ES481917A1 - Procedimiento para la preparacion de nuevos acidos tiazol-2-oxamicos sustituidos en posicion 4. - Google Patents

Procedimiento para la preparacion de nuevos acidos tiazol-2-oxamicos sustituidos en posicion 4.

Info

Publication number
ES481917A1
ES481917A1 ES481917A ES481917A ES481917A1 ES 481917 A1 ES481917 A1 ES 481917A1 ES 481917 A ES481917 A ES 481917A ES 481917 A ES481917 A ES 481917A ES 481917 A1 ES481917 A1 ES 481917A1
Authority
ES
Spain
Prior art keywords
hydrogen
salts
esters
substituted thiazolyl
oxamic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481917A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES481917A1 publication Critical patent/ES481917A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento para la preparación de nuevos ácidos tiazol-2- oxámicos sustituidos en posición 4, de la fórmula general **(Fórmula)** en que R1 significa hidrógeno o un radical alcohilo con 1-4 átomos de carbono, R2 significa hidrógeno, metilo o -COOH, y R3, R4 y R5, que pueden ser iguales o diferentes, significan hidrógeno, hidroxi, alcoxi, alcohilo, halógeno, carboxialcohilo, diacolhilamino, carboxamido, nitro o ciano, o uno de los radicales R3, R4 y R5 significa un radical morfolino, piperidino, hidroxipiperidino o fenilo, así como de sus sales y ésteres.
ES481917A 1978-06-27 1979-06-26 Procedimiento para la preparacion de nuevos acidos tiazol-2-oxamicos sustituidos en posicion 4. Expired ES481917A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782828091 DE2828091A1 (de) 1978-06-27 1978-06-27 4-substituierte thiazoloxamsaeuren sowie ihre salze und ester

Publications (1)

Publication Number Publication Date
ES481917A1 true ES481917A1 (es) 1980-02-16

Family

ID=6042852

Family Applications (1)

Application Number Title Priority Date Filing Date
ES481917A Expired ES481917A1 (es) 1978-06-27 1979-06-26 Procedimiento para la preparacion de nuevos acidos tiazol-2-oxamicos sustituidos en posicion 4.

Country Status (36)

Country Link
US (1) US4238496A (es)
JP (1) JPS557290A (es)
AT (1) AT373884B (es)
AU (1) AU525312B2 (es)
BE (1) BE877293A (es)
BG (1) BG30324A3 (es)
CA (1) CA1246071A (es)
CH (1) CH644370A5 (es)
CS (1) CS208114B2 (es)
DD (1) DD144542A5 (es)
DE (1) DE2828091A1 (es)
DK (1) DK147940C (es)
ES (1) ES481917A1 (es)
FI (1) FI69456C (es)
FR (1) FR2429787A1 (es)
GB (1) GB2023580B (es)
GR (1) GR69231B (es)
HK (1) HK66285A (es)
HU (1) HU178996B (es)
IE (1) IE48357B1 (es)
IL (1) IL57659A0 (es)
IT (1) IT1120443B (es)
LU (1) LU81424A1 (es)
MY (1) MY8600653A (es)
NL (1) NL7904957A (es)
NO (1) NO151500C (es)
NZ (1) NZ190842A (es)
PH (1) PH17226A (es)
PL (1) PL117333B1 (es)
PT (1) PT69822A (es)
RO (1) RO77553A (es)
SE (1) SE446182B (es)
SG (1) SG61985G (es)
SU (1) SU791237A3 (es)
YU (1) YU41645B (es)
ZA (1) ZA793176B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321372A (en) * 1980-06-16 1982-03-23 Pfizer Inc. Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides
DE3027528A1 (de) * 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen Ueberbrueckte thiazolyloxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE3027527A1 (de) 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen Neue oxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
FR2494272A1 (fr) * 1980-11-19 1982-05-21 Fabre Sa Pierre Derives de l'acide thiazolyl-2 oxamique substitues en position 4 par un radical thienyle ou furyle, leur preparation et leur utilisation comme medicaments
DE3135250A1 (de) * 1981-09-05 1983-03-17 Basf Ag, 6700 Ludwigshafen Tricyclische thiazolyloxamate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
ATE38224T1 (de) * 1983-09-01 1988-11-15 Boehringer Ingelheim Ltd Diazin-ethenylphenyloxamidsaeuren und deren ester und salze.
US4788198A (en) * 1983-09-01 1988-11-29 Boehringer Ingelheim Pharmaceuticals, Inc. Diazine-ethyenylphenyl oxamic acids and esters and salts thereof
US4681884A (en) * 1983-09-01 1987-07-21 Boehringer Ingelheim Pharmaceuticals, Inc. Diazine-ethenylphenyl oxamic acids and esters and salts thereof
IT1204959B (it) * 1987-03-25 1989-03-10 Zambon Farmaceutici Spa Composti dotati di attivita' antiallergica
IT1204960B (it) * 1987-03-25 1989-03-10 Zambon Farmaceutici Spa Composti dotati di attivita' antiallergica
DE3807232A1 (de) * 1988-03-05 1989-09-14 Bayer Ag Substituierte acrylsaeureester
JPH0667836B2 (ja) * 1989-03-01 1994-08-31 東洋紡績株式会社 アミド系化合物からなる抗アレルギー剤
FR2671552B1 (fr) * 1991-01-15 1993-05-07 Pf Medicament Procede de preparation de thiazolyl-2 oxamates d'alkyle.
EP1027050B1 (en) * 1997-10-27 2004-01-14 Takeda Chemical Industries, Ltd. 1,3-thiazoles as adenosine a3 receptor antagonists for the treatment of allergy, asthma and diabetes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1062245B (de) * 1957-10-17 1959-07-30 Ciba Geigy Verfahren zur Herstellung von 2-Amino-4-pyridyl-(2')-thiazol und seinen Salzen
FR1526074A (fr) * 1967-03-22 1968-05-24 Rech S Ind S O R I Soc D Méthoxy-phényl-amino-2-thiazoles, leurs amides et leurs procédés de préparation
BE795907A (fr) * 1972-02-25 1973-06-18 Luso Farmaco Inst 2-amino-4-arylthiazoles 5-substitues et leur preparation
US3966965A (en) * 1973-03-23 1976-06-29 American Home Products Corporation Oxamic acid derivatives for the prevention of immediate type hypersensitivity reactions
US4054666A (en) * 1973-03-23 1977-10-18 American Home Products Corporation Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives
FR2429210A1 (fr) * 1978-06-19 1980-01-18 Fabre Sa Pierre Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme

Also Published As

Publication number Publication date
NO151500B (no) 1985-01-07
FI69456C (fi) 1986-02-10
DK269879A (da) 1979-12-28
ZA793176B (en) 1981-03-25
JPS6356225B2 (es) 1988-11-07
CS208114B2 (en) 1981-08-31
SU791237A3 (ru) 1980-12-23
BG30324A3 (en) 1981-05-15
NO792139L (no) 1979-12-28
CA1246071A (en) 1988-12-06
PT69822A (de) 1979-07-01
AT373884B (de) 1984-02-27
DD144542A5 (de) 1980-10-22
BE877293A (fr) 1979-12-27
IT7949533A0 (it) 1979-06-25
LU81424A1 (de) 1980-07-21
PL216608A1 (es) 1980-03-24
NZ190842A (en) 1981-01-23
PH17226A (en) 1984-07-03
FR2429787A1 (fr) 1980-01-25
US4238496A (en) 1980-12-09
CH644370A5 (de) 1984-07-31
MY8600653A (en) 1986-12-31
IE48357B1 (en) 1984-12-26
DK147940B (da) 1985-01-14
NL7904957A (nl) 1980-01-02
IE791200L (en) 1979-12-27
SE446182B (sv) 1986-08-18
GB2023580A (en) 1980-01-03
DK147940C (da) 1985-09-02
SG61985G (en) 1986-05-02
PL117333B1 (en) 1981-07-31
AU4839779A (en) 1980-01-03
HK66285A (en) 1985-09-13
FR2429787B1 (es) 1982-12-31
GR69231B (es) 1982-05-10
NO151500C (no) 1985-04-24
YU41645B (en) 1987-12-31
RO77553A (ro) 1982-02-01
FI69456B (fi) 1985-10-31
SE7905608L (sv) 1979-12-28
YU149779A (en) 1982-10-31
GB2023580B (en) 1982-08-25
DE2828091C2 (es) 1988-05-26
IL57659A0 (en) 1979-10-31
FI792006A (fi) 1979-12-28
IT1120443B (it) 1986-03-26
AU525312B2 (en) 1982-10-28
DE2828091A1 (de) 1980-01-10
ATA431879A (de) 1983-07-15
JPS557290A (en) 1980-01-19
HU178996B (en) 1982-07-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970301