AR226894A1 - Procedimiento para obtener(4-trifluormetil anilida de acido 5-metil isoxazol-4-carboxilico - Google Patents

Procedimiento para obtener(4-trifluormetil anilida de acido 5-metil isoxazol-4-carboxilico

Info

Publication number
AR226894A1
AR226894A1 AR285378A AR28537881A AR226894A1 AR 226894 A1 AR226894 A1 AR 226894A1 AR 285378 A AR285378 A AR 285378A AR 28537881 A AR28537881 A AR 28537881A AR 226894 A1 AR226894 A1 AR 226894A1
Authority
AR
Argentina
Prior art keywords
procedure
carboxylic acid
methyl isoxazole
trifluoromethyl anilide
anilide
Prior art date
Application number
AR285378A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19782854439 priority Critical patent/DE2854439A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AR226894A1 publication Critical patent/AR226894A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/825Arthritis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/903Multiple sclerosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/916Pyretic
AR285378A 1978-12-16 1981-05-19 Procedimiento para obtener(4-trifluormetil anilida de acido 5-metil isoxazol-4-carboxilico AR226894A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19782854439 DE2854439A1 (de) 1978-12-16 1978-12-16 Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung

Publications (1)

Publication Number Publication Date
AR226894A1 true AR226894A1 (es) 1982-08-31

Family

ID=6057414

Family Applications (2)

Application Number Title Priority Date Filing Date
AR279310A AR222680A1 (es) 1978-12-16 1979-12-14 Procedimiento para la preparacion de (4-trifluor-metil)-anilida de acido 5-metilisoxazol-4-carboxilico
AR285378A AR226894A1 (es) 1978-12-16 1981-05-19 Procedimiento para obtener(4-trifluormetil anilida de acido 5-metil isoxazol-4-carboxilico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AR279310A AR222680A1 (es) 1978-12-16 1979-12-14 Procedimiento para la preparacion de (4-trifluor-metil)-anilida de acido 5-metilisoxazol-4-carboxilico

Country Status (25)

Country Link
US (2) US4284786A (es)
EP (1) EP0013376B1 (es)
JP (1) JPH0133470B2 (es)
AR (2) AR222680A1 (es)
AT (1) AT1067T (es)
AU (1) AU529341B2 (es)
BG (1) BG60764B2 (es)
CA (1) CA1129867A (es)
DE (2) DE2854439A1 (es)
DK (1) DK149886C (es)
EG (1) EG13926A (es)
ES (2) ES486750A1 (es)
FI (1) FI64154C (es)
GR (1) GR72731B (es)
HU (1) HU178015B (es)
IE (1) IE49126B1 (es)
IL (1) IL58951A (es)
LU (1) LU90466I2 (es)
MX (2) MX6174E (es)
NL (1) NL990037I2 (es)
NO (1) NO148925C (es)
NZ (1) NZ192400A (es)
PH (1) PH16627A (es)
PT (1) PT70596A (es)
ZA (2) ZA7906793B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3247454A1 (de) * 1982-12-22 1984-06-28 Bago Sa Labor Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2538806B1 (fr) * 1982-12-30 1986-02-21 Bago Sa Labor Composes phenyl-3 methyl isoxazole-5 carboxy-4 anilides substitues, actifs therapeutiquement contre l'inflammation et la douleur
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) * 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
US4935434A (en) * 1988-01-26 1990-06-19 Bristol-Myers Company Antiarthritic isoxazole-4-carboxamides
US5258397A (en) * 1988-11-30 1993-11-02 Novapharme 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
DD297328A5 (de) 1989-08-18 1992-01-09 Alcon Laboratories,Inc.,Us 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
ES2102367T3 (es) * 1990-05-18 1997-08-01 Hoechst Ag Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion.
FR2662692B1 (fr) * 1990-05-30 1995-04-28 Novapharme Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique.
US6133301A (en) * 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
DE4127737A1 (de) 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
DE59407413D1 (de) * 1993-01-08 1999-01-21 Hoechst Ag Verwendung von Leflunomid zur Hemmung von Interleukin 1 beta
AT174219T (de) * 1993-01-08 1998-12-15 Hoechst Ag Verwendung von leflunomid zur hemmung von tumornekrosefaktor alpha
EP0607777B1 (de) * 1993-01-08 1998-12-09 Hoechst Aktiengesellschaft Verwendung von Leflunomid zur Hemmung von Interleukin 8
AT174217T (de) * 1993-01-08 1998-12-15 Hoechst Ag Verwendung von leflunomid zur hemmung von interleukin 1 alpha
TW314467B (es) * 1993-03-31 1997-09-01 Hoechst Ag
DE4323636A1 (de) * 1993-07-15 1995-01-19 Hoechst Ag Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung
LT3589B (en) 1993-11-30 1995-12-27 Hoechst Ag Using of known combination for treatment of rejection reaction by transplantation of organs
US5610173A (en) * 1994-01-07 1997-03-11 Sugen, Inc. Formulations for lipophilic compounds
US6335356B1 (en) 1994-01-07 2002-01-01 Sugen, Inc. Method of treating a patient by parenteral administration of a lipophilic compound
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
US5624946A (en) * 1994-07-05 1997-04-29 Williams; James Use of leflunomide to control and reverse chronic allograft rejection
AU695907B2 (en) * 1994-10-17 1998-08-27 Hoechst Pharmaceuticals & Chemicals K.K. Pharmaceutical composition for prophylaxis and treatment of type I allergic diseases
US5721277A (en) * 1995-04-21 1998-02-24 Sugen, Inc. Compounds and methods for inhibiting hyper-proliferative cell growth
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
DE19539638A1 (de) * 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
DE19702988A1 (de) * 1997-01-28 1998-07-30 Hoechst Ag Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
PT903345E (pt) * 1997-08-08 2001-01-31 Aventis Pharma Gmbh Forma cristalina de n-(4-trifluorometilfenil)-5-metil-isoxazolo-4-carboxamida
US7691890B2 (en) 1998-03-11 2010-04-06 James W. Williams Anti-viral uses of leflunomide products
US20050255071A1 (en) * 1998-12-10 2005-11-17 Aventis Pharma Deutschland Gmbh Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
DE19908527C2 (de) * 1999-02-26 2001-08-30 Aventis Pharma Gmbh Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
US6566395B1 (en) 1999-05-25 2003-05-20 Biomedicines, Inc. Methods of treating proliferative disorders
DE19960443C2 (de) * 1999-12-15 2002-05-08 Aventis Pharma Gmbh Verfahren zur Auffindung von Nukleotidsyntheseinhibitoren mit weniger Nebenwirkungen
CN1411373A (zh) * 1999-12-16 2003-04-16 特瓦制药工业有限公司 制备来氟米特的新方法和新晶形的来氟米特
SK12992002A3 (sk) * 2000-02-15 2003-05-02 Teva Pharmaceutical Industries Ltd. Spôsob syntézy leflunomidu
EP1473035A1 (en) * 2000-02-15 2004-11-03 Teva Pharmaceutical Industries Ltd. Leflunomide of high purity
WO2002013822A1 (en) * 2000-08-14 2002-02-21 Teva Pharmaceutical Industries Ltd. Micronized leflunomide
GB0123571D0 (en) 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
EP1381356B1 (en) 2001-04-05 2008-05-28 Aventis Pharmaceuticals Inc. Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
US20030139606A1 (en) * 2001-11-09 2003-07-24 Ray Anup Kumar Process for preparing 5-methylisoxazole-4-carboxylic- (4'-trifluoromethyl)-anilide
US20050158371A1 (en) * 2002-02-12 2005-07-21 Sumitomo Pharmaceuticals Co., Ltd. Novel external agent
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US20060024376A1 (en) * 2004-07-30 2006-02-02 The University Of Chicago Methods and compositions for reducing toxicity associated with leflunomide treatment
EP1920772A4 (en) * 2005-08-31 2010-11-17 Kowa Co PROPHYLACTIC AND / OR THERAPEUTIC METHOD FOR COMBATING RHEUMATOID ARTHRITIS
EP2125895B1 (en) * 2007-02-02 2015-04-08 Vegenics Pty Ltd Vegf receptor antagonists for treating organ transplant alloimmunity and arteriosclerosis
CN101817797B (zh) * 2009-02-26 2013-04-10 江苏亚邦爱普森药业有限公司 高纯度3-甲基-n-[4-(三氟甲基)苯基]-4-异噁唑甲酰胺的合成方法
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
EP3595657A1 (en) 2017-03-14 2020-01-22 Actelion Pharmaceuticals Ltd Pharmaceutical combination comprising ponesimod
CA3094324A1 (en) 2018-03-26 2019-10-03 Clear Creek Bio, Inc. Compositions and methods for inhibiting dihydroorotate dehydrogenase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087534A (en) * 1974-05-22 1978-05-02 David Ovadia N-haloalkylmio urazole pesticides
DE2524959C2 (es) * 1975-06-05 1983-02-10 Hoechst Ag, 6000 Frankfurt, De
ES448386A1 (es) * 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
DE2654797A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Verfahren zur herstellung von isoxazolderivaten

Also Published As

Publication number Publication date
BG60764B2 (bg) 1996-02-29
EP0013376A3 (en) 1980-09-17
NO794094L (no) 1980-06-17
EP0013376A2 (de) 1980-07-23
IL58951A (en) 1984-01-31
MX8403A (es) 1994-03-31
DK149886B (da) 1986-10-20
JPS5583767A (en) 1980-06-24
NO148925B (no) 1983-10-03
JPH0133470B2 (es) 1989-07-13
DE2962929D1 (en) 1982-07-08
IE792426L (en) 1980-06-16
PH16627A (en) 1983-12-05
ES486758A1 (es) 1980-05-16
MX6174E (es) 1984-12-04
FI793899A (fi) 1980-06-17
AU5385379A (en) 1980-06-19
IL58951D0 (en) 1980-03-31
EG13926A (en) 1982-09-30
DE2854439A1 (de) 1980-07-03
ES486750A1 (es) 1980-06-16
EP0013376B1 (de) 1982-05-19
ZA796793B (en) 1980-11-26
IE49126B1 (en) 1985-08-07
CA1129867A (en) 1982-08-17
HU178015B (en) 1982-02-28
US4351841A (en) 1982-09-28
LU90466A9 (es)
NZ192400A (en) 1982-02-23
PT70596A (en) 1980-01-01
GR72731B (es) 1983-12-01
AR222680A1 (es) 1981-06-15
CA1129867A1 (es)
ZA7906793B (en) 1980-11-26
FI64154C (fi) 1983-10-10
NL990037I2 (nl) 2000-01-03
LU90466I2 (fr) 2000-01-03
AU529341B2 (en) 1983-06-02
NL990037I1 (nl) 2000-01-03
NO148925C (no) 1984-01-11
AT1067T (de) 1982-06-15
FI64154B (fi) 1983-06-30
DK534279A (da) 1980-06-17
US4284786A (en) 1981-08-18
DK149886C (da) 1987-04-21

Similar Documents

Publication Publication Date Title
AR222680A1 (es) Procedimiento para la preparacion de (4-trifluor-metil)-anilida de acido 5-metilisoxazol-4-carboxilico
AR219150A1 (es) Procedimiento para preparar nuevos derivados de aminoazucares
AR218753A1 (es) Metodo de tratamiento de vidrio plano para reducir su vulnerabilidad a los rayados
AR215983A1 (es) Mejoras en un instrumento de medicion de masas y fuerzas
AR212401A1 (es) Elemento intermediario para sosten y conexiones de artefactos luminosos colgantes
AR212404A1 (es) Dispositivo cortador de masa
AR214951A1 (es) Una valvula de escape para bolsitas para cafe u otro producto granular envasado en caliente
AR215062A1 (es) Transductor electroacustico mejorado
AR212147A1 (es) Mejoras en filtros aplicables en los canos de escape de los vehiculos automotores
AR214766A1 (es) Un freno de disco
AR212143A1 (es) Mejoras en pantografos mecanicos
AR215165A1 (es) Silla plegadiza
AR212145A1 (es) Terminal receptor para conexiones electricas
AR212068A1 (es) Maquina agricola cosechadora y acordonadora
AR214476A1 (es) Dispositivo mejorado para el corte y el encendido automatico regulable de aparatos v artefactos electricos y electronicos
AR219642A1 (es) Aparato para la preparacion del armado de un accesorio de un cable electrico de aceite fluido
AR212067A1 (es) Maquina recolectora de flores
AR212066A1 (es) Maquina-herramienta de mesa
AR216184A1 (es) Un brazo de suspension,regulable para vehiculos automotores
AR214029A1 (es) Zanco de altura regulable
AR213798A1 (es) Cierre mejorado para la boca de descarga de compactadoras de residuos
AR212065A1 (es) Nuevos contactos para circuitos integrados
AR212063A1 (es) Silenciador para motores de combustion interna
AR212062A1 (es) Dispositivo para el montaje rapido de estructuras modulares del tipo formador de nudos provistos de insertos enchufables axialmente en tubulaciones adecuadas
AR214143A1 (es) Pico vertedor aplicable a tapas de hojalata