ES497458A0 - Procedimiento de preparar acido 1-(3-mercapto-(2s)-metilpro-pionil)-pirrolidina-(2s)-carboxilico - Google Patents
Procedimiento de preparar acido 1-(3-mercapto-(2s)-metilpro-pionil)-pirrolidina-(2s)-carboxilicoInfo
- Publication number
- ES497458A0 ES497458A0 ES497458A ES497458A ES497458A0 ES 497458 A0 ES497458 A0 ES 497458A0 ES 497458 A ES497458 A ES 497458A ES 497458 A ES497458 A ES 497458A ES 497458 A0 ES497458 A0 ES 497458A0
- Authority
- ES
- Spain
- Prior art keywords
- pionil
- metilpro
- pirrolidina
- carboxilico
- mercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/38—Acyl halides
- C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
- C07C53/50—Acyl halides containing halogen outside the carbonyl halide group of acids containing three or more carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU79EE2720A HU184082B (en) | 1979-12-29 | 1979-12-29 | Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
ES497458A0 true ES497458A0 (es) | 1981-11-16 |
ES8200340A1 ES8200340A1 (es) | 1981-11-16 |
Family
ID=10995884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES497458A Expired ES8200340A1 (es) | 1979-12-29 | 1980-12-04 | Procedimiento de preparar acido 1-(3-mercapto-(2s)-metilpro-pionil)-pirrolidina-(2s)-carboxilico |
Country Status (21)
Country | Link |
---|---|
US (1) | US4332725A (es) |
JP (1) | JPS6058230B2 (es) |
AT (1) | AT375340B (es) |
CA (1) | CA1137499A (es) |
CH (1) | CH646423A5 (es) |
CS (1) | CS219935B2 (es) |
DD (1) | DD155898A5 (es) |
DE (1) | DE3049273C2 (es) |
DK (1) | DK157009C (es) |
ES (1) | ES8200340A1 (es) |
FI (1) | FI67693C (es) |
GB (1) | GB2066252B (es) |
GR (1) | GR72303B (es) |
HU (1) | HU184082B (es) |
NL (1) | NL186960C (es) |
NO (1) | NO154307C (es) |
PL (1) | PL130249B1 (es) |
PT (1) | PT72222B (es) |
SE (1) | SE440350B (es) |
SU (1) | SU1139374A3 (es) |
YU (1) | YU43485B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4385062A (en) * | 1980-01-09 | 1983-05-24 | Gruppo Lepetit S.P.A. | 1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
HU208954B (en) * | 1990-09-21 | 1994-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn |
DE3124091C2 (de) * | 1981-06-19 | 1983-06-01 | Degussa Ag, 6000 Frankfurt | N-(3-Cyanopropanoyl)-aminocarbonsäureester und deren Verwendung |
JPS58124764A (ja) * | 1982-01-20 | 1983-07-25 | Kanegafuchi Chem Ind Co Ltd | 光学活性チオ−ル化合物の製造法 |
KR860001391B1 (ko) * | 1984-07-23 | 1986-09-22 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
KR870001570B1 (ko) * | 1984-12-19 | 1987-09-04 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
KR870001569B1 (ko) * | 1985-02-11 | 1987-09-04 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
HU196368B (en) * | 1986-07-04 | 1988-11-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid |
JPH026833A (ja) * | 1988-06-24 | 1990-01-11 | Nippon Alum Mfg Co Ltd | 粉粒体混合装置 |
US5166361A (en) * | 1988-09-13 | 1992-11-24 | Sepracor, Inc. | Methods for preparing captopril and its analogues |
IL91581A (en) * | 1988-09-13 | 1993-07-08 | Sepracor Inc | Methods for preparing optically active captopril and its analogues |
US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
KR940005014B1 (ko) * | 1991-11-07 | 1994-06-09 | 보령제약 주식회사 | 피롤리딘카르복실산 유도체의 제조방법 |
HUT64965A (en) * | 1992-03-13 | 1994-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for the production of 2-imino-selenazolydes and medical preparations containing them |
CN102452970A (zh) * | 2010-10-16 | 2012-05-16 | 华中药业股份有限公司 | D-3-溴-2-甲基丙酰-l-脯氨酸的制备方法 |
CN103086940B (zh) * | 2011-10-28 | 2014-07-09 | 华中药业股份有限公司 | 一种1-(3-巯基-2-d-甲基丙酰基)-l-脯氨酸的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4241076A (en) * | 1978-02-21 | 1980-12-23 | E. R. Squibb & Sons, Inc. | Halogenated substituted mercaptoacylamino acids |
CA1132985A (en) * | 1978-12-22 | 1982-10-05 | John Krapcho | Ketal and thioketal derivatives of mercaptoacyl prolines |
US4181663A (en) * | 1979-01-29 | 1980-01-01 | E. R. Squibb & Sons, Inc. | Selenium containing derivatives of proline and pipecolic acid |
US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
US4284561A (en) * | 1979-12-03 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of mercaptoacyl amino acids |
-
1979
- 1979-12-29 HU HU79EE2720A patent/HU184082B/hu unknown
-
1980
- 1980-11-28 AT AT0582080A patent/AT375340B/de not_active IP Right Cessation
- 1980-12-03 CA CA000366072A patent/CA1137499A/en not_active Expired
- 1980-12-04 ES ES497458A patent/ES8200340A1/es not_active Expired
- 1980-12-04 NL NLAANVRAGE8006613,A patent/NL186960C/xx not_active IP Right Cessation
- 1980-12-15 SU SU803228098A patent/SU1139374A3/ru active
- 1980-12-18 PT PT72222A patent/PT72222B/pt not_active IP Right Cessation
- 1980-12-18 SE SE8008942A patent/SE440350B/sv not_active IP Right Cessation
- 1980-12-18 CS CS809026A patent/CS219935B2/cs unknown
- 1980-12-22 US US06/218,814 patent/US4332725A/en not_active Expired - Lifetime
- 1980-12-23 FI FI804016A patent/FI67693C/fi not_active IP Right Cessation
- 1980-12-23 GR GR63748A patent/GR72303B/el unknown
- 1980-12-23 DK DK553680A patent/DK157009C/da not_active IP Right Cessation
- 1980-12-23 PL PL1980228689A patent/PL130249B1/pl unknown
- 1980-12-23 DD DD80226586A patent/DD155898A5/de unknown
- 1980-12-23 NO NO803939A patent/NO154307C/no unknown
- 1980-12-24 CH CH956480A patent/CH646423A5/de unknown
- 1980-12-24 YU YU3259/80A patent/YU43485B/xx unknown
- 1980-12-29 GB GB8041403A patent/GB2066252B/en not_active Expired
- 1980-12-29 DE DE3049273A patent/DE3049273C2/de not_active Expired
- 1980-12-29 JP JP55189498A patent/JPS6058230B2/ja not_active Expired
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