NL186960C - Werkwijze voor het bereiden van 1-(3-mercapto-(2s)methylpropionyl)-pyrrolidine-(2s)-carbonzuur. - Google Patents
Werkwijze voor het bereiden van 1-(3-mercapto-(2s)methylpropionyl)-pyrrolidine-(2s)-carbonzuur.Info
- Publication number
- NL186960C NL186960C NLAANVRAGE8006613,A NL8006613A NL186960C NL 186960 C NL186960 C NL 186960C NL 8006613 A NL8006613 A NL 8006613A NL 186960 C NL186960 C NL 186960C
- Authority
- NL
- Netherlands
- Prior art keywords
- methylpropionyl
- pyrrolidine
- mercapto
- preparing
- carbonic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/38—Acyl halides
- C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
- C07C53/50—Acyl halides containing halogen outside the carbonyl halide group of acids containing three or more carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU79EE2720A HU184082B (en) | 1979-12-29 | 1979-12-29 | Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid |
HUEE002720 | 1979-12-29 |
Publications (3)
Publication Number | Publication Date |
---|---|
NL8006613A NL8006613A (nl) | 1981-08-03 |
NL186960B NL186960B (nl) | 1990-11-16 |
NL186960C true NL186960C (nl) | 1991-04-16 |
Family
ID=10995884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NLAANVRAGE8006613,A NL186960C (nl) | 1979-12-29 | 1980-12-04 | Werkwijze voor het bereiden van 1-(3-mercapto-(2s)methylpropionyl)-pyrrolidine-(2s)-carbonzuur. |
Country Status (21)
Country | Link |
---|---|
US (1) | US4332725A (nl) |
JP (1) | JPS6058230B2 (nl) |
AT (1) | AT375340B (nl) |
CA (1) | CA1137499A (nl) |
CH (1) | CH646423A5 (nl) |
CS (1) | CS219935B2 (nl) |
DD (1) | DD155898A5 (nl) |
DE (1) | DE3049273C2 (nl) |
DK (1) | DK157009C (nl) |
ES (1) | ES497458A0 (nl) |
FI (1) | FI67693C (nl) |
GB (1) | GB2066252B (nl) |
GR (1) | GR72303B (nl) |
HU (1) | HU184082B (nl) |
NL (1) | NL186960C (nl) |
NO (1) | NO154307C (nl) |
PL (1) | PL130249B1 (nl) |
PT (1) | PT72222B (nl) |
SE (1) | SE440350B (nl) |
SU (1) | SU1139374A3 (nl) |
YU (1) | YU43485B (nl) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4385062A (en) * | 1980-01-09 | 1983-05-24 | Gruppo Lepetit S.P.A. | 1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
HU208954B (en) * | 1990-09-21 | 1994-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn |
DE3124091C2 (de) * | 1981-06-19 | 1983-06-01 | Degussa Ag, 6000 Frankfurt | N-(3-Cyanopropanoyl)-aminocarbonsäureester und deren Verwendung |
JPS58124764A (ja) * | 1982-01-20 | 1983-07-25 | Kanegafuchi Chem Ind Co Ltd | 光学活性チオ−ル化合物の製造法 |
KR860001391B1 (ko) * | 1984-07-23 | 1986-09-22 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
KR870001570B1 (ko) * | 1984-12-19 | 1987-09-04 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
KR870001569B1 (ko) * | 1985-02-11 | 1987-09-04 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
HU196368B (en) * | 1986-07-04 | 1988-11-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid |
JPH026833A (ja) * | 1988-06-24 | 1990-01-11 | Nippon Alum Mfg Co Ltd | 粉粒体混合装置 |
US5166361A (en) * | 1988-09-13 | 1992-11-24 | Sepracor, Inc. | Methods for preparing captopril and its analogues |
IL91581A (en) * | 1988-09-13 | 1993-07-08 | Sepracor Inc | Methods for preparing optically active captopril and its analogues |
US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
KR940005014B1 (ko) * | 1991-11-07 | 1994-06-09 | 보령제약 주식회사 | 피롤리딘카르복실산 유도체의 제조방법 |
HUT64965A (en) * | 1992-03-13 | 1994-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for the production of 2-imino-selenazolydes and medical preparations containing them |
CN102452970A (zh) * | 2010-10-16 | 2012-05-16 | 华中药业股份有限公司 | D-3-溴-2-甲基丙酰-l-脯氨酸的制备方法 |
CN103086940B (zh) * | 2011-10-28 | 2014-07-09 | 华中药业股份有限公司 | 一种1-(3-巯基-2-d-甲基丙酰基)-l-脯氨酸的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4241076A (en) * | 1978-02-21 | 1980-12-23 | E. R. Squibb & Sons, Inc. | Halogenated substituted mercaptoacylamino acids |
CA1132985A (en) * | 1978-12-22 | 1982-10-05 | John Krapcho | Ketal and thioketal derivatives of mercaptoacyl prolines |
US4181663A (en) * | 1979-01-29 | 1980-01-01 | E. R. Squibb & Sons, Inc. | Selenium containing derivatives of proline and pipecolic acid |
US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
US4284561A (en) * | 1979-12-03 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of mercaptoacyl amino acids |
-
1979
- 1979-12-29 HU HU79EE2720A patent/HU184082B/hu unknown
-
1980
- 1980-11-28 AT AT0582080A patent/AT375340B/de not_active IP Right Cessation
- 1980-12-03 CA CA000366072A patent/CA1137499A/en not_active Expired
- 1980-12-04 ES ES497458A patent/ES497458A0/es active Granted
- 1980-12-04 NL NLAANVRAGE8006613,A patent/NL186960C/nl not_active IP Right Cessation
- 1980-12-15 SU SU803228098A patent/SU1139374A3/ru active
- 1980-12-18 PT PT72222A patent/PT72222B/pt not_active IP Right Cessation
- 1980-12-18 SE SE8008942A patent/SE440350B/sv not_active IP Right Cessation
- 1980-12-18 CS CS809026A patent/CS219935B2/cs unknown
- 1980-12-22 US US06/218,814 patent/US4332725A/en not_active Expired - Lifetime
- 1980-12-23 DK DK553680A patent/DK157009C/da not_active IP Right Cessation
- 1980-12-23 DD DD80226586A patent/DD155898A5/de unknown
- 1980-12-23 GR GR63748A patent/GR72303B/el unknown
- 1980-12-23 FI FI804016A patent/FI67693C/fi not_active IP Right Cessation
- 1980-12-23 PL PL1980228689A patent/PL130249B1/pl unknown
- 1980-12-23 NO NO803939A patent/NO154307C/no unknown
- 1980-12-24 YU YU3259/80A patent/YU43485B/xx unknown
- 1980-12-24 CH CH956480A patent/CH646423A5/de unknown
- 1980-12-29 GB GB8041403A patent/GB2066252B/en not_active Expired
- 1980-12-29 JP JP55189498A patent/JPS6058230B2/ja not_active Expired
- 1980-12-29 DE DE3049273A patent/DE3049273C2/de not_active Expired
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL189759C (nl) | Werkwijze voor het bereiden van aromatische etherimiden. | |
NL186960C (nl) | Werkwijze voor het bereiden van 1-(3-mercapto-(2s)methylpropionyl)-pyrrolidine-(2s)-carbonzuur. | |
NL185930C (nl) | Werkwijze voor het bereiden van een polyurethanelastomeer. | |
NL8003888A (nl) | Werkwijze voor het bereiden van aryl-1 arylsulfonyl-4-gamma aminopropoxy-3 ih-pyrazolen. | |
NL188691C (nl) | Werkwijze voor het bereiden van alfa-aminozuuramiden. | |
NL7904585A (nl) | Werkwijze voor het bereiden van 1-hydroxycalciferol- derivaten. | |
NL7903975A (nl) | Werkwijze voor het bereiden van pregnaanderivaten. | |
NL7805438A (nl) | Werkwijze voor het bereiden van p-hydroxyfenylazijnzuur. | |
NL7800488A (nl) | Werkwijze voor het bereiden van fenylazijnzuur. | |
NL190845C (nl) | Werkwijze voor het bereiden van linksdraaiend N-(1-ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoyl-benzamide. | |
NL7807439A (nl) | Werkwijze voor het bereiden van alpha-ketocarbonzuur- amiden; alphaketocarbonzuuramiden. | |
NL190756B (nl) | Werkwijze voor het bereiden van polychloor-3-trifluormethylpyridineverbindingen. | |
NL181436C (nl) | Werkwijze voor het bereiden van polyacetalcopolymeren. | |
NL7712999A (nl) | Werkwijze voor het bereiden van 6-aminopenicil- linezuur. | |
NL173644C (nl) | Werkwijze voor het bereiden van alfa-alkylthioazijnzuurderivaten. | |
NL7901164A (nl) | Werkwijze voor het bereiden van beta-santalol, beta-santaleen, dihydro-beta-santalol en verwante verbindingen. | |
NL192833B (nl) | Werkwijze voor het bereiden van een beta-hydroxyisoboterzuur. | |
NL190159C (nl) | Werkwijze voor het bereiden van n-ethylethyleendiamine. | |
NL7901788A (nl) | Werkwijze voor het bereiden van gesubstitueerde pyridinen. | |
NL7610557A (nl) | Werkwijze voor het bereiden van cyanuurzuur. | |
NL7811353A (nl) | Werkwijze voor het bereiden van 2,5-diketogluconzuur. | |
NL185076C (nl) | Werkwijze voor het bereiden van d,1-beta-benzoylamino-isoboterzuur. | |
NL7706899A (nl) | Werkwijze voor het bereiden van 3,3-dimethylpent- -4-enoisch zuur. | |
NL7610556A (nl) | Werkwijze voor het bereiden van cyanuurzuur. | |
NL7903063A (nl) | Werkwijze ter bereiding van p-chloorfenoxyacetyl- piperonylpiperazinehydrochloride. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A85 | Still pending on 85-01-01 | ||
BA | A request for search or an international-type search has been filed | ||
BB | A search report has been drawn up | ||
BC | A request for examination has been filed | ||
V1 | Lapsed because of non-payment of the annual fee |
Effective date: 20000701 |