ES8301981A1 - Procedimiento de preparar compuestos benzoheterociclicos. - Google Patents

Procedimiento de preparar compuestos benzoheterociclicos.

Info

Publication number
ES8301981A1
ES8301981A1 ES507493A ES507493A ES8301981A1 ES 8301981 A1 ES8301981 A1 ES 8301981A1 ES 507493 A ES507493 A ES 507493A ES 507493 A ES507493 A ES 507493A ES 8301981 A1 ES8301981 A1 ES 8301981A1
Authority
ES
Spain
Prior art keywords
pyrroloquinoline
compounds
antimicrobial compositions
hydrogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507493A
Other languages
English (en)
Spanish (es)
Other versions
ES507493A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55158652A external-priority patent/JPS5781486A/ja
Priority claimed from JP56063170A external-priority patent/JPS57176987A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES507493A0 publication Critical patent/ES507493A0/es
Publication of ES8301981A1 publication Critical patent/ES8301981A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES507493A 1980-11-10 1981-11-10 Procedimiento de preparar compuestos benzoheterociclicos. Expired ES8301981A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55158652A JPS5781486A (en) 1980-11-10 1980-11-10 Benzo(ij)quinolidine-2-carboxylic acid derivative
JP56063170A JPS57176987A (en) 1981-04-24 1981-04-24 Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative

Publications (2)

Publication Number Publication Date
ES507493A0 ES507493A0 (es) 1983-02-01
ES8301981A1 true ES8301981A1 (es) 1983-02-01

Family

ID=26404260

Family Applications (2)

Application Number Title Priority Date Filing Date
ES507493A Expired ES8301981A1 (es) 1980-11-10 1981-11-10 Procedimiento de preparar compuestos benzoheterociclicos.
ES516523A Granted ES516523A0 (es) 1980-11-10 1982-10-15 "metodo de preparar compuestos benzoheterociclicos".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES516523A Granted ES516523A0 (es) 1980-11-10 1982-10-15 "metodo de preparar compuestos benzoheterociclicos".

Country Status (19)

Country Link
US (2) US4399134A (enExample)
KR (1) KR880001625B1 (enExample)
AT (2) AT395150B (enExample)
AU (1) AU546358B2 (enExample)
CA (1) CA1179341A (enExample)
CH (1) CH648845A5 (enExample)
DE (2) DE3144455A1 (enExample)
DK (1) DK160940C (enExample)
ES (2) ES8301981A1 (enExample)
FI (1) FI71141C (enExample)
FR (1) FR2493849A1 (enExample)
GB (1) GB2086905B (enExample)
IT (1) IT1171646B (enExample)
NL (1) NL193457C (enExample)
NO (1) NO156828C (enExample)
PH (1) PH16685A (enExample)
PT (1) PT73957B (enExample)
SE (1) SE448542B (enExample)
SU (2) SU1366055A3 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
US4380543A (en) * 1981-11-06 1983-04-19 Riker Laboratories, Inc. Antimicrobial 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids
PH22140A (en) * 1982-06-29 1988-06-01 Daiichi Seiyaku Co Tricyclic compounds
US4443447A (en) * 1982-10-25 1984-04-17 Riker Laboratories, Inc. Phenyl-substituted tricyclic antibacterial agents
JPS5978189A (ja) * 1982-10-26 1984-05-04 Otsuka Pharmaceut Co Ltd ピロロ〔３，２，１−ｉｊ〕キノリン−５−カルボン酸誘導体
US4472406A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
JPS59137482A (ja) * 1983-01-26 1984-08-07 Otsuka Pharmaceut Co Ltd ピロロ〔３，２，１，−ｉｊ〕キノリン−５−カルボン酸誘導体
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法
US4473568A (en) * 1983-03-01 1984-09-25 Warner Lambert Company Antibacterial thiazolidine or thiomorpholine substituted quinolines
US4472407A (en) * 1983-03-17 1984-09-18 Riker Laboratories, Inc. Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu
US4562195A (en) * 1984-02-02 1985-12-31 Warner-Lambert Company Reversing amnesia with saturated tricyclic nitrogen-containing diones
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4550103A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
AU585981B2 (en) * 1985-05-24 1989-06-29 Tokyo Tanabe Company Limited Benzo (IJ) quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and processes for preparing the same
US5210193A (en) * 1986-01-17 1993-05-11 American Cyanamid Company Piperazine derivatives
US4940710A (en) * 1986-01-17 1990-07-10 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
US4948894A (en) * 1989-02-21 1990-08-14 American Cyanamid Company 8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-(C)quinolizine-5-carboxylic acids
KR900014383A (ko) * 1989-03-29 1990-10-23 원본미기재 피롤로퀴놀린 유도체, 이의 제조방법 및 이를 사용한 항균제
WO1994020105A1 (en) * 1993-03-10 1994-09-15 Otsuka Pharmaceutical Company, Limited Interleukin-1 inhibitor
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
WO1997044034A1 (en) * 1996-05-20 1997-11-27 Otsuka Pharmaceutical Co., Ltd. Remedy for rosacea
DE19718065A1 (de) * 1997-04-29 1998-11-05 Henkel Kgaa Reinigungsmittel für nachvernetzende Polyurethan-Hotmelts
US7247642B2 (en) 1999-05-07 2007-07-24 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
US6750224B1 (en) 1999-05-07 2004-06-15 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
US6514986B2 (en) 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
DE19962470A1 (de) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
US6608078B2 (en) * 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
ATE378335T1 (de) * 2000-05-08 2007-11-15 Wockhardt Ltd Chirale fluorochinolizinon arginine salze
WO2001085728A2 (en) * 2000-05-08 2001-11-15 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i, j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
EP1453824A1 (en) * 2001-12-13 2004-09-08 Wockhardt Limited New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2003099815A1 (en) * 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
EP1918289A3 (en) 2002-05-28 2009-08-19 Wockhardt Limited Crystalline nadifloxacin arginine salt form
WO2004058262A1 (en) * 2002-12-31 2004-07-15 Wockhardt Limited Benzoquinolizine-2-carboxylic acid-containing compositions
US20040176321A1 (en) * 2002-12-31 2004-09-09 Wockhardt Limited Compositions of benzoquinolizine carboxylic acid antibiotic drugs
CA2537066C (en) 2003-09-04 2011-05-24 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
WO2007081597A2 (en) * 2005-10-21 2007-07-19 Glaxo Group Limited Peri condensed tricyclic compounds useful as antibacterial agents
JP6240063B2 (ja) 2011-04-28 2017-11-29 ザ ブロード インスティテュート， インコーポレイテッド ヒストンデアセチラーゼ阻害剤
CA2880117C (en) 2012-07-27 2021-04-06 The Broad Institute, Inc. Inhibitors of histone deacetylase
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
RS59911B1 (sr) 2013-10-14 2020-03-31 Eisai R&D Man Co Ltd Selektivno supstituisana jedinjenja hinolina
CA2920791C (en) 2013-10-14 2021-11-16 Eisai R&D Management Co., Ltd. Selectively substituted quinoline compounds
EP3737362B1 (en) 2018-01-12 2025-10-15 Kdac Therapeutics, Inc. Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
US4001243A (en) * 1972-11-02 1977-01-04 Riker Laboratories, Inc. Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof
US3917609A (en) * 1973-06-27 1975-11-04 Minnesota Mining & Mfg Pyrroloquinoline carboxylic acids and derivatives
JPS6019910B2 (ja) * 1979-10-11 1985-05-18 大塚製薬株式会社 ベンゾ〔ｉｊ〕キノリジン−２−カルボン酸誘導体及びその製造法
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
DE2953973C2 (enExample) * 1978-04-12 1989-02-02 Otsuka Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp
JPS5540616A (en) * 1978-09-14 1980-03-22 Otsuka Pharmaceut Co Ltd Preparation of benzo-hetero-compound
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
JPS55149284A (en) * 1980-05-02 1980-11-20 Otsuka Pharmaceut Co Ltd Piperazinylbenzo heterocyclic derivative
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
SU1428201A3 (ru) * 1980-12-18 1988-09-30 Оцука Фармасьютикал Ко.,Лтд (Фирма) Способ получени бензогетероциклических соединений

Also Published As

Publication number Publication date
ATA474881A (de) 1992-02-15
KR880001625B1 (ko) 1988-09-02
DK495281A (da) 1982-05-11
FR2493849B1 (enExample) 1984-12-28
DE3144455C2 (enExample) 1990-10-04
DE3144455A1 (de) 1982-06-24
NO156828C (no) 1987-12-02
DE10075035I1 (de) 2001-02-22
FI71141B (fi) 1986-08-14
GB2086905A (en) 1982-05-19
NO813726L (no) 1982-05-11
PH16685A (en) 1983-12-13
ATA288789A (de) 1991-03-15
KR830007643A (ko) 1983-11-04
SU1277896A3 (ru) 1986-12-15
US4552879A (en) 1985-11-12
CH648845A5 (de) 1985-04-15
FI71141C (fi) 1986-11-24
DK160940C (da) 1991-10-21
AU7733581A (en) 1982-08-05
IT1171646B (it) 1987-06-10
CA1179341A (en) 1984-12-11
NO156828B (no) 1987-08-24
NL193457B (nl) 1999-07-01
IT8149656A0 (it) 1981-11-09
US4399134A (en) 1983-08-16
AT395150B (de) 1992-09-25
ES507493A0 (es) 1983-02-01
ES8401035A1 (es) 1983-12-01
SU1366055A3 (ru) 1988-01-07
GB2086905B (en) 1984-12-05
AT393383B (de) 1991-10-10
FR2493849A1 (fr) 1982-05-14
DE10075035I2 (de) 2002-03-28
IT8149656A1 (it) 1983-05-09
SE448542B (sv) 1987-03-02
NL193457C (nl) 1999-11-02
SE8106642L (sv) 1982-06-14
AU546358B2 (en) 1985-08-29
PT73957B (en) 1983-04-18
PT73957A (en) 1981-12-01
FI813526L (fi) 1982-05-11
NL8105075A (nl) 1982-06-01
DK160940B (da) 1991-05-06
ES516523A0 (es) 1983-12-01

Similar Documents

Publication Publication Date Title
ES8301981A1 (es) Procedimiento de preparar compuestos benzoheterociclicos.
KR840000515A (ko) N-아릴-피페라진알칸아미드의 제조법
KR840000463A (ko) 광학적으로 활성인 1-방향족 그룹으로 치환된-1- 알카논의 제조방법
DE3462498D1 (en) Alkanoyloxybenzenesulfonate salt production
ES8104243A1 (es) Un procedimiento para la preparacion de derivados de imida- zolidina
DK557281A (da) Fremgangsmaade til indfoering af alkoxy- og aralkyloxygrupper i organiske forbindelser
AU579116B2 (en) Use of quinoline derivatives for the protection of cultivated plants
ES2054231T3 (es) Procedimiento para preparar oxido de estireno.
PT84467B (en) Process for preparing 1-phenylimidazolcarbonic acid amides and of growth plant regulators containing the same
BG48694A3 (en) Method for preparing alkandiol- dicarboxilates
ES8304920A1 (es) Un procedimiento para preparar derivados de n-acil-n-hidroxi-a minoacidos.
ES8506632A1 (es) Un derivado de quinolina
ES8301919A1 (es) Procedimiento para preparar derivados de indano
DE69311999D1 (de) Verfahren zur Herstellung von Amino-Thiadiazolylacetylhaliden
ES485801A1 (es) Un procedimiento de preparacion de ciclo-1,3,2-oxazafosfo- ril-derivados
JPS57212172A (en) Preparation of cyanuric halide derivative
NO861574L (no) Fremgangsmaate for fremstilling av 2,2,2-trifluoretanol.
ES8302640A1 (es) Procedimiento para preparar derivados de benzoilurea
JPS5794003A (en) Perfluorocarbon polymer and its production
JPS55151547A (en) Production of guanidinocapronic ester
DK145948C (da) Fremgangsmaade til fremstilling af sulfonimidoylxanthon-2-carboxylsyrederivater
GB1161057A (en) A process for Amidating Alcohols
JPS6468354A (en) Novel indoleacetic acid derivative
JPS5540633A (en) Preparation of isocyanuric acid triester
GB1087089A (en) Sulphurised diacids and the preparation thereof

Legal Events

Date Code Title Description
SPCF Request for supplementary protection certificate filed

Free format text: NADIFLOXACINO (NADIXA)

Spc suppl protection certif: C200200003

Filing date: 20020122

SPCG Supplementary protection certificate granted

Free format text: NADIFLOXACINO (NADIXA)

Spc suppl protection certif: C200200003

Filing date: 20020122

Expiry date: 20071110

Effective date: 20020403