ES8303279A1 - "procedimiento para preparar nuevos derivados de acidos fenil-alifatico-carboxilicos". - Google Patents
"procedimiento para preparar nuevos derivados de acidos fenil-alifatico-carboxilicos".Info
- Publication number
- ES8303279A1 ES8303279A1 ES511489A ES511489A ES8303279A1 ES 8303279 A1 ES8303279 A1 ES 8303279A1 ES 511489 A ES511489 A ES 511489A ES 511489 A ES511489 A ES 511489A ES 8303279 A1 ES8303279 A1 ES 8303279A1
- Authority
- ES
- Spain
- Prior art keywords
- ailments
- duodenal
- gastro
- derivatives
- carboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002496 gastric effect Effects 0.000 title abstract 2
- -1 of phenyl aliphatic carboxylic acids Chemical class 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDOS FENIL-ALIFATICO-CARBOXILICOS Y DE SUS SALES ALCALINAS, ALCALINOTERREAS O DE AMINAS, DE FORMULA (I), EN LA QUE A ES HIDROGENO Y B ES HIDROXI O A Y B REPRESENTAN UN DOBLE ENLACE; Y R ES HIDROGENO O ALCOHILO C <- . CONSISTE EN LA REACCION DEL ACIDO GLIOXILICO O UNO DE SUS ESTERES DE ALCOHILO DE FORMULA OHC-COOR, EN LA QUE R ES HIDROGENO O ALCOHILO, CON UNA ACETOFENONA DE FORMULA (II), EN LA QUE LOS GRUPOS METOXI TIENEN LAS MISMAS POSICIONES QUE EN EL COMPUESTO DE FORMULA (I). LA REACCION SE EFECTUA EN MEDIO FUERTEMENTE ACIDO, A UNA TEMPERATURA ENTRE 120 C Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIULCEROSA, ANTISECRECION GASTRICA Y CITOPROTECTORA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8107801A FR2504127B1 (fr) | 1981-04-17 | 1981-04-17 | Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8303279A1 true ES8303279A1 (es) | 1983-02-01 |
| ES511489A0 ES511489A0 (es) | 1983-02-01 |
Family
ID=9257553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES511489A Granted ES511489A0 (es) | 1981-04-17 | 1982-04-16 | "procedimiento para preparar nuevos derivados de acidos fenil-alifatico-carboxilicos". |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4450292A (es) |
| JP (2) | JPS57183736A (es) |
| KR (1) | KR870001537B1 (es) |
| AT (1) | AT390054B (es) |
| AU (1) | AU550822B2 (es) |
| BE (1) | BE892886A (es) |
| CA (1) | CA1168255A (es) |
| CH (1) | CH652387A5 (es) |
| DE (1) | DE3214082A1 (es) |
| DK (1) | DK157673C (es) |
| ES (1) | ES511489A0 (es) |
| FI (1) | FI73965C (es) |
| FR (1) | FR2504127B1 (es) |
| GB (1) | GB2096999B (es) |
| GR (1) | GR75457B (es) |
| HU (1) | HU186857B (es) |
| IE (1) | IE52444B1 (es) |
| IL (1) | IL65445A (es) |
| IT (1) | IT1147846B (es) |
| LU (1) | LU84090A1 (es) |
| MA (1) | MA19444A1 (es) |
| NL (1) | NL8201579A (es) |
| OA (1) | OA07539A (es) |
| PT (1) | PT74767B (es) |
| SE (1) | SE453493B (es) |
| SU (1) | SU1264836A3 (es) |
| ZA (1) | ZA822571B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2515037A1 (fr) * | 1981-10-22 | 1983-04-29 | Roussel Uclaf | A titre de medicaments, certains derives mono-substitues de l'acide 4-phenyl 4-oxo buten-2-oique, ainsi que les compositions les renfermant |
| IT1190340B (it) * | 1986-06-06 | 1988-02-16 | Roussel Maestretti Spa | Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali |
| DK49688A (da) * | 1987-03-20 | 1988-09-21 | Hoffmann La Roche | Propiolophenonderivater |
| HU198294B (en) * | 1987-06-10 | 1989-09-28 | Richter Gedeon Vegyeszet | Process for producing butenoic acid amides and pharmaceutical compositions comprising such active ingredient |
| US4777288A (en) * | 1987-06-11 | 1988-10-11 | Pfizer Inc. | Process for preparing a 4,4-diphenylbutanoic acid derivative |
| DE3881770T2 (de) * | 1987-07-20 | 1993-10-07 | Cometec Srl | Zusammensetzungen zum Fördern der Tierwachstums. |
| HU198446B (en) * | 1987-09-25 | 1989-10-30 | Richter Gedeon Vegyeszet | Process for production of new amids of buten acid and medical compositions containing such active substances |
| US5849729A (en) * | 1995-12-26 | 1998-12-15 | Hershey Foods Corporation | Use of hydrolyzed cocoa butter for percutaneous absorption |
| US5837227A (en) * | 1995-12-26 | 1998-11-17 | Hershey Foods Corporation | Use of cocoa butter or partially hydrolyzed cocoa butter for the treatment of burns and wounds |
| GB9816358D0 (en) | 1998-07-27 | 1998-09-23 | Angeletti P Ist Richerche Bio | Enzyme inhibitors |
| US6492423B1 (en) | 1998-07-27 | 2002-12-10 | Istituto Di Ricerche Di Biologia Molecolare Pangeletti Spa | Diketoacid-derivatives as inhibitors of polymerases |
| RU2771565C1 (ru) * | 2021-05-28 | 2022-05-05 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новые соединения |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE708617A (es) * | 1966-12-30 | 1968-06-28 | ||
| NL6717403A (es) * | 1966-12-30 | 1968-07-01 | ||
| US3803222A (en) * | 1970-06-26 | 1974-04-09 | Istituto Chem It Spa | Oxo-trialkoxyphenyl-alkanoic acids and salts thereof |
| US3857949A (en) * | 1970-06-26 | 1974-12-31 | Inst Chemioterapico Italiano S | Prophylaxis and treatment of cardiac disorders |
| DE2116293A1 (de) * | 1971-04-02 | 1972-10-19 | Cassella Farbwerke Mainkur Ag, 6000 Frankfurt | Ketonderivate und Verfahren zu ihrer Herstellung |
| BE788749A (fr) * | 1971-09-13 | 1973-03-13 | Takeda Chemical Industries Ltd | Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation |
| US4017517A (en) * | 1971-09-13 | 1977-04-12 | Takeda Chemical Industries, Ltd. | 2-(Trisubstituted benzoyl)-propionic acid and a method for the production thereof |
| AT319215B (de) * | 1972-09-13 | 1974-12-10 | Takeda Chemical Industries Ltd | Verfahren zur Herstellung von neuen 3-(2',4',5'-trisubst. Benzoyl)-propionsäuren |
| FR2481118A1 (fr) * | 1980-04-24 | 1981-10-30 | Roussel Uclaf | Application a titre de medicaments de derives substitues de l'acide phenyl-4-oxo-2-butenoique |
-
1981
- 1981-04-17 FR FR8107801A patent/FR2504127B1/fr not_active Expired
-
1982
- 1982-03-23 SE SE8201840A patent/SE453493B/sv not_active IP Right Cessation
- 1982-04-06 IL IL65445A patent/IL65445A/xx unknown
- 1982-04-12 GR GR67892A patent/GR75457B/el unknown
- 1982-04-13 MA MA19649A patent/MA19444A1/fr unknown
- 1982-04-14 US US06/368,208 patent/US4450292A/en not_active Expired - Fee Related
- 1982-04-14 AT AT0144682A patent/AT390054B/de not_active IP Right Cessation
- 1982-04-14 FI FI821305A patent/FI73965C/fi not_active IP Right Cessation
- 1982-04-15 NL NL8201579A patent/NL8201579A/nl not_active Application Discontinuation
- 1982-04-15 ZA ZA822571A patent/ZA822571B/xx unknown
- 1982-04-16 JP JP57062641A patent/JPS57183736A/ja active Granted
- 1982-04-16 CH CH2342/82A patent/CH652387A5/fr not_active IP Right Cessation
- 1982-04-16 PT PT74767A patent/PT74767B/pt unknown
- 1982-04-16 DK DK170382A patent/DK157673C/da active IP Right Grant
- 1982-04-16 BE BE0/207859A patent/BE892886A/fr not_active IP Right Cessation
- 1982-04-16 KR KR8201678A patent/KR870001537B1/ko active
- 1982-04-16 CA CA000401128A patent/CA1168255A/fr not_active Expired
- 1982-04-16 IE IE896/82A patent/IE52444B1/en unknown
- 1982-04-16 IT IT48240/82A patent/IT1147846B/it active
- 1982-04-16 ES ES511489A patent/ES511489A0/es active Granted
- 1982-04-16 SU SU823423751A patent/SU1264836A3/ru active
- 1982-04-16 HU HU821177A patent/HU186857B/hu not_active IP Right Cessation
- 1982-04-16 LU LU84090A patent/LU84090A1/fr unknown
- 1982-04-16 AU AU82690/82A patent/AU550822B2/en not_active Ceased
- 1982-04-16 DE DE19823214082 patent/DE3214082A1/de not_active Ceased
- 1982-04-19 GB GB8211278A patent/GB2096999B/en not_active Expired
-
1983
- 1983-09-22 OA OA58109A patent/OA07539A/xx unknown
-
1987
- 1987-01-26 JP JP62014322A patent/JPS62174012A/ja active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960401 |