ES2705698T3 - Terapia de combinación para el tratamiento del cáncer que comprende eribulina y lenvatinib - Google Patents

Terapia de combinación para el tratamiento del cáncer que comprende eribulina y lenvatinib Download PDF

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Publication number
ES2705698T3
ES2705698T3 ES14739971T ES14739971T ES2705698T3 ES 2705698 T3 ES2705698 T3 ES 2705698T3 ES 14739971 T ES14739971 T ES 14739971T ES 14739971 T ES14739971 T ES 14739971T ES 2705698 T3 ES2705698 T3 ES 2705698T3
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Spain
Prior art keywords
cancer
pharmaceutically acceptable
acceptable salt
eribulin
lenvatinib
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Application number
ES14739971T
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English (en)
Spanish (es)
Inventor
Kenichi Nomoto
Jiayi Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dermatology (AREA)
ES14739971T 2013-06-26 2014-06-26 Terapia de combinación para el tratamiento del cáncer que comprende eribulina y lenvatinib Active ES2705698T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361839542P 2013-06-26 2013-06-26
PCT/JP2014/067723 WO2014208774A1 (en) 2013-06-26 2014-06-26 Use of eribulin and lenvatinib as combination therapy for treatment of cancer

Publications (1)

Publication Number Publication Date
ES2705698T3 true ES2705698T3 (es) 2019-03-26

Family

ID=51210708

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14739971T Active ES2705698T3 (es) 2013-06-26 2014-06-26 Terapia de combinación para el tratamiento del cáncer que comprende eribulina y lenvatinib

Country Status (12)

Country Link
US (1) US9549922B2 (enExample)
EP (1) EP3013335B1 (enExample)
JP (1) JP6404242B2 (enExample)
KR (1) KR102265952B1 (enExample)
CN (1) CN105338977B (enExample)
AU (1) AU2014299699B2 (enExample)
BR (1) BR112015029386B1 (enExample)
CA (1) CA2915005C (enExample)
ES (1) ES2705698T3 (enExample)
IL (1) IL242386B (enExample)
RU (1) RU2672585C2 (enExample)
WO (1) WO2014208774A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2415470T3 (pl) 2009-03-30 2016-12-30 Kompozycja liposomowa
US20120077842A1 (en) 2009-08-19 2012-03-29 Eisai R&D Management Co., Ltd. Quinoline derivative-containing pharmaceutical composition
US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
EP3187491A4 (en) 2014-08-28 2018-08-01 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
WO2016136745A1 (ja) 2015-02-25 2016-09-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体の苦味抑制方法
MX386547B (es) * 2015-03-04 2025-03-19 Merck Sharp & Dohme Combinación de un antagonista con muerte programada 1 (pd-1) y eribulina para el tratamiento de cáncer.
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
MX373231B (es) 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
EP3338779B1 (en) 2015-08-20 2021-06-30 Eisai R&D Management Co., Ltd. Lenvatinib in combination with etoposide and ifosfamide for use in treating a tumor
ES2952680T3 (es) * 2016-04-28 2023-11-03 Eisai R&D Man Co Ltd Eribulina para inhibir el crecimiento tumoral
CN105832732A (zh) * 2016-05-30 2016-08-10 青岛云天生物技术有限公司 一种用于胃癌治疗的药物组合物及其应用
WO2018124847A1 (ko) * 2017-01-02 2018-07-05 연성정밀화학(주) 에리불린 메실산염의 제조 중간체 및 그의 제조방법
AU2018219637B2 (en) * 2017-02-08 2023-07-13 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
CN110831597A (zh) 2017-05-16 2020-02-21 卫材R&D管理有限公司 肝细胞癌的治疗
US11419856B2 (en) 2017-11-20 2022-08-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
CN107973804B (zh) * 2017-11-29 2020-07-03 戊言医药科技(上海)有限公司 艾瑞布林中间体的合成方法
US11833119B2 (en) * 2018-01-10 2023-12-05 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of hepatocellular carcinoma
CN109793736A (zh) * 2019-01-31 2019-05-24 徐州医科大学 一种乐伐替尼在制备自然杀伤细胞激动剂中的应用
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN114028394A (zh) * 2021-05-21 2022-02-11 中山大学 低剂量仑伐替尼在制备治疗肝癌的药物中的用途
US20250064794A1 (en) * 2021-08-10 2025-02-27 Eisai R&D Management Co., Ltd. A therapeutic combination comprising a tigit antagonist, a pd-1 antagonist, and lenvatinib

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
EP2277873B1 (en) 1998-06-17 2012-05-30 Eisai R&D Management Co., Ltd. Intermediate compound for the preparation of halichondrin analogs
CN1308310C (zh) 2000-10-20 2007-04-04 卫材R&D管理有限公司 含氮芳环衍生物
EP1481678A4 (en) 2002-03-05 2009-12-30 Eisai R&D Man Co Ltd ANTITUMORAL AGENT CONTAINING A SULFONAMIDE-CONTAINING HETEROCYCLIC COMPOUND AND AN ANGIOGENESIS INHIBITOR
JP4303726B2 (ja) 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア誘導体およびその製造方法
KR100839554B1 (ko) 2003-12-25 2008-06-20 에자이 알앤드디 매니지먼트 가부시키가이샤 4-(3-클로로-4-(시클로프로필아미노카르보닐)아미노페녹시)-7-메톡시-6-퀴놀린카르복사미드의 염 또는 그 용매화물의결정 및 이들의 제조 방법
EP1771431A1 (en) * 2004-06-03 2007-04-11 Eisai Co., Ltd. Intermediates for the preparation of halichondrin b
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
US20090053236A1 (en) 2005-11-07 2009-02-26 Eisai R & D Management Co., Ltd. USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR
US20090209580A1 (en) 2006-05-18 2009-08-20 Eisai R & D Management Co., Ltd. Antitumor agent for thyroid cancer
US20100048503A1 (en) 2007-01-19 2010-02-25 Eisai R & D Management Co., Ltd. Composition for treatment of pancreatic cancer
AU2008211952B2 (en) 2007-01-29 2012-07-19 Eisai R & D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
KR101667960B1 (ko) * 2007-07-25 2016-10-20 에자이 알앤드디 매니지먼트 가부시키가이샤 암 치료에서 이용하기 위한 멀티키나아제 억제제
JP5735277B2 (ja) 2007-10-03 2015-06-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンb類似体の合成のための中間体および方法
CN101848895B (zh) 2007-11-09 2013-10-23 卫材R&D管理有限公司 血管新生抑制物质和抗肿瘤性铂络合物的组合使用
US20100324087A1 (en) 2008-01-29 2010-12-23 Eisai R&D Management Co., Ltd. Combined use of angiogenesis inhibitor and taxane
EP2528914B1 (en) 2010-01-26 2014-06-11 Eisai R&D Management Co., Ltd. Furo[3,2-b]pyrane derivatives useful in the synthesis of halichondrin b analogs
JP5898074B2 (ja) 2010-06-25 2016-04-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 キナーゼ阻害作用を有する化合物の併用による抗腫瘍剤
US20120077837A1 (en) 2010-09-24 2012-03-29 Eisai R&D Management Co., Ltd. Anti-tumor agent
JP2014508165A (ja) * 2011-03-02 2014-04-03 モルフォテック、インク. 乳癌の治療のためのエリブリンおよびファーレツズマブの共投与
EP2686441B1 (en) * 2011-03-18 2019-05-08 Eisai R&D Management Co., Ltd. Methods and uses for predicting response to eribulin
AU2012246490B2 (en) 2011-04-18 2016-08-04 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
WO2012154935A1 (en) 2011-05-12 2012-11-15 Eisai R&D Management Co., Ltd. Biomarkers that are predictive of responsiveness or non-responsiveness to treatment with lenvatinib or a pharmaceutically acceptable salt thereof
US9945862B2 (en) * 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
AU2015225436A1 (en) 2014-03-03 2016-09-08 Eisai R&D Management Co., Ltd. Use of eribulin and mTOR inhibitors as combination therapy for the treatment of cancer
US10238630B2 (en) 2014-05-28 2019-03-26 Eisai R&D Management Co., Ltd. Use of eribulin and poly (ADP ribose) polymerase (PARP) inhibitors as combination therapy for the treatment of cancer
JP2017516802A (ja) 2014-05-28 2017-06-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 がんの治療におけるエリブリンの使用
JP6644479B2 (ja) 2014-06-24 2020-02-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 がん治療のための併用療法としてのエリブリンとs−1(もしくは5−fu)の使用

Also Published As

Publication number Publication date
CN105338977B (zh) 2018-10-16
US20150005343A1 (en) 2015-01-01
RU2672585C2 (ru) 2018-11-16
CN105338977A (zh) 2016-02-17
BR112015029386A8 (pt) 2020-03-17
EP3013335B1 (en) 2018-11-07
JP2016528162A (ja) 2016-09-15
AU2014299699A1 (en) 2015-12-10
JP6404242B2 (ja) 2018-10-10
EP3013335A1 (en) 2016-05-04
US9549922B2 (en) 2017-01-24
RU2016102158A (ru) 2017-07-31
IL242386B (en) 2019-06-30
AU2014299699B2 (en) 2019-10-10
BR112015029386A2 (pt) 2017-07-25
CA2915005C (en) 2021-12-28
BR112015029386B1 (pt) 2023-11-14
WO2014208774A1 (en) 2014-12-31
KR20160023816A (ko) 2016-03-03
CA2915005A1 (en) 2014-12-31
KR102265952B1 (ko) 2021-06-16

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