ES480281A1 - Procedimiento de preparar compuestos de la serie de las be- ta-lactamas y similares. - Google Patents

Procedimiento de preparar compuestos de la serie de las be- ta-lactamas y similares.

Info

Publication number
ES480281A1
ES480281A1 ES480281A ES480281A ES480281A1 ES 480281 A1 ES480281 A1 ES 480281A1 ES 480281 A ES480281 A ES 480281A ES 480281 A ES480281 A ES 480281A ES 480281 A1 ES480281 A1 ES 480281A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
beta
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480281A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP53043624A external-priority patent/JPS6034957B2/ja
Priority claimed from JP53110464A external-priority patent/JPS6037118B2/ja
Priority claimed from JP53141785A external-priority patent/JPS6037119B2/ja
Priority claimed from JP53145638A external-priority patent/JPS5951959B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES480281A1 publication Critical patent/ES480281A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Preparación de derivados de beta-lactama representados por la fórmula (I): **(Fórmula)** definida posteriormente y de sus farmacéuticamente aceptables, que son útiles como agentes antimicrobianos. Sin embargo, los derivados beta-lactama preparados según la presente invención son estructuralmente diferentes de estos compuestos de quinolina y quinolicina. Además, los derivados beta-lactama preparados según la presente invención tienen una potente actividad antimicrobiana contra varias bacterias, especialmente Pseudomonas aeruginosa.
ES480281A 1978-04-12 1979-04-11 Procedimiento de preparar compuestos de la serie de las be- ta-lactamas y similares. Expired ES480281A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP53043624A JPS6034957B2 (ja) 1978-04-12 1978-04-12 ペニシラン酸誘導体
JP53110464A JPS6037118B2 (ja) 1978-09-07 1978-09-07 ペニシラン酸誘導体
JP53141785A JPS6037119B2 (ja) 1978-11-16 1978-11-16 ペニシラン酸誘導体
JP53145638A JPS5951959B2 (ja) 1978-11-24 1978-11-24 ペニシラン酸誘導体

Publications (1)

Publication Number Publication Date
ES480281A1 true ES480281A1 (es) 1980-08-16

Family

ID=27461393

Family Applications (2)

Application Number Title Priority Date Filing Date
ES480281A Expired ES480281A1 (es) 1978-04-12 1979-04-11 Procedimiento de preparar compuestos de la serie de las be- ta-lactamas y similares.
ES488833A Granted ES488833A0 (es) 1978-04-12 1980-01-30 Metodo de preparar compuestos de la serie de las beta-lacta-mas y similares

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES488833A Granted ES488833A0 (es) 1978-04-12 1980-01-30 Metodo de preparar compuestos de la serie de las beta-lacta-mas y similares

Country Status (18)

Country Link
US (1) US4317820A (es)
AR (2) AR227005A1 (es)
AT (1) AT368159B (es)
AU (1) AU524795B2 (es)
CA (1) CA1133469A (es)
CH (1) CH642081A5 (es)
DE (1) DE2914218C2 (es)
DK (1) DK149479A (es)
ES (2) ES480281A1 (es)
FI (1) FI70219C (es)
FR (1) FR2422666A1 (es)
IT (1) IT1162605B (es)
MX (1) MX5704E (es)
NL (1) NL180589C (es)
NO (2) NO791223L (es)
PT (1) PT69473A (es)
SE (1) SE7903297L (es)
SU (1) SU1151212A3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
US6525049B2 (en) 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
ES2340531T3 (es) * 2005-10-21 2010-06-04 Glaxo Group Limited Compuestos triciclos peri-condensados utiles como agentes antibacterianos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL175419C (nl) * 1971-10-23 1984-11-01 Bayer Ag Werkwijze ter bereiding of vervaardiging van antibiotisch werkzame farmaceutische preparaten, alsmede werkwijze ter bereiding van antibiotisch werkzame alfa-gesubstitueerde 6-(alfa-(3-acylureido)acetylamino) penicillanzuurderivaten.
US3780034A (en) * 1971-11-29 1973-12-18 Merck & Co Inc Process for preparing substituted cephalosporins
US3778432A (en) * 1971-12-13 1973-12-11 Merck & Co Inc Isocyanates and carbamates of penicillins and 3-cephem-4-carboxylic acids
BE793524A (fr) 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
US3954731A (en) * 1972-07-03 1976-05-04 Eli Lilly And Company Process for preparing 6-alkoxypenicillanic and 7-alkoxycephalosporin acids
US3917609A (en) 1973-06-27 1975-11-04 Minnesota Mining & Mfg Pyrroloquinoline carboxylic acids and derivatives
US4062842A (en) * 1973-09-06 1977-12-13 E. R. Squibb & Sons, Inc. Method for preparing 7-substituted cephalosporins and 6-substituted penicillins by replacement of sulfur-containing groups
DE2559932C2 (de) 1974-05-09 1983-04-21 Toyama Chemical Co. Ltd., Tokyo Cephalosporine, Verfahren zur Herstellung derselben und Mittel mit einem Gehalt derselben
US3962214A (en) * 1974-07-11 1976-06-08 Eli Lilly And Company Process for preparing amino substituted β-lactam antibiotics

Also Published As

Publication number Publication date
SE7903297L (sv) 1979-12-21
DK149479A (da) 1979-10-13
MX5704E (es) 1983-12-16
FR2422666B1 (es) 1983-02-04
NL180589B (nl) 1986-10-16
CA1133469A (en) 1982-10-12
NO840617L (no) 1979-10-15
NL7902906A (nl) 1979-10-16
IT1162605B (it) 1987-04-01
CH642081A5 (de) 1984-03-30
DE2914218A1 (de) 1979-10-25
AU4603879A (en) 1979-10-18
US4317820A (en) 1982-03-02
PT69473A (en) 1979-05-01
AU524795B2 (en) 1982-10-07
AR226883A1 (es) 1982-08-31
FI70219B (fi) 1986-02-28
AR227005A1 (es) 1982-09-15
FI791190A (fi) 1979-10-13
FI70219C (fi) 1986-09-15
NL180589C (nl) 1987-03-16
ATA269079A (de) 1982-01-15
NO791223L (no) 1979-10-15
DE2914218C2 (de) 1985-10-24
ES8200339A1 (es) 1981-11-16
IT7948691A0 (it) 1979-04-10
SU1151212A3 (ru) 1985-04-15
FR2422666A1 (fr) 1979-11-09
AT368159B (de) 1982-09-27
ES488833A0 (es) 1981-11-16

Similar Documents

Publication Publication Date Title
ES8301981A1 (es) Procedimiento de preparar compuestos benzoheterociclicos.
ES8306159A1 (es) Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
IL57648A (en) 2-substituted-5,9-dimethyl-2'-hydroxy-6,7-benzomorphanes,their preparation and pharmaceutical compositions containing them
IE802612L (en) Bicyclo £2.2.1| heptane derivatives
ES471822A1 (es) Un procedimiento para la prepracion de derivados del acido n-acilhidroxiaminohidrocarbonfosfonico.
ES468173A1 (es) Un procedimiento para la preparacion de derivados de morfina
GB2019844A (en) A beta -lactam series compound
ES8106903A1 (es) Procedimiento de preparar compuestos de acido benzo(ij)qui- nolicin-2-carboxilico
IE42618L (en) Piperidyl-indoles
ES8205770A1 (es) Procedimiento para la preparacion de derivados de 2,3-indo- lediona
ES8200339A1 (es) Metodo de preparar compuestos de la serie de las beta-lacta-mas y similares
ES8200669A1 (es) Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos
ES8304973A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiocarbapenem 3-sustituidos.
SE8004129L (sv) Nya tetrahydropyridin-4-yl-indolderivat samt salter derav, framstellning och anvendning derav sasom lekemedel samt kompositioner innehallande dessa foreningar
ES8101646A1 (es) Un procedimiento para producir un compuesto opticamente ac- tivo
CA1268183A (en) INTERMEDIATES OF PHOSPHORANE USED IN THE PREPARATION OF ANTIBIOTIC PENEMS
SE7412163L (es)
IL65213A (en) 1,4-benzoxazine derivatives,cyclopent(b)(1,4)oxazine derivatives,their preparation and pharmaceutical compositions containing them
IE40836B1 (en) Benzoxazoline derivatives,their preparation and use as plant growth regulants
ES464773A1 (es) Procedimiento para la preparacion de 2,9-dioxatriciclo (4,3,1,03,7)decanos.
GB1512930A (en) Substituted 4-hydroxybenzylidene malononitriles
ES8203328A1 (es) Un procedimiento para la preparacion de 6-fluordihidroxifenilalaninas.
GB1307255A (en) Substituted basic benzhydryl ethers
ES8206435A1 (es) Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981001