ES2886979T3 - Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos - Google Patents
Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos Download PDFInfo
- Publication number
- ES2886979T3 ES2886979T3 ES18162713T ES18162713T ES2886979T3 ES 2886979 T3 ES2886979 T3 ES 2886979T3 ES 18162713 T ES18162713 T ES 18162713T ES 18162713 T ES18162713 T ES 18162713T ES 2886979 T3 ES2886979 T3 ES 2886979T3
- Authority
- ES
- Spain
- Prior art keywords
- patients
- determinants
- bacterial
- viral
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000015181 infectious disease Diseases 0.000 title description 166
- 238000000034 method Methods 0.000 title description 98
- 102100032752 C-reactive protein Human genes 0.000 claims abstract description 99
- 230000001580 bacterial effect Effects 0.000 claims abstract description 99
- 108010074051 C-Reactive Protein Proteins 0.000 claims abstract description 98
- 208000036142 Viral infection Diseases 0.000 claims abstract description 97
- 230000009385 viral infection Effects 0.000 claims abstract description 89
- 208000035143 Bacterial infection Diseases 0.000 claims abstract description 69
- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract description 68
- 208000003322 Coinfection Diseases 0.000 claims abstract description 40
- 101710097160 Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 claims abstract description 5
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims abstract 4
- 239000011159 matrix material Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- 108010008978 Chemokine CXCL10 Proteins 0.000 claims description 2
- 102000006579 Chemokine CXCL10 Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 abstract description 262
- 102000004169 proteins and genes Human genes 0.000 abstract description 149
- 235000018102 proteins Nutrition 0.000 description 144
- 102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 description 125
- 108700012411 TNFSF10 Proteins 0.000 description 122
- -1 IL1a Proteins 0.000 description 108
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 description 100
- 108090000765 processed proteins & peptides Proteins 0.000 description 91
- 102000004196 processed proteins & peptides Human genes 0.000 description 81
- 230000003612 virological effect Effects 0.000 description 81
- 241000699666 Mus <mouse, genus> Species 0.000 description 78
- 229920001184 polypeptide Polymers 0.000 description 77
- 238000005259 measurement Methods 0.000 description 64
- 238000012360 testing method Methods 0.000 description 63
- 101710190759 Serum amyloid A protein Proteins 0.000 description 58
- 102100032277 Serum amyloid A-1 protein Human genes 0.000 description 58
- 238000003556 assay Methods 0.000 description 54
- 239000000090 biomarker Substances 0.000 description 53
- 230000006870 function Effects 0.000 description 51
- 239000000523 sample Substances 0.000 description 47
- 238000003745 diagnosis Methods 0.000 description 45
- 108090001007 Interleukin-8 Proteins 0.000 description 44
- 102000004890 Interleukin-8 Human genes 0.000 description 42
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 42
- 210000004027 cell Anatomy 0.000 description 41
- 108010048233 Procalcitonin Proteins 0.000 description 40
- CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 description 40
- 102000005962 receptors Human genes 0.000 description 40
- 108020003175 receptors Proteins 0.000 description 40
- 208000024891 symptom Diseases 0.000 description 40
- 229940096397 interleukin-8 Drugs 0.000 description 37
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 37
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 36
- 244000052769 pathogen Species 0.000 description 36
- 230000000694 effects Effects 0.000 description 34
- 208000035473 Communicable disease Diseases 0.000 description 32
- 108090000695 Cytokines Proteins 0.000 description 31
- 238000009826 distribution Methods 0.000 description 30
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 29
- 102100029681 Triggering receptor expressed on myeloid cells 1 Human genes 0.000 description 29
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 29
- 238000011282 treatment Methods 0.000 description 29
- 238000004458 analytical method Methods 0.000 description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 28
- 102000004127 Cytokines Human genes 0.000 description 27
- 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 description 27
- 208000031662 Noncommunicable disease Diseases 0.000 description 27
- 201000010099 disease Diseases 0.000 description 27
- 210000000265 leukocyte Anatomy 0.000 description 27
- 102100038196 Chitinase-3-like protein 1 Human genes 0.000 description 26
- 108010029485 Protein Isoforms Proteins 0.000 description 26
- 102000001708 Protein Isoforms Human genes 0.000 description 26
- 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 description 26
- 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 description 25
- 230000036541 health Effects 0.000 description 25
- 102100027314 Beta-2-microglobulin Human genes 0.000 description 24
- 102000004889 Interleukin-6 Human genes 0.000 description 24
- 108090001005 Interleukin-6 Proteins 0.000 description 24
- 230000001717 pathogenic effect Effects 0.000 description 24
- 230000035945 sensitivity Effects 0.000 description 24
- 238000001514 detection method Methods 0.000 description 23
- 210000004698 lymphocyte Anatomy 0.000 description 23
- 210000000440 neutrophil Anatomy 0.000 description 23
- 230000004044 response Effects 0.000 description 23
- 210000002966 serum Anatomy 0.000 description 23
- 108010066813 Chitinase-3-Like Protein 1 Proteins 0.000 description 22
- 102100026236 Interleukin-8 Human genes 0.000 description 22
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 description 22
- 239000003814 drug Substances 0.000 description 22
- 102100025277 C-X-C motif chemokine 13 Human genes 0.000 description 21
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 21
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 description 21
- 102100034170 Interferon-induced, double-stranded RNA-activated protein kinase Human genes 0.000 description 21
- 239000004202 carbamide Substances 0.000 description 21
- 230000008569 process Effects 0.000 description 21
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 description 20
- 101001018097 Homo sapiens L-selectin Proteins 0.000 description 20
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 description 20
- 102100033467 L-selectin Human genes 0.000 description 20
- 229940079593 drug Drugs 0.000 description 20
- 241000894006 Bacteria Species 0.000 description 19
- 101710121996 Hexon protein p72 Proteins 0.000 description 19
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 description 19
- 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 description 19
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 description 19
- 101710125418 Major capsid protein Proteins 0.000 description 19
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 19
- 241000700605 Viruses Species 0.000 description 19
- 230000027455 binding Effects 0.000 description 19
- 210000002751 lymph Anatomy 0.000 description 19
- 239000011591 potassium Substances 0.000 description 19
- 229910052700 potassium Inorganic materials 0.000 description 19
- 101000926535 Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 18
- 238000004422 calculation algorithm Methods 0.000 description 18
- 229940109239 creatinine Drugs 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- YMZPQKXPKZZSFV-CPWYAANMSA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-2-[(1r)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H]([C@H]2C=CCCC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 YMZPQKXPKZZSFV-CPWYAANMSA-N 0.000 description 17
- PCLCDPVEEFVAAQ-UHFFFAOYSA-N BCA 1 Chemical compound CC(CO)CCCC(C)C1=CCC(C)(O)C1CC2=C(O)C(O)CCC2=O PCLCDPVEEFVAAQ-UHFFFAOYSA-N 0.000 description 17
- 102100023688 Eotaxin Human genes 0.000 description 17
- 101710139422 Eotaxin Proteins 0.000 description 17
- 230000006907 apoptotic process Effects 0.000 description 17
- 239000011324 bead Substances 0.000 description 17
- 230000014509 gene expression Effects 0.000 description 17
- 210000001616 monocyte Anatomy 0.000 description 17
- 102100021723 Arginase-1 Human genes 0.000 description 16
- 101710129000 Arginase-1 Proteins 0.000 description 16
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 description 16
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 description 16
- 210000002381 plasma Anatomy 0.000 description 16
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 description 15
- 102100038805 Lysophospholipid acyltransferase 2 Human genes 0.000 description 15
- 206010028980 Neoplasm Diseases 0.000 description 15
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 description 15
- 210000001744 T-lymphocyte Anatomy 0.000 description 15
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 description 15
- 239000000427 antigen Substances 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 15
- 102000036639 antigens Human genes 0.000 description 15
- 102100040510 Galectin-3-binding protein Human genes 0.000 description 14
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 description 14
- 101000942626 Homo sapiens UMP-CMP kinase 2, mitochondrial Proteins 0.000 description 14
- 102100029216 SLAM family member 5 Human genes 0.000 description 14
- 102100032947 UMP-CMP kinase 2, mitochondrial Human genes 0.000 description 14
- 230000004913 activation Effects 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 230000001419 dependent effect Effects 0.000 description 14
- 238000003018 immunoassay Methods 0.000 description 14
- 230000002458 infectious effect Effects 0.000 description 14
- 230000004054 inflammatory process Effects 0.000 description 14
- 230000003834 intracellular effect Effects 0.000 description 14
- 239000012528 membrane Substances 0.000 description 14
- 238000000338 in vitro Methods 0.000 description 13
- 238000012706 support-vector machine Methods 0.000 description 13
- 102100027621 2'-5'-oligoadenylate synthase 2 Human genes 0.000 description 12
- 102100022464 5'-nucleotidase Human genes 0.000 description 12
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 description 12
- 108010017009 CD11b Antigen Proteins 0.000 description 12
- 102000004354 CD11b Antigen Human genes 0.000 description 12
- 108010012236 Chemokines Proteins 0.000 description 12
- 102100041022 Coronin-1C Human genes 0.000 description 12
- 102100030341 Ethanolaminephosphotransferase 1 Human genes 0.000 description 12
- 101001008910 Homo sapiens 2'-5'-oligoadenylate synthase 2 Proteins 0.000 description 12
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 12
- 101000916059 Homo sapiens C-X-C chemokine receptor type 2 Proteins 0.000 description 12
- 101000748856 Homo sapiens Coronin-1C Proteins 0.000 description 12
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 description 12
- 101000589307 Homo sapiens Natural cytotoxicity triggering receptor 3 Proteins 0.000 description 12
- 101000857759 Homo sapiens Probable G-protein coupled receptor 162 Proteins 0.000 description 12
- 101000584600 Homo sapiens Ras-related protein Rap-1b Proteins 0.000 description 12
- 101000727462 Homo sapiens Reticulon-3 Proteins 0.000 description 12
- 101100172525 Homo sapiens SELENOI gene Proteins 0.000 description 12
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 12
- 102100020881 Interleukin-1 alpha Human genes 0.000 description 12
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 description 12
- 102000048238 Neuregulin-1 Human genes 0.000 description 12
- 108090000556 Neuregulin-1 Proteins 0.000 description 12
- 102100025358 Probable G-protein coupled receptor 162 Human genes 0.000 description 12
- 102100030705 Ras-related protein Rap-1b Human genes 0.000 description 12
- 102100029832 Reticulon-3 Human genes 0.000 description 12
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 12
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 12
- 239000012491 analyte Substances 0.000 description 12
- 230000000840 anti-viral effect Effects 0.000 description 12
- 208000035850 clinical syndrome Diseases 0.000 description 12
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 12
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 12
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 12
- 102100038008 60S ribosomal protein L22-like 1 Human genes 0.000 description 11
- 102000019034 Chemokines Human genes 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 11
- 108090000790 Enzymes Proteins 0.000 description 11
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 11
- 108010075704 HLA-A Antigens Proteins 0.000 description 11
- 101000661567 Homo sapiens 60S ribosomal protein L22-like 1 Proteins 0.000 description 11
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 11
- 101001034844 Homo sapiens Interferon-induced transmembrane protein 1 Proteins 0.000 description 11
- 101000957316 Homo sapiens Lysophospholipid acyltransferase 2 Proteins 0.000 description 11
- 101000589301 Homo sapiens Natural cytotoxicity triggering receptor 1 Proteins 0.000 description 11
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 11
- 102100032818 Integrin alpha-4 Human genes 0.000 description 11
- 102100040021 Interferon-induced transmembrane protein 1 Human genes 0.000 description 11
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 description 11
- 102100035488 Nectin-2 Human genes 0.000 description 11
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 11
- 102100040952 Tetraspanin-7 Human genes 0.000 description 11
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 11
- 230000001154 acute effect Effects 0.000 description 11
- 230000036760 body temperature Effects 0.000 description 11
- 239000003153 chemical reaction reagent Substances 0.000 description 11
- 229940088598 enzyme Drugs 0.000 description 11
- 230000011664 signaling Effects 0.000 description 11
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 description 10
- 102100033497 Adiponectin receptor protein 1 Human genes 0.000 description 10
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 10
- 102100034871 C-C motif chemokine 8 Human genes 0.000 description 10
- 101710155833 C-C motif chemokine 8 Proteins 0.000 description 10
- 102100038712 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Human genes 0.000 description 10
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 10
- 102100029602 Eukaryotic translation initiation factor 4B Human genes 0.000 description 10
- 241000282414 Homo sapiens Species 0.000 description 10
- 101001135206 Homo sapiens Adiponectin receptor protein 1 Proteins 0.000 description 10
- 101000883304 Homo sapiens Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Proteins 0.000 description 10
- 101000840282 Homo sapiens Eukaryotic translation initiation factor 4B Proteins 0.000 description 10
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 description 10
- 101000663639 Homo sapiens Kunitz-type protease inhibitor 2 Proteins 0.000 description 10
- 101000735459 Homo sapiens Protein mono-ADP-ribosyltransferase PARP9 Proteins 0.000 description 10
- 206010061218 Inflammation Diseases 0.000 description 10
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 description 10
- 102100039020 Kunitz-type protease inhibitor 2 Human genes 0.000 description 10
- 102100034930 Protein mono-ADP-ribosyltransferase PARP9 Human genes 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 10
- 230000001965 increasing effect Effects 0.000 description 10
- 238000011534 incubation Methods 0.000 description 10
- AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 description 10
- 108020004999 messenger RNA Proteins 0.000 description 10
- 230000002906 microbiologic effect Effects 0.000 description 10
- 102000054765 polymorphisms of proteins Human genes 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 9
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 9
- 102100039922 E3 ISG15-protein ligase HERC5 Human genes 0.000 description 9
- 238000002965 ELISA Methods 0.000 description 9
- 102100024977 Glutamine-tRNA ligase Human genes 0.000 description 9
- 101001035145 Homo sapiens E3 ISG15-protein ligase HERC5 Proteins 0.000 description 9
- 101001005211 Homo sapiens Lipoyltransferase 1, mitochondrial Proteins 0.000 description 9
- 101000938676 Homo sapiens Liver carboxylesterase 1 Proteins 0.000 description 9
- 101000873927 Homo sapiens Squamous cell carcinoma antigen recognized by T-cells 3 Proteins 0.000 description 9
- 101000954434 Homo sapiens V-type proton ATPase 21 kDa proteolipid subunit c'' Proteins 0.000 description 9
- 101001129796 Homo sapiens p53-induced death domain-containing protein 1 Proteins 0.000 description 9
- 108010050904 Interferons Proteins 0.000 description 9
- 102000014150 Interferons Human genes 0.000 description 9
- 102100025853 Lipoyltransferase 1, mitochondrial Human genes 0.000 description 9
- 102100031347 Metallothionein-2 Human genes 0.000 description 9
- 206010037660 Pyrexia Diseases 0.000 description 9
- 102100035748 Squamous cell carcinoma antigen recognized by T-cells 3 Human genes 0.000 description 9
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 9
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 9
- 102100037167 V-type proton ATPase 21 kDa proteolipid subunit c'' Human genes 0.000 description 9
- 238000013459 approach Methods 0.000 description 9
- 238000002405 diagnostic procedure Methods 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 210000000987 immune system Anatomy 0.000 description 9
- 239000002609 medium Substances 0.000 description 9
- 230000035772 mutation Effects 0.000 description 9
- 238000010606 normalization Methods 0.000 description 9
- 102100031691 p53-induced death domain-containing protein 1 Human genes 0.000 description 9
- 208000019206 urinary tract infection Diseases 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 9
- 102100040637 60S ribosomal protein L34 Human genes 0.000 description 8
- 102100021636 Actin-related protein 2/3 complex subunit 2 Human genes 0.000 description 8
- 102100028233 Coronin-1A Human genes 0.000 description 8
- 102100034597 E3 ubiquitin-protein ligase TRIM22 Human genes 0.000 description 8
- 108700024394 Exon Proteins 0.000 description 8
- 101710197901 Galectin-3-binding protein Proteins 0.000 description 8
- 101000672659 Homo sapiens 60S ribosomal protein L34 Proteins 0.000 description 8
- 101000754220 Homo sapiens Actin-related protein 2/3 complex subunit 2 Proteins 0.000 description 8
- 101000860852 Homo sapiens Coronin-1A Proteins 0.000 description 8
- 101000848629 Homo sapiens E3 ubiquitin-protein ligase TRIM22 Proteins 0.000 description 8
- 101000625192 Homo sapiens Glutamine-tRNA ligase Proteins 0.000 description 8
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 description 8
- 101000630284 Homo sapiens Proline-tRNA ligase Proteins 0.000 description 8
- 101000620529 Homo sapiens Ras-related protein Rab-13 Proteins 0.000 description 8
- 101000644684 Homo sapiens Ubiquitin-conjugating enzyme E2 N Proteins 0.000 description 8
- 101000964436 Homo sapiens Z-DNA-binding protein 1 Proteins 0.000 description 8
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 description 8
- 108010002586 Interleukin-7 Proteins 0.000 description 8
- 102100021592 Interleukin-7 Human genes 0.000 description 8
- 108010052285 Membrane Proteins Proteins 0.000 description 8
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 8
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 8
- 102100022303 Ras-related protein Rab-13 Human genes 0.000 description 8
- 102100020695 Ubiquitin-conjugating enzyme E2 N Human genes 0.000 description 8
- 102100040310 Z-DNA-binding protein 1 Human genes 0.000 description 8
- 210000000170 cell membrane Anatomy 0.000 description 8
- 230000001413 cellular effect Effects 0.000 description 8
- 210000000349 chromosome Anatomy 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 8
- 102000006495 integrins Human genes 0.000 description 8
- 108010044426 integrins Proteins 0.000 description 8
- 229940079322 interferon Drugs 0.000 description 8
- 238000011835 investigation Methods 0.000 description 8
- 210000002540 macrophage Anatomy 0.000 description 8
- 230000009871 nonspecific binding Effects 0.000 description 8
- 230000037361 pathway Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 102100026032 BRI3-binding protein Human genes 0.000 description 7
- 101000933488 Homo sapiens BRI3-binding protein Proteins 0.000 description 7
- 102100024573 Macrophage-capping protein Human genes 0.000 description 7
- 102000018697 Membrane Proteins Human genes 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- 101000599776 Rattus norvegicus Insulin-like growth factor 2 mRNA-binding protein 1 Proteins 0.000 description 7
- 241000710886 West Nile virus Species 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 7
- 229940024606 amino acid Drugs 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 238000004820 blood count Methods 0.000 description 7
- 201000011510 cancer Diseases 0.000 description 7
- 230000001684 chronic effect Effects 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 230000003993 interaction Effects 0.000 description 7
- 229940100994 interleukin-7 Drugs 0.000 description 7
- 150000002632 lipids Chemical class 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000003550 marker Substances 0.000 description 7
- 208000017667 Chronic Disease Diseases 0.000 description 6
- 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 description 6
- 101000804865 Homo sapiens E3 ubiquitin-protein ligase XIAP Proteins 0.000 description 6
- 101000967904 Homo sapiens Galectin-3-binding protein Proteins 0.000 description 6
- 102000015696 Interleukins Human genes 0.000 description 6
- 108010063738 Interleukins Proteins 0.000 description 6
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 6
- 108010004729 Phycoerythrin Proteins 0.000 description 6
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 6
- 238000002790 cross-validation Methods 0.000 description 6
- 230000001086 cytosolic effect Effects 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 208000037797 influenza A Diseases 0.000 description 6
- 239000003446 ligand Substances 0.000 description 6
- 238000007403 mPCR Methods 0.000 description 6
- 238000004949 mass spectrometry Methods 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 239000002207 metabolite Substances 0.000 description 6
- 230000005012 migration Effects 0.000 description 6
- 238000013508 migration Methods 0.000 description 6
- 210000003470 mitochondria Anatomy 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000009885 systemic effect Effects 0.000 description 6
- 108091006112 ATPases Proteins 0.000 description 5
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 5
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 5
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 description 5
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 5
- OABOXRPGTFRBFZ-IMJSIDKUSA-N Cys-Cys Chemical compound SC[C@H](N)C(=O)N[C@@H](CS)C(O)=O OABOXRPGTFRBFZ-IMJSIDKUSA-N 0.000 description 5
- 241000711549 Hepacivirus C Species 0.000 description 5
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 description 5
- 101000814514 Homo sapiens XIAP-associated factor 1 Proteins 0.000 description 5
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 description 5
- 208000037581 Persistent Infection Diseases 0.000 description 5
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 5
- 241000725643 Respiratory syncytial virus Species 0.000 description 5
- 206010057190 Respiratory tract infections Diseases 0.000 description 5
- 102100039488 XIAP-associated factor 1 Human genes 0.000 description 5
- 230000004075 alteration Effects 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 229940088710 antibiotic agent Drugs 0.000 description 5
- 244000052616 bacterial pathogen Species 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000007635 classification algorithm Methods 0.000 description 5
- 239000002131 composite material Substances 0.000 description 5
- 108010004073 cysteinylcysteine Proteins 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000004069 differentiation Effects 0.000 description 5
- 210000003979 eosinophil Anatomy 0.000 description 5
- 210000003714 granulocyte Anatomy 0.000 description 5
- 230000028993 immune response Effects 0.000 description 5
- 230000028709 inflammatory response Effects 0.000 description 5
- 230000015788 innate immune response Effects 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 150000003905 phosphatidylinositols Chemical class 0.000 description 5
- 230000026731 phosphorylation Effects 0.000 description 5
- 238000006366 phosphorylation reaction Methods 0.000 description 5
- 238000003752 polymerase chain reaction Methods 0.000 description 5
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 5
- 238000007637 random forest analysis Methods 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 239000011534 wash buffer Substances 0.000 description 5
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 4
- 102100026548 Caspase-8 Human genes 0.000 description 4
- 108090000538 Caspase-8 Proteins 0.000 description 4
- 206010007882 Cellulitis Diseases 0.000 description 4
- 208000005577 Gastroenteritis Diseases 0.000 description 4
- 102000003886 Glycoproteins Human genes 0.000 description 4
- 108090000288 Glycoproteins Proteins 0.000 description 4
- 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 description 4
- 101000610609 Homo sapiens Tumor necrosis factor receptor superfamily member 10D Proteins 0.000 description 4
- 230000006133 ISGylation Effects 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 102000000589 Interleukin-1 Human genes 0.000 description 4
- 108010002352 Interleukin-1 Proteins 0.000 description 4
- 108090000177 Interleukin-11 Proteins 0.000 description 4
- 102000003815 Interleukin-11 Human genes 0.000 description 4
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 4
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 206010035664 Pneumonia Diseases 0.000 description 4
- 206010036790 Productive cough Diseases 0.000 description 4
- 102100027720 SH2 domain-containing protein 1A Human genes 0.000 description 4
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 4
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 4
- 102100040110 Tumor necrosis factor receptor superfamily member 10D Human genes 0.000 description 4
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 4
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 description 4
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 4
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 238000011088 calibration curve Methods 0.000 description 4
- 230000003399 chemotactic effect Effects 0.000 description 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 230000002596 correlated effect Effects 0.000 description 4
- 238000013500 data storage Methods 0.000 description 4
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 4
- 210000002889 endothelial cell Anatomy 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 239000000833 heterodimer Substances 0.000 description 4
- 244000052637 human pathogen Species 0.000 description 4
- 230000001900 immune effect Effects 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 239000007791 liquid phase Substances 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 238000002483 medication Methods 0.000 description 4
- 244000000010 microbial pathogen Species 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 230000004481 post-translational protein modification Effects 0.000 description 4
- 230000010076 replication Effects 0.000 description 4
- 230000019491 signal transduction Effects 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 238000004611 spectroscopical analysis Methods 0.000 description 4
- 210000003802 sputum Anatomy 0.000 description 4
- 208000024794 sputum Diseases 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000012549 training Methods 0.000 description 4
- 230000014616 translation Effects 0.000 description 4
- 230000005945 translocation Effects 0.000 description 4
- 230000032258 transport Effects 0.000 description 4
- 210000004881 tumor cell Anatomy 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
- 108010052187 1-Acylglycerophosphocholine O-Acyltransferase Proteins 0.000 description 3
- SRNWOUGRCWSEMX-KEOHHSTQSA-N ADP-beta-D-ribose Chemical group C([C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1C=2N=CN=C(C=2N=C1)N)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O SRNWOUGRCWSEMX-KEOHHSTQSA-N 0.000 description 3
- 108700028369 Alleles Proteins 0.000 description 3
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 description 3
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 description 3
- 208000031729 Bacteremia Diseases 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 241000283707 Capra Species 0.000 description 3
- 102000012286 Chitinases Human genes 0.000 description 3
- 108010022172 Chitinases Proteins 0.000 description 3
- 102000010170 Death domains Human genes 0.000 description 3
- 108050001718 Death domains Proteins 0.000 description 3
- 241000725619 Dengue virus Species 0.000 description 3
- 102000016955 Erythrocyte Anion Exchange Protein 1 Human genes 0.000 description 3
- 241000192125 Firmicutes Species 0.000 description 3
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 3
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 3
- 108010058607 HLA-B Antigens Proteins 0.000 description 3
- 108010052199 HLA-C Antigens Proteins 0.000 description 3
- 241000700721 Hepatitis B virus Species 0.000 description 3
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 description 3
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 3
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 description 3
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 description 3
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 description 3
- 101000795107 Homo sapiens Triggering receptor expressed on myeloid cells 1 Proteins 0.000 description 3
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 description 3
- 241000725303 Human immunodeficiency virus Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 102100040019 Interferon alpha-1/13 Human genes 0.000 description 3
- 102100037850 Interferon gamma Human genes 0.000 description 3
- 108010074328 Interferon-gamma Proteins 0.000 description 3
- 102100029607 Interferon-induced protein 44 Human genes 0.000 description 3
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 description 3
- 101710097496 Lysophospholipid acyltransferase Proteins 0.000 description 3
- 101710163746 Lysophospholipid acyltransferase 2 Proteins 0.000 description 3
- 208000001572 Mycoplasma Pneumonia Diseases 0.000 description 3
- 201000008235 Mycoplasma pneumoniae pneumonia Diseases 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 206010034686 Peritonsillar abscess Diseases 0.000 description 3
- 206010057249 Phagocytosis Diseases 0.000 description 3
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 description 3
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 description 3
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- 108010000605 Ribosomal Proteins Proteins 0.000 description 3
- 102000002278 Ribosomal Proteins Human genes 0.000 description 3
- 108091006318 SLC4A1 Proteins 0.000 description 3
- 206010040047 Sepsis Diseases 0.000 description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 3
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 description 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 3
- 108091027569 Z-DNA Proteins 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 238000013528 artificial neural network Methods 0.000 description 3
- 230000006399 behavior Effects 0.000 description 3
- 210000001772 blood platelet Anatomy 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 150000001720 carbohydrates Chemical group 0.000 description 3
- 230000024245 cell differentiation Effects 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 230000033077 cellular process Effects 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 238000004590 computer program Methods 0.000 description 3
- 230000021615 conjugation Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 235000018417 cysteine Nutrition 0.000 description 3
- 150000001945 cysteines Chemical group 0.000 description 3
- 210000000805 cytoplasm Anatomy 0.000 description 3
- 238000013480 data collection Methods 0.000 description 3
- 230000007123 defense Effects 0.000 description 3
- 230000005860 defense response to virus Effects 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000003862 health status Effects 0.000 description 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 230000004957 immunoregulator effect Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 239000012678 infectious agent Substances 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 230000008611 intercellular interaction Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000008782 phagocytosis Effects 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012502 risk assessment Methods 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000000405 serological effect Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000013517 stratification Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 241000701161 unidentified adenovirus Species 0.000 description 3
- 241000712461 unidentified influenza virus Species 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 2
- 102000018659 1-Acylglycerophosphocholine O-Acyltransferase Human genes 0.000 description 2
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 description 2
- NCMVOABPESMRCP-SHYZEUOFSA-N 2'-deoxycytosine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 NCMVOABPESMRCP-SHYZEUOFSA-N 0.000 description 2
- PWJFNRJRHXWEPT-UHFFFAOYSA-N ADP ribose Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C1O PWJFNRJRHXWEPT-UHFFFAOYSA-N 0.000 description 2
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 2
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 102000006306 Antigen Receptors Human genes 0.000 description 2
- 108010083359 Antigen Receptors Proteins 0.000 description 2
- 102000007592 Apolipoproteins Human genes 0.000 description 2
- 108010071619 Apolipoproteins Proteins 0.000 description 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 2
- 101100325788 Arabidopsis thaliana BCA1 gene Proteins 0.000 description 2
- 102000004452 Arginase Human genes 0.000 description 2
- 108700024123 Arginases Proteins 0.000 description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 2
- 108091012583 BCL2 Proteins 0.000 description 2
- 108091007065 BIRCs Proteins 0.000 description 2
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 2
- 208000020925 Bipolar disease Diseases 0.000 description 2
- 241000588832 Bordetella pertussis Species 0.000 description 2
- 206010006448 Bronchiolitis Diseases 0.000 description 2
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 description 2
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 description 2
- 101710098272 C-X-C motif chemokine 11 Proteins 0.000 description 2
- 108050006947 CXC Chemokine Proteins 0.000 description 2
- 102000004631 Calcineurin Human genes 0.000 description 2
- 108010042955 Calcineurin Proteins 0.000 description 2
- 102400000113 Calcitonin Human genes 0.000 description 2
- 108060001064 Calcitonin Proteins 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 102000011727 Caspases Human genes 0.000 description 2
- 108010076667 Caspases Proteins 0.000 description 2
- 208000000362 Chlamydial Pneumonia Diseases 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 101100232684 Cryptosporidium parvum EIF4-A gene Proteins 0.000 description 2
- 102100026234 Cytokine receptor common subunit gamma Human genes 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- FDKWRPBBCBCIGA-UWTATZPHSA-N D-Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 description 2
- 230000033616 DNA repair Effects 0.000 description 2
- 238000012286 ELISA Assay Methods 0.000 description 2
- 241000710188 Encephalomyocarditis virus Species 0.000 description 2
- 102400001368 Epidermal growth factor Human genes 0.000 description 2
- 101800003838 Epidermal growth factor Proteins 0.000 description 2
- 101710196841 Erythrocyte-binding antigen 175 Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 102000013446 GTP Phosphohydrolases Human genes 0.000 description 2
- 102000030782 GTP binding Human genes 0.000 description 2
- 108091000058 GTP-Binding Proteins 0.000 description 2
- 108091006109 GTPases Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 2
- 102100035716 Glycophorin-A Human genes 0.000 description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 102100034221 Growth-regulated alpha protein Human genes 0.000 description 2
- 241000606768 Haemophilus influenzae Species 0.000 description 2
- 208000005176 Hepatitis C Diseases 0.000 description 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 description 2
- 241000709721 Hepatovirus A Species 0.000 description 2
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 2
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 description 2
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 2
- 101100222383 Homo sapiens CXCL13 gene Proteins 0.000 description 2
- 101001055227 Homo sapiens Cytokine receptor common subunit gamma Proteins 0.000 description 2
- 101001074244 Homo sapiens Glycophorin-A Proteins 0.000 description 2
- 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 description 2
- 101001011382 Homo sapiens Interferon regulatory factor 3 Proteins 0.000 description 2
- 101001059644 Homo sapiens MAP kinase-activating death domain protein Proteins 0.000 description 2
- 101000610626 Homo sapiens Serine protease 33 Proteins 0.000 description 2
- 101000830565 Homo sapiens Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 description 2
- 101000610602 Homo sapiens Tumor necrosis factor receptor superfamily member 10C Proteins 0.000 description 2
- 101000801228 Homo sapiens Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 241000712431 Influenza A virus Species 0.000 description 2
- 102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 description 2
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 description 2
- 102100029843 Interferon regulatory factor 3 Human genes 0.000 description 2
- 101710089751 Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 2
- 108050001109 Interleukin-1 receptor type 1 Proteins 0.000 description 2
- 102100025837 JNK1/MAPK8-associated membrane protein Human genes 0.000 description 2
- 101710176060 JNK1/MAPK8-associated membrane protein Proteins 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 241000589242 Legionella pneumophila Species 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
- 101710163717 Lysophospholipid acyltransferase 5 Proteins 0.000 description 2
- 102100028822 MAP kinase-activating death domain protein Human genes 0.000 description 2
- 206010027202 Meningitis bacterial Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 2
- 208000014767 Myeloproliferative disease Diseases 0.000 description 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 2
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 2
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 2
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 2
- 108010026552 Proteome Proteins 0.000 description 2
- 108091008109 Pseudogenes Proteins 0.000 description 2
- 102000057361 Pseudogenes Human genes 0.000 description 2
- 206010037596 Pyelonephritis Diseases 0.000 description 2
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 2
- 102100028516 Receptor-type tyrosine-protein phosphatase U Human genes 0.000 description 2
- 108091006647 SLC9A1 Proteins 0.000 description 2
- 108010074686 Selenoproteins Proteins 0.000 description 2
- 206010040070 Septic Shock Diseases 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 102100040342 Serine protease 33 Human genes 0.000 description 2
- 102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 108010002687 Survivin Proteins 0.000 description 2
- 108091008874 T cell receptors Proteins 0.000 description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- 102000002689 Toll-like receptor Human genes 0.000 description 2
- 108020000411 Toll-like receptor Proteins 0.000 description 2
- 101710120037 Toxin CcdB Proteins 0.000 description 2
- 108020004566 Transfer RNA Proteins 0.000 description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 description 2
- 102100040115 Tumor necrosis factor receptor superfamily member 10C Human genes 0.000 description 2
- 108090000848 Ubiquitin Proteins 0.000 description 2
- 102000044159 Ubiquitin Human genes 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- BAWFJGJZGIEFAR-DQQFMEOOSA-N [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)O[P@@](O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-DQQFMEOOSA-N 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 230000004721 adaptive immunity Effects 0.000 description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 201000009904 bacterial meningitis Diseases 0.000 description 2
- 210000003651 basophil Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 238000011325 biochemical measurement Methods 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 238000009640 blood culture Methods 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 2
- 229960004015 calcitonin Drugs 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000020411 cell activation Effects 0.000 description 2
- 230000021164 cell adhesion Effects 0.000 description 2
- 230000034303 cell budding Effects 0.000 description 2
- 230000006369 cell cycle progression Effects 0.000 description 2
- 230000012292 cell migration Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 239000002975 chemoattractant Substances 0.000 description 2
- 239000005482 chemotactic factor Substances 0.000 description 2
- 238000011976 chest X-ray Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 229960003920 cocaine Drugs 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 102000003675 cytokine receptors Human genes 0.000 description 2
- 108010057085 cytokine receptors Proteins 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000013523 data management Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 238000003066 decision tree Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 229950008963 emoctakin Drugs 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 239000003532 endogenous pyrogen Substances 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 229940116977 epidermal growth factor Drugs 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 210000001650 focal adhesion Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000003209 gene knockout Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 230000008105 immune reaction Effects 0.000 description 2
- 238000003119 immunoblot Methods 0.000 description 2
- 238000010166 immunofluorescence Methods 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000005007 innate immune system Anatomy 0.000 description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical group O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 229940115932 legionella pneumophila Drugs 0.000 description 2
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 2
- 235000019136 lipoic acid Nutrition 0.000 description 2
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 238000007477 logistic regression Methods 0.000 description 2
- 210000003712 lysosome Anatomy 0.000 description 2
- 230000001868 lysosomic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000007620 mathematical function Methods 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 238000003909 pattern recognition Methods 0.000 description 2
- 230000008823 permeabilization Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 230000004983 pleiotropic effect Effects 0.000 description 2
- 229920001469 poly(aryloxy)thionylphosphazene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 230000017854 proteolysis Effects 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 108700015048 receptor decoy activity proteins Proteins 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- 238000003118 sandwich ELISA Methods 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000005212 secondary lymphoid organ Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 229940055619 selenocysteine Drugs 0.000 description 2
- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 description 2
- 235000016491 selenocysteine Nutrition 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 230000036303 septic shock Effects 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 230000004960 subcellular localization Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 210000002437 synoviocyte Anatomy 0.000 description 2
- 229960002663 thioctic acid Drugs 0.000 description 2
- 208000037816 tissue injury Diseases 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000000844 transformation Methods 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 102000035160 transmembrane proteins Human genes 0.000 description 2
- 108091005703 transmembrane proteins Proteins 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
- 230000005760 tumorsuppression Effects 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 230000034512 ubiquitination Effects 0.000 description 2
- 238000010798 ubiquitination Methods 0.000 description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- HKWJHKSHEWVOSS-OMDJCSNQSA-N 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O HKWJHKSHEWVOSS-OMDJCSNQSA-N 0.000 description 1
- 101710124165 1-acyl-sn-glycerol-3-phosphate acyltransferase Proteins 0.000 description 1
- 102100026205 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Human genes 0.000 description 1
- 108010086241 2',5'-Oligoadenylate Synthetase Proteins 0.000 description 1
- 102000007445 2',5'-Oligoadenylate Synthetase Human genes 0.000 description 1
- 102100027962 2-5A-dependent ribonuclease Human genes 0.000 description 1
- 108010000834 2-5A-dependent ribonuclease Proteins 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- 108020005345 3' Untranslated Regions Proteins 0.000 description 1
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 101150051089 A3 gene Proteins 0.000 description 1
- 101150112998 ADIPOQ gene Proteins 0.000 description 1
- 101150096655 APM1 gene Proteins 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- 240000005020 Acaciella glauca Species 0.000 description 1
- 102000004373 Actin-related protein 2 Human genes 0.000 description 1
- 108090000963 Actin-related protein 2 Proteins 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 102100033647 Activity-regulated cytoskeleton-associated protein Human genes 0.000 description 1
- 206010048998 Acute phase reaction Diseases 0.000 description 1
- 206010001076 Acute sinusitis Diseases 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 102100034336 Acyl-coenzyme A synthetase ACSM1, mitochondrial Human genes 0.000 description 1
- 101710152920 AdoMet-dependent rRNA methyltransferase SPB1 Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 description 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 description 1
- 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 description 1
- 108010083590 Apoproteins Proteins 0.000 description 1
- 102000006410 Apoproteins Human genes 0.000 description 1
- 229940088872 Apoptosis inhibitor Drugs 0.000 description 1
- 102100027308 Apoptosis regulator BAX Human genes 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 208000034318 Argininemia Diseases 0.000 description 1
- 101100503323 Artemisia annua FPS1 gene Proteins 0.000 description 1
- 200000000007 Arterial disease Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
- 108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
- 101100002068 Bacillus subtilis (strain 168) araR gene Proteins 0.000 description 1
- 201000001178 Bacterial Pneumonia Diseases 0.000 description 1
- KZFBHCCLJSAHBQ-UHFFFAOYSA-N Benzoylecgonine Natural products CN1C2CCC1C(C(C2)OC(=C)c3ccccc3)C(=O)O KZFBHCCLJSAHBQ-UHFFFAOYSA-N 0.000 description 1
- 102100021257 Beta-secretase 1 Human genes 0.000 description 1
- 241000124740 Bocaparvovirus Species 0.000 description 1
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- ODZBBRURCPAEIQ-DJLDLDEBSA-N Brivudine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C=CBr)=C1 ODZBBRURCPAEIQ-DJLDLDEBSA-N 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 210000003771 C cell Anatomy 0.000 description 1
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 1
- 102100036842 C-C motif chemokine 19 Human genes 0.000 description 1
- 101710098275 C-X-C motif chemokine 10 Proteins 0.000 description 1
- 102000002086 C-type lectin-like Human genes 0.000 description 1
- 108050009406 C-type lectin-like Proteins 0.000 description 1
- 102000002110 C2 domains Human genes 0.000 description 1
- 108050009459 C2 domains Proteins 0.000 description 1
- 108010059108 CD18 Antigens Proteins 0.000 description 1
- 108010062802 CD66 antigens Proteins 0.000 description 1
- 102000039968 CEA family Human genes 0.000 description 1
- 108091069214 CEA family Proteins 0.000 description 1
- 101150045267 CEA gene Proteins 0.000 description 1
- IERHLVCPSMICTF-XVFCMESISA-N CMP group Chemical group P(=O)(O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C(=O)N=C(N)C=C1)O)O IERHLVCPSMICTF-XVFCMESISA-N 0.000 description 1
- 102000019388 CXC chemokine Human genes 0.000 description 1
- 108010061300 CXCR3 Receptors Proteins 0.000 description 1
- 102000011963 CXCR3 Receptors Human genes 0.000 description 1
- 102100029761 Cadherin-5 Human genes 0.000 description 1
- 101001120790 Caenorhabditis elegans UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase Proteins 0.000 description 1
- 101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 description 1
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108090000397 Caspase 3 Proteins 0.000 description 1
- 102100029855 Caspase-3 Human genes 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 101710150820 Cellular tumor antigen p53 Proteins 0.000 description 1
- 208000014912 Central Nervous System Infections Diseases 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 101710113585 Chitinase-like protein 1 Proteins 0.000 description 1
- 241001185363 Chlamydiae Species 0.000 description 1
- 108700022831 Clostridium difficile toxB Proteins 0.000 description 1
- 108010060434 Co-Repressor Proteins Proteins 0.000 description 1
- 102000008169 Co-Repressor Proteins Human genes 0.000 description 1
- NMPOSNRHZIWLLL-XUWVNRHRSA-N Cocaethylene Chemical group O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OCC)C(=O)C1=CC=CC=C1 NMPOSNRHZIWLLL-XUWVNRHRSA-N 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 108010078015 Complement C3b Proteins 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 208000034657 Convalescence Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000606678 Coxiella burnetii Species 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 102000001189 Cyclic Peptides Human genes 0.000 description 1
- 108010069514 Cyclic Peptides Proteins 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 102000005927 Cysteine Proteases Human genes 0.000 description 1
- 108010005843 Cysteine Proteases Proteins 0.000 description 1
- 102100030497 Cytochrome c Human genes 0.000 description 1
- 108010075031 Cytochromes c Proteins 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 241000450599 DNA viruses Species 0.000 description 1
- AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 101100162826 Dictyostelium discoideum apm2 gene Proteins 0.000 description 1
- 102100028571 Disabled homolog 2-interacting protein Human genes 0.000 description 1
- 101710117072 Dual specificity protein phosphatase Proteins 0.000 description 1
- 102000043859 Dynamin Human genes 0.000 description 1
- 108700021058 Dynamin Proteins 0.000 description 1
- 102100029944 E3 ubiquitin-protein ligase SHPRH Human genes 0.000 description 1
- 102100029211 E3 ubiquitin-protein ligase TTC3 Human genes 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 230000008341 ER-associated protein catabolic process Effects 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 206010014909 Enterovirus infection Diseases 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 102000003782 Eukaryotic Initiation Factor-4F Human genes 0.000 description 1
- 108010057194 Eukaryotic Initiation Factor-4F Proteins 0.000 description 1
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 description 1
- 108010087819 Fc receptors Proteins 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 101710140958 Formimidoyltetrahydrofolate cyclodeaminase Proteins 0.000 description 1
- 208000001914 Fragile X syndrome Diseases 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 108091006027 G proteins Proteins 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 230000010190 G1 phase Effects 0.000 description 1
- 108010001498 Galectin 1 Proteins 0.000 description 1
- 102100021736 Galectin-1 Human genes 0.000 description 1
- 102100039558 Galectin-3 Human genes 0.000 description 1
- 102000007563 Galectins Human genes 0.000 description 1
- 108010046569 Galectins Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010017918 Gastroenteritis viral Diseases 0.000 description 1
- 101100503326 Gibberella fujikuroi FPPS gene Proteins 0.000 description 1
- YIWFXZNIBQBFHR-LURJTMIESA-N Gly-His Chemical compound [NH3+]CC(=O)N[C@H](C([O-])=O)CC1=CN=CN1 YIWFXZNIBQBFHR-LURJTMIESA-N 0.000 description 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 description 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 102100027489 Helicase-like transcription factor Human genes 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241001473947 Helicobacter pylori SS1 Species 0.000 description 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 description 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 108010025076 Holoenzymes Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000691599 Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Proteins 0.000 description 1
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 description 1
- 101000975766 Homo sapiens Actin-related protein 2 Proteins 0.000 description 1
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 description 1
- 101100437218 Homo sapiens B2M gene Proteins 0.000 description 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 description 1
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 1
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 description 1
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 description 1
- 101000942118 Homo sapiens C-reactive protein Proteins 0.000 description 1
- 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 description 1
- 101000981093 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 1 Proteins 0.000 description 1
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 description 1
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 description 1
- 101000863869 Homo sapiens E3 ubiquitin-protein ligase SHPRH Proteins 0.000 description 1
- 101000633723 Homo sapiens E3 ubiquitin-protein ligase TTC3 Proteins 0.000 description 1
- 101000920800 Homo sapiens Endoplasmic reticulum-Golgi intermediate compartment protein 2 Proteins 0.000 description 1
- 101000926530 Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Proteins 0.000 description 1
- 101000608757 Homo sapiens Galectin-3 Proteins 0.000 description 1
- 101001081105 Homo sapiens Helicase-like transcription factor Proteins 0.000 description 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 description 1
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
- 101001034842 Homo sapiens Interferon-induced transmembrane protein 2 Proteins 0.000 description 1
- 101000599056 Homo sapiens Interleukin-6 receptor subunit beta Proteins 0.000 description 1
- 101001052490 Homo sapiens Mitogen-activated protein kinase 3 Proteins 0.000 description 1
- 101000950695 Homo sapiens Mitogen-activated protein kinase 8 Proteins 0.000 description 1
- 101001135199 Homo sapiens Partitioning defective 3 homolog Proteins 0.000 description 1
- 101000741788 Homo sapiens Peroxisome proliferator-activated receptor alpha Proteins 0.000 description 1
- 101000583156 Homo sapiens Pituitary homeobox 1 Proteins 0.000 description 1
- 101000971468 Homo sapiens Protein kinase C zeta type Proteins 0.000 description 1
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 description 1
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 description 1
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 description 1
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 description 1
- 101100053794 Homo sapiens ZBTB7C gene Proteins 0.000 description 1
- 241000711467 Human coronavirus 229E Species 0.000 description 1
- 241000482741 Human coronavirus NL63 Species 0.000 description 1
- 241001428935 Human coronavirus OC43 Species 0.000 description 1
- 241000701027 Human herpesvirus 6 Species 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 206010020575 Hyperammonaemia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102400001233 IL-8(5-77) Human genes 0.000 description 1
- 101800004598 IL-8(5-77) Proteins 0.000 description 1
- 102400001232 IL-8(6-77) Human genes 0.000 description 1
- 101800002919 IL-8(6-77) Proteins 0.000 description 1
- 102400001231 IL-8(7-77) Human genes 0.000 description 1
- 101800003411 IL-8(7-77) Proteins 0.000 description 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 241001500351 Influenzavirus A Species 0.000 description 1
- 241001500350 Influenzavirus B Species 0.000 description 1
- 102100023915 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 108060004056 Integrin alpha Chain Proteins 0.000 description 1
- 102100026720 Interferon beta Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 102100040020 Interferon-induced transmembrane protein 2 Human genes 0.000 description 1
- 108010066719 Interleukin Receptor Common gamma Subunit Proteins 0.000 description 1
- 102000018682 Interleukin Receptor Common gamma Subunit Human genes 0.000 description 1
- 102000019223 Interleukin-1 receptor Human genes 0.000 description 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 description 1
- 102000003812 Interleukin-15 Human genes 0.000 description 1
- 108090000172 Interleukin-15 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000004388 Interleukin-4 Human genes 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 description 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 description 1
- 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 description 1
- 108010018976 Interleukin-8A Receptors Proteins 0.000 description 1
- 108010018951 Interleukin-8B Receptors Proteins 0.000 description 1
- 102000002791 Interleukin-8B Receptors Human genes 0.000 description 1
- 102000000585 Interleukin-9 Human genes 0.000 description 1
- 108010002335 Interleukin-9 Proteins 0.000 description 1
- 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 description 1
- 102000019145 JUN kinase activity proteins Human genes 0.000 description 1
- 108010024121 Janus Kinases Proteins 0.000 description 1
- 102000015617 Janus Kinases Human genes 0.000 description 1
- 206010023230 Joint stiffness Diseases 0.000 description 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
- 108700042464 KRIT1 Proteins 0.000 description 1
- 102000056028 KRIT1 Human genes 0.000 description 1
- 101150090242 KRIT1 gene Proteins 0.000 description 1
- 241000087799 Koma Species 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- 125000000899 L-alpha-glutamyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(O[H])=O 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- 241000589248 Legionella Species 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- 208000004852 Lung Injury Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
- 108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
- 102000019149 MAP kinase activity proteins Human genes 0.000 description 1
- 108040008097 MAP kinase activity proteins Proteins 0.000 description 1
- 108091054437 MHC class I family Proteins 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 210000002361 Megakaryocyte Progenitor Cell Anatomy 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 241000351643 Metapneumovirus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108091092919 Minisatellite Proteins 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 description 1
- 102100024192 Mitogen-activated protein kinase 3 Human genes 0.000 description 1
- 102100037808 Mitogen-activated protein kinase 8 Human genes 0.000 description 1
- 241001430197 Mollicutes Species 0.000 description 1
- 108090000143 Mouse Proteins Proteins 0.000 description 1
- 108010093369 Multienzyme Complexes Proteins 0.000 description 1
- 102000002568 Multienzyme Complexes Human genes 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
- 101100533945 Mus musculus Serpina3g gene Proteins 0.000 description 1
- 101100369993 Mus musculus Tnfsf10 gene Proteins 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010068871 Myotonic dystrophy Diseases 0.000 description 1
- 108010083736 Myxovirus Resistance Proteins Proteins 0.000 description 1
- 102000006421 Myxovirus Resistance Proteins Human genes 0.000 description 1
- 108010057466 NF-kappa B Proteins 0.000 description 1
- 102000003945 NF-kappa B Human genes 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 108010015832 Non-Receptor Type 2 Protein Tyrosine Phosphatase Proteins 0.000 description 1
- 241000532183 Norovirus GI Species 0.000 description 1
- 241000532184 Norovirus GII Species 0.000 description 1
- 108020003217 Nuclear RNA Proteins 0.000 description 1
- 102000043141 Nuclear RNA Human genes 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 239000012661 PARP inhibitor Substances 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 102100033496 Partitioning defective 3 homolog Human genes 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- KJWMGLBVDNMNQW-VWTMXFPPSA-N Pectenotoxin 1 Chemical compound O[C@@H]1[C@H](C)CCO[C@]1(O)[C@H]1O[C@@H]2/C=C/C(/C)=C/[C@H](C)C[C@](C)(O3)CC[C@@H]3[C@](O3)(O4)CC[C@@]3(CO)C[C@@H]4[C@@H](O3)C(=O)C[C@]3(C)[C@@H](O)[C@@H](O3)CC[C@@]3(O3)CCC[C@H]3[C@@H](C)C(=O)O[C@@H]2C1 KJWMGLBVDNMNQW-VWTMXFPPSA-N 0.000 description 1
- 101800001442 Peptide pr Proteins 0.000 description 1
- 108010013639 Peptidoglycan Proteins 0.000 description 1
- 102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000233805 Phoenix Species 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 101900101471 Plasmodium falciparum Erythrocyte-binding antigen 175 Proteins 0.000 description 1
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 description 1
- 108010068086 Polyubiquitin Proteins 0.000 description 1
- 102100037935 Polyubiquitin-C Human genes 0.000 description 1
- 101710172946 Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase Proteins 0.000 description 1
- 108010049395 Prokaryotic Initiation Factor-2 Proteins 0.000 description 1
- 102100036691 Proliferating cell nuclear antigen Human genes 0.000 description 1
- 102100021538 Protein kinase C zeta type Human genes 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 108010039518 Proton-Translocating ATPases Proteins 0.000 description 1
- 102000015176 Proton-Translocating ATPases Human genes 0.000 description 1
- 206010037688 Q fever Diseases 0.000 description 1
- 101710113459 RAC-alpha serine/threonine-protein kinase Proteins 0.000 description 1
- 108020005067 RNA Splice Sites Proteins 0.000 description 1
- 230000004570 RNA-binding Effects 0.000 description 1
- 108091030071 RNAI Proteins 0.000 description 1
- 102000056817 RNF5 Human genes 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108091005682 Receptor kinases Proteins 0.000 description 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 241001325464 Rhinovirus A Species 0.000 description 1
- 241001325459 Rhinovirus B Species 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 102000014400 SH2 domains Human genes 0.000 description 1
- 108050003452 SH2 domains Proteins 0.000 description 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 1
- 108010029477 STAT5 Transcription Factor Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 102000008114 Selenoproteins Human genes 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
- 108700028909 Serum Amyloid A Proteins 0.000 description 1
- 102000054727 Serum Amyloid A Human genes 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 description 1
- 102100024481 Signal transducer and activator of transcription 5A Human genes 0.000 description 1
- 108010011033 Signaling Lymphocytic Activation Molecule Associated Protein Proteins 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 102000004598 Small Nuclear Ribonucleoproteins Human genes 0.000 description 1
- 108010003165 Small Nuclear Ribonucleoproteins Proteins 0.000 description 1
- 102100022897 Sodium/hydrogen exchanger 10 Human genes 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 108010092262 T-Cell Antigen Receptors Proteins 0.000 description 1
- 108090000925 TNF receptor-associated factor 2 Proteins 0.000 description 1
- 102000003718 TNF receptor-associated factor 5 Human genes 0.000 description 1
- 108090000001 TNF receptor-associated factor 5 Proteins 0.000 description 1
- 108091007178 TNFRSF10A Proteins 0.000 description 1
- 108700031126 Tetraspanins Proteins 0.000 description 1
- 102000043977 Tetraspanins Human genes 0.000 description 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 1
- 108700009124 Transcription Initiation Site Proteins 0.000 description 1
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 1
- 206010069363 Traumatic lung injury Diseases 0.000 description 1
- 241000245032 Trillium Species 0.000 description 1
- PEEAINPHPNDNGE-JQWIXIFHSA-N Trp-Asp Chemical compound C1=CC=C2C(C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(O)=O)=CNC2=C1 PEEAINPHPNDNGE-JQWIXIFHSA-N 0.000 description 1
- 101710098580 Tubulin gamma-1 chain Proteins 0.000 description 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 1
- 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 description 1
- 102100033141 Tyrosine-protein phosphatase non-receptor type 2 Human genes 0.000 description 1
- 101710087750 Ubiquitin-like protein ISG15 Proteins 0.000 description 1
- 108091008605 VEGF receptors Proteins 0.000 description 1
- 108010037026 Vacuolar Proton-Translocating ATPases Proteins 0.000 description 1
- 102000011731 Vacuolar Proton-Translocating ATPases Human genes 0.000 description 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 102100023250 Zinc finger and BTB domain-containing protein 7C Human genes 0.000 description 1
- CWRILEGKIAOYKP-SSDOTTSWSA-M [(2r)-3-acetyloxy-2-hydroxypropyl] 2-aminoethyl phosphate Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCCN CWRILEGKIAOYKP-SSDOTTSWSA-M 0.000 description 1
- APERIXFHHNDFQV-UHFFFAOYSA-N [2-[2-[2-[bis(carboxymethyl)amino]-5-methylphenoxy]ethoxy]-4-[3,6-bis(dimethylamino)xanthen-9-ylidene]cyclohexa-2,5-dien-1-ylidene]-bis(carboxymethyl)azanium;chloride Chemical compound [Cl-].C12=CC=C(N(C)C)C=C2OC2=CC(N(C)C)=CC=C2C1=C(C=1)C=CC(=[N+](CC(O)=O)CC(O)=O)C=1OCCOC1=CC(C)=CC=C1N(CC(O)=O)CC(O)=O APERIXFHHNDFQV-UHFFFAOYSA-N 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 108010029777 actin interacting protein 1 Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 230000004658 acute-phase response Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- 102000035181 adaptor proteins Human genes 0.000 description 1
- 108091005764 adaptor proteins Proteins 0.000 description 1
- 229960001570 ademetionine Drugs 0.000 description 1
- 210000002867 adherens junction Anatomy 0.000 description 1
- 102000019997 adhesion receptor Human genes 0.000 description 1
- 108010013985 adhesion receptor Proteins 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 201000009961 allergic asthma Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- CMQZRJBJDCVIEY-JEOLMMCMSA-N alpha-L-Fucp-(1->3)-[beta-D-Galp-(1->4)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glcp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O[C@@H]2[C@H]([C@H](O[C@@H]3[C@H](OC(O)[C@H](O)[C@H]3O)CO)O[C@H](CO)[C@@H]2O)O)[C@@H]1NC(C)=O CMQZRJBJDCVIEY-JEOLMMCMSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000006229 amino acid addition Effects 0.000 description 1
- 230000019552 anatomical structure morphogenesis Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000002870 angiogenesis inducing agent Substances 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000003524 antilipemic agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 239000000158 apoptosis inhibitor Substances 0.000 description 1
- 230000005775 apoptotic pathway Effects 0.000 description 1
- 230000009118 appropriate response Effects 0.000 description 1
- 101150044616 araC gene Proteins 0.000 description 1
- 101150010487 are gene Proteins 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 208000028922 artery disease Diseases 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 244000309743 astrovirus Species 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 238000002555 auscultation Methods 0.000 description 1
- 230000003305 autocrine Effects 0.000 description 1
- 230000035578 autophosphorylation Effects 0.000 description 1
- 238000013476 bayesian approach Methods 0.000 description 1
- 101150056798 bca-1 gene Proteins 0.000 description 1
- 238000003339 best practice Methods 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 230000008436 biogenesis Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000008236 biological pathway Effects 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000010504 bond cleavage reaction Methods 0.000 description 1
- 238000009583 bone marrow aspiration Methods 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000004094 calcium homeostasis Effects 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 208000001969 capillary hemangioma Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 108020001778 catalytic domains Proteins 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 239000008004 cell lysis buffer Substances 0.000 description 1
- 230000008619 cell matrix interaction Effects 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 230000005465 channeling Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 210000003763 chloroplast Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000031154 cholesterol homeostasis Effects 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 210000001366 chromaffin granule Anatomy 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 102000039291 class-I aminoacyl-tRNA synthetase family Human genes 0.000 description 1
- 108091068431 class-I aminoacyl-tRNA synthetase family Proteins 0.000 description 1
- 238000013145 classification model Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 210000002314 coated vesicle Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 208000025081 congenital sodium diarrhea Diseases 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 238000007821 culture assay Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000013211 curve analysis Methods 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- 238000012350 deep sequencing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 239000013024 dilution buffer Substances 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000008482 dysregulation Effects 0.000 description 1
- 108010037623 eIF-2 Kinase Proteins 0.000 description 1
- GVGYEFKIHJTNQZ-RFQIPJPRSA-N ecgonine benzoate Chemical compound O([C@@H]1[C@@H]([C@H]2CC[C@@H](C1)N2C)C(O)=O)C(=O)C1=CC=CC=C1 GVGYEFKIHJTNQZ-RFQIPJPRSA-N 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000531 effect on virus Effects 0.000 description 1
- 210000001163 endosome Anatomy 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 230000009483 enzymatic pathway Effects 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- 201000010063 epididymitis Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 208000028329 epileptic seizure Diseases 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- RYNBQQWODYCGRR-UHFFFAOYSA-N ethyl 5-(4-chlorophenyl)-2-methyl-1-phenylpyrrole-3-carboxylate Chemical compound C=1C=CC=CC=1N1C(C)=C(C(=O)OCC)C=C1C1=CC=C(Cl)C=C1 RYNBQQWODYCGRR-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 108010063260 fatty acyl ethyl ester synthase Proteins 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000009795 fibrotic process Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000007849 functional defect Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 201000006585 gastric adenocarcinoma Diseases 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 230000009368 gene silencing by RNA Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 238000011331 genomic analysis Methods 0.000 description 1
- 231100000024 genotoxic Toxicity 0.000 description 1
- 230000001738 genotoxic effect Effects 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 230000004190 glucose uptake Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 108010051239 glutaminyl-tRNA synthetase Proteins 0.000 description 1
- 229920000550 glycopolymer Polymers 0.000 description 1
- 102000040343 glycosyl hydrolase 18 family Human genes 0.000 description 1
- 108091072148 glycosyl hydrolase 18 family Proteins 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 108010020688 glycylhistidine Proteins 0.000 description 1
- 210000002288 golgi apparatus Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000010005 growth-factor like effect Effects 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 208000006359 hepatoblastoma Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 208000019408 hereditary arterial and articular multiple calcification syndrome Diseases 0.000 description 1
- 239000000710 homodimer Substances 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 102000048995 human ACTR2 Human genes 0.000 description 1
- 210000003917 human chromosome Anatomy 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 201000011286 hyperargininemia Diseases 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 230000010057 immune-inflammatory process Effects 0.000 description 1
- 229940124622 immune-modulator drug Drugs 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000007233 immunological mechanism Effects 0.000 description 1
- 238000013198 immunometric assay Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 238000002650 immunosuppressive therapy Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- PNDZEEPOYCVIIY-UHFFFAOYSA-N indo-1 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=C(C=2)C=2N=C3[CH]C(=CC=C3C=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 PNDZEEPOYCVIIY-UHFFFAOYSA-N 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000022760 infectious otitis media Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- CIPFCGZLFXVXBG-ZIQZFLOESA-N inositol 1,3,4,5-tetrakisphosphate Chemical compound O[C@H]1[C@H](OP(O)(O)=O)[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O CIPFCGZLFXVXBG-ZIQZFLOESA-N 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 102000017777 integrin alpha chain Human genes 0.000 description 1
- 210000004692 intercellular junction Anatomy 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 108010038415 interleukin-8 receptors Proteins 0.000 description 1
- 102000010681 interleukin-8 receptors Human genes 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 210000003963 intermediate filament Anatomy 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 1
- 238000000021 kinase assay Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000011545 laboratory measurement Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 108010052620 leukocyte endogenous mediator Proteins 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 108010093908 lipoate activating enzyme Proteins 0.000 description 1
- 125000003977 lipoyl group Chemical group S1SC(C([H])([H])C(C(C(C(=O)[*])([H])[H])([H])[H])([H])[H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- QWEGOCJRZOKSOE-NLJBGGCZSA-N lipoyl-AMP Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1C=2N=CN=C(C=2N=C1)N)OP(O)(=O)OC(=O)CCCCC1CCSS1 QWEGOCJRZOKSOE-NLJBGGCZSA-N 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 231100000515 lung injury Toxicity 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 208000018555 lymphatic system disease Diseases 0.000 description 1
- 230000004170 mRNA methylation Effects 0.000 description 1
- 108091005446 macrophage receptors Proteins 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- 230000008172 membrane trafficking Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 125000004492 methyl ester group Chemical group 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000012009 microbiological test Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004925 microvascular endothelial cell Anatomy 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000037230 mobility Effects 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 150000004712 monophosphates Chemical class 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 238000000491 multivariate analysis Methods 0.000 description 1
- 210000000066 myeloid cell Anatomy 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
- 102000042628 natural cytotoxicity receptor (NCR) family Human genes 0.000 description 1
- 108091053394 natural cytotoxicity receptor (NCR) family Proteins 0.000 description 1
- 239000006225 natural substrate Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000004848 nephelometry Methods 0.000 description 1
- 230000004766 neurogenesis Effects 0.000 description 1
- 230000014511 neuron projection development Effects 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 125000002796 nucleotidyl group Chemical group 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- XDUHQPOXLUAVEE-BPMMELMSSA-N oleoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCCC\C=C/CCCCCCCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 XDUHQPOXLUAVEE-BPMMELMSSA-N 0.000 description 1
- 210000004248 oligodendroglia Anatomy 0.000 description 1
- 230000006548 oncogenic transformation Effects 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 description 1
- 229960003752 oseltamivir Drugs 0.000 description 1
- 208000002865 osteopetrosis Diseases 0.000 description 1
- 206010033072 otitis externa Diseases 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000003076 paracrine Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 108010089193 pattern recognition receptors Proteins 0.000 description 1
- 102000007863 pattern recognition receptors Human genes 0.000 description 1
- 230000011340 peptidyl-tyrosine autophosphorylation Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000001986 peyer's patch Anatomy 0.000 description 1
- 210000000680 phagosome Anatomy 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003910 phosphatidylinositol 3-phosphates Chemical class 0.000 description 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
- 150000003906 phosphoinositides Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 108091005981 phosphorylated proteins Proteins 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 210000002729 polyribosome Anatomy 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000000513 principal component analysis Methods 0.000 description 1
- 230000000861 pro-apoptotic effect Effects 0.000 description 1
- 108091008077 processed pseudogenes Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000009696 proliferative response Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 108020003519 protein disulfide isomerase Proteins 0.000 description 1
- 230000020978 protein processing Effects 0.000 description 1
- 230000007398 protein translocation Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000002213 purine nucleotide Substances 0.000 description 1
- 239000002718 pyrimidine nucleoside Substances 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 238000000009 pyrolysis mass spectrometry Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 108010014420 rab GTP-Binding Proteins Proteins 0.000 description 1
- 102000016949 rab GTP-Binding Proteins Human genes 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000005514 radiochemical analysis Methods 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 108091006084 receptor activators Proteins 0.000 description 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 description 1
- 230000010837 receptor-mediated endocytosis Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 235000003499 redwood Nutrition 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000025915 regulation of apoptotic process Effects 0.000 description 1
- 230000007980 regulation of cell activation Effects 0.000 description 1
- 230000023252 regulation of cell development Effects 0.000 description 1
- 230000021014 regulation of cell growth Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 208000012263 renal involvement Diseases 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 230000028617 response to DNA damage stimulus Effects 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000009589 serological test Methods 0.000 description 1
- 208000002491 severe combined immunodeficiency Diseases 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 125000005629 sialic acid group Chemical group 0.000 description 1
- 108091006024 signal transducing proteins Proteins 0.000 description 1
- 102000034285 signal transducing proteins Human genes 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 102000030938 small GTPase Human genes 0.000 description 1
- 108060007624 small GTPase Proteins 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000001324 spliceosome Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 102000009076 src-Family Kinases Human genes 0.000 description 1
- 108010087686 src-Family Kinases Proteins 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 239000011232 storage material Substances 0.000 description 1
- 208000023516 stroke disease Diseases 0.000 description 1
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 208000014201 susceptibility to mild malaria Diseases 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000007056 transamidation reaction Methods 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 108091006107 transcriptional repressors Proteins 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- 102000057702 transmembrane signaling receptor Human genes 0.000 description 1
- 108700011013 transmembrane signaling receptor Proteins 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000002993 trophoblast Anatomy 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 230000004143 urea cycle Effects 0.000 description 1
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000009447 viral pathogenesis Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 229960001028 zanamivir Drugs 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
- G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44739—Collecting the separated zones, e.g. blotting to a membrane or punching of gel spots
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261596950P | 2012-02-09 | 2012-02-09 | |
| US201261652631P | 2012-05-29 | 2012-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2886979T3 true ES2886979T3 (es) | 2021-12-21 |
Family
ID=47678877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18162713T Active ES2886979T3 (es) | 2012-02-09 | 2013-02-08 | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos |
| ES13703112.6T Active ES2679107T3 (es) | 2012-02-09 | 2013-02-08 | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13703112.6T Active ES2679107T3 (es) | 2012-02-09 | 2013-02-08 | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos |
Country Status (12)
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2387627E (pt) | 2009-01-15 | 2016-06-03 | Adaptive Biotechnologies Corp | Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais |
| CN106442984B (zh) | 2010-04-21 | 2020-03-13 | 米密德诊断学有限公司 | 区分细菌与病毒感染的标记物和决定因素以及其使用方法 |
| ES2886979T3 (es) * | 2012-02-09 | 2021-12-21 | Memed Diagnostics Ltd | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos |
| JP6302847B2 (ja) | 2012-03-05 | 2018-03-28 | アダプティヴ バイオテクノロジーズ コーポレーション | 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定 |
| BR112014027309A2 (pt) | 2012-05-08 | 2017-07-11 | Adaptive Biotechnologies Corp | composições e métodos para medir e calibrar a tendên-cia de amplificação em reações de pcr multiplexadas |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US20170292149A1 (en) | 2014-03-05 | 2017-10-12 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| WO2015138991A2 (en) * | 2014-03-13 | 2015-09-17 | Opgen, Inc. | Methods of detecting multi-drug resistant organisms |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| EP3149639A1 (en) | 2014-05-27 | 2017-04-05 | Opgen, Inc. | Systems, apparatus, and methods for generating and analyzing resistome profiles |
| US10308989B2 (en) | 2014-06-13 | 2019-06-04 | North Carolina State University | Aptamers with binding affinity to norovirus |
| BR112017002884A2 (pt) | 2014-08-14 | 2018-01-30 | Memed Diagnostics Ltd | ?análise computacional de dados biológicos por meio do uso de variedade e hiperplano? |
| WO2016059636A1 (en) | 2014-10-14 | 2016-04-21 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| EP3715455A1 (en) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| ES2981450T3 (es) | 2014-11-19 | 2024-10-08 | P & M Venge Ab | Métodos de diagnóstico que emplean HNL |
| CA2968650A1 (en) * | 2014-12-11 | 2016-06-16 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
| AU2016222788B2 (en) * | 2015-02-24 | 2022-03-31 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
| CA2979726A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| EP3139171B1 (en) * | 2015-09-02 | 2020-02-12 | Labsystems Diagnostics Oy | Novel methods and kits for detecting of urea cycle disorders using mass spectrometry |
| US11884978B2 (en) | 2015-09-30 | 2024-01-30 | Immunexpress Pty Ltd | Pathogen biomarkers and uses therefor |
| CN106918698B (zh) * | 2015-12-25 | 2019-11-22 | 广州瑞博奥生物科技有限公司 | 一种检测人受体酪氨酸激酶的磷酸化抗体芯片试剂盒 |
| IL287757B (en) * | 2016-03-03 | 2022-07-01 | Memed Diagnostics Ltd | Analyzing rna for diagnosing infection type |
| CN108699583B (zh) * | 2016-03-03 | 2022-11-01 | 米密德诊断学有限公司 | 用于区分细菌和病毒感染的rna决定子 |
| CN106053831A (zh) * | 2016-06-05 | 2016-10-26 | 潘时辉 | 一种用于自身免疫病检测的试剂盒 |
| KR20240100488A (ko) * | 2016-06-07 | 2024-07-01 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 세균성 감염 및 바이러스성 감염의 진단 방법 |
| CN109642900A (zh) * | 2016-06-23 | 2019-04-16 | 米密德诊断学有限公司 | 通过侧流免疫测定测量trail |
| CA3027341A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| WO2018011796A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| WO2018029690A1 (en) | 2016-08-10 | 2018-02-15 | Memed Diagnostics Ltd. | System and method for analysis of biological data |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| US11385241B2 (en) | 2016-09-29 | 2022-07-12 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| EP3519834A4 (en) * | 2016-09-29 | 2020-06-17 | MeMed Diagnostics Ltd. | RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS |
| JP6903494B2 (ja) * | 2017-06-09 | 2021-07-14 | シスメックス株式会社 | 感染症を識別するための粒子分析方法 |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| CA3070522A1 (en) * | 2017-07-31 | 2019-02-07 | University Health Network | Biomarkers in ex vivo lung perfusion (evlp) perfusate |
| EP3707161A4 (en) * | 2017-11-07 | 2021-10-27 | Memed Diagnostics Ltd. | ANTI-TRAIL ANTIBODIES AND METHOD OF USING THEM |
| EP3718462A4 (en) * | 2017-11-28 | 2021-08-18 | Mie University | DETECTION PROCESS |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN108039206B (zh) * | 2017-12-21 | 2021-11-09 | 北京大学深圳研究生院 | 一种传染病的诊治方法及系统 |
| CN117783514A (zh) * | 2018-01-27 | 2024-03-29 | 贝克顿·迪金森公司 | 区分细菌感染和病毒感染的多重横向流测定物 |
| US11484273B2 (en) * | 2018-03-06 | 2022-11-01 | International Business Machines Corporation | Determining functional age indices based upon sensor data |
| US12344893B2 (en) | 2018-06-05 | 2025-07-01 | Washington University | Nasal genes used to identify, characterize, and diagnose viral respiratory infections |
| CN108486246B (zh) * | 2018-06-06 | 2020-06-09 | 青岛泱深生物医药有限公司 | 子痫前期的诊治标志物 |
| TWI819049B (zh) * | 2018-08-02 | 2023-10-21 | 香港商布萊特臨床研究有限公司 | 對正在運行中的臨床試驗進行動態數據監測和實時優化的系統，方法及實施過程 |
| EA202092684A1 (ru) | 2018-08-27 | 2021-03-11 | Ридженерон Фармасьютикалз, Инк. | Применение рамановской спектроскопии для последующей очистки |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020092443A1 (en) * | 2018-10-29 | 2020-05-07 | Thomas Jefferson University | Compositions and methods for discriminating infectious from non-infectious cns disorders |
| WO2021057986A1 (zh) * | 2019-09-27 | 2021-04-01 | 成都中医药大学 | 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途 |
| EP4073514A4 (en) * | 2019-12-11 | 2024-02-28 | Ichilov Tech Ltd. | NON-INVASIVE TEST TO DIFFERENTIATE FROM BACTERIAL AND VIRAL INFECTIONS |
| CN110923333B (zh) * | 2019-12-11 | 2020-09-29 | 湖北省农业科学院畜牧兽医研究所 | 山羊zbp1基因第一内含子内与产羔数关联的单倍型标记及其应用 |
| EP4097485A4 (en) * | 2020-01-29 | 2024-05-15 | MeMed Diagnostics Ltd. | METHODS OF DIAGNOSIS AND CLASSIFICATION OF VIRAL INFECTIONS |
| JP2023513334A (ja) | 2020-02-09 | 2023-03-30 | エヌエルシー ファーマ リミテッド | Ｓａｒｓ－ｃｏｖ－２の迅速検出検査 |
| WO2021204984A1 (en) | 2020-04-09 | 2021-10-14 | B.R.A.H.M.S Gmbh | Biomarkers for the diagnosis of respiratory tract infections |
| CN113533170A (zh) * | 2020-04-21 | 2021-10-22 | 贝克曼考尔特公司 | 病毒感染的血液学参数 |
| WO2022004730A1 (ja) * | 2020-06-30 | 2022-01-06 | 株式会社堀場製作所 | 体液分析装置、体液検体を判定するための方法、および、コンピュータープログラム |
| CN111816245B (zh) * | 2020-07-20 | 2022-09-09 | 成都博欣医学检验实验室有限公司 | 结合mNGS和临床知识库的病原微生物检测方法及系统 |
| US20240103001A1 (en) * | 2021-01-18 | 2024-03-28 | Memed Diagnostics Ltd. | Markers for diagnosing infections |
| US20220298572A1 (en) * | 2021-03-16 | 2022-09-22 | Cepheid | Compositions and methods for discriminating bacterial and viral infections in a human subject |
| CN113945712A (zh) * | 2021-12-21 | 2022-01-18 | 山东中鸿特检生物科技有限公司 | 一种区别细菌、病毒感染的检测方法及检测试剂盒 |
| CN114441506B (zh) * | 2022-04-08 | 2022-06-21 | 港湾之星健康生物(深圳)有限公司 | 量子磁光传感器 |
| EP4357778A1 (en) | 2022-10-20 | 2024-04-24 | Heraeus Medical GmbH | Treatment of microbial infections diagnosed using the biomarker d-lactate |
Family Cites Families (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230767A (en) | 1978-02-08 | 1980-10-28 | Toyo Boseki Kabushiki Kaisha | Heat sealable laminated propylene polymer packaging material |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| US4727022A (en) | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
| US5018067A (en) | 1987-01-12 | 1991-05-21 | Iameter Incorporated | Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators |
| DE4322330A1 (de) | 1992-08-31 | 1994-03-03 | Behringwerke Ag | Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen |
| DE4227454C1 (de) | 1992-08-19 | 1994-02-03 | Henning Berlin Gmbh | Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens |
| SE9401351D0 (sv) | 1994-04-21 | 1994-04-21 | Venge | A method for diagnosis |
| US5910421A (en) | 1995-12-21 | 1999-06-08 | University Of Florida | Rapid diagnostic method for distinguishing allergies and infections |
| US6077665A (en) | 1996-05-07 | 2000-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Rapid assay for infection in neonates |
| WO1999033965A1 (en) | 1997-12-24 | 1999-07-08 | Diatech Pty. Ltd. | Bifunctional molecules |
| CA2329868A1 (en) | 1998-05-18 | 1999-11-25 | Apoptosis Technology, Inc. | Compounds, screening methods, and uses involving anti-apoptotic genes and gene products |
| DE19847690A1 (de) | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| US6709855B1 (en) | 1998-12-18 | 2004-03-23 | Scios, Inc. | Methods for detection and use of differentially expressed genes in disease states |
| CA2359816C (en) | 1999-01-06 | 2010-08-03 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| CA2384978C (en) | 1999-08-24 | 2012-10-23 | Glycozym Aps | Udp-n-acetylglucosamine: galactose-.beta.1,3-n-acetylgalactosamine-.alpha.-r/(glcnac to galnac) .beta.1,6-n-acetylglucosaminyltransferase, c2gnt3 |
| IL132687A0 (en) | 1999-11-01 | 2001-03-19 | Keren Mechkarim Ichilov Pnimit | System and method for evaluating body fluid samples |
| US20020038227A1 (en) | 2000-02-25 | 2002-03-28 | Fey Christopher T. | Method for centralized health data management |
| US7668661B2 (en) | 2000-04-28 | 2010-02-23 | Siemens Healthcare Diagnostics Inc. | Liver disease-related methods and systems |
| AU2001273486A1 (en) | 2000-07-17 | 2002-01-30 | Labnetics, Inc. | Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities |
| US20020055176A1 (en) | 2000-11-08 | 2002-05-09 | Ray Robert A. | Diagnostic assay system |
| RU2229719C2 (ru) | 2001-03-27 | 2004-05-27 | Кабусики Кайся Тосиба | Обнаружение имеющей отношение к заболеванию нуклеиновой кислоты |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| DE10119804A1 (de) | 2001-04-23 | 2002-10-24 | Brahms Ag | Entzündungsspezifische Peptide und deren Verwendungen |
| CN100475848C (zh) | 2001-05-18 | 2009-04-08 | 麒麟麦酒株式会社 | 抗trail-r抗体 |
| FI115165B (fi) | 2001-06-04 | 2005-03-15 | Aboatech Ab Oy | Menetelmä infektion laadun määrittämiseksi |
| DE10130985B4 (de) | 2001-06-27 | 2004-03-18 | B.R.A.H.M.S Ag | Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente |
| US20040209307A1 (en) * | 2001-08-20 | 2004-10-21 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| ATE278194T1 (de) | 2001-12-07 | 2004-10-15 | Brahms Ag | Verwendungen der aldose-1-epimerase (mutarotase) für die diagnose von entzündungserkrankungen und sepsis |
| DE60207183T2 (de) | 2001-12-10 | 2006-08-10 | Kabushiki Gaisha K-And-S | Vorrichtung zur Beobachtung biologischer Daten |
| US20040038201A1 (en) | 2002-01-22 | 2004-02-26 | Whitehead Institute For Biomedical Research | Diagnostic and therapeutic applications for biomarkers of infection |
| US20040122296A1 (en) | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for triaging health-related data |
| US7468032B2 (en) | 2002-12-18 | 2008-12-23 | Cardiac Pacemakers, Inc. | Advanced patient management for identifying, displaying and assisting with correlating health-related data |
| US7351547B2 (en) | 2002-10-31 | 2008-04-01 | Health Research, Inc. | Diagnostic test for West Nile virus |
| US20050227223A1 (en) | 2002-03-22 | 2005-10-13 | Toshio Miyawaki | Method of judging viral infection |
| US7485298B2 (en) * | 2002-05-23 | 2009-02-03 | Michael Powell | Diagnosis and treatment of human dormancy-related sequellae |
| WO2003104496A1 (en) | 2002-06-11 | 2003-12-18 | Idaho Research Foundation | Type i interferon-inducible proteins to detect viral infection |
| US8563476B2 (en) | 2002-11-15 | 2013-10-22 | Morehouse School Of Medicine | Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders |
| AU2004245998A1 (en) | 2003-06-04 | 2004-12-16 | The Government of the United States as represented by The Secretary of the Department of Health and Human Services, Centres for Disease Control and Prevention | PNI microarray and uses |
| CA2537668A1 (en) | 2003-09-29 | 2005-04-14 | Biosite Incorporated | Methods and compositions for the diagnosis of sepsis |
| JP2005106694A (ja) | 2003-09-30 | 2005-04-21 | Mochida Pharmaceut Co Ltd | 敗血症早期検出及び重篤度評価 |
| GB0401730D0 (en) | 2004-01-27 | 2004-03-03 | Bioxell Spa | Diagnosis method |
| US8906630B2 (en) | 2004-02-27 | 2014-12-09 | The Trustees Of The University Of Pennsylvania | Assays for detecting pathogenic respiratory bacteria |
| US7892539B2 (en) * | 2004-03-24 | 2011-02-22 | The Regents Of The University Of California | Modulation of an innate immune response by altering TRIAL-R signaling |
| US8155993B2 (en) | 2004-06-15 | 2012-04-10 | Janssen Pharmaceutica, N.V. | Apparatus and methods for assessing a pharmaceutical product |
| WO2006085984A2 (en) | 2004-07-09 | 2006-08-17 | Amaox, Inc. | Immune cell biosensors and methods of using same |
| WO2006023312A2 (en) | 2004-08-20 | 2006-03-02 | Carl Deirmengian | Diagnostic assay for source of inflammation |
| US20060078998A1 (en) | 2004-09-28 | 2006-04-13 | Singulex, Inc. | System and methods for sample analysis |
| US7572640B2 (en) | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
| KR20070085817A (ko) | 2004-11-05 | 2007-08-27 | 미합중국 (관리부서 : 미합중국 해군성) | 혈액 내 숙주 유전자 표현 바이오마커를 사용한 전염성질병 임상 표현형 및 기타 생리상태의 진단 및 예측방법 |
| WO2007018574A2 (en) | 2004-11-10 | 2007-02-15 | The United States Of America As Represented By The Secretary Of The Navy | Diagnostic assay for rickettsia prowazekii disease by detection of responsive gene expression |
| CA2605143A1 (en) | 2005-04-15 | 2006-10-26 | Becton, Dickinson And Company | Diagnosis of sepsis |
| CN101208602A (zh) | 2005-04-15 | 2008-06-25 | 贝克顿迪金森公司 | 脓毒症的诊断 |
| US20070015172A1 (en) | 2005-06-01 | 2007-01-18 | Z-Biomed, Inc. | Expression profiles for microbial infection |
| UA78641C2 (en) | 2005-08-29 | 2007-04-10 | Open Joint Stock Company Conce | A process for the preparation of carbamide-formaldehyde resin |
| DE102005050933A1 (de) | 2005-10-21 | 2007-04-26 | Justus-Liebig-Universität Giessen | Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen |
| CN101378764A (zh) | 2005-12-09 | 2009-03-04 | 贝勒研究院 | 通过血液白细胞微阵列分析对系统性红斑狼疮的诊断、预后和疾病发展的监测 |
| GB0601959D0 (en) | 2006-01-31 | 2006-03-15 | King S College London | Sepsis test |
| US20070184460A1 (en) | 2006-02-09 | 2007-08-09 | Wei-Mei Ching | Diagnostic assay for Orientia tsutsugamushi by detection of responsive gene expression |
| EP2016195A4 (en) | 2006-04-26 | 2010-03-10 | Vertex Pharma | BIOMARKERS FOR HEPATITIS C VIRUS INFECTION |
| WO2008024642A2 (en) | 2006-08-11 | 2008-02-28 | Baylor Research Institute | Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections |
| AU2012244350B2 (en) | 2006-09-05 | 2013-08-15 | Statens Serum Institut | Ip-10 based immunological monitoring |
| JP5805368B2 (ja) | 2006-09-05 | 2015-11-04 | ステイテンス・セラム・インスティテュート | Ｉｐ−１０に基づく免疫学的モニタリング |
| EP2078201A2 (en) | 2006-10-05 | 2009-07-15 | Agency for Science, Technology and Research | Dengue diagnosis and treatment |
| EP2073844A4 (en) | 2006-12-06 | 2011-06-01 | Medimmune Llc | METHOD FOR TREATING SYSTEMIC LUPUS ERYTHEMATODES |
| DE102006060112A1 (de) | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| WO2008076077A1 (en) | 2006-12-21 | 2008-06-26 | Innogene Kalbiotech Pte Ltd | Method of early diagnosis of epstein-barr virus-related cancer and respective reagents and kits |
| EP2102370A4 (en) * | 2007-01-11 | 2010-01-13 | Univ Duke | METHOD FOR MONITORING HIV INFECTION |
| WO2008095136A2 (en) | 2007-01-31 | 2008-08-07 | Henkin Robert I | Methods for detection of biological substances |
| DE102007009751A1 (de) * | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| WO2008104953A2 (en) | 2007-02-28 | 2008-09-04 | The Procter & Gamble Company | Methods and targets for identifying compounds for regulating rhinovirus infection |
| CA2689306C (en) | 2007-06-01 | 2019-01-15 | Council Of Scientific & Industrial Research | A novel method for simultaneous detection and discrimination of bacterial, fungal, parasitic and viral infections of eye and central nervous system |
| RU2352948C1 (ru) | 2007-06-15 | 2009-04-20 | Государственное образовательное учреждение высшего профессионального образования "КРАСНОЯРСКАЯ ГОСУДАРСТВЕННАЯ МЕДИЦИНСКАЯ АКАДЕМИЯ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" | Способ прогноза исхода заболевания пациентов с ургентной хирургической патологией органов брюшной полости |
| IL184478A (en) | 2007-07-08 | 2017-07-31 | Hadasit Medical Res Services & Development Ltd | Preparations, methods and kits for identifying carriers of mutations in genes 1brca and 2brca and for the early detection of cancers associated with mutations in these genes |
| DE102007035640A1 (de) | 2007-07-27 | 2009-01-29 | Lkh-Kunststoffwerk Gmbh & Co. Kg | Tauchkolben |
| EP2020603A1 (en) | 2007-08-03 | 2009-02-04 | BRAHMS Aktiengesellschaft | Method for risk stratification in stable coronary artery disease |
| CN101790687A (zh) * | 2007-08-03 | 2010-07-28 | B.R.A.H.M.S有限公司 | 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用 |
| TW200920358A (en) | 2007-08-13 | 2009-05-16 | Lundbeck & Co As H | Method of treating stress-mediated depression |
| WO2009025743A2 (en) * | 2007-08-17 | 2009-02-26 | University Of Massachusetts Medical School | Use of trail compositions as antiviral agents |
| EP2039980B1 (de) | 2007-09-24 | 2010-04-07 | BMDSys Production GmbH | Kryostat mit stabilisiertem Aussengefäss |
| EP2071334A1 (en) | 2007-12-14 | 2009-06-17 | Transmedi SA | Compositions and methods of detecting TIABS |
| WO2009100907A1 (en) | 2008-02-14 | 2009-08-20 | Dianeering Diagnostics Engineering And Research Gmbh | Means and methods for assessing the risk of patients presenting to emergency departments based on very low concentrations of troponin i or t or using a combination of markers |
| WO2009120800A2 (en) | 2008-03-25 | 2009-10-01 | University Of Southern California | Prognostic panel for urinary bladder cancer |
| RU2010146701A (ru) | 2008-04-21 | 2012-05-27 | Новартис Форшунгсстифтунг Цвайгнидерлассунг Фридрих Мишер Инститьют Фор Байомедикал Рисерч (Ch) | Противовирусная терапия |
| US9910036B2 (en) | 2008-05-20 | 2018-03-06 | Rapid Pathogen Screening, Inc. | Method and device for combined detection of viral and bacterial infections |
| CA2721742A1 (en) | 2008-05-23 | 2009-11-26 | Pronota N.V. | New biomarkers for diagnosis, prediction and/or prognosis of sepsis and uses thereof |
| AP2011005546A0 (en) | 2008-06-25 | 2011-02-28 | Baylor Res Intitute | Blood transcriptional signature of mycobacterium tuberculosis infection. |
| JP5902479B2 (ja) | 2008-10-24 | 2016-04-13 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | マーカーペプチドのレベルを決定することによる脳卒中患者における予後判定及びリスク評価のための方法 |
| TW201021778A (en) | 2008-11-12 | 2010-06-16 | Alcon Res Ltd | Intraocular lens delivery device with a multi-part plunger tip |
| US20160041153A1 (en) | 2008-11-12 | 2016-02-11 | Kirk Brown | Biomarker compositions and markers |
| BRPI0921043A2 (pt) | 2008-11-12 | 2018-08-07 | Caris Life Sciences Luxembourg Holdings | métodos e sistemas para usar exossomas para determinar fenótipos |
| UA92843C2 (ru) | 2009-05-21 | 2010-12-10 | Институт Технической Теплофизики Национальной Академии Наук Украины | Способ получения порошкообразного пищевого красителя из столовой свеклы |
| WO2010138618A1 (en) | 2009-05-26 | 2010-12-02 | Duke University | Molecular predictors of fungal infection |
| US8507210B2 (en) | 2009-06-05 | 2013-08-13 | B.R.A.H.M.S Gmbh | Detection of bacterial infections in subjects suffering from dyspnea |
| US20110065608A1 (en) | 2009-08-07 | 2011-03-17 | Rules-Based Medicine, Inc. | Devices for Detecting Renal Disorders |
| JP5667353B2 (ja) | 2009-09-25 | 2015-02-12 | シスメックス株式会社 | 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム |
| EP2320237B1 (en) | 2009-10-13 | 2016-08-03 | B.R.A.H.M.S GmbH | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack |
| EP2488659B1 (en) | 2009-10-15 | 2019-12-11 | Crescendo Bioscience, Inc. | Biomarkers and methods for measuring and monitoring inflammatory disease activity |
| US20110144914A1 (en) | 2009-12-09 | 2011-06-16 | Doug Harrington | Biomarker assay for diagnosis and classification of cardiovascular disease |
| US20110312534A1 (en) | 2010-03-05 | 2011-12-22 | Erasmus University Medical Center Rotterdam | Method for prediction of human iris color |
| EP2365456B1 (en) | 2010-03-11 | 2016-07-20 | CompuGroup Medical SE | Data structure, method and system for predicting medical conditions |
| CN106442984B (zh) | 2010-04-21 | 2020-03-13 | 米密德诊断学有限公司 | 区分细菌与病毒感染的标记物和决定因素以及其使用方法 |
| CN103097891B (zh) | 2010-05-31 | 2015-09-09 | 国立大学法人德岛大学 | 疾病重症度的检查方法 |
| GB2482187A (en) | 2010-07-23 | 2012-01-25 | Univ Exeter | Predicting response to surgery |
| US8877212B2 (en) | 2011-02-07 | 2014-11-04 | Trudeau Institute | Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis |
| RU2476887C2 (ru) | 2011-03-29 | 2013-02-27 | Учреждение Российской академии медицинских наук Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМН | Способ прогнозирования развития осложнений у больных внебольничной пневмонией |
| WO2012176779A1 (ja) | 2011-06-20 | 2012-12-27 | 協和発酵キリン株式会社 | 抗ｅｒｂＢ３抗体 |
| EP2756103A4 (en) | 2011-09-12 | 2015-06-03 | Univ Vanderbilt | CHARACTERIZATION OF MULTIPLE SCLEROSIS |
| JP5842107B2 (ja) | 2011-10-19 | 2016-01-13 | パナソニックＩｐマネジメント株式会社 | 循環動態測定装置 |
| ES2656150T3 (es) | 2011-11-14 | 2018-02-23 | Universitätsklinikum Jena | Diagnóstico de la sepsis y del síndrome de respuesta inflamatoria sistémica |
| WO2013119632A1 (en) | 2012-02-07 | 2013-08-15 | Ingber Michael | Apparatus and methods for analyzing a medical condition |
| ES2886979T3 (es) | 2012-02-09 | 2021-12-21 | Memed Diagnostics Ltd | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos |
| EP2637023A1 (en) | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| EP2822602B1 (en) | 2012-03-08 | 2020-06-03 | Thommen Medical Ag | Chewing gum for the diagnosis of inflammatory tissues in dental applications |
| US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| GB201211982D0 (en) | 2012-07-05 | 2012-08-22 | Isis Innovation | Biomarker |
| DK2872891T3 (da) | 2012-07-10 | 2019-05-13 | Nepean Blue Mountains Local Health Distr | Risikostratificering ved influenza |
| FR2996003B1 (fr) | 2012-09-25 | 2014-10-17 | Commissariat Energie Atomique | Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active |
| US20140127827A1 (en) | 2012-11-05 | 2014-05-08 | Gwangju Institute Of Science And Technology | Method for detection of antigen using fluorescence resonance energy transfer immunoassay |
| WO2014085826A2 (en) | 2012-11-30 | 2014-06-05 | Applied Proteomics, Inc. | Method for evaluation of presence of or risk of colon tumors |
| WO2014114688A1 (en) | 2013-01-22 | 2014-07-31 | Imicroq, S.L. | Rapid method for detection of pathogen |
| US20150363559A1 (en) | 2013-01-29 | 2015-12-17 | Molecular Health Gmbh | Systems and methods for clinical decision support |
| US9474903B2 (en) | 2013-03-15 | 2016-10-25 | Boston Scientific Neuromodulation Corporation | Clinical response data mapping |
| US10689701B2 (en) | 2013-03-15 | 2020-06-23 | Duke University | Biomarkers for the molecular classification of bacterial infection |
| CN108627651A (zh) | 2013-09-20 | 2018-10-09 | 阿斯图特医药公司 | 用于阑尾炎的诊断和预后及腹痛病因的区分的方法和组合物 |
| WO2015048098A1 (en) | 2013-09-24 | 2015-04-02 | Washington University | Diagnostic methods for infectious disease using endogenous gene expression |
| BR112017002884A2 (pt) | 2014-08-14 | 2018-01-30 | Memed Diagnostics Ltd | ?análise computacional de dados biológicos por meio do uso de variedade e hiperplano? |
| WO2016059636A1 (en) | 2014-10-14 | 2016-04-21 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| ES2981450T3 (es) | 2014-11-19 | 2024-10-08 | P & M Venge Ab | Métodos de diagnóstico que emplean HNL |
| CA2968650A1 (en) * | 2014-12-11 | 2016-06-16 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
| KR20160072626A (ko) | 2014-12-15 | 2016-06-23 | 전북대학교산학협력단 | 패혈증 인자 il-6 간이 진단 키트 |
| US20180310854A1 (en) | 2015-11-01 | 2018-11-01 | Elminda Ltd. | Method and system for estimating potential distribution on cortical surface |
| IL287757B (en) | 2016-03-03 | 2022-07-01 | Memed Diagnostics Ltd | Analyzing rna for diagnosing infection type |
| CN108699583B (zh) | 2016-03-03 | 2022-11-01 | 米密德诊断学有限公司 | 用于区分细菌和病毒感染的rna决定子 |
| CN109642900A (zh) | 2016-06-23 | 2019-04-16 | 米密德诊断学有限公司 | 通过侧流免疫测定测量trail |
| CA3027341A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| WO2018011796A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| WO2018052137A1 (ja) | 2016-09-16 | 2018-03-22 | 株式会社オンチップ・バイオテクノロジーズ | 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法 |
| EP3519834A4 (en) | 2016-09-29 | 2020-06-17 | MeMed Diagnostics Ltd. | RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS |
| US11385241B2 (en) | 2016-09-29 | 2022-07-12 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| US12348304B2 (en) | 2021-04-08 | 2025-07-01 | Infinidome Ltd. | Adjustable null steering in a stationary network |
-
2013
- 2013-02-08 ES ES18162713T patent/ES2886979T3/es active Active
- 2013-02-08 JP JP2014556086A patent/JP6169619B2/ja active Active
- 2013-02-08 CA CA2863819A patent/CA2863819C/en active Active
- 2013-02-08 EP EP13703112.6A patent/EP2812700B1/en active Active
- 2013-02-08 CN CN201810781584.9A patent/CN108802385B/zh active Active
- 2013-02-08 IN IN1780MUN2014 patent/IN2014MN01780A/en unknown
- 2013-02-08 AU AU2013217935A patent/AU2013217935B2/en active Active
- 2013-02-08 CA CA3133249A patent/CA3133249C/en active Active
- 2013-02-08 WO PCT/EP2013/052619 patent/WO2013117746A1/en active Application Filing
- 2013-02-08 CN CN201380019055.0A patent/CN104204803B/zh active Active
- 2013-02-08 BR BR112014019733-4A patent/BR112014019733B1/pt active IP Right Grant
- 2013-02-08 EP EP18162713.4A patent/EP3367099B1/en active Active
- 2013-02-08 US US14/377,887 patent/US9726668B2/en active Active
- 2013-02-08 ES ES13703112.6T patent/ES2679107T3/es active Active
- 2013-02-08 EP EP21170448.1A patent/EP3882633A1/en not_active Withdrawn
-
2014
- 2014-08-07 IL IL233998A patent/IL233998A/en active IP Right Grant
- 2014-08-15 ZA ZA2014/05993A patent/ZA201405993B/en unknown
-
2016
- 2016-08-16 US US15/237,728 patent/US10502739B2/en active Active
-
2017
- 2017-06-28 JP JP2017126712A patent/JP6725456B2/ja active Active
- 2017-08-22 IL IL254095A patent/IL254095B/en unknown
-
2018
- 2018-03-29 AU AU2018202302A patent/AU2018202302C1/en active Active
-
2019
- 2019-11-19 US US16/687,726 patent/US11175291B2/en active Active
-
2020
- 2020-06-25 JP JP2020109710A patent/JP2020180975A/ja active Pending
-
2021
- 2021-06-30 IL IL284506A patent/IL284506B/en unknown
- 2021-10-22 US US17/507,994 patent/US12188934B2/en active Active
-
2024
- 2024-12-24 US US19/000,814 patent/US20250189526A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2886979T3 (es) | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos | |
| US10209260B2 (en) | Signatures and determinants for diagnosing infections and methods of use thereof | |
| US10859574B2 (en) | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof | |
| EP2561363B1 (en) | Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof | |
| BR112017010268B1 (pt) | Agente de ligação, composição de diagnóstico, kit de diagnóstico, método de diagnóstico de uma infecção bacteriana ou de diferenciação entre uma infecção bacteriana e uma infecção de viral, métodos para descartar uma infecção bacteriana ou viral em um indivíduo, métodos para considerar uma infecção bacteriana ou viral em um indivíduo, método para distinguir entre uma infecção bacteriana ou mista e uma infecção viral em um indivíduo, método para descartar uma doença infecciosa, método para identificação do tipo de infecção e dispositivo para o diagnóstico de infecções bacterianas | |
| Class et al. | Patent application title: SIGNATURES AND DETERMINANTS FOR DIAGNOSING INFECTIONS AND METHODS OF USE THEREOF Inventors: Kfir Oved (Moshav Megadim, IL) Eran Eden (Haifa, IL) Ilan Ifergan (Haifa, IL) | |
| HK1253780B (en) | Signatures and determinants for diagnosing infections and methods of use thereof | |
| HK1204065B (en) | Signatures and determinants for diagnosing infections and methods of use thereof |