MX377809B - Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b. - Google Patents

Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b.

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Publication number
MX377809B
MX377809B MX2017013298A MX2017013298A MX377809B MX 377809 B MX377809 B MX 377809B MX 2017013298 A MX2017013298 A MX 2017013298A MX 2017013298 A MX2017013298 A MX 2017013298A MX 377809 B MX377809 B MX 377809B
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MX
Mexico
Prior art keywords
cars
cell maturation
antigen
immune cells
engineered immune
Prior art date
Application number
MX2017013298A
Other languages
English (en)
Other versions
MX2017013298A (es
Inventor
Alexandre Juillerat
Arvind Rajpal
Barbra Johnson Sasu
Bijan Andre Boldajipour
Cesar Adolfo Sommer
Riggers Javier Fernando Chaparro
Julien Valton
Philippe Duchateau
Roman Galetto
Thomas Charles Pertel
Blarcom Thomas John Van
Tracy Chia- Chien Kuo
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2017013298A publication Critical patent/MX2017013298A/es
Publication of MX377809B publication Critical patent/MX377809B/es

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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract

La presente invención se refiere a CARs (CARs) que específicamente unen a BCMA (antígeno de maduración de célula B). La invención además se refiere a células inmunes manipuladas que comprenden dichos CARs, ácidos nucleicos que codifican CAR, y métodos de hacer dichos CARs, células inmunes manipuladas, y ácidos nucleicos. La invención además se refiere a métodos terapéuticos para uso de estos CARs y células inmunes manipuladas para el tratamiento de una condición asociada con células malignas que expresan BCMA (por ejemplo, cáncer).
MX2017013298A 2015-04-13 2016-03-30 Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b. MX377809B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562146825P 2015-04-13 2015-04-13
US201662286473P 2016-01-25 2016-01-25
US201662301177P 2016-02-29 2016-02-29
PCT/IB2016/051808 WO2016166630A1 (en) 2015-04-13 2016-03-30 Chimeric antigen receptors targeting b-cell maturation antigen

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MX2017013298A MX2017013298A (es) 2018-06-19
MX377809B true MX377809B (es) 2025-03-11

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MX2020012573A MX2020012573A (es) 2015-04-13 2017-10-13 Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b.

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Families Citing this family (107)

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