ES485199A1 - Procedimiento para la preparacion de derivados prostanicos - Google Patents

Procedimiento para la preparacion de derivados prostanicos

Info

Publication number
ES485199A1
ES485199A1 ES485199A ES485199A ES485199A1 ES 485199 A1 ES485199 A1 ES 485199A1 ES 485199 A ES485199 A ES 485199A ES 485199 A ES485199 A ES 485199A ES 485199 A1 ES485199 A1 ES 485199A1
Authority
ES
Spain
Prior art keywords
production
pharmaceutical compositions
compositions containing
prostane derivatives
prostacyclin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485199A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES485199A1 publication Critical patent/ES485199A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES485199A 1978-10-19 1979-10-19 Procedimiento para la preparacion de derivados prostanicos Expired ES485199A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782845770 DE2845770A1 (de) 1978-10-19 1978-10-19 Neue prostacyclin-derivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES485199A1 true ES485199A1 (es) 1980-05-16

Family

ID=6052699

Family Applications (1)

Application Number Title Priority Date Filing Date
ES485199A Expired ES485199A1 (es) 1978-10-19 1979-10-19 Procedimiento para la preparacion de derivados prostanicos

Country Status (25)

Country Link
US (1) US4692464A (en, 2012)
EP (1) EP0011591B1 (en, 2012)
JP (1) JPS5557559A (en, 2012)
AT (1) ATE1283T1 (en, 2012)
AU (1) AU534090B2 (en, 2012)
CA (1) CA1181747A (en, 2012)
CS (1) CS219260B2 (en, 2012)
DD (1) DD146594B3 (en, 2012)
DE (2) DE2845770A1 (en, 2012)
DK (1) DK160246C (en, 2012)
ES (1) ES485199A1 (en, 2012)
FI (1) FI69056C (en, 2012)
GR (1) GR72247B (en, 2012)
HU (1) HU184926B (en, 2012)
IE (1) IE49085B1 (en, 2012)
IL (1) IL58475A (en, 2012)
LU (1) LU88288I2 (en, 2012)
MX (1) MX9203690A (en, 2012)
NL (1) NL930070I2 (en, 2012)
NO (2) NO151318C (en, 2012)
NZ (1) NZ191827A (en, 2012)
PH (1) PH20359A (en, 2012)
SU (2) SU1003754A3 (en, 2012)
YU (1) YU41668B (en, 2012)
ZA (1) ZA795598B (en, 2012)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495552A (en) 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation
GB2038333B (en) * 1978-01-26 1982-10-06 Erba Farmitalia 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives
DE3021895A1 (de) * 1980-06-06 1981-12-24 Schering Ag Berlin Und Bergkamen, 1000 Berlin Neues verfahren zur herstellung von carbacyclin-zwischenprodukten
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3104044A1 (de) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3204443A1 (de) * 1982-02-08 1983-08-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
DE3306125A1 (de) * 1983-02-18 1984-08-23 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
HU191110B (en) * 1982-10-01 1987-01-28 Farmitala Carlo Erba Spa,It Process for the production of the 15-cycloaliphatic derivatives 13,14-didehydro-carbaprostacyclines
GB2129427B (en) * 1982-10-01 1986-01-08 Erba Farmitalia 15-cycloaliphatic derivatives of 13,14-didehydrocarboprostacyclins and process for their preparation
EP0136779B1 (en) * 1983-07-26 1988-09-14 Sankyo Company Limited New carbacyclin derivatives, processes for their preparation and compositions containing them
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2156341B (en) * 1984-03-26 1987-10-21 Erba Farmitalia Furyl and imidazolyl derivatives of carboprostacyclins and process for their preparation
GB2156343B (en) * 1984-03-26 1988-01-13 Erbo Spa Farmitalia Carlo 13,14,19,19,20,20-hexadehydro derivatives of carboprostacyclins and process for their preparation
DE3448257C2 (en) * 1984-07-25 1988-08-18 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De Cytoprotective action of prostacyclin derivatives on the kidney
DE3448256C2 (en) * 1984-07-25 1988-08-18 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De Cytoprotective action of prostacyclin derivatives on the pancreas
DE3428266A1 (de) * 1984-07-27 1986-01-30 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ZA861919B (en) * 1985-03-18 1987-05-27 Searle & Co Allenic prostacyclins
JPS6216A (ja) * 1985-03-19 1987-01-06 Sankyo Co Ltd カルバサイクリン類及びこれを有効成分とする抗潰瘍剤
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3631169A1 (de) * 1986-09-11 1988-03-24 Schering Ag Prostacyclinderivate enthaltende mittel fuer die topische anwendung
US5663203A (en) * 1986-09-11 1997-09-02 Schering Aktiengesellschaft Agents containing prostacyclin derivatives for topical application
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5891910A (en) * 1987-07-17 1999-04-06 Schering Aktiengesellschaft 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
EP0299914B2 (de) 1987-07-17 2003-04-23 Schering Aktiengesellschaft 9-Halogen-(Z)-prostaglandinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3839155A1 (de) * 1988-11-17 1990-05-23 Schering Ag Verfahren zur herstellung von carbacyclin-derivaten durch stereoselektive einfuehrung der 5,6-doppelbindung
DE4010355A1 (de) * 1990-03-28 1991-10-02 Schering Ag Bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4104606C1 (en, 2012) * 1991-02-12 1992-10-15 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
DE4135193C1 (en, 2012) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
EP0686036B1 (de) * 1992-08-07 1997-03-12 Schering Aktiengesellschaft Verwendung von prostanderivaten zur herstellung eines arzneimittels zur behandlung der chronischen polyarthritis
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
US5534589A (en) * 1994-05-04 1996-07-09 Minnesota Mining And Manufacturing Company Repulpable plastic films
DE69534075T2 (de) * 1994-06-07 2005-07-21 Chugai Seiyaku K.K. Vorbeugungs- und heilmittel für erkrankungen, die durch fibrin- oder thrombusbildung hervorgerufen werden
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
DE19828881A1 (de) * 1998-06-22 1999-12-23 Schering Ag Oxidationsinhibitor bei Prostan-Derivaten
AU4976599A (en) * 1998-07-08 2000-02-01 Fibrogen, Inc. Method for treatment of fibrosis related diseases by the administration of prostacyclin derivatives
DE60336485D1 (de) 2002-08-19 2011-05-05 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
US20060128810A1 (en) * 2002-10-10 2006-06-15 Kyoto University Remedies for allergic diseases
US20050043391A1 (en) * 2003-07-17 2005-02-24 Fong Benson M. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
WO2005009468A1 (ja) 2003-07-25 2005-02-03 Ono Pharmaceutical Co., Ltd. 軟骨関連疾患治療剤
US8765813B2 (en) * 2003-12-16 2014-07-01 United Therapeutics Corporation Use of treprostinil to treat and prevent ischemic lesions
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
RU2007106714A (ru) * 2004-07-26 2008-09-10 Байер Шеринг Фарма Аг (De) Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
EP2026816B1 (en) 2006-05-15 2018-10-24 United Therapeutics Corporation Treprostinil administration using a metered dose inhaler
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
JP5271272B2 (ja) 2006-11-16 2013-08-21 ジェンムス ファーマ インコーポレイティド Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2065054A1 (en) 2007-11-29 2009-06-03 Bayer Schering Pharma Aktiengesellschaft Combinations comprising a prostaglandin and uses thereof
SMT201900740T1 (it) 2008-08-13 2020-01-14 Actelion Pharmaceuticals Ltd Composizioni terapeutiche contenenti macitentan
JP2013508282A (ja) 2009-10-14 2013-03-07 ジェンムス ファーマ インコーポレイティド ウイルス感染のための併用療法処置
CA2780683A1 (en) 2009-11-13 2011-05-19 Toray Industries, Inc. Therapeutic or prophylactic combination of a prostaglandin i2 and a thiazolidine for diabetes
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US10799653B2 (en) 2017-01-09 2020-10-13 United Therapeutics Corporation Aerosol delivery device and method for manufacturing and operating the same
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
AU2021255621A1 (en) 2020-04-17 2022-10-20 United Therapeutics Corporation Treprostinil for use in the treatment of intersitial lung disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation
GB2038333B (en) * 1978-01-26 1982-10-06 Erba Farmitalia 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives
US4238414A (en) * 1978-02-13 1980-12-09 The Upjohn Company 2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds
JPS54119441A (en) * 1978-03-09 1979-09-17 Sumitomo Chem Co Ltd Novel bicyclooctane derivative
JPS54130543A (en) * 1978-03-31 1979-10-09 Ono Pharmaceut Co Ltd Prostagladin i2 analog, and its preparation
JPS5528945A (en) * 1978-08-22 1980-02-29 Sankyo Co Ltd Prostacycline-family compound and its preparation

Also Published As

Publication number Publication date
US4692464A (en) 1987-09-08
NO1995010I1 (no) 1995-12-19
DD146594A5 (de) 1981-02-18
IL58475A0 (en) 1980-01-31
FI69056C (fi) 1985-12-10
DK160246C (da) 1991-07-22
CS219260B2 (en) 1983-03-25
IE49085B1 (en) 1985-07-24
IE791993L (en) 1980-04-19
NO793353L (no) 1980-04-22
JPS6312051B2 (en, 2012) 1988-03-17
DK441479A (da) 1980-04-20
AU5198779A (en) 1980-04-24
LU88288I2 (fr) 1994-05-04
YU41668B (en) 1987-12-31
SU1003754A3 (ru) 1983-03-07
DK160246B (da) 1991-02-18
DE2963260D1 (en) 1982-08-19
NL930070I2 (nl) 1994-01-03
DE2845770A1 (de) 1980-04-30
MX9203690A (es) 1992-09-01
NO151318B (no) 1984-12-10
ATE1283T1 (de) 1982-07-15
IL58475A (en) 1989-09-10
EP0011591B1 (de) 1982-06-30
DD146594B3 (de) 1989-09-06
FI793263A7 (fi) 1980-04-20
EP0011591A1 (de) 1980-05-28
JPS5557559A (en) 1980-04-28
FI69056B (fi) 1985-08-30
NL930070I1 (nl) 1993-09-01
CA1181747A (en) 1985-01-29
NZ191827A (en) 1982-05-25
SU1310390A1 (ru) 1987-05-15
GR72247B (en, 2012) 1983-10-05
HU184926B (en) 1984-11-28
PH20359A (en) 1986-12-04
NO151318C (no) 1985-03-20
ZA795598B (en) 1980-10-29
AU534090B2 (en) 1984-01-05
YU253079A (en) 1983-01-21

Similar Documents

Publication Publication Date Title
ES485199A1 (es) Procedimiento para la preparacion de derivados prostanicos
ES542323A0 (es) Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
FR2401914A1 (fr) Nouveaux composes heterocycliques, procede pour leur preparation et compositions medicinales contenant lesdits composes
IL58782A0 (en) Hydroxypropyl-triazole compounds,their production and pharmaceutical compositions containing them
IL47529A (en) Substituted (1-(-4,4-bisphenylbutyl)-4-piperidyl-)1,3-dihydro-2h-benzimidazol-2-one derivatives and certain intermediates for obtaining such compounds,their preparation and pharmaceutical compositions containing them
FR2362845A1 (fr) Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant
ES436613A1 (es) Un procedimiento para la preparacion de una composicion far-maceutica estabilizada.
FR2354764A1 (fr) Nouveaux ethers cycliques derives de l'acide prostanoique et leur procede de preparation
ES433860A1 (es) Procedimiento de preparacion de derivados del acido ciclo- pentano-carboxilico.
FR2361380A1 (fr) Nouveaux analogues de prostaglandines et leur preparation
ES424274A1 (es) Procedimiento para la preparacion de 2,4-diamino-5-(3',5'- dimetoxi-4'-metoxialcoxibencil)-pirimidinas.
IL59768A (en) Prostaglandin derivatives of the 6-keto-pge1 series,process for their preparation and pharmaceutical compositions containing them
FR2357551A1 (fr) Nouvelles 2,5-dideoxystreptamines et leur procede de preparation
MY101765A (en) Benzopyran derivatives, compositions containing them and processes for their production
ES427198A1 (es) Procedimiento para la preparacion de derivados de ciclopen-tano.
ES474575A1 (es) Procedimiento de producir (omega-aminoalcoxi)bibencilos far-maceuticamente activos
ES428047A1 (es) Un procedimiento para la preparacion de nuevos derivados de prostaglandina.
ES8500057A1 (es) Procedimiento para la obtencion de derivados de 1,4-dihidropiridina.
JPS5557560A (en) Prostane derivative*its manufacture and medicine and veterinary drug composition containing it
OA05390A (fr) Procédé pour la préparation de composition anthelmintique.
ES369815A1 (es) Procedimiento para la preparacion de 1 - ciano - 0 - carba-moil - formoximas sustituidas basicamente
ES454347A1 (es) Procedimiento para la preparacion de pirrolidonas.
IT7948907A0 (it) Derivati di 1,3 benzodiossina procedimento per la loro produzione e composizioni farmaceutiche che licontengono come ingredienti attivi
FR2449680A1 (fr) Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant
FR2326184A1 (fr) Analogues de prostaglandines et leur preparation