PE20221757A1 - Celulas t con car de bcma con actividades mejoradas - Google Patents
Celulas t con car de bcma con actividades mejoradasInfo
- Publication number
- PE20221757A1 PE20221757A1 PE2022001799A PE2022001799A PE20221757A1 PE 20221757 A1 PE20221757 A1 PE 20221757A1 PE 2022001799 A PE2022001799 A PE 2022001799A PE 2022001799 A PE2022001799 A PE 2022001799A PE 20221757 A1 PE20221757 A1 PE 20221757A1
- Authority
- PE
- Peru
- Prior art keywords
- cells
- bcma
- immune cells
- car
- caccrs
- Prior art date
Links
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 title abstract 5
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 title abstract 5
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 6
- 210000002865 immune cell Anatomy 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 230000000735 allogeneic effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000003675 cytokine receptors Human genes 0.000 abstract 1
- 108010057085 cytokine receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005931 immune cell recruitment Effects 0.000 abstract 1
- 230000002688 persistence Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
En la presente descripcion se proporcionan celulas inmunitarias modificadas por ingenieria genetica que comprenden un receptor quimerico de citocina constitutivamente activo (CACCR) y un receptor quimerico de antigeno (CAR) especifico para el antigeno de maduracion de celulas B (BCMA). En la presente descripcion tambien se proporcionan celulas inmunitarias modificadas por ingenieria genetica que comprenden uno o mas acidos nucleicos, por ejemplo, un vector bicistronico, como un vector viral que codifica los CACCR y los CAR de BCMA, y celulas inmunitarias modificadas por ingenieria genetica, por ejemplo, las celulas T autologas o alogenicas modificadas por ingenieria genetica que expresan tanto los CACCR como los CAR de BCMA a partir de acidos nucleicos. Cuando estan presentes en las celulas inmunitarias modificadas por ingenieria genetica que tienen el receptor quimerico de antigeno (CAR), los CACCR permiten una mayor activacion, proliferacion, persistencia y/o potencia de las celulas inmunitarias. Tambien se proporcionan en la presente descripcion los metodos para fabricar y usar las celulas inmunitarias modificadas por ingenieria genetica descritas en la presente descripcion, tales como los metodos para tratar una enfermedad o afeccion mediante la administracion de al menos una dosis apropiada de las celulas a un paciente que padece la afeccion
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062980914P | 2020-02-24 | 2020-02-24 | |
US202063020713P | 2020-05-06 | 2020-05-06 | |
US202063053409P | 2020-07-17 | 2020-07-17 | |
US202063092681P | 2020-10-16 | 2020-10-16 | |
PCT/US2021/019362 WO2021173630A1 (en) | 2020-02-24 | 2021-02-24 | Bcma car-t cells with enhanced activities |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20221757A1 true PE20221757A1 (es) | 2022-11-11 |
Family
ID=75108802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022001799A PE20221757A1 (es) | 2020-02-24 | 2021-02-24 | Celulas t con car de bcma con actividades mejoradas |
Country Status (14)
Country | Link |
---|---|
US (1) | US20210260118A1 (es) |
EP (1) | EP4110805A1 (es) |
JP (1) | JP2023514407A (es) |
KR (1) | KR20220145846A (es) |
CN (1) | CN115175929A (es) |
AU (1) | AU2021227191A1 (es) |
BR (1) | BR112022016657A2 (es) |
CA (1) | CA3167065A1 (es) |
CO (1) | CO2022011684A2 (es) |
IL (1) | IL295470A (es) |
MX (1) | MX2022010340A (es) |
PE (1) | PE20221757A1 (es) |
TW (1) | TW202146439A (es) |
WO (1) | WO2021173630A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022221737A1 (en) | 2021-04-16 | 2022-10-20 | Juno Therapeutics, Inc. | T cell therapy in patients who have had prior stem cell transplant |
WO2023081735A1 (en) | 2021-11-03 | 2023-05-11 | Celgene Corporation | Chimeric antigen receptors specific for b-cell maturation antigen for use in treating myeloma |
WO2023147515A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Methods of manufacturing cellular compositions |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
WO2024026445A1 (en) | 2022-07-29 | 2024-02-01 | Allogene Therapeutics Inc. | Engineered cells with reduced gene expression to mitigate immune cell recognition |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6010613A (en) | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
WO2011069004A1 (en) * | 2009-12-04 | 2011-06-09 | Quest Diagnostics Investments Incorporated | Mpl mutations in jak2 v617f negative patients with myeloproliferative disease |
GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
EP3964567A1 (en) | 2012-05-25 | 2022-03-09 | Cellectis | Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy |
MX2017009181A (es) | 2015-01-26 | 2017-11-22 | Cellectis | Receptores de antigenos quimericos de cadena sencilla especificos de anti-cll1 para inmunoterapia de cancer. |
PE20171653A1 (es) * | 2015-04-13 | 2017-11-13 | Pfizer | Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b |
CN114773476A (zh) * | 2015-04-13 | 2022-07-22 | 辉瑞公司 | 治疗性抗体和它们的用途 |
US20190183936A1 (en) * | 2016-08-26 | 2019-06-20 | Baylor College Of Medicine | Constitutively active cytokine receptors for cell therapy |
KR20200128054A (ko) * | 2018-03-02 | 2020-11-11 | 알로젠 테라퓨틱스 인코포레이티드 | 유도성 키메라 사이토카인 수용체 |
JP2021525530A (ja) * | 2018-06-01 | 2021-09-27 | ワシントン・ユニバーシティWashington University | キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制 |
JP2022522654A (ja) * | 2019-03-01 | 2022-04-20 | アロジーン セラピューティクス,インコーポレイテッド | Pd-1外部ドメインを担持するキメラサイトカイン受容体 |
PE20211902A1 (es) * | 2019-03-01 | 2021-09-27 | Allogene Therapeutics Inc | Receptores de citocinas quimericos constitutivamente activos |
-
2021
- 2021-02-24 IL IL295470A patent/IL295470A/en unknown
- 2021-02-24 PE PE2022001799A patent/PE20221757A1/es unknown
- 2021-02-24 CA CA3167065A patent/CA3167065A1/en active Pending
- 2021-02-24 CN CN202180016621.7A patent/CN115175929A/zh active Pending
- 2021-02-24 BR BR112022016657A patent/BR112022016657A2/pt unknown
- 2021-02-24 JP JP2022550184A patent/JP2023514407A/ja active Pending
- 2021-02-24 EP EP21713206.7A patent/EP4110805A1/en active Pending
- 2021-02-24 AU AU2021227191A patent/AU2021227191A1/en active Pending
- 2021-02-24 MX MX2022010340A patent/MX2022010340A/es unknown
- 2021-02-24 WO PCT/US2021/019362 patent/WO2021173630A1/en active Application Filing
- 2021-02-24 TW TW110106494A patent/TW202146439A/zh unknown
- 2021-02-24 KR KR1020227030983A patent/KR20220145846A/ko unknown
- 2021-02-24 US US17/183,689 patent/US20210260118A1/en active Pending
-
2022
- 2022-08-19 CO CONC2022/0011684A patent/CO2022011684A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2021227191A1 (en) | 2022-08-25 |
KR20220145846A (ko) | 2022-10-31 |
CN115175929A (zh) | 2022-10-11 |
IL295470A (en) | 2022-10-01 |
EP4110805A1 (en) | 2023-01-04 |
US20210260118A1 (en) | 2021-08-26 |
BR112022016657A2 (pt) | 2022-12-20 |
JP2023514407A (ja) | 2023-04-05 |
WO2021173630A1 (en) | 2021-09-02 |
CO2022011684A2 (es) | 2022-08-30 |
CA3167065A1 (en) | 2021-09-02 |
TW202146439A (zh) | 2021-12-16 |
MX2022010340A (es) | 2022-09-19 |
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