ES2807379T3 - Composiciones y métodos para regular la expresión de Tau - Google Patents

Composiciones y métodos para regular la expresión de Tau Download PDF

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Publication number
ES2807379T3
ES2807379T3 ES14767904T ES14767904T ES2807379T3 ES 2807379 T3 ES2807379 T3 ES 2807379T3 ES 14767904 T ES14767904 T ES 14767904T ES 14767904 T ES14767904 T ES 14767904T ES 2807379 T3 ES2807379 T3 ES 2807379T3
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certain embodiments
modified
tau
oligonucleotide
compound
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Spanish (es)
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Frank Rigo
C Bennett
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/32Chemical structure of the sugar
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    • C12N2310/33415-Methylcytosine
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/33Alteration of splicing

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  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES14767904T 2013-03-14 2014-03-14 Composiciones y métodos para regular la expresión de Tau Active ES2807379T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361785177P 2013-03-14 2013-03-14
US201461943931P 2014-02-24 2014-02-24
PCT/US2014/029752 WO2014153236A1 (en) 2013-03-14 2014-03-14 Compositions and methods for modulating tau expression

Publications (1)

Publication Number Publication Date
ES2807379T3 true ES2807379T3 (es) 2021-02-22

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ID=51581461

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14767904T Active ES2807379T3 (es) 2013-03-14 2014-03-14 Composiciones y métodos para regular la expresión de Tau

Country Status (13)

Country Link
US (3) US9644207B2 (https=)
EP (2) EP2971142B1 (https=)
JP (2) JP6629716B2 (https=)
KR (1) KR20150130430A (https=)
CN (2) CN105264091B (https=)
AU (1) AU2014236156C1 (https=)
BR (1) BR112015022156A2 (https=)
CA (1) CA2906119A1 (https=)
ES (1) ES2807379T3 (https=)
IL (1) IL241439B (https=)
MX (1) MX2015012621A (https=)
RU (1) RU2745324C2 (https=)
WO (1) WO2014153236A1 (https=)

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EP2831232A4 (en) 2012-03-30 2015-11-04 Univ Washington METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME
CN105264091B (zh) 2013-03-14 2020-02-28 Ionis制药公司 用于调节tau表达的组合物和方法
TW202246503A (zh) 2013-07-19 2022-12-01 美商百健Ma公司 用於調節τ蛋白表現之組合物
US11077132B2 (en) * 2015-02-04 2021-08-03 F. Hoffmann-La Roche Ag Tau antisense oligomers and uses thereof
CN115181778A (zh) 2015-02-04 2022-10-14 百时美施贵宝公司 选择治疗性分子的方法
US10513701B2 (en) * 2015-03-25 2019-12-24 Università Degli Studi Di Trento RNA interference mediated therapy for neurodegenerative diseases
WO2017087282A1 (en) 2015-11-18 2017-05-26 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
PH12018501207B1 (en) * 2015-12-21 2024-02-23 Novartis Ag Compositions and methods for decreasing tau expression
HUE065170T2 (hu) 2016-09-29 2024-05-28 Biogen Ma Inc Vegyületek és módszerek a TAU expresszió csökkentésére
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IL266862B2 (en) * 2016-12-01 2024-01-01 Sangamo Therapeutics Inc Tau modulators and methods and preparations for their administration
TWI809004B (zh) * 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
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PE20210346A1 (es) 2018-07-03 2021-02-25 Hoffmann La Roche Oligonucleotidos para modular la expresion de tau
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AU2021246024A1 (en) * 2020-03-30 2022-10-27 Alnylam Pharmaceuticals, Inc. Microtubule associated protein Tau (MAPT) iRNA agent compositions and methods of use thereof
US20240401055A1 (en) * 2021-07-23 2024-12-05 University Of Kentucky Research Foundation Inhibition of neurofibrillary tangles using oligonucleotides against circular rnas from the microtubule associated protein tau (mapt) locus
US11761284B2 (en) 2021-07-26 2023-09-19 Benton Frederick Baugh Method for BOP stack structure
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