ES2643640T3 - Agentes para tratamiento de enfermedad - Google Patents
Agentes para tratamiento de enfermedad Download PDFInfo
- Publication number
- ES2643640T3 ES2643640T3 ES10782326.2T ES10782326T ES2643640T3 ES 2643640 T3 ES2643640 T3 ES 2643640T3 ES 10782326 T ES10782326 T ES 10782326T ES 2643640 T3 ES2643640 T3 ES 2643640T3
- Authority
- ES
- Spain
- Prior art keywords
- antibody
- peptide
- heavy chain
- lymphocytes
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 48
- 108090000765 processed proteins & peptides Proteins 0.000 description 42
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 30
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 28
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 28
- 150000001413 amino acids Chemical class 0.000 description 24
- 108090000623 proteins and genes Proteins 0.000 description 21
- 102000004169 proteins and genes Human genes 0.000 description 20
- 238000000034 method Methods 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 18
- 230000027455 binding Effects 0.000 description 15
- 102000004196 processed proteins & peptides Human genes 0.000 description 15
- 102220316641 rs146101365 Human genes 0.000 description 14
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 description 13
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 description 13
- 210000003289 regulatory T cell Anatomy 0.000 description 13
- 238000006467 substitution reaction Methods 0.000 description 13
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 12
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 12
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 12
- 230000003993 interaction Effects 0.000 description 11
- 210000001744 T-lymphocyte Anatomy 0.000 description 9
- 125000003275 alpha amino acid group Chemical group 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 7
- 229920001184 polypeptide Polymers 0.000 description 7
- 102220243540 rs1280004443 Human genes 0.000 description 7
- 108010041397 CD4 Antigens Proteins 0.000 description 6
- 210000004698 lymphocyte Anatomy 0.000 description 6
- 230000035772 mutation Effects 0.000 description 6
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 210000003162 effector t lymphocyte Anatomy 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 230000035755 proliferation Effects 0.000 description 5
- 102220280443 rs80358540 Human genes 0.000 description 5
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 108020004999 messenger RNA Proteins 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 230000000890 antigenic effect Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 102220364140 c.55A>G Human genes 0.000 description 3
- 238000004590 computer program Methods 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000684 flow cytometry Methods 0.000 description 3
- 238000000099 in vitro assay Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 230000003278 mimic effect Effects 0.000 description 3
- 238000007799 mixed lymphocyte reaction assay Methods 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 102220004887 rs121913664 Human genes 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 108010067902 Peptide Library Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000001616 monocyte Anatomy 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000000816 peptidomimetic Substances 0.000 description 2
- 210000002729 polyribosome Anatomy 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 2
- 229960002930 sirolimus Drugs 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 210000005253 yeast cell Anatomy 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 102100025698 Cytosolic carboxypeptidase 4 Human genes 0.000 description 1
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 description 1
- 101000932590 Homo sapiens Cytosolic carboxypeptidase 4 Proteins 0.000 description 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 description 1
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 description 1
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 description 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 102000019298 Lipocalin Human genes 0.000 description 1
- 108050006654 Lipocalin Proteins 0.000 description 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 description 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101001033003 Mus musculus Granzyme F Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108010004729 Phycoerythrin Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002788 anti-peptide Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 238000003782 apoptosis assay Methods 0.000 description 1
- 230000005775 apoptotic pathway Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- JFIOVJDNOJYLKP-UHFFFAOYSA-N bithionol Chemical compound OC1=C(Cl)C=C(Cl)C=C1SC1=CC(Cl)=CC(Cl)=C1O JFIOVJDNOJYLKP-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003501 co-culture Methods 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940095074 cyclic amp Drugs 0.000 description 1
- 230000001461 cytolytic effect Effects 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000000432 density-gradient centrifugation Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000000710 homodimer Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000001948 isotopic labelling Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000012917 library technology Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000005232 molecular self-assembly Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 229940023041 peptide vaccine Drugs 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Natural products C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 1
- 229950010131 puromycin Drugs 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000003335 steric effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0920944.6A GB0920944D0 (en) | 2009-11-30 | 2009-11-30 | Agents for treating disease |
| GB0920944 | 2009-11-30 | ||
| PCT/EP2010/068579 WO2011064407A1 (en) | 2009-11-30 | 2010-11-30 | Agents for treating disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2643640T3 true ES2643640T3 (es) | 2017-11-23 |
Family
ID=41572903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10782326.2T Active ES2643640T3 (es) | 2009-11-30 | 2010-11-30 | Agentes para tratamiento de enfermedad |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9995733B2 (enExample) |
| EP (1) | EP2470902B1 (enExample) |
| JP (1) | JP5959438B2 (enExample) |
| KR (1) | KR101872746B1 (enExample) |
| CN (1) | CN102687010B (enExample) |
| AU (1) | AU2010323045B2 (enExample) |
| BR (1) | BR112012012911A8 (enExample) |
| CA (1) | CA2781836A1 (enExample) |
| ES (1) | ES2643640T3 (enExample) |
| GB (1) | GB0920944D0 (enExample) |
| IL (1) | IL219956B (enExample) |
| MX (1) | MX347247B (enExample) |
| NZ (1) | NZ600889A (enExample) |
| RU (1) | RU2598719C2 (enExample) |
| SG (2) | SG181117A1 (enExample) |
| WO (1) | WO2011064407A1 (enExample) |
| ZA (1) | ZA201204845B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1460088A1 (en) | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| EP2471543A1 (en) * | 2010-12-02 | 2012-07-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Tolerance induction or immunosupression to prevent in particular Graft-versus-Host-Disease (GvHD) by short-term pre-incubation of transplanted cell suspensions, tissues or organs coated with ligands to cell surface molecules |
| US20170232084A1 (en) | 2013-04-26 | 2017-08-17 | Enzo Biochem Inc. | Immune modulation for the treatment of age-related macular degeneration |
| US20140322188A1 (en) | 2013-04-26 | 2014-10-30 | Enzo Biochem, Inc. | Tolerizing treatments for autoimmune disease |
| GB201413899D0 (en) | 2014-08-06 | 2014-09-17 | Johnson Matthey Plc | Catalyst and use therof |
| CR20170482A (es) * | 2015-04-24 | 2018-03-07 | Viiv Healthcare Uk No 5 Ltd | Polipéptidos dirigidos a la fusión de vih |
| US20180126021A1 (en) * | 2016-11-04 | 2018-05-10 | Covidien Lp | Sterilization system and method |
| GB202017681D0 (en) | 2020-11-09 | 2020-12-23 | T Balance Therapeutics Gmbh | Anti-CD4 antibody or fragment thereof for medical use |
| AU2022492449A1 (en) * | 2022-12-29 | 2025-07-10 | Chang Gung Memorial Hospital, Linkou | Antibodies specific to transmembrane and coiled-coil domain family 3 and uses thereof |
| GB202401501D0 (en) | 2024-02-05 | 2024-03-20 | T Balance Therapeutics Gmbh | Medical use of regulatory t cell activator |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT90657B (pt) | 1988-05-27 | 1995-03-01 | Ortho Pharma Corp | Processo para a preparacao de peptidos que bloqueiam a ligacao de hiv-1 a proteina cd4 receptora |
| JPH0768273B2 (ja) * | 1988-12-02 | 1995-07-26 | カルピス食品工業株式会社 | 抗hivペプチド |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1990013562A1 (en) | 1989-05-02 | 1990-11-15 | Genelabs Incorporated | Chemically modified cd4 peptide fragments having anti-retroviral properties |
| US5690933A (en) | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
| GB8912497D0 (en) | 1989-05-31 | 1989-07-19 | Cobbold Stephen P | Monoclonal antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US20020099179A1 (en) | 1989-12-21 | 2002-07-25 | Linda K. Jolliffe | Cdr-grafted antibodies |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| HUT60768A (en) | 1990-03-16 | 1992-10-28 | Sandoz Ag | Process for producing cd25 fixing molecules |
| US7084260B1 (en) | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
| ATE153536T1 (de) | 1990-11-27 | 1997-06-15 | Biogen Inc | Hiv-induzierte synzytien blockierender anti-cd-4- antikörper |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
| US5777085A (en) | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
| IL101769A (en) | 1992-05-03 | 2007-02-11 | Yeda Res & Dev | Modulation of TNF receptor action |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| JP3616091B2 (ja) | 1992-10-08 | 2005-02-02 | ザ ケネディー インスティチュート オブ リューマトロジー | 自己免疫疾患および炎症性疾患の治療 |
| DK0614984T4 (da) | 1993-03-05 | 2010-12-20 | Bayer Healthcare Llc | Humane monoklonale anti-TNF-alfa-antistoffer |
| EP0631783A1 (en) | 1993-06-03 | 1995-01-04 | Mitsubishi Chemical Corporation | Antiviral combinations of 2',3'-di-deoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substituted uracil derivatives |
| JPH09510952A (ja) | 1993-10-06 | 1997-11-04 | ザ ケネディー インスティチュート オブ リューマトロジー | 自己免疫疾患および炎症性疾患の治療 |
| US20020068057A1 (en) | 1994-03-10 | 2002-06-06 | Marc Feldmann | Treatment of autoimmune and inflammatory disorders |
| PT840618E (pt) | 1995-05-18 | 2003-08-29 | Ortho Mcneil Pharm Inc | Inducao de tolerancia imunologica atraves de anticorpos anti-cd4 nao-depletores |
| DE69721548T2 (de) | 1996-02-09 | 2004-04-01 | Abbott Laboratories(Bermuda)Ltd. | HUMANE ANTIKÖRPER WELCHE AN HUMANEN TNFalpha BINDEN |
| US20010056066A1 (en) | 1996-07-26 | 2001-12-27 | Smithkline Beecham Corporation | Method of treating immune cell mediated systemic diseases |
| AU4563197A (en) | 1996-10-01 | 1998-04-24 | Celltech Therapeutics Limited | Pharmaceutical products containing protein-tyrosine kinase inhibitors and anti-cd4 antibodies |
| US6037454A (en) | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| DE19722888A1 (de) | 1997-05-28 | 1998-12-03 | Thomas Prof Dr Huenig | Human-CD28 spezifische monoklonale Antikörper zur antigenunspezifischen Aktivierung von T-Lymphozyten |
| WO2000058362A1 (en) | 1999-03-26 | 2000-10-05 | Human Genome Sciences, Inc. | Neutrokine-alpha binding proteins and methods based thereon |
| WO2000074718A1 (en) | 1999-06-09 | 2000-12-14 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target b-cells |
| AU6941000A (en) * | 1999-08-27 | 2001-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Polypeptides that bind hiv gp120 and related nucleic acids, antibodies, compositions, and methods of use |
| US7304127B2 (en) | 1999-08-27 | 2007-12-04 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use |
| AU2001275186A1 (en) | 2000-06-02 | 2001-12-17 | Nicole Kirchhof | Immunotherapeutic method to prevent islet cell rejection |
| CN1592645A (zh) | 2000-09-18 | 2005-03-09 | 拜奥根Idec公司 | 使用b细胞耗尽/免疫调节抗体组合治疗自身免疫病的联合疗法 |
| DE10050935A1 (de) | 2000-10-11 | 2002-05-02 | Tegenero Gmbh | Verwendung CD28 spezifischer monoklonaler Antikörper zur Stimulation von Blutzellen, welche kein CD28 tragen |
| EP2314293B1 (en) | 2001-01-16 | 2017-01-04 | Vascular Therapies, LLC | Implantable device containing resorbable matrix material and rapamycin for preventing or treating vasuloproliferative diseases |
| EP1372721A4 (en) | 2001-03-07 | 2008-04-02 | Childrens Medical Center | METHOD FOR SCREENING PEPTIDE DISPLAY LIBRARIES WITH A MINIMUM DISPLAY |
| EP1241249A1 (en) | 2001-03-12 | 2002-09-18 | Gerold Schuler | CD4+CD25+regulatory T cells from human blood |
| AU2002316855B2 (en) | 2001-04-24 | 2008-03-13 | Merck Patent Gmbh | Combination therapy using anti-angiogenic agents and TNFalpha |
| DE60238533D1 (de) | 2001-06-14 | 2011-01-20 | Cambridge Entpr Ltd | Nicht-depletierender Antikörper TRX-1 gegen CD4 und dessen Verwendungen |
| GB2376466A (en) | 2001-06-14 | 2002-12-18 | Mark Frewin | TRX1 antibody |
| US7541443B2 (en) | 2001-06-14 | 2009-06-02 | Tolerrx, Inc. | Anti-CD4 antibodies |
| EP1451224B1 (de) | 2001-12-04 | 2012-08-15 | TheraMAB LLC | Peptid oder protein enthaltend ein c'-d loop der cd28 rezeptorfamilie |
| DE10212108A1 (de) | 2002-03-13 | 2003-10-02 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung |
| DE10230223A1 (de) | 2002-07-04 | 2004-01-22 | Tegenero Ag | Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern |
| JP2006515165A (ja) | 2002-09-16 | 2006-05-25 | ジェネンテック・インコーポレーテッド | 免疫関連疾患の治療のための新規組成物と方法 |
| US7388079B2 (en) | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| US7501494B2 (en) | 2003-01-15 | 2009-03-10 | United Biomedical, Inc. | Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection |
| EP1460088A1 (en) * | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| HRP20090325T1 (en) | 2003-04-09 | 2009-07-31 | Genentech | Therapy of autoimmune disease in a patient with an inadequate response to a tnf-alpha inhibitor |
| GB0314461D0 (en) | 2003-06-20 | 2003-07-23 | Isis Innovation | Suppression of transplant rejection |
| US7691970B2 (en) | 2003-08-25 | 2010-04-06 | Pieris Ag | Muteins of a bilin-binding protein with affinity for a given target |
| EP1600164A3 (de) | 2003-09-22 | 2006-05-17 | TeGenero AG | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer Pharmazeutischen Zusammensetzung mit dosisabhängiger Wirkung |
| DE10352900A1 (de) | 2003-11-11 | 2005-06-16 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von B-CLL |
| BRPI0512017A (pt) | 2004-06-22 | 2008-02-06 | Tolerrx Inc | dosagem otimizada com anticorpos anti-cd4 para indução de toleráncia em primatas |
| CN101010342A (zh) | 2004-07-02 | 2007-08-01 | 健泰科生物技术公司 | 用于治疗非何杰金淋巴瘤的组合物和方法 |
| EP1797882A4 (en) | 2004-09-29 | 2009-11-18 | Kowa Co | PREVENTIVE AND / OR THERAPEUTIC MEDICAMENT FOR RHEUMATOID ARTHRITIS |
| ES2437571T3 (es) | 2004-11-11 | 2014-01-13 | Theramab Llc | Anticuerpos anti-CD28 superagonistas |
| WO2006055077A2 (en) | 2004-11-12 | 2006-05-26 | The University Of North Carolina At Charlotte | Modulation of cd4+ t cell responses by a tick saliva protein, salp15 and polypeptides derived therefrom |
| DE102004063494A1 (de) | 2004-12-23 | 2006-07-13 | Tegenero Ag | Antikörper |
| JP4730733B2 (ja) | 2005-05-02 | 2011-07-20 | 国立大学法人京都大学 | 4型葉酸受容体の発現を指標とした制御性t細胞の検出方法、及び免疫賦活剤 |
| SG163615A1 (en) | 2005-07-11 | 2010-08-30 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| DE602006019977D1 (de) | 2005-08-18 | 2011-03-17 | Genmab As | Therapie mit anti-cd4-antikörpern und bestrahlung |
| WO2007031875A2 (en) | 2005-08-26 | 2007-03-22 | Glycart Biotechnology Ag | Modified antigen binding molecules with altered cell signaling activity |
| WO2007130697A2 (en) * | 2006-01-05 | 2007-11-15 | Genentech, Inc. | Anti-ephb4 antibodies and methods using same |
| KR20080112300A (ko) | 2006-03-16 | 2008-12-24 | 제넨테크, 인크. | Cd4 항체를 사용하여 루푸스를 치료하는 방법 |
| WO2007111661A2 (en) | 2006-03-20 | 2007-10-04 | Xoma Technology Ltd. | Human antibodies specific for gastrin materials and methods |
| US20090208471A1 (en) | 2006-04-07 | 2009-08-20 | Yun Theodore J | Isolation and Use of Human Regulatory T Cells |
| GEP20125628B (en) | 2006-04-21 | 2012-09-10 | Novartis Ag | Pharmaceutical compositions containing antagonist anti-cd40 antibody |
| WO2007135684A2 (en) * | 2006-05-22 | 2007-11-29 | Hadasit Medical Research Services & Development Limited | Method of treatment of anti-cd4 autoimmunity |
| ES2593789T3 (es) | 2007-02-01 | 2016-12-13 | Universitätsmedizin Der Johannes Gutenberg-Universität Mainz | Activación específica de una célula T reguladora y su uso para el tratamiento del asma, enfermedades alérgicas, enfermedades autoinmunes, rechazo de injertos y para la inducción de tolerancia |
| WO2008134046A1 (en) | 2007-04-27 | 2008-11-06 | Genentech, Inc. | Potent, stable and non-immunosuppressive anti-cd4 antibodies |
| CA2718184A1 (en) | 2008-03-13 | 2009-10-08 | Biotest Ag | Agent for treating disease |
| KR20100135807A (ko) | 2008-03-13 | 2010-12-27 | 바이오테스트 아게 | 질병 치료제 |
| JP5604311B2 (ja) * | 2008-03-13 | 2014-10-08 | バイオテスト・アクチエンゲゼルシヤフト | 疾患治療剤 |
| EP2101173A1 (en) | 2008-03-14 | 2009-09-16 | Vivalis | In vitro method to determine whether a drug candidate active against a target protein is active against a variant of said protein |
| WO2010022341A1 (en) | 2008-08-21 | 2010-02-25 | The United State Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of enriching and using regulatory t cells |
| ES2335381B1 (es) | 2008-09-24 | 2011-02-28 | Fundacio Institut De Recerca De L'hospital Universitari Vall D'hebron | Metodo in vitro y kit para el pronostico o prediccion de la respuestapor parte de pacientes con artritis reumatoide al tratamiento con agentes bloqueantes del factor tnfalfa. |
| RU2531548C2 (ru) | 2008-09-29 | 2014-10-20 | Биотест Аг | Композиция для лечения заболевания |
| ES2351456B1 (es) | 2009-06-24 | 2011-11-28 | Fundacio Institut De Recerca De L'hospital Universitari Vall D'hebron | Metodo in vitro para el pronostico o prediccion de la respuesta por parte de pacientes con artritis reumatoide al tratamiento con agentes que reconocen el receptor de membrana cd20 de los linfocitos b |
| JP5399219B2 (ja) | 2009-11-24 | 2014-01-29 | 株式会社ケイティーバイオ | 関節リウマチに対するヒト型抗TNFα抗体薬の薬効予測方法、及び薬効予測装置 |
| WO2011158798A1 (ja) | 2010-06-14 | 2011-12-22 | 国立大学法人山口大学 | 乾癬治療効果の経過観察及び早期の予測方法並びにそれらに使用するキット |
-
2009
- 2009-11-30 GB GBGB0920944.6A patent/GB0920944D0/en not_active Ceased
-
2010
- 2010-11-30 SG SG2012039442A patent/SG181117A1/en unknown
- 2010-11-30 NZ NZ600889A patent/NZ600889A/en not_active IP Right Cessation
- 2010-11-30 CA CA2781836A patent/CA2781836A1/en not_active Abandoned
- 2010-11-30 BR BR112012012911A patent/BR112012012911A8/pt not_active Application Discontinuation
- 2010-11-30 ES ES10782326.2T patent/ES2643640T3/es active Active
- 2010-11-30 KR KR1020127016947A patent/KR101872746B1/ko not_active Expired - Fee Related
- 2010-11-30 AU AU2010323045A patent/AU2010323045B2/en not_active Ceased
- 2010-11-30 SG SG10201407938TA patent/SG10201407938TA/en unknown
- 2010-11-30 WO PCT/EP2010/068579 patent/WO2011064407A1/en not_active Ceased
- 2010-11-30 CN CN201080059459.9A patent/CN102687010B/zh active Active
- 2010-11-30 JP JP2012541473A patent/JP5959438B2/ja active Active
- 2010-11-30 MX MX2012006199A patent/MX347247B/es active IP Right Grant
- 2010-11-30 EP EP10782326.2A patent/EP2470902B1/en active Active
- 2010-11-30 RU RU2012127378/10A patent/RU2598719C2/ru not_active IP Right Cessation
-
2012
- 2012-05-23 IL IL219956A patent/IL219956B/en not_active IP Right Cessation
- 2012-05-30 US US13/483,280 patent/US9995733B2/en active Active
- 2012-06-28 ZA ZA2012/04845A patent/ZA201204845B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012012911A8 (pt) | 2018-02-27 |
| EP2470902B1 (en) | 2017-07-19 |
| IL219956B (en) | 2019-07-31 |
| RU2598719C2 (ru) | 2016-09-27 |
| KR20120102733A (ko) | 2012-09-18 |
| KR101872746B1 (ko) | 2018-06-29 |
| SG181117A1 (en) | 2012-07-30 |
| ZA201204845B (en) | 2016-06-29 |
| NZ600889A (en) | 2015-09-25 |
| GB0920944D0 (en) | 2010-01-13 |
| EP2470902A1 (en) | 2012-07-04 |
| RU2012127378A (ru) | 2014-01-10 |
| MX2012006199A (es) | 2012-06-19 |
| JP5959438B2 (ja) | 2016-08-02 |
| CN102687010B (zh) | 2016-06-15 |
| SG10201407938TA (en) | 2015-01-29 |
| US20130004513A1 (en) | 2013-01-03 |
| AU2010323045A1 (en) | 2012-07-19 |
| AU2010323045B2 (en) | 2015-09-24 |
| CN102687010A (zh) | 2012-09-19 |
| IL219956A0 (en) | 2012-07-31 |
| CA2781836A1 (en) | 2011-06-03 |
| US9995733B2 (en) | 2018-06-12 |
| JP2013511996A (ja) | 2013-04-11 |
| BR112012012911A2 (pt) | 2016-10-25 |
| WO2011064407A1 (en) | 2011-06-03 |
| MX347247B (es) | 2017-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2643640T3 (es) | Agentes para tratamiento de enfermedad | |
| Rich et al. | Survey of the year 2007 commercial optical biosensor literature | |
| US20220389615A1 (en) | Comprehensive monoclonal antibody generation | |
| ES2954183T3 (es) | Anticuerpo humanizado o fragmento de este específico para CD3 | |
| ES2573404T3 (es) | Anticuerpos contra un ligando inductor de proliferación (APRIL) | |
| JP7371039B2 (ja) | 抗原結合分子及びその使用方法 | |
| Simonsen et al. | Compound Receptors in the Cell Membrane: Ruminations from the Borderland of | |
| JP2013511966A5 (enExample) | ||
| Sun et al. | T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics | |
| Oda et al. | Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono-or multi-valent antigens | |
| Rossi et al. | Biosensor analysis of anti-citrullinated protein/peptide antibody affinity | |
| JP2011502244A (ja) | Edta耐性s100a12複合体(erac) | |
| Almeida et al. | Direct recognition of an intact foreign protein by an αβ T cell receptor | |
| PT1817342E (pt) | Método de purificação por afinidade | |
| WO2022043861A1 (en) | Anti-idiotype antibodies targeting anti-bcma chimeric antigen receptor | |
| JP2006115716A (ja) | 抗c反応性タンパク質モノクローナル抗体産生細胞ライン、その作製方法、およびそれにより産生されたモノクローナル抗体 | |
| ES2367032T3 (es) | Anticuerpo monoclonal anti-fibrina soluble humana y procedimiento de ensayo inmunológico usando el anticuerpo. | |
| CN109791149A (zh) | 用于功能分析多特异性分子的基于spr的双重结合测定法 | |
| Nakamura et al. | Prediction of human pharmacokinetics profile of monoclonal antibody using hFcRn transgenic mouse model | |
| JP2021534393A (ja) | 疑似インビボ条件での治療用タンパク質の選択 | |
| CN117999097A (zh) | 用于产生个人化癌症免疫疗法的方法 | |
| CN115819575B (zh) | 针对人肿瘤坏死因子-α的单克隆抗体 | |
| JPH1010127A (ja) | 凝集イムノアッセイ法 | |
| JP7614647B2 (ja) | 1型糖尿病、その他の自己免疫疾患の処置 | |
| Messeter et al. | Blood Bank and Dpt of Clinical Chemistry, University hospital, Lund, Sweden, and Dpt of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland. |