ES8304147A1 - Procedimiento para la preparacion de mono-esteres amonio-al-cohilicos de acidos alcanol-fosforicos - Google Patents

Procedimiento para la preparacion de mono-esteres amonio-al-cohilicos de acidos alcanol-fosforicos

Info

Publication number
ES8304147A1
ES8304147A1 ES81506386A ES506386A ES8304147A1 ES 8304147 A1 ES8304147 A1 ES 8304147A1 ES 81506386 A ES81506386 A ES 81506386A ES 506386 A ES506386 A ES 506386A ES 8304147 A1 ES8304147 A1 ES 8304147A1
Authority
ES
Spain
Prior art keywords
compounds
phospholipids
preparation
medicines containing
contain sulphur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES81506386A
Other languages
English (en)
Other versions
ES506386A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803039629 external-priority patent/DE3039629A1/de
Priority claimed from DE19813118965 external-priority patent/DE3118965A1/de
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES8304147A1 publication Critical patent/ES8304147A1/es
Publication of ES506386A0 publication Critical patent/ES506386A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE MONOESTERES AMINO-ALCOHILICOS DE ACIDOS ALCANOL-FOSFORICOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE Y ES OXIGENO O AZUFRE; R ES UNA CADENA ALCOHILENO C <- ; R ES HIDROGENO O ALCOHILO INFERIOR; X, R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 0-2. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) O (IV), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS. SI SE UTILIZA EL COMPUESTO DE FORMULA (III), EL PRODUCTO OBTENIDO SE HIDROLIZA Y EL ATOMO DE BROMO SE INTERCAMBIA POR UN GRUPO AMONIO. SI SE UTILIZA EL COMPUESTO DE FORMULA (IV), EL PRODUCTO OBTENIDO SE TRATA DIRECTAMENTE CON AMONIACO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTITUMORALES.
ES81506386A 1980-10-21 1981-10-20 Procedimiento para la preparacion de mono-esteres amonio-al-cohilicos de acidos alcanol-fosforicos Granted ES506386A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803039629 DE3039629A1 (de) 1980-10-21 1980-10-21 Neue schwefelhaltige phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE19813118965 DE3118965A1 (de) 1981-05-13 1981-05-13 Neue schwefelhaltige phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8304147A1 true ES8304147A1 (es) 1983-03-01
ES506386A0 ES506386A0 (es) 1983-03-01

Family

ID=25788614

Family Applications (1)

Application Number Title Priority Date Filing Date
ES81506386A Granted ES506386A0 (es) 1980-10-21 1981-10-20 Procedimiento para la preparacion de mono-esteres amonio-al-cohilicos de acidos alcanol-fosforicos

Country Status (10)

Country Link
US (1) US4444766A (es)
EP (1) EP0050327B1 (es)
CA (1) CA1174244A (es)
DD (1) DD201685A5 (es)
DE (1) DE3164332D1 (es)
ES (1) ES506386A0 (es)
HK (1) HK68987A (es)
HU (1) HU186789B (es)
SG (1) SG22187G (es)
SU (2) SU1241994A3 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3127503A1 (de) * 1981-07-11 1983-02-17 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4981989A (en) * 1984-12-10 1991-01-01 American Cyanamid Company Antihypertensive phosphate derivatives and intermediates thereof
US4619917A (en) * 1985-07-18 1986-10-28 Sandoz Pharm. Corp. Substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
DE3906952A1 (de) * 1989-03-04 1990-09-06 Boehringer Mannheim Gmbh (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel
DE3929217A1 (de) * 1989-09-02 1991-03-07 Boehringer Mannheim Gmbh Verwendung von phospholipid-derivaten als antivirale arzneimittel und neue phospholipide
JPH0791301B2 (ja) * 1989-10-02 1995-10-04 新日本理化株式会社 ジアセタールの製造方法
EP0521297B1 (de) * 1991-07-04 1997-09-17 ASTA Medica Aktiengesellschaft Verfahren zur Herstellung von Alkylphosphocholinen und Reinherstellung derselben
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
WO1994002153A1 (en) * 1992-07-22 1994-02-03 Boehringer Mannheim Gmbh Use of sulphur containing phospholipids for treating leishmaniasis
US5489580A (en) * 1992-11-05 1996-02-06 University Of Connecticut Phospholipid compounds and use therefor
ATE226437T1 (de) * 1993-06-10 2002-11-15 Univ Wake Forest (phospho)lipide zum bekämpfen einer hepatitis b- infektion
US5610198A (en) * 1994-03-18 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services Anti-mycobacterial compositions and their use for the treatment of tuberculosis and related diseases
EP1852121A3 (en) 1994-08-29 2007-11-21 Wake Forest University Lipid analogs for treating viral infections
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
TW343975B (en) * 1995-12-15 1998-11-01 Boehringer Mannheim Gmbh New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents
US6121477A (en) * 1996-08-02 2000-09-19 Kaneka Corporation Sulfonic ester derivatives, process for preparing the same, and use thereof
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
WO2002096826A2 (en) * 2001-05-29 2002-12-05 Koninklijke Philips Electronics N.V. Metal-ceramic bond
JP4714413B2 (ja) * 2001-08-31 2011-06-29 トムソン ライセンシング オーディオビジュアルストリームのためのシーケンスカウンタ
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
SI2574341T1 (sl) 2004-03-29 2017-08-31 University Of South Florida Učinkovito zdravljenje tumorjev in raka s triciribin fosfatom
EP1868628B1 (en) 2005-04-08 2014-06-11 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
EP2842559A3 (en) 2005-04-08 2015-03-18 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders
ES2733353T3 (es) * 2007-11-09 2019-11-28 Basf As Compuestos lípidos para uso en productos cosméticos, como suplemento alimenticio o como un medicamento
EP2254582B1 (en) * 2008-01-25 2016-01-20 Chimerix, Inc. Methods of treating viral infections
EP2147910A1 (en) 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Novel lipid compounds
US8735436B2 (en) 2009-05-08 2014-05-27 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES
SG10201509127YA (en) 2010-11-05 2015-12-30 Pronova Biopharma Norge As Methods of treatment using lipid compounds
CN105120842B (zh) 2013-02-28 2020-12-01 普罗诺瓦生物医药挪威公司 包含脂质化合物、甘油三酯和表面活性剂的组合物以及使用它们的方法
EP3288550B1 (en) 2015-04-28 2024-06-05 Basf As Structurally enhanced fatty acids containing sulphur for their use in treating non-alcoholic steatohepatitis
IL308604A (en) 2017-12-06 2024-01-01 Basf As Fatty acid antecedents for the treatment of nonalcoholic fatty liver disease
LU101206B1 (en) * 2019-05-06 2020-11-06 Univ Luxembourg PDEdelta Inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543937C3 (de) * 1966-01-14 1982-12-09 Unilever N.V., 3000 Rotterdam Verwendung modifizierter kephalinhaltiger Phosphatidgemische als Emulgatoren für O/W-Emulsionen und Verfahren zur Herstellung solcher Emulgatoren
DE2009341C3 (de) * 1970-02-27 1979-06-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung
US4119714A (en) * 1970-02-27 1978-10-10 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. Glycerin-alkylether-(1)-phosphoric acid-(3)-monocholine esters as enhancers of the natural resistance of the mammalian organism against non-carcinogenic pathogens
DE2033359C3 (de) * 1970-07-06 1980-02-14 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Acylpropandiol-(l,3)-phosphorsäuremono-cholinester und Verfahren zu deren Herstellung
US4159988A (en) * 1974-08-06 1979-07-03 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Synthetic phospholipids, a process for their manufacture and their use
DE2619715A1 (de) * 1976-05-04 1977-11-24 Max Planck Gesellschaft Tumor-antigen und verfahren zu dessen herstellung
DE2619686C2 (de) * 1976-05-04 1986-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verwendung eines Lysolecithins zur Tumorbehandlung
DE2642661C2 (de) * 1976-09-22 1984-06-28 A. Nattermann & Cie GmbH, 5000 Köln Acetoin-dialkyl-phosphorsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung
JPS55118494A (en) * 1979-03-07 1980-09-11 Toyama Chem Co Ltd Novel phosphorylcholine compound, its preparation, and antitumor agent comprising it
US4329302A (en) * 1980-06-27 1982-05-11 Board Of Regents, The University Of Texas System Synthetic phosphoglycerides possessing platelet activating properties
DE3025804C2 (de) * 1980-07-08 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln 1-S-Alkyl-2-0-acyl-3-phosphocholin-1-mercapto-2,3-propandiole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
HK68987A (en) 1987-10-02
SU1376948A3 (ru) 1988-02-23
DD201685A5 (de) 1983-08-03
CA1174244A (en) 1984-09-11
DE3164332D1 (en) 1984-07-26
EP0050327B1 (de) 1984-06-20
US4444766A (en) 1984-04-24
SG22187G (en) 1987-11-13
SU1241994A3 (ru) 1986-06-30
ES506386A0 (es) 1983-03-01
HU186789B (en) 1985-09-30
EP0050327A1 (de) 1982-04-28

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