BR112014019733B1 - Método para determinação de um tipo de infecção em um indivíduo - Google Patents

Método para determinação de um tipo de infecção em um indivíduo Download PDF

Info

Publication number
BR112014019733B1
BR112014019733B1 BR112014019733-4A BR112014019733A BR112014019733B1 BR 112014019733 B1 BR112014019733 B1 BR 112014019733B1 BR 112014019733 A BR112014019733 A BR 112014019733A BR 112014019733 B1 BR112014019733 B1 BR 112014019733B1
Authority
BR
Brazil
Prior art keywords
infection
trail
patients
determinants
viral
Prior art date
Application number
BR112014019733-4A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112014019733A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Kfir Oved
Eran Eden
Ilan Ifergan
Original Assignee
Memed Diagnostics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memed Diagnostics filed Critical Memed Diagnostics
Publication of BR112014019733A2 publication Critical patent/BR112014019733A2/pt
Publication of BR112014019733B1 publication Critical patent/BR112014019733B1/pt

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44739—Collecting the separated zones, e.g. blotting to a membrane or punching of gel spots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866—Interferon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112014019733-4A 2012-02-09 2013-02-08 Método para determinação de um tipo de infecção em um indivíduo BR112014019733B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261596950P 2012-02-09 2012-02-09
US61/596,950 2012-02-09
US201261652631P 2012-05-29 2012-05-29
US61/652,631 2012-05-29
PCT/EP2013/052619 WO2013117746A1 (en) 2012-02-09 2013-02-08 Signatures and determinants for diagnosing infections and methods of use thereof

Publications (2)

Publication Number Publication Date
BR112014019733A2 BR112014019733A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2017-08-22
BR112014019733B1 true BR112014019733B1 (pt) 2022-09-13

Family

ID=47678877

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019733-4A BR112014019733B1 (pt) 2012-02-09 2013-02-08 Método para determinação de um tipo de infecção em um indivíduo

Country Status (12)

Country Link
US (5) US9726668B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (3) EP3367099B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (3) JP6169619B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN108802385B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU2013217935B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR112014019733B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (2) CA2863819C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES2886979T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (3) IL233998A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2014MN01780A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2013117746A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA201405993B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2387627T3 (pl) 2009-01-15 2016-10-31 Profilowanie odporności adaptacyjnej i wytwarzanie przeciwciał monoklonalnych
WO2011132086A2 (en) 2010-04-21 2011-10-27 MeMed Diagnostics, Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
ES2886979T3 (es) 2012-02-09 2021-12-21 Memed Diagnostics Ltd Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos
WO2013134162A2 (en) 2012-03-05 2013-09-12 Sequenta, Inc. Determining paired immune receptor chains from frequency matched subunits
KR101621643B1 (ko) 2012-05-08 2016-05-16 어댑티브 바이오테크놀로지스 코포레이션 다중 pcr 반응에서 증폭 바이어스를 측정 및 교정하기 위한 조성물 및 방법
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
WO2015138991A2 (en) * 2014-03-13 2015-09-17 Opgen, Inc. Methods of detecting multi-drug resistant organisms
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
CA2950327A1 (en) 2014-05-27 2015-12-03 Opgen, Inc. Systems, apparatus, and methods for generating and analyzing resistome profiles
WO2015192050A1 (en) * 2014-06-13 2015-12-17 North Carolina State University Aptamers with binding affinity to norovirus
US10303846B2 (en) 2014-08-14 2019-05-28 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) * 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
WO2016079219A1 (en) * 2014-11-19 2016-05-26 Koninklijke Philips N.V. Diagnostic method employing hnl
US20170269081A1 (en) * 2014-12-11 2017-09-21 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
EP3591074B1 (en) * 2015-02-24 2024-10-23 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
US11041202B2 (en) 2015-04-01 2021-06-22 Adaptive Biotechnologies Corporation Method of identifying human compatible T cell receptors specific for an antigenic target
EP3139171B1 (en) * 2015-09-02 2020-02-12 Labsystems Diagnostics Oy Novel methods and kits for detecting of urea cycle disorders using mass spectrometry
CN108513586A (zh) 2015-09-30 2018-09-07 因姆内克斯普雷斯私人有限公司 病原体生物标志物及其用途
CN106918698B (zh) * 2015-12-25 2019-11-22 广州瑞博奥生物科技有限公司 一种检测人受体酪氨酸激酶的磷酸化抗体芯片试剂盒
EP3423589B1 (en) 2016-03-03 2021-07-21 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
CA3015046A1 (en) * 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Rna determinants for distinguishing between bacterial and viral infections
CN106053831A (zh) * 2016-06-05 2016-10-26 潘时辉 一种用于自身免疫病检测的试剂盒
US11274345B2 (en) * 2016-06-07 2022-03-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of bacterial and viral infections
CN109642900A (zh) * 2016-06-23 2019-04-16 米密德诊断学有限公司 通过侧流免疫测定测量trail
EP4141448A1 (en) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
US11340223B2 (en) 2016-07-10 2022-05-24 Memed Diagnostics Ltd. Early diagnosis of infections
CN109844532B (zh) * 2016-08-10 2022-06-17 米密德诊断学有限公司 分析生物数据的系统和方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
CN110073220A (zh) * 2016-09-29 2019-07-30 米密德诊断学有限公司 风险评估和疾病分类的方法
EP3519833B1 (en) 2016-09-29 2024-08-14 MeMed Diagnostics Ltd. Methods of prognosis and treatment
JP6903494B2 (ja) * 2017-06-09 2021-07-14 シスメックス株式会社 感染症を識別するための粒子分析方法
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
WO2019023790A1 (en) * 2017-07-31 2019-02-07 University Health Network BIOMARKERS IN EX VIVO PULMONARY PERFUSION PERFUSION (EVLP)
WO2019092703A1 (en) * 2017-11-07 2019-05-16 Memed Diagnostics Ltd. Anti-trail antibodies and methods of use
WO2019107370A1 (ja) * 2017-11-28 2019-06-06 国立大学法人三重大学 検出方法
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
CN108039206B (zh) * 2017-12-21 2021-11-09 北京大学深圳研究生院 一种传染病的诊治方法及系统
CN117783514A (zh) * 2018-01-27 2024-03-29 贝克顿·迪金森公司 区分细菌感染和病毒感染的多重横向流测定物
US11484273B2 (en) * 2018-03-06 2022-11-01 International Business Machines Corporation Determining functional age indices based upon sensor data
US12344893B2 (en) 2018-06-05 2025-07-01 Washington University Nasal genes used to identify, characterize, and diagnose viral respiratory infections
CN108486246B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 子痫前期的诊治标志物
CN112840314A (zh) * 2018-08-02 2021-05-25 布莱特临床研究有限公司 对正在运行中的临床试验进行动态数据监测和实时优化的系统、方法及实施过程
KR20210052389A (ko) 2018-08-27 2021-05-10 리제너론 파마슈티칼스 인코포레이티드 다운스트림 정제에서의 라만 분광법의 사용
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US20210389329A1 (en) * 2018-10-29 2021-12-16 Thomas Jefferson University Compositions and Methods for Discriminating Infectious from Non-Infectious CNS Disorders
WO2021057986A1 (zh) * 2019-09-27 2021-04-01 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途
WO2021117044A1 (en) 2019-12-11 2021-06-17 Ichilov Tech Ltd. Non-invasive assay for differentiating between bacterial and viral infections
CN110923333B (zh) * 2019-12-11 2020-09-29 湖北省农业科学院畜牧兽医研究所 山羊zbp1基因第一内含子内与产羔数关联的单倍型标记及其应用
US20230094142A1 (en) * 2020-01-29 2023-03-30 Memed Diagnostics Ltd. Methods of diagnosing and classifying viral infections
JP2023513334A (ja) * 2020-02-09 2023-03-30 エヌエルシー ファーマ リミテッド Ｓａｒｓ－ｃｏｖ－２の迅速検出検査
JP2023520813A (ja) 2020-04-09 2023-05-19 ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 気道感染症の診断のためのバイオマーカー
CN113533170A (zh) * 2020-04-21 2021-10-22 贝克曼考尔特公司 病毒感染的血液学参数
EP4152000A4 (en) * 2020-06-30 2024-07-03 HORIBA, Ltd. Body fluid analysis device, method for determining body fluid sample, and computer program
CN111816245B (zh) * 2020-07-20 2022-09-09 成都博欣医学检验实验室有限公司 结合mNGS和临床知识库的病原微生物检测方法及系统
WO2022153323A1 (en) * 2021-01-18 2022-07-21 Memed Diagnostics Ltd. Markers for diagnosing infections
WO2022197351A1 (en) * 2021-03-16 2022-09-22 Cepheid Methods for discriminating bacterial and viral infections in a human subject
CN113945712A (zh) * 2021-12-21 2022-01-18 山东中鸿特检生物科技有限公司 一种区别细菌、病毒感染的检测方法及检测试剂盒
CN114441506B (zh) * 2022-04-08 2022-06-21 港湾之星健康生物(深圳)有限公司 量子磁光传感器
EP4357778A1 (en) 2022-10-20 2024-04-24 Heraeus Medical GmbH Treatment of microbial infections diagnosed using the biomarker d-lactate

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1178414A (en) 1978-02-08 1984-11-27 Toyo Boseki Kabushiki Kaisha (Trading Under The Name Of Toyobo Co., Ltd.) Packaging material having excellent seal packaging property
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4727022A (en) 1984-03-14 1988-02-23 Syntex (U.S.A.) Inc. Methods for modulating ligand-receptor interactions and their application
US5018067A (en) 1987-01-12 1991-05-21 Iameter Incorporated Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators
DE4322330A1 (de) 1992-08-31 1994-03-03 Behringwerke Ag Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen
DE4227454C1 (de) 1992-08-19 1994-02-03 Henning Berlin Gmbh Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens
SE9401351D0 (sv) 1994-04-21 1994-04-21 Venge A method for diagnosis
US5910421A (en) 1995-12-21 1999-06-08 University Of Florida Rapid diagnostic method for distinguishing allergies and infections
US6077665A (en) 1996-05-07 2000-06-20 The Board Of Trustees Of The Leland Stanford Junior University Rapid assay for infection in neonates
US7026446B1 (en) 1997-12-24 2006-04-11 Diatech Pty Ltd. Bifunctional molecules
AU762756B2 (en) 1998-05-18 2003-07-03 Apoptosis Technology, Inc. Compounds, screening methods, and uses involving anti-apoptotic genes and gene products
DE19847690A1 (de) 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
US6709855B1 (en) 1998-12-18 2004-03-23 Scios, Inc. Methods for detection and use of differentially expressed genes in disease states
CA2359816C (en) 1999-01-06 2010-08-03 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
NZ517219A (en) 1999-08-24 2004-06-25 Glycozym Aps Nucleic acids and polypeptides used to modulate the biological activity of a C2GnT3 polypeptide and treat proliferative diseases such as cancer and thymus-related disorders
IL132687A0 (en) 1999-11-01 2001-03-19 Keren Mechkarim Ichilov Pnimit System and method for evaluating body fluid samples
US20020038227A1 (en) 2000-02-25 2002-03-28 Fey Christopher T. Method for centralized health data management
US7668661B2 (en) 2000-04-28 2010-02-23 Siemens Healthcare Diagnostics Inc. Liver disease-related methods and systems
AU2001273486A1 (en) 2000-07-17 2002-01-30 Labnetics, Inc. Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities
US20020055176A1 (en) 2000-11-08 2002-05-09 Ray Robert A. Diagnostic assay system
KR100461715B1 (ko) 2001-03-27 2004-12-17 가부시끼가이샤 도시바 질환과 관련된 핵산의 검출 방법
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
DE10119804A1 (de) 2001-04-23 2002-10-24 Brahms Ag Entzündungsspezifische Peptide und deren Verwendungen
EP1396500A4 (en) 2001-05-18 2005-02-02 Kirin Brewery ANTI-TRAIL-R ANTIBODIES
FI115165B (fi) 2001-06-04 2005-03-15 Aboatech Ab Oy Menetelmä infektion laadun määrittämiseksi
DE10130985B4 (de) 2001-06-27 2004-03-18 B.R.A.H.M.S Ag Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
ATE278194T1 (de) 2001-12-07 2004-10-15 Brahms Ag Verwendungen der aldose-1-epimerase (mutarotase) für die diagnose von entzündungserkrankungen und sepsis
US6953435B2 (en) 2001-12-10 2005-10-11 Kabushiki Gaisha K -And- S Biological data observation apparatus
US20040038201A1 (en) 2002-01-22 2004-02-26 Whitehead Institute For Biomedical Research Diagnostic and therapeutic applications for biomarkers of infection
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US20040122296A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for triaging health-related data
EP1489416A4 (en) 2002-03-22 2005-09-28 Kyowa Medex Co Ltd METHOD FOR THE EVALUATION OF VIRUS INFECTION
US7485298B2 (en) * 2002-05-23 2009-02-03 Michael Powell Diagnosis and treatment of human dormancy-related sequellae
KR20050040866A (ko) 2002-06-11 2005-05-03 아이다호 리서치 파운데이션 바이러스 감염의 검출을 위한 ⅰ형 인터페론-유도성 단백질
EP1601947A2 (en) 2002-10-31 2005-12-07 Health Research, Incorporated Diagnostic test for west nile virus
US8563476B2 (en) 2002-11-15 2013-10-22 Morehouse School Of Medicine Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders
AU2004245998A1 (en) 2003-06-04 2004-12-16 The Government of the United States as represented by The Secretary of the Department of Health and Human Services, Centres for Disease Control and Prevention PNI microarray and uses
CA2537668A1 (en) 2003-09-29 2005-04-14 Biosite Incorporated Methods and compositions for the diagnosis of sepsis
JP2005106694A (ja) 2003-09-30 2005-04-21 Mochida Pharmaceut Co Ltd 敗血症早期検出及び重篤度評価
GB0401730D0 (en) 2004-01-27 2004-03-03 Bioxell Spa Diagnosis method
US8906630B2 (en) 2004-02-27 2014-12-09 The Trustees Of The University Of Pennsylvania Assays for detecting pathogenic respiratory bacteria
US7892539B2 (en) * 2004-03-24 2011-02-22 The Regents Of The University Of California Modulation of an innate immune response by altering TRIAL-R signaling
US8155993B2 (en) 2004-06-15 2012-04-10 Janssen Pharmaceutica, N.V. Apparatus and methods for assessing a pharmaceutical product
EP1787128A2 (en) 2004-07-09 2007-05-23 Amaox, Inc. Immune cell biosensors and methods of using same
WO2006023312A2 (en) 2004-08-20 2006-03-02 Carl Deirmengian Diagnostic assay for source of inflammation
US7572640B2 (en) 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
AU2005290314A1 (en) 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
AU2005334466B2 (en) 2004-11-05 2011-05-26 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Diagnosis and prognosis of infectious disease clinical phenotypes and other physiologic states using host gene expression biomarkers in blood
WO2007018574A2 (en) 2004-11-10 2007-02-15 The United States Of America As Represented By The Secretary Of The Navy Diagnostic assay for rickettsia prowazekii disease by detection of responsive gene expression
CA2605143A1 (en) 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
CN101208602A (zh) 2005-04-15 2008-06-25 贝克顿迪金森公司 脓毒症的诊断
US20070015172A1 (en) 2005-06-01 2007-01-18 Z-Biomed, Inc. Expression profiles for microbial infection
UA78641C2 (en) 2005-08-29 2007-04-10 Open Joint Stock Company Conce A process for the preparation of carbamide-formaldehyde resin
DE102005050933A1 (de) 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
US20070231816A1 (en) 2005-12-09 2007-10-04 Baylor Research Institute Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
GB0601959D0 (en) 2006-01-31 2006-03-15 King S College London Sepsis test
US20070184460A1 (en) 2006-02-09 2007-08-09 Wei-Mei Ching Diagnostic assay for Orientia tsutsugamushi by detection of responsive gene expression
RU2008146518A (ru) 2006-04-26 2010-06-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Биомаркеры инфекции, вызываемой вирусом гепатита с
SG177956A1 (en) 2006-08-11 2012-02-28 Baylor Res Inst Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections
EP2261658B1 (en) 2006-09-05 2015-01-28 Hvidovre Hospital IP-10 based infection diagnosis
AU2012244350B2 (en) 2006-09-05 2013-08-15 Statens Serum Institut Ip-10 based immunological monitoring
EP2078201A2 (en) 2006-10-05 2009-07-15 Agency for Science, Technology and Research Dengue diagnosis and treatment
AU2007327995B2 (en) 2006-12-06 2013-10-10 Medimmune, Llc Interferon alpha-induced pharmacodynamic markers
DE102006060112A1 (de) 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
WO2008076077A1 (en) 2006-12-21 2008-06-26 Innogene Kalbiotech Pte Ltd Method of early diagnosis of epstein-barr virus-related cancer and respective reagents and kits
US20100221700A1 (en) * 2007-01-11 2010-09-02 Haynes Barton F Method of monitoring hiv infection
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
DE102007009751A1 (de) * 2007-02-28 2008-09-04 B.R.A.H.M.S Aktiengesellschaft Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens
RU2009129185A (ru) 2007-02-28 2011-04-10 Дзе Проктер Энд Гэмбл Компани (US) Способы и мишени для идентификации соединений для регуляции риновирусной инфекции
CN101541979B (zh) 2007-06-01 2014-11-05 科学与工业研究委员会 同时检测和鉴别眼睛和中枢神经系统的细菌、真菌、寄生虫和病毒感染的方法
RU2352948C1 (ru) 2007-06-15 2009-04-20 Государственное образовательное учреждение высшего профессионального образования "КРАСНОЯРСКАЯ ГОСУДАРСТВЕННАЯ МЕДИЦИНСКАЯ АКАДЕМИЯ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" Способ прогноза исхода заболевания пациентов с ургентной хирургической патологией органов брюшной полости
IL184478A (en) 2007-07-08 2017-07-31 Hadasit Medical Res Services & Development Ltd Preparations, methods and kits for identifying carriers of mutations in genes 1brca and 2brca and for the early detection of cancers associated with mutations in these genes
DE102007035640A1 (de) 2007-07-27 2009-01-29 Lkh-Kunststoffwerk Gmbh & Co. Kg Tauchkolben
CN103123359B (zh) * 2007-08-03 2015-07-29 B.R.A.H.M.S有限公司 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用
EP2020603A1 (en) 2007-08-03 2009-02-04 BRAHMS Aktiengesellschaft Method for risk stratification in stable coronary artery disease
TW200920358A (en) 2007-08-13 2009-05-16 Lundbeck & Co As H Method of treating stress-mediated depression
WO2009025743A2 (en) * 2007-08-17 2009-02-26 University Of Massachusetts Medical School Use of trail compositions as antiviral agents
ATE463700T1 (de) 2007-09-24 2010-04-15 Bmdsys Production Gmbh Kryostat mit stabilisiertem aussengefäss
EP2071334A1 (en) 2007-12-14 2009-06-17 Transmedi SA Compositions and methods of detecting TIABS
WO2009100907A1 (en) 2008-02-14 2009-08-20 Dianeering Diagnostics Engineering And Research Gmbh Means and methods for assessing the risk of patients presenting to emergency departments based on very low concentrations of troponin i or t or using a combination of markers
WO2009120800A2 (en) 2008-03-25 2009-10-01 University Of Southern California Prognostic panel for urinary bladder cancer
SG190570A1 (en) 2008-04-21 2013-06-28 Novartis Forschungsstiftung Antiviral therapy
US9910036B2 (en) 2008-05-20 2018-03-06 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
US8697370B2 (en) 2008-05-23 2014-04-15 Pronota N.V. Biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof
AP2011005546A0 (en) 2008-06-25 2011-02-28 Baylor Res Intitute Blood transcriptional signature of mycobacterium tuberculosis infection.
CN102257386B (zh) 2008-10-24 2014-12-31 B.R.A.H.M.S有限公司 通过测定标志肽的水平在已患过中风或短暂性缺血性发作的患者中进行预后和风险评估
US20160041153A1 (en) 2008-11-12 2016-02-11 Kirk Brown Biomarker compositions and markers
TW201021778A (en) 2008-11-12 2010-06-16 Alcon Res Ltd Intraocular lens delivery device with a multi-part plunger tip
GB2463401B (en) 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
UA92843C2 (ru) 2009-05-21 2010-12-10 Институт Технической Теплофизики Национальной Академии Наук Украины Способ получения порошкообразного пищевого красителя из столовой свеклы
US8821876B2 (en) 2009-05-26 2014-09-02 Duke University Methods of identifying infectious disease and assays for identifying infectious disease
US8507210B2 (en) 2009-06-05 2013-08-13 B.R.A.H.M.S Gmbh Detection of bacterial infections in subjects suffering from dyspnea
US20110065593A1 (en) 2009-08-07 2011-03-17 Rules-Based Medicine, Inc. Computer Methods and Devices for Detecting Kidney Damage
JP5667353B2 (ja) 2009-09-25 2015-02-12 シスメックス株式会社 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム
EP2320237B1 (en) 2009-10-13 2016-08-03 B.R.A.H.M.S GmbH Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack
US9200324B2 (en) 2009-10-15 2015-12-01 Crescendo Bioscience Biomarkers and methods for measuring and monitoring inflammatory disease activity
US20110144914A1 (en) 2009-12-09 2011-06-16 Doug Harrington Biomarker assay for diagnosis and classification of cardiovascular disease
US20110312534A1 (en) 2010-03-05 2011-12-22 Erasmus University Medical Center Rotterdam Method for prediction of human iris color
EP2365456B1 (en) 2010-03-11 2016-07-20 CompuGroup Medical SE Data structure, method and system for predicting medical conditions
WO2011132086A2 (en) 2010-04-21 2011-10-27 MeMed Diagnostics, Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
EP2579037B1 (en) 2010-05-31 2015-08-12 The University of Tokushima Method for testing the severity of an illness
GB2482187A (en) 2010-07-23 2012-01-25 Univ Exeter Predicting response to surgery
US8877212B2 (en) 2011-02-07 2014-11-04 Trudeau Institute Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis
RU2476887C2 (ru) 2011-03-29 2013-02-27 Учреждение Российской академии медицинских наук Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМН Способ прогнозирования развития осложнений у больных внебольничной пневмонией
CA2840461A1 (en) 2011-06-20 2012-12-27 Kyowa Hakko Kirin Co., Ltd. Anti-erbb3 antibody
WO2013040062A2 (en) 2011-09-12 2013-03-21 Vanderbilt University Characterizing multiple sclerosis
JP5842107B2 (ja) 2011-10-19 2016-01-13 パナソニックＩｐマネジメント株式会社 循環動態測定装置
ES2656150T3 (es) 2011-11-14 2018-02-23 Universitätsklinikum Jena Diagnóstico de la sepsis y del síndrome de respuesta inflamatoria sistémica
WO2013119632A1 (en) 2012-02-07 2013-08-15 Ingber Michael Apparatus and methods for analyzing a medical condition
ES2886979T3 (es) 2012-02-09 2021-12-21 Memed Diagnostics Ltd Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos
EP2637023A1 (en) 2012-03-08 2013-09-11 B.R.A.H.M.S GmbH Prediction of outcome in patients with chronic obstructive pulmonary disease
CN104159616B (zh) 2012-03-08 2017-10-31 托门医学股份公司 在牙科应用中用于诊断炎性组织的口香糖
CN114042171B (zh) 2012-03-30 2024-12-06 文森医学公司 细菌成像剂及其使用方法
GB201211982D0 (en) 2012-07-05 2012-08-22 Isis Innovation Biomarker
BR112015000685A2 (pt) 2012-07-10 2017-11-28 Nepean Blue Mountains Local Health Distr método para a identificação de risco clínico em um paciente possuindo ou suspeito de possuir uma infecção por influenza, método para a identificação de influenza ou pneumonia viral em um paciente, kit, método para avaliar a eficácia de um agente para o tratamento de influenza e para reduzir a severidade da doença em um indivíduo exposto a um vírus influenza.
FR2996003B1 (fr) 2012-09-25 2014-10-17 Commissariat Energie Atomique Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active
US20140127827A1 (en) 2012-11-05 2014-05-08 Gwangju Institute Of Science And Technology Method for detection of antigen using fluorescence resonance energy transfer immunoassay
CN110596385A (zh) 2012-11-30 2019-12-20 迪森德克斯公司 用于评估结肠肿瘤的存在或风险的方法
MX360384B (es) 2013-01-22 2018-10-31 Imicroq S L Metodo rapido para la deteccion de patogenos.
KR20150113113A (ko) 2013-01-29 2015-10-07 몰레큘러 헬스 게엠베하 임상적 판단 지원을 위한 시스템 및 방법
US10689701B2 (en) 2013-03-15 2020-06-23 Duke University Biomarkers for the molecular classification of bacterial infection
AU2014227964B2 (en) 2013-03-15 2016-12-15 Boston Scientific Neuromodulation Corporation Clinical response data mapping
EP3047270A4 (en) 2013-09-20 2017-07-19 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
WO2015048098A1 (en) 2013-09-24 2015-04-02 Washington University Diagnostic methods for infectious disease using endogenous gene expression
US10303846B2 (en) 2014-08-14 2019-05-28 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
WO2016079219A1 (en) 2014-11-19 2016-05-26 Koninklijke Philips N.V. Diagnostic method employing hnl
US20170269081A1 (en) * 2014-12-11 2017-09-21 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
KR20160072626A (ko) 2014-12-15 2016-06-23 전북대학교산학협력단 패혈증 인자 il-6 간이 진단 키트
CA3003104A1 (en) 2015-11-01 2017-05-04 Elminda Ltd. Method and system for estimating potential distribution on cortical surface
CA3015046A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Rna determinants for distinguishing between bacterial and viral infections
EP3423589B1 (en) 2016-03-03 2021-07-21 Memed Diagnostics Ltd. Analyzing rna for diagnosing infection type
CN109642900A (zh) 2016-06-23 2019-04-16 米密德诊断学有限公司 通过侧流免疫测定测量trail
EP4141448A1 (en) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
US11340223B2 (en) 2016-07-10 2022-05-24 Memed Diagnostics Ltd. Early diagnosis of infections
JP7020689B2 (ja) 2016-09-16 2022-02-16 株式会社オンチップ・バイオテクノロジーズ 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法
CN110073220A (zh) 2016-09-29 2019-07-30 米密德诊断学有限公司 风险评估和疾病分类的方法
EP3519833B1 (en) 2016-09-29 2024-08-14 MeMed Diagnostics Ltd. Methods of prognosis and treatment
US10209260B2 (en) * 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US12348304B2 (en) 2021-04-08 2025-07-01 Infinidome Ltd. Adjustable null steering in a stationary network

Also Published As

Publication number Publication date
CN104204803B (zh) 2018-08-07
JP6725456B2 (ja) 2020-07-22
US20170030909A1 (en) 2017-02-02
IL254095A0 (en) 2017-10-31
BR112014019733A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2017-08-22
AU2013217935B2 (en) 2018-05-17
JP2017198696A (ja) 2017-11-02
JP6169619B2 (ja) 2017-07-26
ES2886979T3 (es) 2021-12-21
CN108802385A (zh) 2018-11-13
CA2863819C (en) 2021-11-23
AU2018202302A1 (en) 2018-04-26
IL254095B (en) 2021-07-29
US11175291B2 (en) 2021-11-16
US12188934B2 (en) 2025-01-07
EP2812700A1 (en) 2014-12-17
US10502739B2 (en) 2019-12-10
US9726668B2 (en) 2017-08-08
ZA201405993B (en) 2015-11-25
AU2018202302C1 (en) 2020-06-11
JP2015510122A (ja) 2015-04-02
CN104204803A (zh) 2014-12-10
CA3133249A1 (en) 2013-08-15
HK1253780A1 (en) 2019-07-05
CA2863819A1 (en) 2013-08-15
US20200088728A1 (en) 2020-03-19
EP3367099A1 (en) 2018-08-29
ES2679107T3 (es) 2018-08-22
US20220042994A1 (en) 2022-02-10
IN2014MN01780A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-07-03
HK1204065A1 (en) 2015-11-06
EP3367099B1 (en) 2021-05-26
AU2018202302B2 (en) 2020-01-23
CN108802385B (zh) 2022-02-08
JP2020180975A (ja) 2020-11-05
WO2013117746A1 (en) 2013-08-15
AU2013217935A1 (en) 2014-09-04
IL233998A (en) 2017-08-31
EP2812700B1 (en) 2018-04-18
CA3133249C (en) 2023-07-25
IL284506A (en) 2021-08-31
IL284506B (en) 2022-06-01
IL233998A0 (en) 2014-09-30
US20250189526A1 (en) 2025-06-12
US20150017630A1 (en) 2015-01-15
EP3882633A1 (en) 2021-09-22

Similar Documents

Publication Publication Date Title
JP6725456B2 (ja) 対象における細菌感染または細菌／ウイルス混合感染を除外するためのキット
US10859574B2 (en) Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
US20190011456A1 (en) Signatures and determinants for diagnosing infections and methods of use thereof
EP2561363B1 (en) Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
Class et al. Patent application title: SIGNATURES AND DETERMINANTS FOR DIAGNOSING INFECTIONS AND METHODS OF USE THEREOF Inventors: Kfir Oved (Moshav Megadim, IL) Eran Eden (Haifa, IL) Ilan Ifergan (Haifa, IL)
HK1253780B (en) Signatures and determinants for diagnosing infections and methods of use thereof
HK1204065B (en) Signatures and determinants for diagnosing infections and methods of use thereof

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/02/2013, OBSERVADAS AS CONDICOES LEGAIS