ES2787234T3 - Purificación de proteínas potenciada a través de una elución de proteína A modificada - Google Patents
Purificación de proteínas potenciada a través de una elución de proteína A modificada Download PDFInfo
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- ES2787234T3 ES2787234T3 ES10814394T ES10814394T ES2787234T3 ES 2787234 T3 ES2787234 T3 ES 2787234T3 ES 10814394 T ES10814394 T ES 10814394T ES 10814394 T ES10814394 T ES 10814394T ES 2787234 T3 ES2787234 T3 ES 2787234T3
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| US25343809P | 2009-10-20 | 2009-10-20 | |
| PCT/US2010/047448 WO2011028753A1 (en) | 2009-09-01 | 2010-09-01 | Enhanced protein purification through a modified protein a elution |
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| ES2787234T3 true ES2787234T3 (es) | 2020-10-15 |
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| ES10814394T Active ES2787234T3 (es) | 2009-09-01 | 2010-09-01 | Purificación de proteínas potenciada a través de una elución de proteína A modificada |
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| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| CN103276033A (zh) | 2006-09-13 | 2013-09-04 | 雅培制药有限公司 | 细胞培养改良 |
| CN105111309A (zh) | 2008-10-20 | 2015-12-02 | Abbvie公司 | 使用a蛋白亲和层析分离和纯化抗体 |
| CN104974251A (zh) | 2008-10-20 | 2015-10-14 | Abbvie公司 | 在抗体纯化过程中的病毒灭活 |
| PT2462158T (pt) | 2009-08-06 | 2018-02-23 | H Hoffnabb La Roche Ag | Método para melhorar a remoção de vírus na purificação de proteínas |
| ES2526876T3 (es) * | 2009-09-10 | 2015-01-16 | Lonza Biologics Plc. | Método y sistema para purificación de polipéptidos |
| HRP20181846T1 (hr) * | 2011-12-22 | 2018-12-28 | Genentech, Inc. | Kromatografija membranom za ionsku izmjenu |
| WO2013147691A1 (en) * | 2012-03-28 | 2013-10-03 | Ge Healthcare Bio-Sciences Ab | Affinity chromatography matrix |
| SG11201406407TA (en) | 2012-06-29 | 2014-11-27 | Emd Millipore Corp | Methods for inactivating viruses during a protein purification process |
| US8921113B2 (en) | 2012-12-21 | 2014-12-30 | Dionex Corporation | Buffer kit and method of generating a linear pH gradient |
| KR101838039B1 (ko) * | 2013-03-14 | 2018-03-14 | 이엠디 밀리포어 코포레이션 | 단백질 a 기반 크로마토그래피를 이용한 단백질 순도의 증가 방법 |
| CN105377873B (zh) * | 2013-07-12 | 2021-03-30 | 豪夫迈·罗氏有限公司 | 阐明离子交换层析输入优化 |
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| EP3674310A1 (en) * | 2014-03-10 | 2020-07-01 | Richter Gedeon Nyrt. | Immunoglobulin purification using pre-cleaning steps |
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| TWI848953B (zh) | 2018-06-09 | 2024-07-21 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| CN112566930A (zh) * | 2018-06-19 | 2021-03-26 | 百时美施贵宝公司 | 使用色谱纯化蛋白质的方法 |
| US11022585B2 (en) | 2019-06-09 | 2021-06-01 | Dionex Corporation | Methods and systems for optimizing buffer conditions with liquid chromatography |
| CA3167669A1 (en) * | 2020-01-17 | 2021-07-22 | Regeneron Pharmaceuticals, Inc. | Hydrophobic interaction chromatography for viral clearance |
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- 2010-09-01 EP EP10814394.2A patent/EP2473617B1/en not_active Revoked
- 2010-09-01 PL PL10814394T patent/PL2473617T3/pl unknown
- 2010-09-01 JP JP2012527990A patent/JP5787891B2/ja active Active
- 2010-09-01 CA CA2772653A patent/CA2772653C/en active Active
- 2010-09-01 KR KR1020127008252A patent/KR101764449B1/ko active Active
- 2010-09-01 EP EP20159179.9A patent/EP3736338A1/en not_active Withdrawn
- 2010-09-01 WO PCT/US2010/047448 patent/WO2011028753A1/en not_active Ceased
- 2010-09-01 US US13/393,525 patent/US9428548B2/en active Active
- 2010-09-01 HR HRP20200581TT patent/HRP20200581T1/hr unknown
- 2010-09-01 SI SI201032003T patent/SI2473617T1/sl unknown
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- 2010-09-01 BR BR112012004697A patent/BR112012004697B8/pt active IP Right Grant
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- 2010-09-01 RU RU2012112536/10A patent/RU2571929C2/ru active
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- 2021-12-21 US US17/558,406 patent/US20220324905A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013503877A (ja) | 2013-02-04 |
| HRP20200581T1 (hr) | 2020-07-10 |
| JP5787891B2 (ja) | 2015-09-30 |
| CN108409829A (zh) | 2018-08-17 |
| RU2571929C2 (ru) | 2015-12-27 |
| CA2772653C (en) | 2019-06-25 |
| BR112012004697B8 (pt) | 2021-05-25 |
| EP2473617A1 (en) | 2012-07-11 |
| BR112012004697B1 (pt) | 2021-02-09 |
| PL2473617T3 (pl) | 2020-06-29 |
| WO2011028753A1 (en) | 2011-03-10 |
| BR112012004697A2 (pt) | 2015-09-08 |
| EP3736338A1 (en) | 2020-11-11 |
| US20220081466A1 (en) | 2022-03-17 |
| US9428548B2 (en) | 2016-08-30 |
| US20220324905A1 (en) | 2022-10-13 |
| SI2473617T1 (sl) | 2020-07-31 |
| EP2473617A4 (en) | 2014-04-09 |
| RU2012112536A (ru) | 2013-10-10 |
| CN102686738A (zh) | 2012-09-19 |
| US20130041139A1 (en) | 2013-02-14 |
| CA2772653A1 (en) | 2011-03-10 |
| EP2473617B1 (en) | 2020-02-26 |
| KR101764449B1 (ko) | 2017-08-02 |
| KR20120106719A (ko) | 2012-09-26 |
| MX2012002565A (es) | 2012-05-29 |
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