ES8106903A1 - Benzo[ij]quinolizine-2- carboxylic acid compounds and therapeutic compositions containing them - Google Patents
Benzo[ij]quinolizine-2- carboxylic acid compounds and therapeutic compositions containing themInfo
- Publication number
- ES8106903A1 ES8106903A1 ES496312A ES496312A ES8106903A1 ES 8106903 A1 ES8106903 A1 ES 8106903A1 ES 496312 A ES496312 A ES 496312A ES 496312 A ES496312 A ES 496312A ES 8106903 A1 ES8106903 A1 ES 8106903A1
- Authority
- ES
- Spain
- Prior art keywords
- group substituted
- quinolizine
- benzo
- group
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000005605 benzo group Chemical group 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Benzo[ij]quinolizine-2-carboxylic acids of the formula:- < IMAGE > wherein R<1> represents a hydrogen atom or a lower alkyl group R<2> represents a hydrogen atom or a halogen atom R<3> represents a lower alkyl group substituted with one or more of a halogen atom and a hydroxy group, a lower alkanoyl group substituted with one or more halogen atoms, a phenylalkyl group substituted with one or more lower alkoxy groups on the phenyl ring, a lower alkanesulfonyl group substituted with one or more halogen atoms, a lower alkenyl group or a lower alkynyl group or pharmaceutically acceptable salts thereof, have antimicrobial activity. They are particularly effective on those bacteria resistant to conventional antibiotics and can be maintained at high concentration levels in blood for extended periods of time.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54131630A JPS6019910B2 (en) | 1979-10-11 | 1979-10-11 | Benzo[ij]quinolidine-2-carboxylic acid derivative and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES496312A0 ES496312A0 (en) | 1981-10-01 |
| ES8106903A1 true ES8106903A1 (en) | 1981-10-01 |
Family
ID=15062532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES496312A Expired ES8106903A1 (en) | 1979-10-11 | 1980-10-11 | Benzo[ij]quinolizine-2- carboxylic acid compounds and therapeutic compositions containing them |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS6019910B2 (en) |
| AU (1) | AU536230B2 (en) |
| BE (1) | BE885605A (en) |
| CA (1) | CA1156232A (en) |
| CH (1) | CH644859A5 (en) |
| DE (1) | DE3037103A1 (en) |
| ES (1) | ES8106903A1 (en) |
| FR (1) | FR2467205A1 (en) |
| GB (1) | GB2062627B (en) |
| IT (1) | IT1143997B (en) |
| NL (1) | NL187020C (en) |
| SE (1) | SE445917B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57176987A (en) * | 1981-04-24 | 1982-10-30 | Otsuka Pharmaceut Co Ltd | Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative |
| NO156828C (en) * | 1980-11-10 | 1987-12-02 | Otsuka Pharma Co Ltd | ANALOGY PROCEDURE FOR THE PREPARATION OF ANTIBACTERYLY EFFECTIVE BENZOHETEROCYCLIC COMPOUNDS. |
| US4400386A (en) * | 1981-11-06 | 1983-08-23 | Riker Laboratories, Inc. | Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine |
| US4472406A (en) * | 1982-11-12 | 1984-09-18 | Riker Laboratories, Inc. | Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives |
| JPS59137482A (en) * | 1983-01-26 | 1984-08-07 | Otsuka Pharmaceut Co Ltd | Pyrrolo(3,2,1,-ij)quinoline-5-carboxylic acid derivative |
| JPS59155381A (en) * | 1983-02-22 | 1984-09-04 | Kyorin Pharmaceut Co Ltd | Benzoquinolizinecarboxylic acid derivative and its preparation |
| DE3333719A1 (en) * | 1983-09-17 | 1985-04-04 | Bayer Ag | SOLUTIONS MILK ACID SALTS OF PIPERAZINYL CHINOLONIC AND PIPERAZINYL AZACHINOLONE CARBONIC ACIDS |
| JPS60161987A (en) * | 1984-01-31 | 1985-08-23 | Otsuka Pharmaceut Co Ltd | Benzoheterocyclic ring derivative |
| DE3517709A1 (en) * | 1985-01-05 | 1986-07-10 | Bayer Ag | BASIC PREPARATIONS OF CHINOLON CARBON ACIDS |
| CA1253154A (en) * | 1985-05-24 | 1989-04-25 | Atsushi Takagi | Benzo¬ij|quinolizine-2-carboxylic acid derivatives |
| DE3741026A1 (en) * | 1987-12-03 | 1989-06-15 | Muetek Laser Und Opto Elektron | METHOD AND SYSTEM FOR (TRACK) GAS ANALYSIS |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE793524A (en) * | 1971-12-30 | 1973-06-29 | Riker Laboratories Inc | BENZOQUINOLIZINE-CARBOXYLIC ACIDS AND THEIR DERIVATIVES |
| JPS6034957B2 (en) * | 1978-04-12 | 1985-08-12 | 大塚製薬株式会社 | penicillanic acid derivatives |
-
1979
- 1979-10-11 JP JP54131630A patent/JPS6019910B2/en not_active Expired
-
1980
- 1980-10-01 DE DE19803037103 patent/DE3037103A1/en active Granted
- 1980-10-06 CH CH743580A patent/CH644859A5/en not_active IP Right Cessation
- 1980-10-09 BE BE0/202389A patent/BE885605A/en not_active IP Right Cessation
- 1980-10-09 AU AU63090/80A patent/AU536230B2/en not_active Ceased
- 1980-10-09 IT IT49851/80A patent/IT1143997B/en active
- 1980-10-09 CA CA000362012A patent/CA1156232A/en not_active Expired
- 1980-10-10 NL NLAANVRAGE8005613,A patent/NL187020C/en not_active IP Right Cessation
- 1980-10-10 GB GB8032782A patent/GB2062627B/en not_active Expired
- 1980-10-10 SE SE8007133A patent/SE445917B/en not_active IP Right Cessation
- 1980-10-10 FR FR8021722A patent/FR2467205A1/en active Granted
- 1980-10-11 ES ES496312A patent/ES8106903A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3037103C2 (en) | 1989-06-15 |
| JPS5655389A (en) | 1981-05-15 |
| NL8005613A (en) | 1981-04-14 |
| NL187020C (en) | 1991-05-01 |
| ES496312A0 (en) | 1981-10-01 |
| IT1143997B (en) | 1986-10-29 |
| SE8007133L (en) | 1981-04-12 |
| AU6309080A (en) | 1981-04-16 |
| JPS6019910B2 (en) | 1985-05-18 |
| IT8049851A0 (en) | 1980-10-09 |
| AU536230B2 (en) | 1984-05-03 |
| GB2062627B (en) | 1983-12-07 |
| SE445917B (en) | 1986-07-28 |
| BE885605A (en) | 1981-02-02 |
| CH644859A5 (en) | 1984-08-31 |
| DE3037103A1 (en) | 1981-05-07 |
| GB2062627A (en) | 1981-05-28 |
| FR2467205B1 (en) | 1983-10-07 |
| NL187020B (en) | 1990-12-03 |
| FR2467205A1 (en) | 1981-04-17 |
| CA1156232A (en) | 1983-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |