ES3039918T3 - Chimeric antigen receptors targeting b-cell maturation antigen - Google Patents

Chimeric antigen receptors targeting b-cell maturation antigen

Info

Publication number
ES3039918T3
ES3039918T3 ES20172811T ES20172811T ES3039918T3 ES 3039918 T3 ES3039918 T3 ES 3039918T3 ES 20172811 T ES20172811 T ES 20172811T ES 20172811 T ES20172811 T ES 20172811T ES 3039918 T3 ES3039918 T3 ES 3039918T3
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ES
Spain
Prior art keywords
ser
gly
leu
cell
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20172811T
Other languages
English (en)
Spanish (es)
Inventor
Tracy Chia-Chien Kuo
Riggers Javier Fernando Chaparro
Barbra Johnson Sasu
Roman Galetto
Bijan Andre Boldajipour
Cesar Adolfo Sommer
Blarcom Thomas John Van
Thomas Charles Pertel
Arvind Rajpal
Philippe Duchateau
Alexandre Juillerat
Julien Valton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
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Publication of ES3039918T3 publication Critical patent/ES3039918T3/es
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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ES20172811T 2015-04-13 2016-03-30 Chimeric antigen receptors targeting b-cell maturation antigen Active ES3039918T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562146825P 2015-04-13 2015-04-13
US201662286473P 2016-01-25 2016-01-25
US201662301177P 2016-02-29 2016-02-29

Publications (1)

Publication Number Publication Date
ES3039918T3 true ES3039918T3 (en) 2025-10-27

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Application Number Title Priority Date Filing Date
ES20172811T Active ES3039918T3 (en) 2015-04-13 2016-03-30 Chimeric antigen receptors targeting b-cell maturation antigen
ES16714020T Active ES2807591T3 (es) 2015-04-13 2016-03-30 Receptores de antígeno quimérico dirigidos a antígeno de maduración de células B

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ES16714020T Active ES2807591T3 (es) 2015-04-13 2016-03-30 Receptores de antígeno quimérico dirigidos a antígeno de maduración de células B

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US (3) US10294304B2 (enExample)
EP (2) EP3283520B1 (enExample)
JP (2) JP6921001B2 (enExample)
KR (3) KR102208443B1 (enExample)
CN (2) CN114149511A (enExample)
AU (3) AU2016248947B2 (enExample)
CA (1) CA2925589A1 (enExample)
CO (1) CO2017010502A2 (enExample)
DK (1) DK3283520T3 (enExample)
ES (2) ES3039918T3 (enExample)
IL (2) IL297223B2 (enExample)
MX (2) MX377809B (enExample)
MY (1) MY188432A (enExample)
PE (1) PE20171653A1 (enExample)
PH (1) PH12017501728A1 (enExample)
RU (1) RU2706582C2 (enExample)
SG (2) SG11201707089WA (enExample)
TW (2) TWI631138B (enExample)
WO (1) WO2016166630A1 (enExample)
ZA (1) ZA201706384B (enExample)

Families Citing this family (101)

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Publication number Priority date Publication date Assignee Title
EP3131927B8 (en) 2014-04-14 2020-12-23 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
WO2016014565A2 (en) 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
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