ES8606370A1 - Procedimiento para la obtencion de compuestos de hexapiranosa - Google Patents

Procedimiento para la obtencion de compuestos de hexapiranosa

Info

Publication number
ES8606370A1
ES8606370A1 ES528142A ES528142A ES8606370A1 ES 8606370 A1 ES8606370 A1 ES 8606370A1 ES 528142 A ES528142 A ES 528142A ES 528142 A ES528142 A ES 528142A ES 8606370 A1 ES8606370 A1 ES 8606370A1
Authority
ES
Spain
Prior art keywords
derivatives
pharmaceutical compositions
compositions containing
phosphorylated
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528142A
Other languages
English (en)
Other versions
ES528142A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES528142A0 publication Critical patent/ES528142A0/es
Publication of ES8606370A1 publication Critical patent/ES8606370A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE HEXAPIRANOSA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), CON LOS GRUPOS FUNCIONALES PROTEGIDOS, SALVO EL HIDROXI LIBRE EN LA POSICION 3 DE LA PARTE PIRANOSA, CON UN COMPUESTO DE FORMULA (III), PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R1, R2, R12 Y R13, INDEPENDIENTES ENTRE SI, UN COMPUESTO DE FORMULA (IA); R3, R4, R5, R7, R8 Y R14, H O ALQUILO INFERIOR; R6, H O ALQUILO INFERIOR SUSTITUIDO O NO; R9 Y R11, UN COMPUESTO DE FORMULA (IE); R10, H, CARBOXI Y OTROS; R15, RESTO ALIFATICO DE C7 EN ADELANTE; A1 Y A3, COMPUESTO DE FORMULA (IB); X1, X2, X3, X5 Y X6, UN ATOMO DE OXIGENO, O -N(R14)-; Y1, GRUPO ALQUILENO; Z, HIDROXI ESTEARIFICADO, CAPAZ DE REACCION; Y N, 0 O 1. SE UTILIZAN EN FARMACOLOGIA COMO INMUNOPOTENCIADORES.
ES528142A 1981-01-23 1983-12-16 Procedimiento para la obtencion de compuestos de hexapiranosa Expired ES8606370A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH43981 1981-01-23

Publications (2)

Publication Number Publication Date
ES528142A0 ES528142A0 (es) 1986-04-16
ES8606370A1 true ES8606370A1 (es) 1986-04-16

Family

ID=4187055

Family Applications (3)

Application Number Title Priority Date Filing Date
ES508944A Granted ES508944A0 (es) 1981-01-23 1982-01-21 Procedimiento para la obtencion de compuestos de hexapiranosa.
ES522435A Granted ES522435A0 (es) 1981-01-23 1983-05-16 Procedimiento para la obtencion de compuestos de hexapiranosa.
ES528142A Expired ES8606370A1 (es) 1981-01-23 1983-12-16 Procedimiento para la obtencion de compuestos de hexapiranosa

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES508944A Granted ES508944A0 (es) 1981-01-23 1982-01-21 Procedimiento para la obtencion de compuestos de hexapiranosa.
ES522435A Granted ES522435A0 (es) 1981-01-23 1983-05-16 Procedimiento para la obtencion de compuestos de hexapiranosa.

Country Status (17)

Country Link
US (1) US4423038A (es)
EP (1) EP0056992A1 (es)
JP (1) JPS57142996A (es)
AU (1) AU7975182A (es)
CA (1) CA1190221A (es)
DD (1) DD202169A5 (es)
DK (1) DK28282A (es)
ES (3) ES508944A0 (es)
FI (1) FI820178L (es)
GB (1) GB2092591B (es)
GR (1) GR78246B (es)
IE (1) IE820137L (es)
IL (1) IL64847A (es)
NO (1) NO152904C (es)
NZ (1) NZ199545A (es)
PT (1) PT74326A (es)
ZA (1) ZA82433B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI79330C (fi) * 1982-07-23 1989-12-11 Ciba Geigy Ag Foerfarande foer framstaellning av farmakologiskt verkande muramylpeptid-n-(2-fosfatidyloxietyl)-amider.
US5334583A (en) * 1982-07-23 1994-08-02 Ciba-Geigy Corp. Use of sugar derivatives for the prophylaxis and treatment of virus infections
US5189017A (en) * 1982-07-23 1993-02-23 Ciba-Geigy Corporation Use of sugar derivatives for the prophylaxis and treatment of virus infections
EP0102319B1 (de) * 1982-07-23 1987-08-19 Ciba-Geigy Ag Verwendung von Muramylpeptiden oder deren Analogen zur Prophylaxe und Therapie von Virusinfektionen
JPS5920297A (ja) * 1982-07-27 1984-02-01 Dai Ichi Seiyaku Co Ltd ムラミルジペプチド誘導体
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4933179A (en) * 1983-08-22 1990-06-12 Syntex (U.S.A.) Inc. Feline leukemia virus antigen vaccines
US4770874A (en) * 1983-08-22 1988-09-13 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4772466A (en) * 1983-08-22 1988-09-20 Syntex (U.S.A.) Inc. Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants
AU580061B2 (en) * 1984-04-21 1988-12-22 Sandoz Ag 2,3-diamino-2,3-didesoxyhexose derivatives, processes for their preparation and their use
FR2564096B1 (fr) * 1984-05-11 1988-02-19 Anvar Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir
ATE45744T1 (de) * 1984-07-25 1989-09-15 Ciba Geigy Ag Phosphatidylverbindungen, verfahren zu ihrer herstellung und ihre verwendung.
US4885285A (en) * 1984-09-13 1989-12-05 Ciba-Geigy Corporation Phosphorus compounds, processes for their manufacture, and their use
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US5811088A (en) * 1987-02-20 1998-09-22 Emory University Antiinfective compounds and methods of use
US5674911A (en) * 1987-02-20 1997-10-07 Cytrx Corporation Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use
US7202225B1 (en) 1993-10-15 2007-04-10 Emanuele R Martin Therapeutic delivery compositions and methods of use thereof
WO1992016484A1 (en) 1991-03-19 1992-10-01 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US20020123476A1 (en) * 1991-03-19 2002-09-05 Emanuele R. Martin Therapeutic delivery compositions and methods of use thereof
US6933286B2 (en) 1991-03-19 2005-08-23 R. Martin Emanuele Therapeutic delivery compositions and methods of use thereof
US6267968B1 (en) 1995-04-07 2001-07-31 Vacsyn S.A. MDP derivatives and conjugates having haematipoietic function stimulating activity, and compositions containing same
EP0821068A3 (en) * 1996-03-29 1999-06-02 Rohm And Haas Company Novel sphingolipids and a process thereto
BR0205443A (pt) * 2001-05-31 2003-07-08 Suntory Ltd Método de ensaio para fator de ativação de plaqueta
FR2933984B1 (fr) * 2008-07-15 2013-01-04 Univ Bourgogne D,d muramyldipeptide,composes derives et utilisation pour le traitement des plaques atheromateuses
US8883174B2 (en) 2009-03-25 2014-11-11 The Board Of Regents, The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
US4153684A (en) * 1976-03-10 1979-05-08 Agence Nationale De Valorisation De La Recherche (Anvar) Immunizing and anti-infectious adjuvant agents constituted by N-acetyl-muramyl-L-alanyl-D-glutamic acid derivatives
FR2369292A1 (fr) * 1976-11-02 1978-05-26 Anvar Agents adjuvants immunit
US4082735A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
US4082736A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
GB1563561A (en) * 1976-06-23 1980-03-26 Daiichi Seiyaku Co Muramyldipeptide derivatives and process for the preparation thereof
US4256735A (en) * 1979-01-29 1981-03-17 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
JPS5618996A (en) * 1979-06-21 1981-02-23 Dai Ichi Seiyaku Co Ltd Muramyldipeptide derivative
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
FI803077A (fi) * 1979-10-12 1981-04-13 Ciba Geigy Ag Foerfarande foer framstaellning av myramylpeptider

Also Published As

Publication number Publication date
GB2092591B (en) 1984-07-04
ES528142A0 (es) 1986-04-16
US4423038A (en) 1983-12-27
CA1190221A (en) 1985-07-09
FI820178L (fi) 1982-07-24
NO820200L (no) 1982-07-26
NO152904C (no) 1985-12-11
NZ199545A (en) 1985-07-12
ES8406502A1 (es) 1984-07-01
IE820137L (en) 1982-07-23
DD202169A5 (de) 1983-08-31
EP0056992A1 (de) 1982-08-04
AU7975182A (en) 1982-07-29
PT74326A (en) 1982-02-01
JPS57142996A (en) 1982-09-03
GB2092591A (en) 1982-08-18
GR78246B (es) 1984-09-26
ES8502446A1 (es) 1985-01-01
NO152904B (no) 1985-09-02
ES508944A0 (es) 1984-07-01
ES522435A0 (es) 1985-01-01
IL64847A (en) 1986-02-28
IL64847A0 (en) 1982-03-31
ZA82433B (en) 1982-12-29
DK28282A (da) 1982-07-24

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