ES2652603T3 - Composiciones bioactivas de plantas de Theacea y procedimientos para su producción y uso - Google Patents
Composiciones bioactivas de plantas de Theacea y procedimientos para su producción y uso Download PDFInfo
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- ES2652603T3 ES2652603T3 ES12152951.5T ES12152951T ES2652603T3 ES 2652603 T3 ES2652603 T3 ES 2652603T3 ES 12152951 T ES12152951 T ES 12152951T ES 2652603 T3 ES2652603 T3 ES 2652603T3
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Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8277852B2 (en) * | 2002-01-25 | 2012-10-02 | Akzo Nobel Surface Chemistry Llc | Bioactive botanical cosmetic compositions and processes for their production |
| CA2643255A1 (en) * | 2006-02-21 | 2007-08-30 | Integrated Botanical Technologies, Llc | Parthenolide free bioactive ingredients from feverfew (tanacetum parthenium) and processes for their production |
| JP5624764B2 (ja) * | 2007-07-13 | 2014-11-12 | 小川香料株式会社 | 香味又は香気の劣化抑制剤 |
| EP2211630B1 (en) * | 2007-11-05 | 2012-08-01 | Unilever Plc, A Company Registered In England And Wales under company no. 41424 of Unilever House | Process for manufacturing tea products |
| AU2008324227B2 (en) * | 2007-11-05 | 2012-03-08 | Ekaterra Research and Development UK Limited | Process for manufacturing tea products |
| PL2211632T3 (pl) * | 2007-11-05 | 2011-08-31 | Unilever Nv | Sposób oczyszczania związków pochodzących z herbaty |
| US20090202676A1 (en) * | 2008-02-07 | 2009-08-13 | Conopco, Inc. D/B/A Unilever | Process for manufacturing a tea product |
| CN102164500B (zh) * | 2008-10-02 | 2014-08-20 | 荷兰联合利华有限公司 | 生产茶产品的方法 |
| PL2334192T3 (pl) * | 2008-10-02 | 2013-01-31 | Unilever Nv | Sposób wytwarzania herbacianych produktów |
| JP5287524B2 (ja) * | 2009-06-05 | 2013-09-11 | 東京電力株式会社 | 植物系バイオマスの多元的有効利用システム |
| BR112012010978A8 (pt) * | 2009-11-11 | 2018-06-26 | Akzo Nobel Surface Chemistry Llc | método para produzir um organismo fotossintético induzido por estresse, organismo fotossintético induzido por estresse, método para isolar uma fração bioativa alterada de um organismo fotossintético induzido por estresse, fração bioativa alterada, formulação tópica bioativa adequada para aplicação tópica em um mamifero, método para inibir a atividade inflamatória no tecido da pele de um mamífero, método de proteger o tecido da pele de um mamífero dos danos induzidos por luz ultravioleta, método para normalizar os distúrbios da pele no tecido da pele de um mamífero, e, sistema para cultivar organismos fotossintéticos induzidos por estresse |
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| US9168279B2 (en) | 2010-08-19 | 2015-10-27 | Johnson & Johnson Consumer Inc. | Compositions comprising paulownin and/or Paulownia extracts and uses thereof |
| US9168219B2 (en) | 2010-08-19 | 2015-10-27 | Johnson & Johnson Consumer Inc. | Compositions comprising Paulownia tomentosa wood extracts and uses thereof |
| US9387349B2 (en) | 2010-08-19 | 2016-07-12 | Johnson & Johnson Consumer Inc. | Compositions comprising Paulownia tomentosa wood extracts and uses thereof |
| US9168207B2 (en) | 2010-08-19 | 2015-10-27 | Johnson & Johnson Consumer Inc. | Compositions comprising Paulownia tomentosa wood extracts and uses thereof |
| KR20130099058A (ko) | 2010-08-19 | 2013-09-05 | 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 | 파울로우닌 및/또는 파울로우니아 추출물을 포함하는 조성물 및 이의 용도 |
| US9173913B2 (en) | 2010-08-19 | 2015-11-03 | Johnson & Johnson Consumer Inc. | Compositions comprising Paulownia tomentosa wood extracts and uses thereof |
| US9161958B2 (en) | 2010-08-19 | 2015-10-20 | Johnson & Johnson Consumer Inc. | Methods of treating cellulite |
| US20120201768A1 (en) * | 2010-09-10 | 2012-08-09 | Cheri Lynn Swanson | Cosmetic compositions comprising ficus serum fraction and methods to reduce the appearance of skin hyperpigmentation |
| US8895628B2 (en) | 2010-10-25 | 2014-11-25 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising a retinoid and an NFkB-inhibitor and their methods of use |
| US9421236B2 (en) | 2010-12-17 | 2016-08-23 | Johnson & Johnson Consumer Inc. | Compositions comprising Lilium siberia extracts and uses thereof |
| EP2465490A3 (en) | 2010-12-17 | 2015-06-17 | Johnson & Johnson Consumer Companies Inc. | Compositions comprising Lilium Siberia extracts and uses thereof |
| ES2692536T3 (es) | 2010-12-17 | 2018-12-04 | Johnson & Johnson Consumer Inc. | Composiciones que comprenden extractos de Lilium martagon y usos de los mismos |
| US8486466B2 (en) | 2010-12-17 | 2013-07-16 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising Lilium siberia extracts and uses thereof |
| EP2465518B1 (en) | 2010-12-17 | 2016-03-02 | Johnson & Johnson Consumer Companies Inc. | Compositions Comprising Lilium Candidum Extracts and Uses Thereof |
| US8293293B2 (en) | 2010-12-17 | 2012-10-23 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising Lilium martagon extracts and uses thereof |
| US8481093B2 (en) * | 2010-12-17 | 2013-07-09 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising Lilium candidum extracts and uses thereof |
| US9492492B2 (en) | 2010-12-17 | 2016-11-15 | Johnson & Johnson Consumer Inc. | Compositions comprising Lilium martagon extracts and uses thereof |
| US20130149359A1 (en) * | 2011-12-12 | 2013-06-13 | Eric M. Sanders | Effervescent Mouthwash |
| JP5860166B2 (ja) * | 2011-12-22 | 2016-02-16 | ザ プロクター アンド ギャンブルカンパニー | 皮膚の処置のための組成物及び方法 |
| KR20140107325A (ko) * | 2011-12-22 | 2014-09-04 | 아크조 노벨 케미칼즈 인터내셔널 비.브이. | 피부 항노화 활성을 가진 생활성 조성물 |
| BR112014014572A8 (pt) * | 2011-12-22 | 2017-06-13 | Akzo Nobel Chemicals Int Bv | composição bioativa |
| EP2794011B1 (en) | 2011-12-22 | 2016-12-14 | The Procter and Gamble Company | Compositions and methods for improving the appearance of aging hair |
| US9814659B2 (en) | 2012-04-02 | 2017-11-14 | Johnson & Johnson Consumer Inc. | Methods of lightening the skin |
| US20140086859A1 (en) | 2012-09-24 | 2014-03-27 | Johnson & Johnson Consumer Companies, Inc. | Low oil compositions comprising a 4-substituted resorcinol and a high carbon chain ester |
| ES2606024T3 (es) * | 2012-11-14 | 2017-03-17 | Isp Investments Inc. | Un método para la preparación de composiciones botánicas bioactivas y las composiciones hechas a partir de dicho método utilizando un campo electromagnético de más de 3 GHz |
| KR101474998B1 (ko) * | 2012-11-28 | 2014-12-19 | 롯데푸드 주식회사 | 피부 주름 생성 억제 및 주름 개선 활성을 갖는 백차 추출물을 함유하는 조성물 |
| SG11201506037WA (en) * | 2013-02-08 | 2015-08-28 | Akzo Nobel Chemicals Int Bv | Bioactive compositions from theacea plants and use thereof in beverages, functional foods, nutriceuticals, supplements and the like |
| SG11201506444RA (en) * | 2013-03-13 | 2015-09-29 | Akzo Nobel Chemicals Int Bv | Bioactive botanical compositions and uses thereof |
| WO2014158679A1 (en) * | 2013-03-14 | 2014-10-02 | Avon Products, Inc | Eurya groffii extracts and methods of use |
| US9579278B2 (en) | 2013-05-10 | 2017-02-28 | Johnson & Johnson Consumer Inc. | Compositions comprising extracts of Bursera simaruba |
| US10123966B2 (en) | 2013-05-16 | 2018-11-13 | The Procter And Gamble Company | Hair thickening compositions and methods of use |
| EP2829303A1 (en) | 2013-07-22 | 2015-01-28 | Johnson & Johnson Consumer Companies Inc. | Compositions comprising extract of malva neglecta and method of treating a skin condition with malva neglecta |
| US9522168B2 (en) | 2014-05-29 | 2016-12-20 | Johnson & Johnson Consumer Inc. | Topical compositions comprising Acmella oleracea extracts and uses thereof |
| JP6587678B2 (ja) * | 2014-08-01 | 2019-10-09 | シャネル パフュームズ ビューテ | ツバキ(Camellia japonica)抽出物およびそれを含有する化粧品組成物 |
| BR112017021328A2 (pt) * | 2015-04-07 | 2018-06-26 | Xyleco Inc | métodos de monitoramento e sistemas para processamento de biomassa |
| CN106691902B (zh) | 2015-08-14 | 2021-04-20 | 强生消费者公司 | 包含显齿蛇葡萄和合欢提取物的组合物和使用方法 |
| WO2017100430A1 (en) * | 2015-12-08 | 2017-06-15 | Isp Investments Llc | Bioactive compositions from achachairu (garcinia humilis) and methods for their production |
| KR101723526B1 (ko) * | 2016-02-22 | 2017-04-06 | 주식회사 젠퓨어 | 동백꽃, 벚꽃, 쟈스민꽃, 캐모마일꽃 및 연꽃 혼합추출물을 함유하는 화장료 조성물 |
| US11154493B2 (en) * | 2016-02-25 | 2021-10-26 | Isp Investments Llc | Mitigating adverse effects of sunlight with ingredients obtained from living plants |
| KR101769110B1 (ko) | 2016-02-29 | 2017-08-17 | 전라남도 | 난대 산림수종의 산림욕 성분의 최적 추출 방법 및 그에 따라 제조된 난대 산림수종의 향기 추출물 |
| US10806693B2 (en) | 2016-09-07 | 2020-10-20 | Isp Investments Llc | Method for increasing lipolysis using a composition comprising bioactive Nelumbo nucifera (lotus) extract |
| US10056362B2 (en) | 2016-10-06 | 2018-08-21 | Infineon Technologies Americas Corp. | Multi-phase power converter with common connections |
| US10204847B2 (en) | 2016-10-06 | 2019-02-12 | Infineon Technologies Americas Corp. | Multi-phase common contact package |
| CN107227289B (zh) * | 2017-05-08 | 2020-05-22 | 广州赛莱拉干细胞科技股份有限公司 | 一种山茶花细胞提取物及其提取方法和应用 |
| US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| CN112888450A (zh) | 2018-07-27 | 2021-06-01 | 强生外科视力公司 | 用于治疗眼睛的组合物和方法 |
| US11197841B2 (en) | 2019-07-23 | 2021-12-14 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US20200030226A1 (en) | 2018-07-27 | 2020-01-30 | Johnson & Johnson Consumer Inc. | Botanical and bacterial extracts displaying retinol-like activity |
| JP7374986B2 (ja) | 2018-07-27 | 2023-11-07 | ジョンソン・アンド・ジョンソン・サージカル・ビジョン・インコーポレイテッド | 眼を治療するための組成物及び方法 |
| WO2021011548A1 (en) | 2019-07-15 | 2021-01-21 | Isp Investments Llc | Skin care compositions comprising synergistic blend of sacred lotus and tea plant or sacred lotus and german chamomile and cosmetic applications thereof |
| US11969454B2 (en) | 2019-11-19 | 2024-04-30 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| EP3824895A1 (en) | 2019-11-19 | 2021-05-26 | Johnson & Johnson Consumer Inc. | Compositions and methods for treating the eye |
| US20210299203A1 (en) | 2020-03-26 | 2021-09-30 | Johnson & Johnson Consumer Inc. | Compositions comprising carum carvi and rosmarinus officinalis extracts and methods of using same |
| JP7771499B2 (ja) | 2020-03-26 | 2025-11-18 | ケンビュー・ブランズ・エルエルシー | ヒメウイキョウおよびローズマリー抽出物を含む組成物、並びにそれらを使用する方法 |
| EP4059508A1 (en) | 2021-03-19 | 2022-09-21 | Johnson & Johnson Consumer Inc. | Methods of using compositions comprising an iceland moss extract |
| WO2023114279A1 (en) | 2021-12-17 | 2023-06-22 | Isp Investments Llc | Bioactive serum fractions from fresh rose flowers and methods for their preparation and uses |
| FR3130619B1 (fr) | 2021-12-17 | 2025-10-31 | Lvmh Rech | Fraction bioactive isolée de roses de la variété Evanrat |
| FR3136172B1 (fr) | 2022-06-07 | 2025-07-11 | Lvmh Rech | Composition anti-âge avec extraits de rose et peptides |
| FR3137836A1 (fr) | 2022-07-13 | 2024-01-19 | L V M H Recherche | Fraction bioactive isolée de roses de la variété Evanrat pour une utilisation cosmétique apaisante de la peau et/ou des lèvres |
| FR3143365A1 (fr) | 2022-12-19 | 2024-06-21 | L V M H Recherche | Composition anti-age avec extraits de bourgeons et petales de roses et peptide |
| JP2026504051A (ja) | 2023-01-11 | 2026-02-03 | ケンビュー・ブランズ・エルエルシー | レチノール様活性を有する化合物及び加工オート麦成分を含む組成物 |
| AU2024207487A1 (en) | 2023-01-11 | 2025-07-03 | Kenvue Brands Llc | Skincare formulations comprising phenyl propionic acid derivatives and methods using same |
| WO2024150157A1 (en) | 2023-01-11 | 2024-07-18 | Johnson & Johnson Consumer Inc. | Compositions suitable for use on sensitive skin and methods using same |
| FR3155714A1 (fr) | 2023-11-24 | 2025-05-30 | L V M H Recherche | Association d’extraits de rose et peptide pour la nutrition de la peau |
| WO2026003722A1 (en) | 2024-06-24 | 2026-01-02 | Kenvue Brands Llc | Compositions comprising compounds having retinol-like activity and an n-acetyl compound |
| WO2026003725A1 (en) | 2024-06-24 | 2026-01-02 | Kenvue Brands Llc | Compositions comprising compounds having retinol-like activity and a polyhydroxy acid |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US255945A (en) * | 1882-04-04 | James denton | ||
| US1072666A (en) * | 1912-08-07 | 1913-09-09 | Frank Smith | Nut-lock. |
| US2559459A (en) | 1949-02-01 | 1951-07-03 | Western Condensing Co | Vegetable treatment process |
| US3849391A (en) * | 1969-02-17 | 1974-11-19 | Grain Processing Corp | Recovery of protein |
| US3684520A (en) * | 1969-12-09 | 1972-08-15 | Us Agriculture | Fractionation of leafy green crops |
| US3775133A (en) * | 1971-08-02 | 1973-11-27 | W Batley | Fractionation of alfalfa wetted with molasses serum |
| US3821346A (en) * | 1971-08-02 | 1974-06-28 | W Batley | Pet litter produced by recycled molasses serum |
| US3799806A (en) * | 1972-04-20 | 1974-03-26 | Danske Sukkerfab | Process for the purification and clarification of sugar juices,involving ultrafiltration |
| US3823128A (en) * | 1972-05-16 | 1974-07-09 | Us Agriculture | Preparation of edible protein from leafy green crops such as alfalfa |
| US4006078A (en) * | 1974-07-08 | 1977-02-01 | The United States Of America As Represented By The Secretary Of Agriculture | Preparation of soluble edible protein from leafy green crops |
| US3959246A (en) * | 1974-07-08 | 1976-05-25 | The United States Of America As Represented By The Secretary Of Agriculture | Preparation of soluble edible protein from leafy green crops |
| FR2294647A1 (fr) * | 1974-11-04 | 1976-07-16 | France Luzerne | Procede de traitement de vegetaux verts feuillus en vue d'une extraction de proteines dans les jus de pressage et d'une deshydratation economique du tourteau |
| GB1430566A (en) | 1974-11-15 | 1976-03-31 | Nestel Sa | Isolation of proteins |
| US3993794A (en) * | 1976-01-15 | 1976-11-23 | The United States Of America As Represented By The Secretary Of Agriculture | Method for texturizing proteins |
| HU174943B (hu) * | 1976-06-30 | 1980-04-28 | Vepex Foevallalkozasi Iroda Rt | Sposob poluchenija koncentratov rastitel'nogo belka i pigmenta |
| US4077950A (en) * | 1976-07-12 | 1978-03-07 | Source Proteins, Inc. | Process for the recovery of substantially water-soluble non-toxic protein compounds from fresh non-woody vegetation |
| US4250197A (en) | 1976-10-25 | 1981-02-10 | Vepex Fovallalkopasi Iroda Rt. | Method for processing plant protein |
| US4130553A (en) * | 1977-01-05 | 1978-12-19 | Batley Jr William R | Process for improving the nutritional value of green plant protein |
| CA1099576A (en) * | 1978-03-23 | 1981-04-21 | Chester D. Myers | Improved process for isolation of proteins |
| DE2816474A1 (de) * | 1978-04-15 | 1979-10-25 | Bayer Ag | Dichlorbenzodioxolderivate, verfahren zu ihrer herstellung und ihre verwendung als synergisten in insektiziden und akariziden mitteln |
| US4234620A (en) * | 1978-12-26 | 1980-11-18 | A. E. Staley Manufacturing Company | Water-soluble vegetable protein aggregates |
| GB2054343B (en) | 1979-07-20 | 1983-08-24 | Energiagazdalkodasi Intezet | Preserving green vegetable matter |
| US4347324A (en) * | 1979-09-24 | 1982-08-31 | Leaf Proteins, Inc. | Process for isolation of proteins from plant leaves |
| WO1982000569A1 (fr) * | 1980-08-13 | 1982-03-04 | Verniers C | Procede d'obtention de jus clairs de vegetaux et de recuperation de constituants valorisables |
| US4359530A (en) * | 1980-09-08 | 1982-11-16 | Aluminum Company Of America | Protein extraction from green crops |
| US4334024A (en) * | 1980-11-03 | 1982-06-08 | Sarjit Johal | Preparation and crystallization of fraction I protein from plant sources |
| JPS5914451B2 (ja) | 1981-03-09 | 1984-04-04 | 日本薬品開発株式会社 | 植物緑葉源抗炎症剤 |
| US4333871A (en) * | 1981-03-18 | 1982-06-08 | International Harvester Company | Coagulation method for preparing leaf protein concentrates (LPC) from plant foliage |
| US4421682A (en) * | 1981-04-06 | 1983-12-20 | The United States Of America As Represented By The Secretary Of Agriculture | Heating of proteinaceous liquids |
| FR2523976B1 (fr) * | 1982-03-26 | 1985-08-30 | Pasteur Institut | Nouveau produit proteique, obtention et application comme medicament, en particulier immunoregulateur et antiallergique |
| JPS59130173A (ja) * | 1983-01-14 | 1984-07-26 | Shiraimatsu Shinyaku Kk | 飲料 |
| SU1194361A1 (ru) * | 1983-06-07 | 1985-11-30 | Всесоюзный Научно-Исследовательский Институт Чайной Промышленности | Способ производства ча |
| US4639375A (en) * | 1983-08-12 | 1987-01-27 | The Procter & Gamble Company | Enzymatic treatment of black tea leaf |
| US4588691A (en) * | 1984-02-29 | 1986-05-13 | Johal Sarjit S | Method for preparation of Fraction I protein and by-products thereof |
| US4897346A (en) * | 1986-07-15 | 1990-01-30 | Beckman Instruments, Inc. | Stabilized liquid enzyme composition for glucose determination |
| CH671322A5 (enExample) * | 1986-09-29 | 1989-08-31 | Bucher Guyer Ag Masch | |
| US4897345A (en) | 1987-07-20 | 1990-01-30 | Lubrizol Genetics Inc. | Pollen tube growth assay |
| CN1039525A (zh) * | 1988-05-19 | 1990-02-14 | 浙江农业大学 | 速溶茶加工工艺 |
| FR2632308B1 (fr) * | 1988-06-07 | 1991-08-16 | Fondation Nale Transfusion San | Procede et installation de fractionnement en continu de proteines vegetales animales ou humaines |
| JPH111686A (ja) | 1990-05-14 | 1999-01-06 | Yoshihide Hagiwara | 抗酸化剤 |
| US5723149A (en) * | 1990-11-21 | 1998-03-03 | Lvmh Recherche | Use of medicago saponins for the preparation of cosmetic or pharmaceutical compositions, especially dermatological compositions, promoting renewal of the epidermis, stimulating hair regrowth or delaying hair loss |
| US6221363B1 (en) * | 1991-07-11 | 2001-04-24 | Baxter Aktiengesellschaft | Vaccine for the prevention of lyme disease |
| US5798446A (en) * | 1991-10-10 | 1998-08-25 | Nupron Gmbh Proteinwerk | Method of extracting proteins utilizable in foodstuff from a protein-containing substance |
| JPH05229921A (ja) | 1992-02-21 | 1993-09-07 | Nakano Vinegar Co Ltd | 発毛促進用組成物 |
| JPH07112404B2 (ja) * | 1992-05-08 | 1995-12-06 | 協同組合ティーライフクリエイティブ | 緑茶の製茶方法 |
| CH684924A5 (de) * | 1993-04-02 | 1995-02-15 | Bucher Guyer Ag Masch | Verfahren zum Trennen fester und flüssiger Anteile, sowie Vorrichtung zu dessen Durchführung. |
| US5433968A (en) * | 1993-04-23 | 1995-07-18 | Nestec S.A. | Process for producing a simulated meat product |
| US6068862A (en) * | 1993-06-30 | 2000-05-30 | Taiyo Kagaku Co., Ltd. | Tea-derived feed additive and animal feed containing the same |
| US5777080A (en) * | 1994-05-09 | 1998-07-07 | The Board Of Trustees Of The University Of Arkansas | Highly soluble protein, method for making, and food products made thereof |
| IT1275905B1 (it) * | 1995-03-14 | 1997-10-24 | Indena Spa | Frazioni polifenoliche di te', loro uso e formulazioni che le contengono |
| AR002779A1 (es) * | 1995-07-10 | 1998-04-29 | Nestle Sa | Procedimiento para fabricar una leche de almendras de frutas. |
| JPH09202726A (ja) * | 1996-01-23 | 1997-08-05 | Shiga Yoko | 緑茶浴用剤 |
| US5952023A (en) * | 1996-02-05 | 1999-09-14 | Lipton, Division Of Conopco, Inc. | Enzyme extraction process for tea |
| CN1144652A (zh) * | 1996-06-28 | 1997-03-12 | 青岛医学院附属专科医院 | 茶叶面膜 |
| FR2751878B1 (fr) * | 1996-07-30 | 1998-09-04 | Oreal | Utilisation dans une composition d'un extrait d'au moins une labiee |
| AU734341B2 (en) * | 1996-08-02 | 2001-06-14 | Shiseido Company Ltd. | Composition for enhancing hyaluronic acid productivity and method for preparing same |
| IT1288257B1 (it) * | 1996-11-29 | 1998-09-11 | Paoli Ambrosi Gianfranco De | Composizione per uso cosmetico,farmaceutico o dietetico a base di un aminozucchero e/o di un acido poliidrossilico |
| US6037456A (en) * | 1998-03-10 | 2000-03-14 | Biosource Technologies, Inc. | Process for isolating and purifying viruses, soluble proteins and peptides from plant sources |
| US5994508A (en) * | 1998-04-13 | 1999-11-30 | Protein Technologies International, Inc. | Isoflavone rich protein isolate and process for producing |
| US6013771A (en) * | 1998-06-09 | 2000-01-11 | Protein Technologies International, Inc. | Isoflavone rich protein isolate and process for producing |
| IT1301871B1 (it) * | 1998-07-24 | 2000-07-07 | Marlegreen Holding S A | Procedimento per la produzione di te' in polvere o in foglia a ridotticosti di manodopera e di impianto |
| DK1002521T3 (da) * | 1998-11-19 | 2002-11-11 | Isernhagen Heilmittelbetr Gmbh | Anvendelse af udtræk opnået ved ekstraktion med kuldioxid som deodoranter |
| KR20000033083A (ko) * | 1998-11-19 | 2000-06-15 | 윤종용 | 컨버전스 조정장치 및 이에 적합한 컨버전스 조정방법 |
| US6428818B1 (en) * | 1999-03-30 | 2002-08-06 | Purdue Research Foundation | Tea catechin formulations and processes for making same |
| US6610749B2 (en) * | 2000-02-18 | 2003-08-26 | Arch Development Corporation | Polyhydroxylated benzene-containing compounds |
| KR20010112817A (ko) * | 2000-06-15 | 2001-12-22 | 황재관 | 녹차의 생리활성물질 분리방법 |
| US6616952B1 (en) * | 2000-11-17 | 2003-09-09 | Roseberg Investments, Inc. | Organic fungicide |
| KR100384308B1 (ko) * | 2001-02-12 | 2003-05-14 | 노일섭 | 즉석 분말 인삼녹차 및 그 제조방법 |
| KR100395464B1 (ko) * | 2001-02-12 | 2003-08-25 | 노일섭 | 카테킨류의 신규한 추출방법 및 이를 이용한 카테킨 함유음료 |
| JP4160276B2 (ja) * | 2001-06-12 | 2008-10-01 | 株式会社 伊藤園 | 尿酸値低下剤及び尿酸値低下効果を備えた飲食物 |
| CA2451844A1 (en) * | 2001-06-27 | 2003-01-09 | Unigen Pharmaceuticals, Inc. | Method for generating, screening and dereplicating natural product libraries for the discovery of therapeutic agents |
| JP2003024010A (ja) * | 2001-07-10 | 2003-01-28 | Kenko Seikagaku:Kk | 緑茶カテキンを主成分とする機能強化補助食品 |
| KR20030030332A (ko) * | 2001-10-09 | 2003-04-18 | 제주대학교 | 우묵사스레피의 추출물을 포함하는 항암용 조성물 |
| JP2003171297A (ja) * | 2001-12-07 | 2003-06-17 | Ito En Ltd | 血中ビリルビン濃度低下剤及び黄疸治療・予防剤 |
| JP2003212771A (ja) * | 2002-01-23 | 2003-07-30 | Taiyo Kagaku Co Ltd | 抗ナイセリア菌組成物 |
| US7442391B2 (en) | 2002-01-25 | 2008-10-28 | Integrated Botanical Technologies, Llc | Bioactive botanical cosmetic compositions and processes for their production |
| JP3590032B2 (ja) * | 2002-04-17 | 2004-11-17 | 花王株式会社 | 緑茶ポリフェノールの製造法 |
| WO2004080380A2 (fr) * | 2003-03-05 | 2004-09-23 | L'oreal | Utilisation de polyphenols catechniques pour la preparation de compositions destinees a favoriser la pigmentation naturelle de la peau |
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2005
- 2005-01-12 EP EP05711431.6A patent/EP1722805B1/en not_active Expired - Lifetime
- 2005-01-12 US US11/033,925 patent/US7473435B2/en not_active Expired - Lifetime
- 2005-01-12 ES ES12152951.5T patent/ES2652603T3/es not_active Expired - Lifetime
- 2005-01-12 AU AU2005206875A patent/AU2005206875B2/en not_active Ceased
- 2005-01-12 BR BRPI0506751A patent/BRPI0506751B8/pt not_active IP Right Cessation
- 2005-01-12 JP JP2006549605A patent/JP5276270B2/ja not_active Expired - Fee Related
- 2005-01-12 CA CA002552710A patent/CA2552710A1/en not_active Abandoned
- 2005-01-12 CN CN2005800072719A patent/CN1929851B/zh not_active Expired - Lifetime
- 2005-01-12 ES ES05711431.6T patent/ES2465949T3/es not_active Expired - Lifetime
- 2005-01-12 KR KR1020067016233A patent/KR101224697B1/ko not_active Expired - Fee Related
- 2005-01-12 EP EP12152951.5A patent/EP2491939B1/en not_active Expired - Lifetime
- 2005-01-12 NZ NZ598539A patent/NZ598539A/xx not_active IP Right Cessation
- 2005-01-12 WO PCT/US2005/001132 patent/WO2005069835A2/en not_active Ceased
- 2005-01-12 CN CN201110279917.6A patent/CN102327391B/zh not_active Expired - Lifetime
- 2005-01-12 NZ NZ548718A patent/NZ548718A/en not_active IP Right Cessation
- 2005-01-12 MX MXPA06007942A patent/MXPA06007942A/es active IP Right Grant
- 2005-01-12 PL PL05711431T patent/PL1722805T3/pl unknown
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2006
- 2006-07-11 MX MX2012015177A patent/MX342293B/es unknown
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2008
- 2008-12-15 US US12/335,534 patent/US8043635B2/en not_active Expired - Lifetime
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2010
- 2010-09-15 AU AU2010221784A patent/AU2010221784A1/en not_active Abandoned
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2011
- 2011-10-24 US US13/279,901 patent/US20120045404A1/en not_active Abandoned
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2012
- 2012-03-02 JP JP2012046332A patent/JP5875896B2/ja not_active Expired - Fee Related
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2013
- 2013-02-08 US US13/762,647 patent/US20130146481A1/en not_active Abandoned
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2014
- 2014-05-06 US US14/270,852 patent/US10004777B2/en active Active
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