GB2019844A - A beta -lactam series compound - Google Patents
A beta -lactam series compoundInfo
- Publication number
- GB2019844A GB2019844A GB7913039A GB7913039A GB2019844A GB 2019844 A GB2019844 A GB 2019844A GB 7913039 A GB7913039 A GB 7913039A GB 7913039 A GB7913039 A GB 7913039A GB 2019844 A GB2019844 A GB 2019844A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydrogen atom
- formula
- image
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000003952 β-lactams Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 101100448208 Human herpesvirus 6B (strain Z29) U69 gene Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- -1 beta -lactam compound Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A beta -lactam compound represented by the formula (1> <IMAGE> wherein R<1> represents a hydrogen atom or an alkyl group; R<2> represents a hydrogen atom, R<3> represents a halogen atom, a nitro group, an amino group, a hydroxy group, an alkyl group, an alkoxy group, an alkanoylamino group, an alkanesulfonyloxy group or a group represented by the formula <IMAGE> wherein R<5> represents a hydrogen atom, an alkanoyl group, or an alkanesulfonyl group; R<4> represents a hydrogen atom or a hydroxy group; n is 0 or 1; is 0, 1 or 2; and A represents -C(CH3)2-CH(COOH)- or -CH2C(CH2R<6>)=C(COOH)- where R<6> represents an alkanoyloxy group, a group represented by the formula <IMAGE> where R<7> and R<5> each represents an alkyl group, and when n is 0, R<1> and R<2> can combine to form a cyclohexane ring with the carbon atoms to which they are attached; or a pharmaceutically acceptable salt is made by standard methods. These compounds have antimicrobial activity.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53043624A JPS6034957B2 (en) | 1978-04-12 | 1978-04-12 | penicillanic acid derivatives |
JP10738778A JPS5576875A (en) | 1978-08-31 | 1978-08-31 | Benzo ij quinolizine-2-carboxylic acid derivative and its preparation |
JP53110464A JPS6037118B2 (en) | 1978-09-07 | 1978-09-07 | penicillanic acid derivatives |
JP13715778A JPS5564588A (en) | 1978-11-06 | 1978-11-06 | Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation |
JP53141785A JPS6037119B2 (en) | 1978-11-16 | 1978-11-16 | penicillanic acid derivatives |
JP14273178A JPS5569583A (en) | 1978-11-17 | 1978-11-17 | Pyrido 3,2,1-jk carbazole derivative |
JP53145638A JPS5951959B2 (en) | 1978-11-24 | 1978-11-24 | penicillanic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2019844A true GB2019844A (en) | 1979-11-07 |
GB2019844B GB2019844B (en) | 1983-01-19 |
Family
ID=27564567
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7913040A Expired GB2020279B (en) | 1978-04-12 | 1979-04-12 | Piperazinylbenzoheterocyclic compounds |
GB7913039A Expired GB2019844B (en) | 1978-04-12 | 1979-04-12 | Lactam series compound |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7913040A Expired GB2020279B (en) | 1978-04-12 | 1979-04-12 | Piperazinylbenzoheterocyclic compounds |
Country Status (8)
Country | Link |
---|---|
AU (1) | AU529330B2 (en) |
CA (1) | CA1153374A (en) |
CH (1) | CH640853A5 (en) |
DE (3) | DE2953973C2 (en) |
FR (1) | FR2422658A1 (en) |
GB (2) | GB2020279B (en) |
IT (1) | IT1196531B (en) |
NL (1) | NL180664C (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5630964A (en) * | 1979-08-22 | 1981-03-28 | Kyorin Pharmaceut Co Ltd | Novel substituted quinolinecarboxylic acid and its preparation |
JPS5746986A (en) * | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
NO156828C (en) | 1980-11-10 | 1987-12-02 | Otsuka Pharma Co Ltd | ANALOGY PROCEDURE FOR THE PREPARATION OF ANTIBACTERYLY EFFECTIVE BENZOHETEROCYCLIC COMPOUNDS. |
JPS57176987A (en) * | 1981-04-24 | 1982-10-30 | Otsuka Pharmaceut Co Ltd | Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative |
SU1428201A3 (en) * | 1980-12-18 | 1988-09-30 | Оцука Фармасьютикал Ко.,Лтд (Фирма) | Method of producing benzoheterocyclic compounds |
PH22140A (en) | 1982-06-29 | 1988-06-01 | Daiichi Seiyaku Co | Tricyclic compounds |
JPS59137482A (en) * | 1983-01-26 | 1984-08-07 | Otsuka Pharmaceut Co Ltd | Pyrrolo(3,2,1,-ij)quinoline-5-carboxylic acid derivative |
DE3517709A1 (en) * | 1985-01-05 | 1986-07-10 | Bayer Ag | BASIC PREPARATIONS OF CHINOLON CARBON ACIDS |
AU585981B2 (en) * | 1985-05-24 | 1989-06-29 | Tokyo Tanabe Company Limited | Benzo (IJ) quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and processes for preparing the same |
KR900014383A (en) * | 1989-03-29 | 1990-10-23 | 원본미기재 | Pyrroloquinoline derivatives, preparation method thereof and antibacterial agent using same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE793524A (en) * | 1971-12-30 | 1973-06-29 | Riker Laboratories Inc | BENZOQUINOLIZINE-CARBOXYLIC ACIDS AND THEIR DERIVATIVES |
US3985882A (en) * | 1972-11-02 | 1976-10-12 | Riker Laboratories, Inc. | Substituted benzo[ij]quinolinzine-2-carboxylic acids and derivatives thereof as bactericidal agents |
-
1979
- 1979-04-09 DE DE2953973A patent/DE2953973C2/de not_active Expired
- 1979-04-09 DE DE19792914258 patent/DE2914258A1/en active Granted
- 1979-04-09 DE DE2953974A patent/DE2953974C2/de not_active Expired - Fee Related
- 1979-04-10 IT IT48690/79A patent/IT1196531B/en active
- 1979-04-11 CH CH343379A patent/CH640853A5/en not_active IP Right Cessation
- 1979-04-11 AU AU46037/79A patent/AU529330B2/en not_active Expired
- 1979-04-11 CA CA000325376A patent/CA1153374A/en not_active Expired
- 1979-04-12 NL NLAANVRAGE7902905,A patent/NL180664C/en not_active IP Right Cessation
- 1979-04-12 FR FR7909338A patent/FR2422658A1/en active Granted
- 1979-04-12 GB GB7913040A patent/GB2020279B/en not_active Expired
- 1979-04-12 GB GB7913039A patent/GB2019844B/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
Also Published As
Publication number | Publication date |
---|---|
NL180664B (en) | 1986-11-03 |
IT7948690A0 (en) | 1979-04-10 |
DE2953973C2 (en) | 1989-02-02 |
FR2422658B1 (en) | 1981-12-31 |
DE2914258A1 (en) | 1979-10-25 |
AU529330B2 (en) | 1983-06-02 |
CA1153374A (en) | 1983-09-06 |
DE2914258C2 (en) | 1989-08-03 |
FR2422658A1 (en) | 1979-11-09 |
GB2019844B (en) | 1983-01-19 |
NL7902905A (en) | 1979-10-16 |
AU4603779A (en) | 1979-10-18 |
IT1196531B (en) | 1988-11-16 |
GB2020279A (en) | 1979-11-14 |
NL180664C (en) | 1987-04-01 |
DE2953973A1 (en) | 1982-08-26 |
CH640853A5 (en) | 1984-01-31 |
DE2953974C2 (en) | 1992-06-25 |
GB2020279B (en) | 1983-02-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |