ES8301950A1 - Un procedimiento para la preparacion de un derivado de tia- zol - Google Patents
Un procedimiento para la preparacion de un derivado de tia- zolInfo
- Publication number
- ES8301950A1 ES8301950A1 ES505950A ES505950A ES8301950A1 ES 8301950 A1 ES8301950 A1 ES 8301950A1 ES 505950 A ES505950 A ES 505950A ES 505950 A ES505950 A ES 505950A ES 8301950 A1 ES8301950 A1 ES 8301950A1
- Authority
- ES
- Spain
- Prior art keywords
- relating
- thiazole derivatives
- disubstituted thiazole
- disubstituted
- ethenediamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2,4-disubstituted thiazole Chemical class 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 150000002357 guanidines Chemical class 0.000 abstract 1
- 229940077716 histamine h2 receptor antagonists for peptic ulcer and gord Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/193,192 US4375547A (en) | 1980-10-02 | 1980-10-02 | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES505950A0 ES505950A0 (es) | 1983-01-01 |
| ES8301950A1 true ES8301950A1 (es) | 1983-01-01 |
Family
ID=22712591
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES505950A Expired ES8301950A1 (es) | 1980-10-02 | 1981-10-01 | Un procedimiento para la preparacion de un derivado de tia- zol |
| ES514868A Granted ES514868A0 (es) | 1980-10-02 | 1982-08-09 | "un procedimiento para la preparacion de un derivado de tiazol". |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES514868A Granted ES514868A0 (es) | 1980-10-02 | 1982-08-09 | "un procedimiento para la preparacion de un derivado de tiazol". |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US4375547A (OSRAM) |
| EP (1) | EP0049618B1 (OSRAM) |
| JP (1) | JPS5791980A (OSRAM) |
| KR (1) | KR850001795B1 (OSRAM) |
| AR (1) | AR241439A1 (OSRAM) |
| AU (1) | AU542553B2 (OSRAM) |
| BG (1) | BG60249B1 (OSRAM) |
| CA (1) | CA1166248A (OSRAM) |
| CS (1) | CS227015B2 (OSRAM) |
| CY (1) | CY1351A (OSRAM) |
| DD (1) | DD200371A5 (OSRAM) |
| DE (1) | DE3171819D1 (OSRAM) |
| DK (2) | DK164056C (OSRAM) |
| EG (1) | EG15678A (OSRAM) |
| ES (2) | ES8301950A1 (OSRAM) |
| FI (2) | FI76570C (OSRAM) |
| GB (1) | GB2084581B (OSRAM) |
| GR (1) | GR75023B (OSRAM) |
| HK (1) | HK15987A (OSRAM) |
| HU (1) | HU188697B (OSRAM) |
| IE (1) | IE51603B1 (OSRAM) |
| IL (1) | IL63980A (OSRAM) |
| LU (1) | LU88293I2 (OSRAM) |
| MX (1) | MX5723A (OSRAM) |
| MY (1) | MY8700247A (OSRAM) |
| NL (1) | NL930107I2 (OSRAM) |
| NO (1) | NO155885C (OSRAM) |
| NZ (1) | NZ198523A (OSRAM) |
| PH (1) | PH18135A (OSRAM) |
| PL (2) | PL130626B1 (OSRAM) |
| PT (1) | PT73757B (OSRAM) |
| RO (2) | RO82215A (OSRAM) |
| SU (1) | SU1184443A3 (OSRAM) |
| UA (1) | UA6081A1 (OSRAM) |
| YU (1) | YU42728B (OSRAM) |
| ZA (1) | ZA816817B (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904792A (en) * | 1980-10-02 | 1990-02-27 | Eli Lilly And Company | N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds |
| CA1206151A (en) * | 1981-12-28 | 1986-06-17 | Richard P. Pioch | Pyrimidone anti-ulcer agents |
| US4474794A (en) * | 1982-03-19 | 1984-10-02 | Eli Lilly And Company | N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds |
| FR2531703A1 (fr) * | 1982-08-13 | 1984-02-17 | Sanofi Sa | 2-aza-5-thiahexan-1-ones 1,6-disubstituees, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant |
| ATE84530T1 (de) * | 1983-02-07 | 1993-01-15 | Lilly Co Eli | Synthese von nizatidin. |
| US4587344A (en) * | 1983-02-07 | 1986-05-06 | Eli Lilly And Company | Isothiourea synthesis process |
| US4468517A (en) * | 1983-05-12 | 1984-08-28 | Eli Lilly And Company | Synthesis of thiazoles |
| DE3417127A1 (de) * | 1984-05-09 | 1985-11-14 | Papst-Motoren GmbH & Co KG, 7742 St Georgen | Kleinstventilator |
| DE3531504A1 (de) * | 1985-09-04 | 1987-03-12 | Basf Ag | 3-aminomethylpyrrol-1-yl-alkylamine und diese verbindungen enthaltende therapeutische mittel |
| US4777260A (en) * | 1985-12-18 | 1988-10-11 | Eli Lilly And Company | Synthesis of nizatidine intermediate |
| CA1277325C (en) * | 1985-12-18 | 1990-12-04 | Bruce A. Slomski | Synthesis of nizatidine |
| ES2053462T3 (es) * | 1987-04-06 | 1994-08-01 | Heumann Pharma Gmbh & Co | Procedimiento para la produccion de derivados de nitroetano. |
| ES2007959A6 (es) * | 1988-07-11 | 1989-07-01 | Vinas Lab | Procedimiento para la obtencion de derivados tiazolicos. |
| ES2151480T3 (es) * | 1991-05-21 | 2001-01-01 | Lilly Co Eli | Procedimiento para preparar productos intermedios de nizatidina y compuestos relacionados. |
| ES2038922B1 (es) * | 1991-12-30 | 1994-04-16 | Fermentaciones Y Sintesis Espa | Procedimiento para la obtencion de nizatidina. |
| US5294433A (en) * | 1992-04-15 | 1994-03-15 | The Procter & Gamble Company | Use of H-2 antagonists for treatment of gingivitis |
| AU662454B2 (en) * | 1992-05-12 | 1995-08-31 | Zeria Pharmaceutical Co., Ltd. | Novel quaternary ammonium salts and use thereof as medicine |
| US5541335A (en) * | 1994-07-11 | 1996-07-30 | Torcan Chemical Ltd. | Process for preparing nizatidine |
| US5470865A (en) * | 1994-08-30 | 1995-11-28 | Eli Lilly And Company | Pharmaceutical composition |
| US6069256A (en) * | 1996-09-11 | 2000-05-30 | Knoll Aktiengesellschaft | Process for the preparation of nizatidine |
| IT1299198B1 (it) * | 1998-03-05 | 2000-02-29 | Nicox Sa | Sali nitrati di farmaci antiulcera |
| EP1140066A4 (en) | 1998-11-17 | 2005-11-09 | Nitromed Inc | NITRO- AND NITROSYL COMPOUNDS OF H2 RECEPTOR ANTAGONISTS, COMPOSITIONS AND THEIR USES OF USE |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| WO2005115341A2 (en) * | 2004-05-27 | 2005-12-08 | Advanced Bionutrition Corporation | Microparticles for oral delivery |
| US20080045575A1 (en) * | 2004-12-29 | 2008-02-21 | Van Dyke Thomas E | Delivery of H2 Antagonists |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| US20090275622A1 (en) * | 2008-04-30 | 2009-11-05 | Prasoona Linga | Nizatidine formulations |
| ES2924478T3 (es) | 2012-03-15 | 2022-10-07 | Boehringer Ingelheim Vetmedica Gmbh | Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos |
| CN105377235A (zh) | 2013-07-19 | 2016-03-02 | 勃林格殷格翰动物保健有限公司 | 含有防腐的醚化的环糊精衍生物的液体水性药物组合物 |
| KR102308973B1 (ko) | 2013-12-04 | 2021-10-08 | 베링거잉겔하임베트메디카게엠베하 | 개선된 피모벤단의 약제학적 조성물 |
| EP2929884A1 (en) | 2014-04-11 | 2015-10-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of dabigatran and h2-receptor antagonists |
| WO2015169957A1 (en) | 2014-05-09 | 2015-11-12 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of rivaroxaban and h2-receptor antagonists |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| US3917593A (en) * | 1972-05-22 | 1975-11-04 | Smithkline Corp | N-alkenyl and N-alkynyl (2-quinolyl)thio-acetamides |
| US3853865A (en) * | 1972-06-26 | 1974-12-10 | Smithkline Corp | N-aminomethyl-2-amino(and 2-amino-methyl)-2-heterocyclic-thioacetamides |
| GB1421792A (en) * | 1973-05-17 | 1976-01-21 | Smith Kline French Lab | Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them |
| US4191769A (en) * | 1974-03-12 | 1980-03-04 | Smith Kline & French Laboratories Limited | Isothiourea compounds and pharmacological use |
| US4061637A (en) * | 1974-05-14 | 1977-12-06 | Istituto Luso Farmaco D'italia S.R.L. | Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones |
| US4173644A (en) * | 1975-02-03 | 1979-11-06 | Smith Kline & French Laboratories Limited | Thiourea compounds, compositions and methods and use |
| US4166856A (en) * | 1975-05-21 | 1979-09-04 | Smith Kline & French Laboratories Limited | Thiazole and isothiazole derivative as blockers of histamine H2 -receptors |
| GB1574214A (en) * | 1976-03-11 | 1980-09-03 | Smith Kline French Lab | Amidines |
| GB1602458A (en) * | 1977-05-05 | 1981-11-11 | Smith Kline French Lab | Bisamidines as histamine h2-antagonists |
| JPS5444660A (en) * | 1977-08-29 | 1979-04-09 | Yamanouchi Pharmaceut Co Ltd | Heterocyclic compound and its preparation |
| DE2835695A1 (de) * | 1977-08-29 | 1979-03-15 | Yamanouchi Pharma Co Ltd | Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten |
| US4210658A (en) * | 1977-09-08 | 1980-07-01 | Smith Kline & French Laboratories Limited | Amidinosulphonic acid derivatives |
| DE2905134A1 (de) * | 1978-02-17 | 1979-08-23 | Degussa | Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest |
| EP0006679B1 (en) * | 1978-05-24 | 1982-07-21 | Imperial Chemical Industries Plc | Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| US4200578A (en) * | 1978-12-18 | 1980-04-29 | Bristol-Myers Company | Thiazole derivatives |
-
1980
- 1980-10-02 US US06/193,192 patent/US4375547A/en not_active Expired - Lifetime
-
1981
- 1981-10-01 UA UA3344304A patent/UA6081A1/uk unknown
- 1981-10-01 AU AU75945/81A patent/AU542553B2/en not_active Expired
- 1981-10-01 YU YU2364/81A patent/YU42728B/xx unknown
- 1981-10-01 RO RO81105440A patent/RO82215A/ro unknown
- 1981-10-01 CA CA000387139A patent/CA1166248A/en not_active Expired
- 1981-10-01 NZ NZ198523A patent/NZ198523A/en unknown
- 1981-10-01 PT PT73757A patent/PT73757B/pt unknown
- 1981-10-01 DK DK435181A patent/DK164056C/da not_active IP Right Cessation
- 1981-10-01 CS CS817182A patent/CS227015B2/cs unknown
- 1981-10-01 SU SU813344304A patent/SU1184443A3/ru active
- 1981-10-01 RO RO110860A patent/RO85815B/ro unknown
- 1981-10-01 HU HU812844A patent/HU188697B/hu unknown
- 1981-10-01 PH PH26296A patent/PH18135A/en unknown
- 1981-10-01 IE IE2285/81A patent/IE51603B1/en not_active IP Right Cessation
- 1981-10-01 IL IL63980A patent/IL63980A/xx not_active IP Right Cessation
- 1981-10-01 NO NO813334A patent/NO155885C/no not_active IP Right Cessation
- 1981-10-01 FI FI813058A patent/FI76570C/fi not_active IP Right Cessation
- 1981-10-01 FI FI810358A patent/FI813058L/fi not_active Application Discontinuation
- 1981-10-01 ZA ZA816817A patent/ZA816817B/xx unknown
- 1981-10-01 ES ES505950A patent/ES8301950A1/es not_active Expired
- 1981-10-02 CY CY135181A patent/CY1351A/xx unknown
- 1981-10-02 PL PL1981238035A patent/PL130626B1/pl unknown
- 1981-10-02 BG BG053730A patent/BG60249B1/bg unknown
- 1981-10-02 GB GB8129855A patent/GB2084581B/en not_active Expired
- 1981-10-02 KR KR1019810003721A patent/KR850001795B1/ko not_active Expired
- 1981-10-02 PL PL1981233295A patent/PL130526B1/pl unknown
- 1981-10-02 JP JP56158594A patent/JPS5791980A/ja active Granted
- 1981-10-02 GR GR66193A patent/GR75023B/el unknown
- 1981-10-02 DD DD81233851A patent/DD200371A5/de unknown
- 1981-10-02 EP EP81304572A patent/EP0049618B1/en not_active Expired
- 1981-10-02 DE DE8181304572T patent/DE3171819D1/de not_active Expired
- 1981-10-03 EG EG566/81A patent/EG15678A/xx active
-
1982
- 1982-08-09 ES ES514868A patent/ES514868A0/es active Granted
- 1982-11-09 AR AR82291229A patent/AR241439A1/es active
-
1986
- 1986-11-25 MX MX572386A patent/MX5723A/es unknown
-
1987
- 1987-02-19 HK HK159/87A patent/HK15987A/en not_active IP Right Cessation
- 1987-12-30 MY MY247/87A patent/MY8700247A/xx unknown
-
1991
- 1991-01-24 DK DK012391A patent/DK167759B1/da not_active IP Right Cessation
-
1993
- 1993-06-09 LU LU88293C patent/LU88293I2/fr unknown
- 1993-06-29 NL NL930107C patent/NL930107I2/nl unknown
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