BR112015029386B1 - Uso de eribulina e lenvatinibe como terapia de combinação e kit - Google Patents

Uso de eribulina e lenvatinibe como terapia de combinação e kit Download PDF

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Publication number
BR112015029386B1
BR112015029386B1 BR112015029386-7A BR112015029386A BR112015029386B1 BR 112015029386 B1 BR112015029386 B1 BR 112015029386B1 BR 112015029386 A BR112015029386 A BR 112015029386A BR 112015029386 B1 BR112015029386 B1 BR 112015029386B1
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BR
Brazil
Prior art keywords
pharmaceutically acceptable
acceptable salt
eribulin
cancer
lenvatinib
Prior art date
Application number
BR112015029386-7A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112015029386A2 (pt
BR112015029386A8 (pt
Inventor
Kenichi Nomoto
Jiayi Wu
Original Assignee
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co., Ltd. filed Critical Eisai R&D Management Co., Ltd.
Publication of BR112015029386A2 publication Critical patent/BR112015029386A2/pt
Publication of BR112015029386A8 publication Critical patent/BR112015029386A8/pt
Publication of BR112015029386B1 publication Critical patent/BR112015029386B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dermatology (AREA)
BR112015029386-7A 2013-06-26 2014-06-26 Uso de eribulina e lenvatinibe como terapia de combinação e kit BR112015029386B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361839542P 2013-06-26 2013-06-26
US61/839,542 2013-06-26
PCT/JP2014/067723 WO2014208774A1 (en) 2013-06-26 2014-06-26 Use of eribulin and lenvatinib as combination therapy for treatment of cancer

Publications (3)

Publication Number Publication Date
BR112015029386A2 BR112015029386A2 (pt) 2017-07-25
BR112015029386A8 BR112015029386A8 (pt) 2020-03-17
BR112015029386B1 true BR112015029386B1 (pt) 2023-11-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015029386-7A BR112015029386B1 (pt) 2013-06-26 2014-06-26 Uso de eribulina e lenvatinibe como terapia de combinação e kit

Country Status (12)

Country Link
US (1) US9549922B2 (enExample)
EP (1) EP3013335B1 (enExample)
JP (1) JP6404242B2 (enExample)
KR (1) KR102265952B1 (enExample)
CN (1) CN105338977B (enExample)
AU (1) AU2014299699B2 (enExample)
BR (1) BR112015029386B1 (enExample)
CA (1) CA2915005C (enExample)
ES (1) ES2705698T3 (enExample)
IL (1) IL242386B (enExample)
RU (1) RU2672585C2 (enExample)
WO (1) WO2014208774A1 (enExample)

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EP3265122B1 (en) 2015-03-04 2022-05-04 Merck Sharp & Dohme Corp. Combination of pembrolizumab and eribulin for treating triple-negative breast cancer
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CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
RU2718048C2 (ru) 2015-08-20 2020-03-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое терапевтическое средство
US12029724B2 (en) 2016-04-28 2024-07-09 Eisai R&D Management Co., Ltd. Method for inhibiting tumor growth
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ES2932832T3 (es) 2017-01-02 2023-01-26 Yonsung Fine Chemical Co Ltd Intermedio de producción de mesilato de eribulina, y método para producir el mismo
WO2018147275A1 (ja) * 2017-02-08 2018-08-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療用医薬組成物
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
WO2019097073A1 (en) 2017-11-20 2019-05-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
CN107973804B (zh) * 2017-11-29 2020-07-03 戊言医药科技(上海)有限公司 艾瑞布林中间体的合成方法
MX2020007375A (es) * 2018-01-10 2020-11-09 Eisai R&D Man Co Ltd Terapias de combinacion para el tratamiento de carcinoma hepatocelular.
CN109793736A (zh) * 2019-01-31 2019-05-24 徐州医科大学 一种乐伐替尼在制备自然杀伤细胞激动剂中的应用
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
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CN114028394A (zh) * 2021-05-21 2022-02-11 中山大学 低剂量仑伐替尼在制备治疗肝癌的药物中的用途
WO2023018675A1 (en) * 2021-08-10 2023-02-16 Merck Sharp & Dohme Llc A therapeutic combination comprising a tigit antagonist, a pd-1 antagonist, and lenvatinib

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US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
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EP1506962B1 (en) 2000-10-20 2008-07-02 Eisai R&D Management Co., Ltd. Nitrogen-containing aromatic heterocycles
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WO2012119077A1 (en) * 2011-03-02 2012-09-07 Morphotek Inc. Co -administration of eribulin and farletuzumab for the treatment of breast cancer
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JP6644479B2 (ja) 2014-06-24 2020-02-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 がん治療のための併用療法としてのエリブリンとs−1(もしくは5−fu)の使用

Also Published As

Publication number Publication date
ES2705698T3 (es) 2019-03-26
AU2014299699A1 (en) 2015-12-10
KR20160023816A (ko) 2016-03-03
CN105338977B (zh) 2018-10-16
CN105338977A (zh) 2016-02-17
RU2672585C2 (ru) 2018-11-16
RU2016102158A (ru) 2017-07-31
CA2915005A1 (en) 2014-12-31
EP3013335B1 (en) 2018-11-07
JP2016528162A (ja) 2016-09-15
IL242386B (en) 2019-06-30
KR102265952B1 (ko) 2021-06-16
WO2014208774A1 (en) 2014-12-31
BR112015029386A2 (pt) 2017-07-25
EP3013335A1 (en) 2016-05-04
JP6404242B2 (ja) 2018-10-10
CA2915005C (en) 2021-12-28
BR112015029386A8 (pt) 2020-03-17
AU2014299699B2 (en) 2019-10-10
US9549922B2 (en) 2017-01-24
US20150005343A1 (en) 2015-01-01

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Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/06/2014, OBSERVADAS AS CONDICOES LEGAIS