MX347247B - Agentes capaces de la activación de células t regulatorias cd4+cd25+ y su uso en el tratamiento de enfermedad. - Google Patents

Agentes capaces de la activación de células t regulatorias cd4+cd25+ y su uso en el tratamiento de enfermedad.

Info

Publication number
MX347247B
MX347247B MX2012006199A MX2012006199A MX347247B MX 347247 B MX347247 B MX 347247B MX 2012006199 A MX2012006199 A MX 2012006199A MX 2012006199 A MX2012006199 A MX 2012006199A MX 347247 B MX347247 B MX 347247B
Authority
MX
Mexico
Prior art keywords
agents
treating disease
regulatory
antibodies
activating
Prior art date
Application number
MX2012006199A
Other languages
English (en)
Other versions
MX2012006199A (es
Inventor
Bruecher Christoph
Daelken Benjamin
Osterroth Frank
Uherek Christoph
Zuber Chantal
Schulz Gregor
Czeloth Niklas
Engling André
Wallmeier Holger
Völp Kirsten
Original Assignee
Biotest Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Ag filed Critical Biotest Ag
Publication of MX2012006199A publication Critical patent/MX2012006199A/es
Publication of MX347247B publication Critical patent/MX347247B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a métodos de criba para identificar moléculas capaces de ligar a CD4 y capaces de activar células T regulatorias CD4+CD25+. Además se proporcionan anticuerpos y fragmentos de anticuerpo capaces de activar células T regulatorias CD4+CD25+ y métodos y usos que involucran los anticuerpos y sus fragmentos.
MX2012006199A 2009-11-30 2010-11-30 Agentes capaces de la activación de células t regulatorias cd4+cd25+ y su uso en el tratamiento de enfermedad. MX347247B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0920944.6A GB0920944D0 (en) 2009-11-30 2009-11-30 Agents for treating disease
PCT/EP2010/068579 WO2011064407A1 (en) 2009-11-30 2010-11-30 Agents for treating disease

Publications (2)

Publication Number Publication Date
MX2012006199A MX2012006199A (es) 2012-06-19
MX347247B true MX347247B (es) 2017-04-17

Family

ID=41572903

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012006199A MX347247B (es) 2009-11-30 2010-11-30 Agentes capaces de la activación de células t regulatorias cd4+cd25+ y su uso en el tratamiento de enfermedad.

Country Status (17)

Country Link
US (1) US9995733B2 (es)
EP (1) EP2470902B1 (es)
JP (1) JP5959438B2 (es)
KR (1) KR101872746B1 (es)
CN (1) CN102687010B (es)
AU (1) AU2010323045B2 (es)
BR (1) BR112012012911A8 (es)
CA (1) CA2781836A1 (es)
ES (1) ES2643640T3 (es)
GB (1) GB0920944D0 (es)
IL (1) IL219956B (es)
MX (1) MX347247B (es)
NZ (1) NZ600889A (es)
RU (1) RU2598719C2 (es)
SG (2) SG10201407938TA (es)
WO (1) WO2011064407A1 (es)
ZA (1) ZA201204845B (es)

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Also Published As

Publication number Publication date
CN102687010B (zh) 2016-06-15
WO2011064407A1 (en) 2011-06-03
JP2013511996A (ja) 2013-04-11
EP2470902A1 (en) 2012-07-04
RU2598719C2 (ru) 2016-09-27
SG10201407938TA (en) 2015-01-29
RU2012127378A (ru) 2014-01-10
MX2012006199A (es) 2012-06-19
US20130004513A1 (en) 2013-01-03
KR20120102733A (ko) 2012-09-18
AU2010323045A1 (en) 2012-07-19
BR112012012911A8 (pt) 2018-02-27
SG181117A1 (en) 2012-07-30
CA2781836A1 (en) 2011-06-03
EP2470902B1 (en) 2017-07-19
IL219956B (en) 2019-07-31
NZ600889A (en) 2015-09-25
GB0920944D0 (en) 2010-01-13
IL219956A0 (en) 2012-07-31
CN102687010A (zh) 2012-09-19
KR101872746B1 (ko) 2018-06-29
AU2010323045B2 (en) 2015-09-24
JP5959438B2 (ja) 2016-08-02
BR112012012911A2 (pt) 2016-10-25
US9995733B2 (en) 2018-06-12
ES2643640T3 (es) 2017-11-23
ZA201204845B (en) 2016-06-29

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