ES8407479A1 - Un metodo para la preparacion de 5,6-dihidro-11h-dibenzo-(b,e)-azepin-6-onas. - Google Patents

Un metodo para la preparacion de 5,6-dihidro-11h-dibenzo-(b,e)-azepin-6-onas.

Info

Publication number
ES8407479A1
ES8407479A1 ES520577A ES520577A ES8407479A1 ES 8407479 A1 ES8407479 A1 ES 8407479A1 ES 520577 A ES520577 A ES 520577A ES 520577 A ES520577 A ES 520577A ES 8407479 A1 ES8407479 A1 ES 8407479A1
Authority
ES
Spain
Prior art keywords
group
alkyl
avtivity
azepin
dibenzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520577A
Other languages
English (en)
Other versions
ES520577A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Menarini SAS
Original Assignee
Menarini SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini SAS filed Critical Menarini SAS
Publication of ES520577A0 publication Critical patent/ES520577A0/es
Publication of ES8407479A1 publication Critical patent/ES8407479A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 5,6-DIHIDRO-11H-DIBENZO-(B,E)AZEPIN-6-ONAS, DE FORMULA GENERAL (I).CONSISTE EN REDUCIR, MEDIANTE UN AGENTE REDUCTOR ADECUADO, LA CORRESPONDIENTE 5,6-DIHIDRO-11H-DIBENZO-(B,E)AZEPIN-6, 11-DIONA O SUS 5 ALCOHIL (C1-3) DERIVADOS AL OBJETO DE OBTENER EL HIDROXIDERIVADO, EL CUAL SE TRANSFORMA, MEDIANTE UN AGENTE HALOGENANTE, EN EL 11-HALOGENDERIVADO. DICHO 11-HALOGENDERIVADO POR SUCESIVO TRATAMIENTO CON ALCOHOLATO (C1-8) SODICO PROPORTIONA LA 11-ALQUIL(C1-8)OXI-5,6-DIHIDRO-11H-DIBENZO (B,E)AZEPIN-6-ONA.DE APLICACION COMO AGENTES ACTIVOS SOBRE EL SISTEMA NERVIOSOCENTRAL.
ES520577A 1982-03-15 1983-03-14 Un metodo para la preparacion de 5,6-dihidro-11h-dibenzo-(b,e)-azepin-6-onas. Expired ES8407479A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8209356A IT1207417B (it) 1982-03-15 1982-03-15 Azepina-6-one ad attivita'composti triciclici derivati dalla farmacologica, e procedimenti di 5,6-diidro-11h-dibenzo (b,e)fabbricazione relativi

Publications (2)

Publication Number Publication Date
ES520577A0 ES520577A0 (es) 1984-10-01
ES8407479A1 true ES8407479A1 (es) 1984-10-01

Family

ID=11128909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520577A Expired ES8407479A1 (es) 1982-03-15 1983-03-14 Un metodo para la preparacion de 5,6-dihidro-11h-dibenzo-(b,e)-azepin-6-onas.

Country Status (22)

Country Link
US (1) US4551451A (es)
EP (1) EP0089322B1 (es)
JP (1) JPS58180471A (es)
AT (1) ATE27816T1 (es)
AU (1) AU562360B2 (es)
CA (1) CA1226282A (es)
DD (1) DD209452A5 (es)
DE (1) DE3217236C2 (es)
DK (1) DK158722C (es)
ES (1) ES8407479A1 (es)
GB (1) GB2116539B (es)
GR (1) GR78455B (es)
HU (1) HU189671B (es)
IE (1) IE54859B1 (es)
IT (1) IT1207417B (es)
MX (1) MX156434A (es)
NO (1) NO830877L (es)
PL (3) PL241018A1 (es)
PT (1) PT76372B (es)
SU (1) SU1301830A1 (es)
YU (1) YU63083A (es)
ZA (1) ZA831473B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665664B2 (ja) * 1985-01-18 1994-08-24 大塚製薬株式会社 モルフアントリジン誘導体
IT1233715B (it) * 1989-07-14 1992-04-14 Menarini Farma Ind Uso in terapia della 10-ammino-5,6diidro-11h= dibenzo (b,e) azepina-6,11-dione e derivati, quali farmaci utili per il trattamento dell'incontinenza urinaria
DE4138853A1 (de) * 1991-11-27 1993-06-03 Bayer Ag 5,6-dihydro-dibenz(b,e)azepin-6,11-dion-11- oxime
AU3441193A (en) * 1992-04-14 1993-11-18 Sphinx Pharmaceuticals Corporation Polyhydroxylated dibenz (C,E) azepines as protein kinase C inhibitors
JP2001514253A (ja) * 1997-09-04 2001-09-11 スミスクライン・ビーチャム・コーポレイション インテグリンレセプターアンタゴニスト

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084155A (en) * 1963-04-02 Derivatives of dibenzo
GB972082A (en) * 1961-06-07 1964-10-07 Koninklijke Pharma Fab Nv Dihydrodibenzazepinones
GB1062573A (en) * 1963-10-29 1967-03-22 Colgate Palmolive Co Morphanthridine derivatives,and processes of preparing the same
DE1545856A1 (de) * 1965-09-10 1969-11-27 Bayer Ag Verfahren zur Herstellung von basisch substituierten Derivaten des 5,6-Dihydro-dibenz-[b,e]-azepin-6,11-dion-11-oxims
DE1568217A1 (de) * 1966-12-16 1970-01-02 Boehringer Mannheim Gmbh Verfahren zur Herstellung von tricyclischen Derivaten des Acetamids
JPS4934996B1 (es) * 1969-05-06 1974-09-19
CH569730A5 (es) * 1972-04-04 1975-11-28 Wander Ag Dr A
CH577975A5 (es) * 1972-10-20 1976-07-30 Sandoz Ag
DE2361467A1 (de) * 1973-12-10 1975-06-19 Thiemann Chem Pharm Fab 1-amino-5,6-dihydro-morphanthridin5,11-dion-verbindungen und solche verbindungen enthaltende arzneimittel
CH601287A5 (es) * 1975-08-06 1978-07-14 Sandoz Ag
DE2918778A1 (de) * 1979-05-10 1980-11-20 Basf Ag 6-substituierte 11-alkylen-morphantridine
DE2918832A1 (de) * 1979-05-10 1980-11-20 Basf Ag 5,6-dihydro-11-alkylen-morphantridin- 6-one
DE3113094A1 (de) * 1981-04-01 1982-10-21 Basf Ag, 6700 Ludwigshafen 5,6-dihydro-11-alkylen-morphantridin-6-one, ihre herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
DK86483D0 (da) 1983-02-24
GB2116539A (en) 1983-09-28
DD209452A5 (de) 1984-05-09
JPH0480027B2 (es) 1992-12-17
IT8209356A0 (it) 1982-03-15
CA1226282A (en) 1987-09-01
SU1301830A1 (ru) 1987-04-07
EP0089322B1 (en) 1987-06-16
IE830542L (en) 1983-09-15
YU63083A (en) 1989-08-31
DK86483A (da) 1983-09-16
GB2116539B (en) 1986-04-30
ZA831473B (en) 1983-11-30
AU562360B2 (en) 1987-06-11
US4551451A (en) 1985-11-05
IE54859B1 (en) 1990-02-28
AU1243183A (en) 1983-09-22
DK158722C (da) 1990-12-03
ES520577A0 (es) 1984-10-01
PL252303A1 (en) 1985-12-17
IT1207417B (it) 1989-05-17
DE3217236A1 (de) 1983-09-15
PT76372B (en) 1985-12-05
PL241018A1 (en) 1985-07-16
JPS58180471A (ja) 1983-10-21
NO830877L (no) 1983-09-16
DK158722B (da) 1990-07-09
ATE27816T1 (de) 1987-07-15
EP0089322A1 (en) 1983-09-21
PL140327B1 (en) 1987-04-30
MX156434A (es) 1988-08-22
PT76372A (en) 1983-04-01
HU189671B (en) 1986-07-28
DE3217236C2 (de) 1994-04-14
GR78455B (es) 1984-09-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303