ES8301962A1 - Un procedimiento para la produccion de un derivado de carboslivilo. - Google Patents

Un procedimiento para la produccion de un derivado de carboslivilo.

Info

Publication number
ES8301962A1
ES8301962A1 ES500137A ES500137A ES8301962A1 ES 8301962 A1 ES8301962 A1 ES 8301962A1 ES 500137 A ES500137 A ES 500137A ES 500137 A ES500137 A ES 500137A ES 8301962 A1 ES8301962 A1 ES 8301962A1
Authority
ES
Spain
Prior art keywords
group
image
formula
same
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500137A
Other languages
English (en)
Spanish (es)
Other versions
ES500137A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2880580A external-priority patent/JPS56125370A/ja
Priority claimed from JP11502280A external-priority patent/JPS5738772A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES500137A0 publication Critical patent/ES500137A0/es
Publication of ES8301962A1 publication Critical patent/ES8301962A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES500137A 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo. Expired ES8301962A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2880580A JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative
JP11502280A JPS5738772A (en) 1980-08-20 1980-08-20 Carbostyril derivative

Publications (2)

Publication Number Publication Date
ES500137A0 ES500137A0 (es) 1982-11-01
ES8301962A1 true ES8301962A1 (es) 1982-11-01

Family

ID=26366952

Family Applications (4)

Application Number Title Priority Date Filing Date
ES500137A Expired ES8301962A1 (es) 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo.
ES509659A Expired ES8306141A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES509658A Expired ES8305356A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES518667A Expired ES8405782A1 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES509659A Expired ES8306141A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES509658A Expired ES8305356A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES518667A Expired ES8405782A1 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Country Status (21)

Country Link
US (4) US4455422A (show.php)
AT (1) AT381307B (show.php)
AU (1) AU523005B2 (show.php)
BE (1) BE887800A (show.php)
CA (1) CA1155119A (show.php)
CH (1) CH647775A5 (show.php)
DE (2) DE3152880C2 (show.php)
DK (1) DK155282C (show.php)
ES (4) ES8301962A1 (show.php)
FI (1) FI76323C (show.php)
FR (1) FR2477542A1 (show.php)
GB (1) GB2071094B (show.php)
IT (1) IT1144315B (show.php)
MX (1) MX6980E (show.php)
NL (1) NL184364C (show.php)
NO (1) NO159531C (show.php)
PH (1) PH17194A (show.php)
PT (1) PT72622B (show.php)
RU (1) RU1779249C (show.php)
SE (1) SE447255B (show.php)
SU (1) SU1367857A3 (show.php)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3509131A1 (de) * 1985-03-14 1986-09-18 Fa. Carl Zeiss, 7920 Heidenheim Verfahren zur justierten montage der optischen bauteile eines optischen geraetes
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
DK167187A (da) 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4886809A (en) * 1986-07-31 1989-12-12 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
DE3802030A1 (de) * 1988-01-25 1989-07-27 Hoechst Ag Makroporoese, asymmetrische, hydrophile membran aus polyaramid
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
FR2634206B1 (fr) * 1988-07-12 1992-05-15 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
ATE192149T1 (de) * 1990-05-10 2000-05-15 Pfizer Neuroprotective indolone und verwandte derivate
FR2668149B1 (fr) * 1990-10-18 1994-09-23 Synthelabo Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5189171A (en) * 1991-06-21 1993-02-23 American Home Products Corporation Antipsychotic benzodioxan derivatives
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
FI940192A7 (fi) * 1991-07-17 1994-01-14 Pfizer 2-(4-hydroksipiperidino)-1-alkonolijohdannaisia verettömyyden vastaisi na aineina
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
WO1994022826A1 (en) * 1993-04-07 1994-10-13 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients
ES2128629T3 (es) * 1994-10-31 1999-05-16 Merck Patent Gmbh Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos.
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
DE19812331A1 (de) * 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
FR2823749B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
MY129350A (en) * 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
CN101007803B (zh) * 2002-03-13 2012-03-21 詹森药业有限公司 用作新的组蛋白脱乙酰化酶抑制剂的哌嗪基、哌啶基和吗啉基衍生物
AU2003212335B8 (en) * 2002-03-13 2009-04-23 Janssen Pharmaceutica N.V. Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
AU2003209727B2 (en) 2002-03-13 2008-10-16 Janssen Pharmaceutica N.V. Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
CA2476067C (en) * 2002-03-13 2011-09-20 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
AU2005266312C1 (en) * 2004-07-28 2011-06-16 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
UA86066C2 (ru) * 2004-07-28 2009-03-25 Янссен Фармацевтика Н.В. Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы
AU2005266311B2 (en) * 2004-07-28 2011-08-11 Janssen Pharmaceutica N.V. Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US8138198B2 (en) 2005-05-18 2012-03-20 Angibaud Patrick Rene Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
CN101370790B (zh) 2006-01-19 2015-10-21 詹森药业有限公司 作为组蛋白去乙酰化酶抑制剂的吡啶和嘧啶衍生物
CN101370803B (zh) * 2006-01-19 2012-12-12 詹森药业有限公司 作为组蛋白脱乙酰酶抑制剂的取代的吲哚基-烷基-氨基衍生物
JP5137848B2 (ja) * 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
WO2007082878A1 (en) * 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Aminophenyl derivatives as novel inhibitors of histone deacetylase
WO2007099828A1 (ja) * 2006-02-23 2007-09-07 Shionogi & Co., Ltd. 環式基で置換された含窒素複素環誘導体
WO2009034029A2 (de) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten
AU2010217772B2 (en) 2009-02-26 2014-10-23 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
US9951088B2 (en) * 2012-05-09 2018-04-24 Sunovion Pharmaceuticals Inc. D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders
CN106608875A (zh) 2015-10-26 2017-05-03 江苏恩华药业股份有限公司 一种稠和杂环类衍生物合成及其应用
CN108031471A (zh) * 2017-10-27 2018-05-15 苏州盖德精细材料有限公司 一种静电纺丝制备的负载型纳米纤维催化剂及其在3,5-二羟基甲苯制备中的应用
CN108250058B (zh) * 2018-01-19 2022-02-11 上海怡立舍生物技术有限公司 Ppar激动剂及其在治疗老年痴呆及其他疾病中的用途
CN116554127B (zh) * 2022-01-28 2025-03-21 成都麻沸散医药科技有限公司 哌嗪取代苯酚类衍生物及其用途

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US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
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FR2336674A1 (fr) * 1975-12-24 1977-07-22 Kronenbourg Brasseries Appareil pour la mesure automatique du temps de resorption de la mousse, en particulier d'une boisson gazeuse, notamment la biere
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DE2719562C2 (de) * 1976-05-08 1986-05-07 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo 3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
JPS6026797B2 (ja) * 1976-07-12 1985-06-25 大塚製薬株式会社 新規なカルボスチリル誘導体
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
JPS5527158A (en) * 1978-08-16 1980-02-27 Otsuka Pharmaceut Co Ltd 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative
JPS5583749A (en) * 1978-12-19 1980-06-24 Yoshitomi Pharmaceut Ind Ltd Quinolone derivative
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JPS5589222A (en) * 1978-12-28 1980-07-05 Otsuka Pharmaceut Co Ltd Antihistaminic agent
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
US4455422A (en) 1984-06-19
ES509659A0 (es) 1983-05-01
IT8167311A0 (it) 1981-03-05
BE887800A (fr) 1981-09-07
NO159531C (no) 1989-01-11
ES518667A0 (es) 1984-06-16
SE8101409L (sv) 1981-09-07
NL184364C (nl) 1989-07-03
ES509658A0 (es) 1983-04-01
ATA98481A (de) 1986-02-15
DK99781A (da) 1981-09-07
ES8405782A1 (es) 1984-06-16
GB2071094B (en) 1984-09-26
FI76323B (fi) 1988-06-30
DE3152880C2 (show.php) 1990-03-22
ES500137A0 (es) 1982-11-01
DE3107601C2 (show.php) 1989-07-20
CA1155119A (en) 1983-10-11
PT72622B (en) 1982-06-15
NL8101099A (nl) 1981-10-01
NO810765L (no) 1981-09-07
US4619932A (en) 1986-10-28
RU1779249C (ru) 1992-11-30
AU6797381A (en) 1981-09-10
PH17194A (en) 1984-06-19
DE3107601A1 (de) 1982-02-04
NO159531B (no) 1988-10-03
US4460593A (en) 1984-07-17
GB2071094A (en) 1981-09-16
ES8306141A1 (es) 1983-05-01
IT1144315B (it) 1986-10-29
AU523005B2 (en) 1982-07-08
FI76323C (fi) 1988-10-10
DK155282C (da) 1989-08-07
SU1367857A3 (ru) 1988-01-15
ES8305356A1 (es) 1983-04-01
NL184364B (nl) 1989-02-01
SE447255B (sv) 1986-11-03
FR2477542B1 (show.php) 1983-09-09
FR2477542A1 (fr) 1981-09-11
CH647775A5 (de) 1985-02-15
FI810669L (fi) 1981-09-07
AT381307B (de) 1986-09-25
US4567187A (en) 1986-01-28
PT72622A (en) 1981-04-01
DK155282B (da) 1989-03-20
MX6980E (es) 1987-01-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201