derives du cycloheptindole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Also Published As

Publication number Publication date
EP0105776B1 (fr) 1986-02-26
ZA836539B (en) 1984-10-31
US4503053A (en) 1985-03-05
ATE18227T1 (de) 1986-03-15
ES525712A0 (es) 1984-06-16
JPS5973589A (ja) 1984-04-25
EP0105776A1 (fr) 1984-04-18
CA1208219A (fr) 1986-07-22
HU191097B (en) 1987-01-28
FR2533215B1 (es) 1985-02-22
FR2533215A1 (fr) 1984-03-23
DE3362323D1 (en) 1986-04-03
JPH0521910B2 (es) 1993-03-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519