ES2707548T3 - Administración de treprostinil utilizando un inhalador de dosis medida - Google Patents

Administración de treprostinil utilizando un inhalador de dosis medida Download PDF

Info

Publication number
ES2707548T3
ES2707548T3 ES07783735T ES07783735T ES2707548T3 ES 2707548 T3 ES2707548 T3 ES 2707548T3 ES 07783735 T ES07783735 T ES 07783735T ES 07783735 T ES07783735 T ES 07783735T ES 2707548 T3 ES2707548 T3 ES 2707548T3
Authority
ES
Spain
Prior art keywords
treprostinil
pulmonary
inhalation
tre
pharmaceutical salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07783735T
Other languages
English (en)
Spanish (es)
Inventor
Horst Olschewski
Robert Roscigno
Lewis Rubin
Thomas Schmehl
Werner Seeger
Carl Sterritt
Robert Voswinckel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United Therapeutics Corp
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38544006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2707548(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Application granted granted Critical
Publication of ES2707548T3 publication Critical patent/ES2707548T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES07783735T 2006-05-15 2007-05-14 Administración de treprostinil utilizando un inhalador de dosis medida Active ES2707548T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80001606P 2006-05-15 2006-05-15
PCT/US2007/068884 WO2007134292A2 (en) 2006-05-15 2007-05-14 Treprostinil administration using a metered dose inhaler

Publications (1)

Publication Number Publication Date
ES2707548T3 true ES2707548T3 (es) 2019-04-04

Family

ID=38544006

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07783735T Active ES2707548T3 (es) 2006-05-15 2007-05-14 Administración de treprostinil utilizando un inhalador de dosis medida

Country Status (8)

Country Link
US (10) US20080200449A1 (cg-RX-API-DMAC7.html)
EP (1) EP2026816B1 (cg-RX-API-DMAC7.html)
JP (4) JP5797376B2 (cg-RX-API-DMAC7.html)
KR (1) KR101390579B1 (cg-RX-API-DMAC7.html)
CN (1) CN101495122B (cg-RX-API-DMAC7.html)
CA (1) CA2654492C (cg-RX-API-DMAC7.html)
ES (1) ES2707548T3 (cg-RX-API-DMAC7.html)
WO (1) WO2007134292A2 (cg-RX-API-DMAC7.html)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1744739B1 (en) * 2004-04-12 2010-03-31 United Therapeutics Corporation Use of treprostinil to treat neuropathic diabetic foot ulcers
KR101390579B1 (ko) * 2006-05-15 2014-05-19 유나이티드 세러퓨틱스 코오포레이션 정량 흡입기를 사용한 트레프로스티닐 투여
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
US20080280986A1 (en) * 2007-02-09 2008-11-13 United Therapeutics Corporation Treprostinil treatment for interstitial lung disease and asthma
KR20160048222A (ko) 2007-12-17 2016-05-03 유나이티드 세러퓨틱스 코오포레이션 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법
WO2009115235A1 (en) * 2008-03-20 2009-09-24 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of pulmonary hypertension
US8350079B2 (en) * 2008-05-08 2013-01-08 United Therapeutics Corporation Treprostinil formulation
US20120177693A1 (en) * 2008-09-25 2012-07-12 Aradigm Corporation Deep lung pulmonary delivery of treprostinil
KR101544246B1 (ko) * 2009-05-07 2015-08-12 유나이티드 세러퓨틱스 코오포레이션 프로스타시클린 유사체의 고체 제제
CA2764505C (en) 2009-06-12 2018-09-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
KR20150027846A (ko) * 2010-03-15 2015-03-12 유나이티드 세러퓨틱스 코오포레이션 폐고혈압의 치료
CA3029711A1 (en) 2010-06-03 2011-12-08 United Therapeutics Corporation Treprostinil production
EP2681204B1 (en) 2011-03-02 2016-04-27 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
JP6066350B2 (ja) * 2011-04-26 2017-01-25 ベクチュラ・ゲーエムベーハー エアロゾルボーラスとしてのイロプロストの投与
CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
WO2014067699A1 (en) * 2012-10-31 2014-05-08 Activaero Gmbh Administration of aerosolised iloprost
CN104822372A (zh) * 2012-11-30 2015-08-05 英斯梅德股份有限公司 前列环素组合物及其使用方法
JP6542128B2 (ja) 2013-01-11 2019-07-10 コルセア ファーマ インコーポレイテッド トレプロスチニルのプロドラッグ
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
CN105164098A (zh) 2013-03-14 2015-12-16 联合治疗公司 曲前列环素的固体形式
MX392016B (es) 2013-03-15 2025-03-21 Mannkind Corp Composiciones de dicetopiperazina microcristalina y métodos.
CA2904598C (en) 2013-03-15 2021-10-05 United Therapeutics Corporation Salts of treprostinil
ES2676447T3 (es) 2013-03-25 2018-07-19 United Therapeutics Corporation Procedimiento de fabricación de compuestos de prostaciclina con tiol de unión y formas pegiladas
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EA031604B1 (ru) 2013-10-25 2019-01-31 Инсмед Инкорпорейтед Трепростинильные соединения, композиции и способы их использования
WO2015089105A1 (en) 2013-12-09 2015-06-18 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
CN106573066A (zh) 2014-06-13 2017-04-19 联合治疗学有限公司 曲前列环素制剂
CN107108427A (zh) 2014-10-20 2017-08-29 联合治疗学有限公司 用于制备前列环素衍生物的中间体的合成
EP3904326A1 (en) 2014-11-18 2021-11-03 Insmed Incorporated Methods of manufacturing treprostinil and treprostinil derivative prodrugs
EP3226838A1 (en) 2014-12-03 2017-10-11 Steadymed Ltd. Preservative-free treprostinil formulations and methods and devices for use with same
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
AU2017211410B2 (en) * 2016-01-29 2022-10-13 Mannkind Corporation Dry powder inhaler
US20190321290A1 (en) * 2016-01-29 2019-10-24 Mannkind Corporation Composition and method for inhalation
JP2019519489A (ja) 2016-05-05 2019-07-11 リクイディア・テクノロジーズ・インコーポレーテッド 肺高血圧症を治療するための乾燥粉末トレプロスチニル
WO2018058124A1 (en) 2016-09-26 2018-03-29 United Therapeutics Corporation Treprostinil prodrugs
WO2018112258A1 (en) 2016-12-14 2018-06-21 Respira Therapeutics, Inc. Methods and compositions for treatment of pulmonary hypertension and other lung disorders
US10799653B2 (en) 2017-01-09 2020-10-13 United Therapeutics Corporation Aerosol delivery device and method for manufacturing and operating the same
US10702495B2 (en) 2017-02-20 2020-07-07 Nexien Biopharma, Inc. Method and compositions for treating dystrophies and myotonia
AU2019266171B2 (en) 2018-05-07 2021-10-28 Pharmosa Biopharm Inc. Pharmaceutical composition for controlled release of treprostinil
KR102259824B1 (ko) * 2018-07-24 2021-06-02 주식회사 마더스제약 보센탄을 함유한 약학 제제
CN112739679B (zh) 2018-09-18 2024-03-12 伊莱利利公司 曲前列环素的特丁胺盐
EP3962472A4 (en) 2019-04-29 2023-01-25 Insmed Incorporated DRY POWDER COMPOSITIONS OF TREPROSTINIL PRODRUGS AND METHODS OF USE THEREOF
EP3750528A1 (en) 2019-06-11 2020-12-16 Nexien Biopharma, Inc. Compositions for treating dystrophies and myotonia
WO2021013861A1 (en) 2019-07-22 2021-01-28 Nanomi, B.V. Sustained release trepostinil-compound microparticle compositions
JP2022546314A (ja) 2019-08-23 2022-11-04 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグ
CN112569210B (zh) * 2019-09-27 2023-09-15 盈科瑞（天津）创新医药研究有限公司 一种吸入用马昔腾坦溶液及其制备方法
US12478748B2 (en) 2020-03-31 2025-11-25 Invox Belgium Nv Aerosol delivery of at least two liquid compositions
KR20230011929A (ko) 2020-04-17 2023-01-25 유나이티드 쎄러퓨틱스 코포레이션 간질성 폐 질환의 치료에 사용하기 위한 트레프로스티닐
US11013688B1 (en) * 2020-05-28 2021-05-25 Softhale Nv Methods of treatment of viral diseases
CA3180230A1 (en) 2020-06-09 2021-12-16 Hitesh Batra Fumaryl diketopiperidine prodrugs of treprostinil
JP2023550407A (ja) 2020-11-17 2023-12-01 ユナイテッド セラピューティクス コーポレイション 肺高血圧向けの吸入式イマチニブ
IL303668A (en) 2020-12-14 2023-08-01 United Therapeutics Corp Stable treprostinil prodrugs and their uses for the treatment of diseases
WO2022187352A1 (en) 2021-03-03 2022-09-09 United Therapeutics Corporation A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
CN113876748A (zh) * 2021-11-22 2022-01-04 兆科药业（广州）有限公司 一种用于治疗肺动脉高压的曲前列尼尔气溶胶吸入剂的雾化方法
US20250360097A2 (en) 2022-01-21 2025-11-27 Invox Belgium Nv Treprostinil for the treatment of pulmonary hypertension
AU2023219692A1 (en) 2022-02-08 2024-08-01 United Therapeutics Corporation Treprostinil iloprost combination therapy
EP4516297A1 (en) * 2022-04-29 2025-03-05 Zhaoke Pharmaceutical (Guangzhou) Co., Ltd Treprostinil soft mist inhalant
KR20250139830A (ko) 2023-01-19 2025-09-23 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 유사체
US20250197338A1 (en) 2023-11-09 2025-06-19 United Therapeutics Corporation Syntheses of compounds useful for producing treprostinil

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664337A (en) 1970-04-15 1972-05-23 Bio Logics Inc Respiration assembly and methods
US4001650A (en) 1975-09-02 1977-01-04 Puritan-Bennett Corporation Method and apparatus for ultrasonic transducer protection
US4007238A (en) 1976-02-25 1977-02-08 Glenn Joseph G Nebulizer for use with IPPB equipment
US4473296A (en) 1978-05-03 1984-09-25 Ppm, Inc. System and method and apparatus for a continuous aerosol monitor (CAM) using electro-optical weighing for general aerosols
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
US4281113A (en) * 1979-07-31 1981-07-28 The Upjohn Company 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6.beta.-5-iodo-PGF1 compounds
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4306076A (en) * 1980-04-23 1981-12-15 The Upjohn Company Inter-phenylene CBA compounds
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4349689A (en) * 1980-12-22 1982-09-14 The Upjohn Company Methano carbacyclin analogs
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
US4495944A (en) 1983-02-07 1985-01-29 Trutek Research, Inc. Inhalation therapy apparatus
US4668814A (en) * 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
US4683330A (en) * 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
US4635647A (en) 1984-09-07 1987-01-13 Choksi Pradip V Incentive spirometer employing bellows air flow sensor
NZ209900A (en) 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
US4976259A (en) 1986-12-22 1990-12-11 Mountain Medical Equipment, Inc. Ultrasonic nebulizer
US5080093A (en) 1987-07-08 1992-01-14 Vortran Medical Technology, Inc. Intermittant signal actuated nebulizer
US5322057A (en) 1987-07-08 1994-06-21 Vortran Medical Technology, Inc. Intermittent signal actuated nebulizer synchronized to operate in the exhalation phase, and its method of use
FI82808C (fi) 1987-12-31 1991-04-25 Etelae Haemeen Keuhkovammayhdi Ultraljudfinfoerdelningsanordning.
GB8814438D0 (en) * 1988-06-17 1988-07-20 Wellcome Found Compounds for use in medicine
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
GB9011588D0 (en) * 1990-05-24 1990-07-11 Wellcome Found Prostaglandin analogues for use in medicine
DE69230613T2 (de) 1991-07-02 2000-12-28 Inhale Inc Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform
GB2291605B (en) 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
FR2694215B1 (fr) 1992-07-30 1994-10-21 Dp Medical Appareil pour générer un brouillard à partir d'un liquide, notamment un médicament.
KR100316439B1 (ko) 1992-10-16 2002-08-09 셰이만울트라소닉리서치파운데이션피티와이리미티드 초음파분무장치
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US5752502A (en) 1993-12-16 1998-05-19 King; Russell Wayne General purpose aerosol inhalation apparatus
AU735975B2 (en) 1995-02-27 2001-07-19 Toray Industries, Inc. Remedy for pulmonary heart
WO1997002857A1 (en) 1995-07-10 1997-01-30 A & D Company, Limited Atomizer
FR2746656B1 (fr) 1996-03-26 1999-05-28 System Assistance Medical Nebuliseur a capteur de pression
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
EP1045695B1 (en) 1997-11-14 2004-03-24 United Therapeutics Corporation Use of 9-deoxy-2', 9-alpha-methano-3- oxa-4,5,6- trinor-3, 7-(1',3'-interphenylene) -13,14-dihydro- prostaglandin f 1? to treat peripheral vascular disease
DE19838711C1 (de) 1998-08-26 2000-06-21 Otto Schill Gmbh & Co Kg Inhalator zum Vernebeln von Flüssigkeiten
FR2783431B1 (fr) 1998-09-23 2001-02-02 System Assistance Medical Nebuliseur permettant de delivrer un brouillard a un patient et procede de fonctionnement d'un tel nebuliseur
SE9900369D0 (sv) * 1999-02-04 1999-02-04 Siemens Elema Ab Ultrasonic nebuliser
US6521212B1 (en) * 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
DE19934582C2 (de) 1999-07-23 2003-09-18 Otto Schill Gmbh & Co Kg Aerosolerzeuger
EP1292347B1 (en) 2000-02-11 2009-10-07 Respironics Respiratory Drug Delivery (UK) Ltd. Drug delivery apparatus
DE10022795B4 (de) 2000-05-10 2005-04-14 Pari GmbH Spezialisten für effektive Inhalation Atemgesteuertes Inhalationstherapiegerät
US6242482B1 (en) 2000-06-05 2001-06-05 United Therapeutics Corporation Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
JP2004512101A (ja) * 2000-10-20 2004-04-22 グラクソ　グループ　リミテッド 吸入器
US6700025B2 (en) 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
WO2003026556A2 (en) 2001-09-12 2003-04-03 Ivax Corporation Breath-enhanced ultrasonic nebulizer and dedicated unit dose ampoule
US6626843B2 (en) 2001-09-28 2003-09-30 Deane Hillsman Respiratory timing and lung deflation method and device
US6803386B2 (en) 2002-01-16 2004-10-12 United Therapeutics Corporation Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
US20040063912A1 (en) 2002-03-15 2004-04-01 The Brigham And Women's Hospital, Inc. Central airway administration for systemic delivery of therapeutics
US20030192532A1 (en) 2002-04-12 2003-10-16 Hopkins Andrew David Nebulizer
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
AU2003293197A1 (en) 2002-12-02 2004-06-23 Scott Laboratories, Inc. Respiratory monitoring systems and methods
US7726303B2 (en) 2003-02-25 2010-06-01 Hewlett-Packard Development Company, L.P. Controlled medicament ejection
ES2622471T5 (es) * 2003-05-22 2020-07-23 United Therapeutics Corp Compuestos y procedimientos para la administración de análogos de prostaciclina
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
JP4357230B2 (ja) * 2003-07-14 2009-11-04 帝人株式会社 酸素濃縮装置、在宅酸素療法システム
US7172557B1 (en) 2003-08-29 2007-02-06 Caldyne, Inc. Spirometer, display and method
ES2331187T3 (es) 2003-12-16 2009-12-23 United Therapeutics Corporation Utilizacion de treprostinil para mejorar las funciones renales.
EP1696900B1 (en) 2003-12-16 2010-07-14 United Therapeutics Corporation Use of treprostinil to treat ischemic lesions
US7380550B2 (en) 2004-01-30 2008-06-03 Hewlett-Packard Development Company, L.P. Systems and methods for particle detection
DE102004009436A1 (de) 2004-02-24 2005-10-13 Boehringer Ingelheim International Gmbh Zerstäuber
JP2008507585A (ja) 2004-07-26 2008-03-13 コセリックス インク 微粒子製剤を用いて吸入したイロプロストによる肺高血圧症の治療
US7721729B2 (en) 2005-03-09 2010-05-25 Ric Investments, Llc Nebulizing drug delivery device for ventilator
KR101390579B1 (ko) 2006-05-15 2014-05-19 유나이티드 세러퓨틱스 코오포레이션 정량 흡입기를 사용한 트레프로스티닐 투여
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
US20090036465A1 (en) 2006-10-18 2009-02-05 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
US20080280986A1 (en) 2007-02-09 2008-11-13 United Therapeutics Corporation Treprostinil treatment for interstitial lung disease and asthma
US20120177693A1 (en) 2008-09-25 2012-07-12 Aradigm Corporation Deep lung pulmonary delivery of treprostinil
KR101544246B1 (ko) 2009-05-07 2015-08-12 유나이티드 세러퓨틱스 코오포레이션 프로스타시클린 유사체의 고체 제제

Also Published As

Publication number Publication date
JP2009537246A (ja) 2009-10-29
KR20090007797A (ko) 2009-01-20
JP2016006066A (ja) 2016-01-14
US20100076083A1 (en) 2010-03-25
US20230062605A1 (en) 2023-03-02
US20120216801A1 (en) 2012-08-30
EP2026816A2 (en) 2009-02-25
US20080200449A1 (en) 2008-08-21
KR101390579B1 (ko) 2014-05-19
WO2007134292A3 (en) 2008-01-10
JP5797376B2 (ja) 2015-10-21
CN101495122A (zh) 2009-07-29
US20220008436A1 (en) 2022-01-13
JP2019112434A (ja) 2019-07-11
US20200171044A1 (en) 2020-06-04
US20220218720A1 (en) 2022-07-14
CA2654492A1 (en) 2007-11-22
CA2654492C (en) 2017-06-27
US10716793B2 (en) 2020-07-21
EP2026816B1 (en) 2018-10-24
JP2014114269A (ja) 2014-06-26
US20160143868A1 (en) 2016-05-26
US9358240B2 (en) 2016-06-07
US20220323459A1 (en) 2022-10-13
US9339507B2 (en) 2016-05-17
US20190365778A1 (en) 2019-12-05
WO2007134292A2 (en) 2007-11-22
US10376525B2 (en) 2019-08-13
CN101495122B (zh) 2011-10-05
US11357782B2 (en) 2022-06-14

Similar Documents

Publication Publication Date Title
ES2707548T3 (es) Administración de treprostinil utilizando un inhalador de dosis medida
ES2203449T3 (es) Tratamiento de la hipertension pulmonar por inhalacion de prostaglandinas de bencindeno.
US10940110B2 (en) Method and system for the treatment of chronic COPD with nebulized anticholinergic administrations
BRPI0619475A2 (pt) composições farmacêuticas compreendendo ciclosporina
US10821116B2 (en) Administration of iloprost as aerosol bolus
ES2791775A2 (es) Formulaciones de epinefrina intranasal y metodos para el tratamiento de enfermedades
ES2974809T3 (es) Administración de iloprost en aerosol