RU2672585C2 - Применение эрибулина и ленватиниба в качестве комбинированной терапии для лечения рака - Google Patents
Применение эрибулина и ленватиниба в качестве комбинированной терапии для лечения рака Download PDFInfo
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- RU2672585C2 RU2672585C2 RU2016102158A RU2016102158A RU2672585C2 RU 2672585 C2 RU2672585 C2 RU 2672585C2 RU 2016102158 A RU2016102158 A RU 2016102158A RU 2016102158 A RU2016102158 A RU 2016102158A RU 2672585 C2 RU2672585 C2 RU 2672585C2
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- Prior art keywords
- cancer
- pharmaceutically acceptable
- acceptable salt
- eribulin
- lenvatinib
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| US20100324087A1 (en) | 2008-01-29 | 2010-12-23 | Eisai R&D Management Co., Ltd. | Combined use of angiogenesis inhibitor and taxane |
| CN102803254B (zh) | 2010-01-26 | 2016-09-14 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物 |
| CA2802644C (en) | 2010-06-25 | 2017-02-21 | Eisai R & D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
| US20120077837A1 (en) | 2010-09-24 | 2012-03-29 | Eisai R&D Management Co., Ltd. | Anti-tumor agent |
| WO2012129100A1 (en) * | 2011-03-18 | 2012-09-27 | Eisai R&D Management Co., Ltd. | Methods and compositions for predicting response to eribulin |
| EP2700403B1 (en) | 2011-04-18 | 2015-11-25 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| WO2012154935A1 (en) | 2011-05-12 | 2012-11-15 | Eisai R&D Management Co., Ltd. | Biomarkers that are predictive of responsiveness or non-responsiveness to treatment with lenvatinib or a pharmaceutically acceptable salt thereof |
| EP3113775A4 (en) | 2014-03-03 | 2017-08-23 | Eisai R&D Management Co., Ltd. | Use of eribulin and mtor inhibitors as combination therapy for the treatment of cancer |
| JP2017516802A (ja) | 2014-05-28 | 2017-06-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がんの治療におけるエリブリンの使用 |
| EP3148336B1 (en) | 2014-05-28 | 2019-10-02 | Eisai R&D Management Co., Ltd. | Eribulin and poly (adp ribose) polymerase (parp) inhibitors as combination therapy for the treatment of cancer |
| JP6644479B2 (ja) | 2014-06-24 | 2020-02-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がん治療のための併用療法としてのエリブリンとｓ−１（もしくは５−ｆｕ）の使用 |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012119077A1 (en) * | 2011-03-02 | 2012-09-07 | Morphotek Inc. | Co -administration of eribulin and farletuzumab for the treatment of breast cancer |
| WO2012166899A2 (en) * | 2011-06-03 | 2012-12-06 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
Non-Patent Citations (1)
| Title |
|---|
| Харкевич Д.А. Фармакология / Учебник, 2010, 10-е издание, стр.72-82. Микуляк Н.И. и др. Изучение противоопухолевого и антиметастатического эффектов противоопухолевых антибиотиков при раздельном и совместном применении с мексидолом / Известия ВУЗов. Поволжский регион. Медицинские науки. 2007. Хирургическая онкология / surgery.su, 2009, URL: http://oncosurgery.surgery.su/. * |
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| RU2016102158A (ru) | 2017-07-31 |
| CA2915005A1 (en) | 2014-12-31 |
| KR20160023816A (ko) | 2016-03-03 |
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| CN105338977B (zh) | 2018-10-16 |
| JP2016528162A (ja) | 2016-09-15 |
| ES2705698T3 (es) | 2019-03-26 |
| US9549922B2 (en) | 2017-01-24 |
| BR112015029386A8 (pt) | 2020-03-17 |
| WO2014208774A1 (en) | 2014-12-31 |
| CN105338977A (zh) | 2016-02-17 |
| AU2014299699B2 (en) | 2019-10-10 |
| JP6404242B2 (ja) | 2018-10-10 |
| AU2014299699A1 (en) | 2015-12-10 |
| US20150005343A1 (en) | 2015-01-01 |
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