MX8403A - Procedimiento para la preparacion de (4-trifluro metil)-anilida de acido 5 metil-isoxasol-4-carboxilico. - Google Patents
Procedimiento para la preparacion de (4-trifluro metil)-anilida de acido 5 metil-isoxasol-4-carboxilico.Info
- Publication number
- MX8403A MX8403A MX8403A MX840384A MX8403A MX 8403 A MX8403 A MX 8403A MX 8403 A MX8403 A MX 8403A MX 840384 A MX840384 A MX 840384A MX 8403 A MX8403 A MX 8403A
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- isoxasol
- procedure
- preparation
- anilide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- GGDAWUSJZZHVBR-UHFFFAOYSA-N 3-oxo-n-[4-(trifluoromethyl)phenyl]butanamide Chemical compound CC(=O)CC(=O)NC1=CC=C(C(F)(F)F)C=C1 GGDAWUSJZZHVBR-UHFFFAOYSA-N 0.000 abstract 1
- ODGIMMLDVSWADK-UHFFFAOYSA-N 4-trifluoromethylaniline Chemical compound NC1=CC=C(C(F)(F)F)C=C1 ODGIMMLDVSWADK-UHFFFAOYSA-N 0.000 abstract 1
- WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 abstract 1
- RLAHWVDQYNDAGG-UHFFFAOYSA-N Methanetriol Chemical compound OC(O)O RLAHWVDQYNDAGG-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- WOWBFOBYOAGEEA-UHFFFAOYSA-N diafenthiuron Chemical compound CC(C)C1=C(NC(=S)NC(C)(C)C)C(C(C)C)=CC(OC=2C=CC=CC=2)=C1 WOWBFOBYOAGEEA-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000002443 hydroxylamines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
la presente se relaciona con un procedimiemto para la preparacion de (4-trifluorometil) - anilida de ácido 5-metil-isoxasol-4-carboxilico que cunsiste en hacer reaccinar la 4-trifluorometilanilina con diceteno o un derivado reactivo de ácido acepto-acético; calentar la 4-trifluoro- metilanilida de ácido eceto-acético asi obtenida, con un éter de ácido ortofórmico de la formula hc(or)3, en donde R representa un alquilo de 1 a 4 atomos de carbono y con un anhídrido ácido; y hacer reaccionar la 4- trifluorometilanilida de ácido 2-alcoximetilenacetoacético asi obtenida con hidroxilaminas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782854439 DE2854439A1 (de) | 1978-12-16 | 1978-12-16 | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX8403A true MX8403A (es) | 1994-03-31 |
Family
ID=6057414
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX798546U MX6174E (es) | 1978-12-16 | 1979-12-13 | Procedimiento para la preparacion de(4-trifluorometil)-anilida de acido 5-metil-isoxazol-4-carboxilico |
| MX8403A MX8403A (es) | 1978-12-16 | 1984-03-12 | Procedimiento para la preparacion de (4-trifluro metil)-anilida de acido 5 metil-isoxasol-4-carboxilico. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX798546U MX6174E (es) | 1978-12-16 | 1979-12-13 | Procedimiento para la preparacion de(4-trifluorometil)-anilida de acido 5-metil-isoxazol-4-carboxilico |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US4284786A (es) |
| EP (1) | EP0013376B1 (es) |
| JP (1) | JPS5583767A (es) |
| AR (2) | AR222680A1 (es) |
| AT (1) | ATE1067T1 (es) |
| AU (1) | AU529341B2 (es) |
| BG (1) | BG60764B2 (es) |
| CA (1) | CA1129867A (es) |
| DE (2) | DE2854439A1 (es) |
| DK (1) | DK149886C (es) |
| EG (1) | EG13926A (es) |
| ES (2) | ES486750A1 (es) |
| FI (1) | FI64154C (es) |
| GR (1) | GR72731B (es) |
| HU (1) | HU178015B (es) |
| IE (1) | IE49126B1 (es) |
| IL (1) | IL58951A (es) |
| LU (1) | LU90466I2 (es) |
| MX (2) | MX6174E (es) |
| NL (1) | NL990037I1 (es) |
| NO (1) | NO148925C (es) |
| NZ (1) | NZ192400A (es) |
| PH (1) | PH16627A (es) |
| PT (1) | PT70596A (es) |
| ZA (1) | ZA796793B (es) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3247454A1 (de) * | 1982-12-22 | 1984-06-28 | Laboratorios Bago S.A., Buenos Aires | Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2538806B1 (fr) * | 1982-12-30 | 1986-02-21 | Bago Sa Labor | Composes phenyl-3 methyl isoxazole-5 carboxy-4 anilides substitues, actifs therapeutiquement contre l'inflammation et la douleur |
| US5268382A (en) * | 1985-09-27 | 1993-12-07 | Hoechst Aktiengesellschaft | Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus |
| DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
| US4935434A (en) * | 1988-01-26 | 1990-06-19 | Bristol-Myers Company | Antiarthritic isoxazole-4-carboxamides |
| FR2662692B1 (fr) * | 1990-05-30 | 1995-04-28 | Novapharme | Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique. |
| US5258397A (en) * | 1988-11-30 | 1993-11-02 | Novapharme | 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions |
| DD297328A5 (de) * | 1989-08-18 | 1992-01-09 | �������@���������k���Kk�� | 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen |
| US5583150A (en) * | 1989-08-18 | 1996-12-10 | Alcon Laboratories, Inc. | 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases |
| US5108999A (en) * | 1990-02-02 | 1992-04-28 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| WO1991017748A1 (de) * | 1990-05-18 | 1991-11-28 | Hoechst Aktiengesellschaft | Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung |
| DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
| US6133301A (en) * | 1991-08-22 | 2000-10-17 | Aventis Pharma Deutschland Gmbh | Pharmaceuticals for the treatment of rejection reactions in organ transplantations |
| ATE174218T1 (de) * | 1993-01-08 | 1998-12-15 | Hoechst Ag | Verwendung von leflunomid zur hemmung von interleukin 1 beta |
| ES2124799T3 (es) * | 1993-01-08 | 1999-02-16 | Hoechst Ag | Empleo de leflunomida para la inhibicion de interleuquina 1 alfa. |
| ATE174219T1 (de) * | 1993-01-08 | 1998-12-15 | Hoechst Ag | Verwendung von leflunomid zur hemmung von tumornekrosefaktor alpha |
| ES2125356T3 (es) * | 1993-01-08 | 1999-03-01 | Hoechst Ag | Empleo de leflunomida para la inhibicion de interleuquina 8. |
| TW314467B (es) * | 1993-03-31 | 1997-09-01 | Hoechst Ag | |
| DE4323636A1 (de) * | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
| LT3589B (en) | 1993-11-30 | 1995-12-27 | Hoechst Ag | Using of known combination for treatment of rejection reaction by transplantation of organs |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US5610173A (en) * | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
| US6335356B1 (en) | 1994-01-07 | 2002-01-01 | Sugen, Inc. | Method of treating a patient by parenteral administration of a lipophilic compound |
| US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
| US5624946A (en) * | 1994-07-05 | 1997-04-29 | Williams; James | Use of leflunomide to control and reverse chronic allograft rejection |
| HU222888B1 (hu) * | 1994-10-17 | 2003-12-29 | Hoechst Pharmaceuticals & Chemicals K.K. | Anilid vegyületek alkalmazása I típusú allergiás betegségek megelőzésére és kezelésére alkalmas gyógyszerkészítmények előállítására |
| US5721277A (en) * | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
| US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
| DE19539638A1 (de) * | 1995-10-25 | 1997-04-30 | Hoechst Ag | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
| DE19702988A1 (de) * | 1997-01-28 | 1998-07-30 | Hoechst Ag | Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika |
| US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
| ATE207065T1 (de) * | 1997-08-08 | 2001-11-15 | Aventis Pharma Gmbh | Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid |
| US7691890B2 (en) | 1998-03-11 | 2010-04-06 | James W. Williams | Anti-viral uses of leflunomide products |
| US20050255071A1 (en) * | 1998-12-10 | 2005-11-17 | Aventis Pharma Deutschland Gmbh | Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors |
| DE19908527C2 (de) | 1999-02-26 | 2001-08-30 | Aventis Pharma Gmbh | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
| US6566395B1 (en) | 1999-05-25 | 2003-05-20 | Biomedicines, Inc. | Methods of treating proliferative disorders |
| DE19960443C2 (de) * | 1999-12-15 | 2002-05-08 | Aventis Pharma Gmbh | Verfahren zur Auffindung von Nukleotidsyntheseinhibitoren mit weniger Nebenwirkungen |
| HRP20050176A2 (en) * | 1999-12-16 | 2005-08-31 | Teva Pharmaceutical Industries Ltd. | Novel processes for making - and a new crystalline form of-leflunomide |
| EP1473035A1 (en) * | 2000-02-15 | 2004-11-03 | Teva Pharmaceutical Industries Ltd. | Leflunomide of high purity |
| KR20020072312A (ko) * | 2000-02-15 | 2002-09-14 | 테바 파마슈티컬 인더스트리즈 리미티드 | 레플루노미드를 합성하는 방법 |
| AU2001284891A1 (en) * | 2000-08-14 | 2002-02-25 | Teva Pharmaceutical Industries Ltd. | Micronized leflunomide |
| DK1381356T3 (da) | 2001-04-05 | 2008-09-22 | Aventis Pharma Inc | Anvendelse af (z)-z-cyano-3-hydroxy-but-2-enoinsyre-(4-trifluoromethylphenyl) - amide til behandling af multipel sclerose |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| WO2003042193A1 (en) * | 2001-11-09 | 2003-05-22 | Geneva Pharmaceuticals, Inc. | Process for preparing 5-methylisoxazole-4-carboxylic-(4'-trifluoromethyl)-anilide |
| US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US20060024376A1 (en) * | 2004-07-30 | 2006-02-02 | The University Of Chicago | Methods and compositions for reducing toxicity associated with leflunomide treatment |
| EP1920772A4 (en) * | 2005-08-31 | 2010-11-17 | Kowa Co | PROPHYLACTIC AND / OR THERAPEUTIC METHOD FOR COMBATING RHEUMATOID ARTHRITIS |
| US9073997B2 (en) * | 2007-02-02 | 2015-07-07 | Vegenics Pty Limited | Growth factor antagonists for organ transplant alloimmunity and arteriosclerosis |
| CN101817797B (zh) * | 2009-02-26 | 2013-04-10 | 江苏亚邦爱普森药业有限公司 | 高纯度3-甲基-n-[4-(三氟甲基)苯基]-4-异噁唑甲酰胺的合成方法 |
| US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
| US9205577B2 (en) * | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
| US11202853B2 (en) * | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| EP3773579A4 (en) | 2018-03-26 | 2022-03-09 | Clear Creek Bio, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE |
| CN114144175A (zh) | 2019-07-22 | 2022-03-04 | 埃科特莱茵药品有限公司 | 治疗多发性硬化症的方法 |
| WO2021176070A1 (en) | 2020-03-06 | 2021-09-10 | Actelion Pharmaceuticals Ltd | Methods of slowing brain volume loss |
| US20210308117A1 (en) | 2020-03-20 | 2021-10-07 | Clear Creek Bio, Inc. | Methods of treating viral infections using inhibitors of nucleotide synthesis pathways |
| US12357616B2 (en) | 2021-10-11 | 2025-07-15 | Vanda Pharmaceuticals Inc. | Methods of treating multiple sclerosis |
| US11951097B2 (en) | 2021-10-11 | 2024-04-09 | Vanda Pharmaceuticals Inc. | Methods of treating multiple sclerosis |
| WO2023152290A1 (en) | 2022-02-11 | 2023-08-17 | Actelion Pharmaceuticals Ltd | Methods of slowing an increase in brain ventricular volume |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087534A (en) * | 1974-05-22 | 1978-05-02 | David Ovadia | N-haloalkylmio urazole pesticides |
| DE2524959C2 (de) * | 1975-06-05 | 1983-02-10 | Hoechst Ag, 6000 Frankfurt | 5-Methyl-isoxazol-4-carbonsäureanilide, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel |
| NL178596C (nl) * | 1975-06-05 | 1986-04-16 | Hoechst Ag | Werkwijze voor het bereiden van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor het bereiden van daarin als geneeskrachtige verbindingen te gebruiken 5-methylisoxazool-4-carbonzuuraniliden. |
| DE2654797A1 (de) * | 1976-12-03 | 1978-06-08 | Hoechst Ag | Verfahren zur herstellung von isoxazolderivaten |
-
1978
- 1978-12-16 DE DE19782854439 patent/DE2854439A1/de not_active Withdrawn
-
1979
- 1979-12-11 ES ES486750A patent/ES486750A1/es not_active Expired
- 1979-12-11 ES ES486758A patent/ES486758A1/es not_active Expired
- 1979-12-12 EG EG748/79A patent/EG13926A/xx active
- 1979-12-13 DE DE7979105142T patent/DE2962929D1/de not_active Expired
- 1979-12-13 US US06/103,551 patent/US4284786A/en not_active Expired - Lifetime
- 1979-12-13 EP EP79105142A patent/EP0013376B1/de not_active Expired
- 1979-12-13 AT AT79105142T patent/ATE1067T1/de active
- 1979-12-13 MX MX798546U patent/MX6174E/es unknown
- 1979-12-13 FI FI793899A patent/FI64154C/fi not_active IP Right Cessation
- 1979-12-14 PH PH23418A patent/PH16627A/en unknown
- 1979-12-14 HU HU79HO2201A patent/HU178015B/hu unknown
- 1979-12-14 ZA ZA00796793A patent/ZA796793B/xx unknown
- 1979-12-14 CA CA342,109A patent/CA1129867A/en not_active Expired
- 1979-12-14 GR GR60761A patent/GR72731B/el unknown
- 1979-12-14 NZ NZ192400A patent/NZ192400A/xx unknown
- 1979-12-14 IL IL58951A patent/IL58951A/xx unknown
- 1979-12-14 PT PT70596A patent/PT70596A/pt active IP Right Revival
- 1979-12-14 JP JP16170079A patent/JPS5583767A/ja active Granted
- 1979-12-14 IE IE2426/79A patent/IE49126B1/en active Protection Beyond IP Right Term
- 1979-12-14 NO NO794094A patent/NO148925C/no unknown
- 1979-12-14 AR AR279310A patent/AR222680A1/es active
- 1979-12-14 AU AU53853/79A patent/AU529341B2/en not_active Expired
- 1979-12-14 DK DK534279A patent/DK149886C/da active
-
1981
- 1981-03-03 US US06/239,986 patent/US4351841A/en not_active Expired - Lifetime
- 1981-05-19 AR AR285378A patent/AR226894A1/es active
-
1984
- 1984-03-12 MX MX8403A patent/MX8403A/es unknown
-
1994
- 1994-02-23 BG BG098534A patent/BG60764B2/bg unknown
-
1999
- 1999-10-27 LU LU90466C patent/LU90466I2/fr unknown
- 1999-10-29 NL NL990037C patent/NL990037I1/nl unknown
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