IL242386B - Use of Aribolin and Lavetinib as a combination therapy for cancer treatment - Google Patents
Use of Aribolin and Lavetinib as a combination therapy for cancer treatmentInfo
- Publication number
- IL242386B IL242386B IL242386A IL24238615A IL242386B IL 242386 B IL242386 B IL 242386B IL 242386 A IL242386 A IL 242386A IL 24238615 A IL24238615 A IL 24238615A IL 242386 B IL242386 B IL 242386B
- Authority
- IL
- Israel
- Prior art keywords
- lenvatinib
- eribulin
- cancer
- treatment
- combination therapy
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- UFNVPOGXISZXJD-XJPMSQCNSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-XJPMSQCNSA-N 0.000 title 1
- 229960003649 eribulin Drugs 0.000 title 1
- WOSKHXYHFSIKNG-UHFFFAOYSA-N lenvatinib Chemical compound C=12C=C(C(N)=O)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC1CC1 WOSKHXYHFSIKNG-UHFFFAOYSA-N 0.000 title 1
- 229960003784 lenvatinib Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361839542P | 2013-06-26 | 2013-06-26 | |
| PCT/JP2014/067723 WO2014208774A1 (en) | 2013-06-26 | 2014-06-26 | Use of eribulin and lenvatinib as combination therapy for treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL242386B true IL242386B (en) | 2019-06-30 |
Family
ID=51210708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL242386A IL242386B (en) | 2013-06-26 | 2015-11-01 | Use of Aribolin and Lavetinib as a combination therapy for cancer treatment |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9549922B2 (enExample) |
| EP (1) | EP3013335B1 (enExample) |
| JP (1) | JP6404242B2 (enExample) |
| KR (1) | KR102265952B1 (enExample) |
| CN (1) | CN105338977B (enExample) |
| AU (1) | AU2014299699B2 (enExample) |
| BR (1) | BR112015029386B1 (enExample) |
| CA (1) | CA2915005C (enExample) |
| ES (1) | ES2705698T3 (enExample) |
| IL (1) | IL242386B (enExample) |
| RU (1) | RU2672585C2 (enExample) |
| WO (1) | WO2014208774A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE029577T2 (en) | 2009-03-30 | 2017-03-28 | Eisai R&D Man Co Ltd | Liposome preparation |
| ES2564797T3 (es) | 2009-08-19 | 2016-03-29 | Eisai R&D Management Co., Ltd. | Composición farmacéutica con contenido en un derivado de quinolina |
| ES2705950T3 (es) | 2011-06-03 | 2019-03-27 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
| SMT202200367T1 (it) | 2014-08-28 | 2022-11-18 | Eisai R&D Man Co Ltd | Derivato di chinolina a elevata purezza e metodo per la produzione dello stesso |
| DK3263106T3 (da) | 2015-02-25 | 2024-01-08 | Eisai R&D Man Co Ltd | Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat |
| KR20250020678A (ko) | 2015-03-04 | 2025-02-11 | 머크 샤프 앤드 돔 엘엘씨 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| KR20170122810A (ko) | 2015-03-04 | 2017-11-06 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 에리불린의 조합 |
| ES2886107T3 (es) | 2015-06-16 | 2021-12-16 | Prism Biolab Co Ltd | Antineoplásico |
| CA2994925C (en) | 2015-08-20 | 2023-08-29 | Eisai R&D Management Co., Ltd. | Tumor therapeutic agent |
| JP7015237B2 (ja) * | 2016-04-28 | 2022-02-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍の成長を抑制する方法 |
| CN105832732A (zh) * | 2016-05-30 | 2016-08-10 | 青岛云天生物技术有限公司 | 一种用于胃癌治疗的药物组合物及其应用 |
| US10865212B2 (en) | 2017-01-02 | 2020-12-15 | Yonsung Fine Chemical Co.. Ltd. | Intermediate for preparing eribulin mesylate and process for preparing the same |
| RU2750539C2 (ru) * | 2017-02-08 | 2021-06-29 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Фармацевтическая композиция для лечения опухоли |
| CA3061888A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| WO2019097073A1 (en) | 2017-11-20 | 2019-05-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| CN107973804B (zh) * | 2017-11-29 | 2020-07-03 | 戊言医药科技（上海）有限公司 | 艾瑞布林中间体的合成方法 |
| SG11202006617RA (en) * | 2018-01-10 | 2020-08-28 | Eisai R&D Man Co Ltd | Combination therapies for the treatment of hepatocellular carcinoma |
| CN109793736A (zh) * | 2019-01-31 | 2019-05-24 | 徐州医科大学 | 一种乐伐替尼在制备自然杀伤细胞激动剂中的应用 |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| CN114028394A (zh) * | 2021-05-21 | 2022-02-11 | 中山大学 | 低剂量仑伐替尼在制备治疗肝癌的药物中的用途 |
| EP4384550A4 (en) * | 2021-08-10 | 2025-06-18 | Merck Sharp & Dohme LLC | THERAPEUTIC COMBINATION WITH A TIGIT ANTAGONIST, A PD-1 ANTAGONIST AND LENVATINIB |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| EP2277873B1 (en) | 1998-06-17 | 2012-05-30 | Eisai R&D Management Co., Ltd. | Intermediate compound for the preparation of halichondrin analogs |
| EP1506962B1 (en) | 2000-10-20 | 2008-07-02 | Eisai R&D Management Co., Ltd. | Nitrogen-containing aromatic heterocycles |
| EP1481678A4 (en) | 2002-03-05 | 2009-12-30 | Eisai R&D Man Co Ltd | ANTITUMORAL AGENT CONTAINING A SULFONAMIDE-CONTAINING HETEROCYCLIC COMPOUND AND AN ANGIOGENESIS INHIBITOR |
| JP4303726B2 (ja) | 2003-11-11 | 2009-07-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウレア誘導体およびその製造方法 |
| DK1698623T3 (da) | 2003-12-25 | 2015-06-15 | Eisai R&D Man Co Ltd | Krystal af salt af 4-(3-chlor-4-(cyclopropylaminocarbonyl)amino-phenoxy)-7-methoxy-6-quinolinecarboxamid eller af solvat deraf og fremgangsmåder til fremstilling af disse |
| KR101434673B1 (ko) | 2004-06-03 | 2014-08-26 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 ｂ 유사체의 제조를 위한 중간체 |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| EP2281901B1 (en) | 2005-08-02 | 2013-11-27 | Eisai R&D Management Co., Ltd. | Anti-tumour pharmaceutical composition with angiogenesis inhibitors |
| CA2627598C (en) | 2005-11-07 | 2013-06-25 | Eisai R & D Management Co., Ltd. | Use of combination of anti-angiogenic substance and c-kit kinase inhibitor |
| WO2007136103A1 (ja) | 2006-05-18 | 2007-11-29 | Eisai R & D Management Co., Ltd. | 甲状腺癌に対する抗腫瘍剤 |
| EP2116246A1 (en) | 2007-01-19 | 2009-11-11 | Eisai R&D Management Co., Ltd. | Composition for treatment of pancreatic cancer |
| KR101445892B1 (ko) | 2007-01-29 | 2014-09-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 미분화형 위암 치료용 조성물 |
| ES2670423T3 (es) * | 2007-07-25 | 2018-05-30 | Eisai R&D Management Co., Ltd. | Inhibidores de multicinasas para uso en el tratamiento de cáncer |
| US8093410B2 (en) | 2007-10-03 | 2012-01-10 | Eisai R&D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin B analogs |
| KR101513326B1 (ko) | 2007-11-09 | 2015-04-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 혈관 신생 저해 물질과 항종양성 백금 착물의 병용 |
| CN102036962B (zh) | 2008-01-29 | 2013-08-07 | 卫材R&D管理有限公司 | 血管生成抑制剂和紫杉烷的组合使用 |
| SG10201500552PA (en) | 2010-01-26 | 2015-03-30 | Eisai R&D Man Co Ltd | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
| KR101677790B1 (ko) | 2010-06-25 | 2016-11-18 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 키나제 저해 작용을 갖는 화합물의 병용에 의한 항종양제 |
| US20120077837A1 (en) | 2010-09-24 | 2012-03-29 | Eisai R&D Management Co., Ltd. | Anti-tumor agent |
| EP2680839A1 (en) * | 2011-03-02 | 2014-01-08 | Morphotek, Inc. | Co -administration of eribulin and farletuzumab for the treatment of breast cancer |
| WO2012129100A1 (en) | 2011-03-18 | 2012-09-27 | Eisai R&D Management Co., Ltd. | Methods and compositions for predicting response to eribulin |
| KR101762999B1 (ko) * | 2011-04-18 | 2017-07-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 종양 치료제 |
| WO2012154935A1 (en) | 2011-05-12 | 2012-11-15 | Eisai R&D Management Co., Ltd. | Biomarkers that are predictive of responsiveness or non-responsiveness to treatment with lenvatinib or a pharmaceutically acceptable salt thereof |
| ES2705950T3 (es) * | 2011-06-03 | 2019-03-27 | Eisai R&D Man Co Ltd | Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
| CN106029070A (zh) | 2014-03-03 | 2016-10-12 | 卫材R&D管理有限公司 | 艾日布林和mTOR抑制剂作为治疗癌症的联合疗法的用途 |
| MX2016015378A (es) | 2014-05-28 | 2017-12-04 | Eisai R&D Man Co Ltd | Uso de eribulina en el tratamiento de cancer. |
| US10238630B2 (en) | 2014-05-28 | 2019-03-26 | Eisai R&D Management Co., Ltd. | Use of eribulin and poly (ADP ribose) polymerase (PARP) inhibitors as combination therapy for the treatment of cancer |
| JP6644479B2 (ja) | 2014-06-24 | 2020-02-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がん治療のための併用療法としてのエリブリンとｓ−１（もしくは５−ｆｕ）の使用 |
-
2014
- 2014-06-26 WO PCT/JP2014/067723 patent/WO2014208774A1/en not_active Ceased
- 2014-06-26 AU AU2014299699A patent/AU2014299699B2/en active Active
- 2014-06-26 ES ES14739971T patent/ES2705698T3/es active Active
- 2014-06-26 JP JP2015562231A patent/JP6404242B2/ja active Active
- 2014-06-26 RU RU2016102158A patent/RU2672585C2/ru active
- 2014-06-26 US US14/315,930 patent/US9549922B2/en active Active
- 2014-06-26 BR BR112015029386-7A patent/BR112015029386B1/pt active IP Right Grant
- 2014-06-26 EP EP14739971.1A patent/EP3013335B1/en active Active
- 2014-06-26 CA CA2915005A patent/CA2915005C/en active Active
- 2014-06-26 CN CN201480036218.0A patent/CN105338977B/zh active Active
- 2014-06-26 KR KR1020167001713A patent/KR102265952B1/ko active Active
-
2015
- 2015-11-01 IL IL242386A patent/IL242386B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR102265952B1 (ko) | 2021-06-16 |
| BR112015029386B1 (pt) | 2023-11-14 |
| US20150005343A1 (en) | 2015-01-01 |
| US9549922B2 (en) | 2017-01-24 |
| BR112015029386A2 (pt) | 2017-07-25 |
| EP3013335A1 (en) | 2016-05-04 |
| RU2672585C2 (ru) | 2018-11-16 |
| JP2016528162A (ja) | 2016-09-15 |
| AU2014299699A1 (en) | 2015-12-10 |
| BR112015029386A8 (pt) | 2020-03-17 |
| CN105338977B (zh) | 2018-10-16 |
| EP3013335B1 (en) | 2018-11-07 |
| WO2014208774A1 (en) | 2014-12-31 |
| ES2705698T3 (es) | 2019-03-26 |
| CA2915005A1 (en) | 2014-12-31 |
| CN105338977A (zh) | 2016-02-17 |
| KR20160023816A (ko) | 2016-03-03 |
| CA2915005C (en) | 2021-12-28 |
| JP6404242B2 (ja) | 2018-10-10 |
| AU2014299699B2 (en) | 2019-10-10 |
| RU2016102158A (ru) | 2017-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL242386B (en) | Use of Aribolin and Lavetinib as a combination therapy for cancer treatment | |
| IL273090B (en) | Methods and preparations for the treatment of cancer | |
| LT3033086T (lt) | Kombinuota terapija vėžiui gydyti | |
| IL239007B (en) | Eribulin for use in the treatment of breast cancer | |
| ZA201602380B (en) | Cancer treatment with combination of plinabulin and taxane | |
| IL239453B (en) | Preparations and methods for treating cancer using bacteria | |
| PT2804599T (pt) | Terapêutica de associação para o tratamento de cancro | |
| PL3060211T3 (pl) | Leczenie nowotworu i łagodnych chorób proliferacyjnych | |
| IL247586A0 (en) | Use of Aribolin and mtor inhibitors as a combined treatment for cancer | |
| GB201607581D0 (en) | Treatment of cancer | |
| TWI561255B (en) | Use of umirolimus and its derivatives for treating cancer | |
| GB201301685D0 (en) | Diagnosis and treatment of cancer | |
| GB201322346D0 (en) | Combination treatment of cancer | |
| PL3010513T3 (pl) | Skojarzenie RO5503781 i kapecytabiny do leczenia raka | |
| GB201317373D0 (en) | Treatment and prevention of cancer | |
| SG10201802995SA (en) | Cancer treatment with combination of plinabulin and taxane | |
| GB201416605D0 (en) | Combination therapy to reduce the risk of and to treat cancer | |
| GB201322958D0 (en) | Uses of oligouronates in cancer treatment | |
| GB201322347D0 (en) | Treatment of cancer | |
| GB201318742D0 (en) | Treatment of cancer | |
| GB201308529D0 (en) | Treatment of cancer | |
| IL233495A0 (en) | Combination for cancer treatment | |
| GB201305020D0 (en) | Treatment of cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |