CN102687010B - 疾病治疗用试剂 - Google Patents

疾病治疗用试剂 Download PDF

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Publication number
CN102687010B
CN102687010B CN201080059459.9A CN201080059459A CN102687010B CN 102687010 B CN102687010 B CN 102687010B CN 201080059459 A CN201080059459 A CN 201080059459A CN 102687010 B CN102687010 B CN 102687010B
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China
Prior art keywords
antibody
antibody fragment
heavy chain
light chain
cdr1
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Chinese (zh)
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CN102687010A (zh
Inventor
弗兰克·奥斯特罗斯
克里斯托夫·尤尔克
克里斯托夫·布鲁切尔
本杰明·德尔肯
A·英格利恩
尚塔尔·祖伯
尼古拉斯·蔡洛特
H·沃梅尔
K·沃勒普
格雷戈尔·舒尔茨
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Ogyne Co Ltd
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Biotest AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080059459.9A 2009-11-30 2010-11-30 疾病治疗用试剂 Active CN102687010B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0920944.6 2009-11-30
GBGB0920944.6A GB0920944D0 (en) 2009-11-30 2009-11-30 Agents for treating disease
PCT/EP2010/068579 WO2011064407A1 (en) 2009-11-30 2010-11-30 Agents for treating disease

Publications (2)

Publication Number Publication Date
CN102687010A CN102687010A (zh) 2012-09-19
CN102687010B true CN102687010B (zh) 2016-06-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080059459.9A Active CN102687010B (zh) 2009-11-30 2010-11-30 疾病治疗用试剂

Country Status (17)

Country Link
US (1) US9995733B2 (enExample)
EP (1) EP2470902B1 (enExample)
JP (1) JP5959438B2 (enExample)
KR (1) KR101872746B1 (enExample)
CN (1) CN102687010B (enExample)
AU (1) AU2010323045B2 (enExample)
BR (1) BR112012012911A8 (enExample)
CA (1) CA2781836A1 (enExample)
ES (1) ES2643640T3 (enExample)
GB (1) GB0920944D0 (enExample)
IL (1) IL219956B (enExample)
MX (1) MX347247B (enExample)
NZ (1) NZ600889A (enExample)
RU (1) RU2598719C2 (enExample)
SG (2) SG181117A1 (enExample)
WO (1) WO2011064407A1 (enExample)
ZA (1) ZA201204845B (enExample)

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US20170232084A1 (en) 2013-04-26 2017-08-17 Enzo Biochem Inc. Immune modulation for the treatment of age-related macular degeneration
US20140322188A1 (en) 2013-04-26 2014-10-30 Enzo Biochem, Inc. Tolerizing treatments for autoimmune disease
GB201413899D0 (en) 2014-08-06 2014-09-17 Johnson Matthey Plc Catalyst and use therof
CR20170482A (es) * 2015-04-24 2018-03-07 Viiv Healthcare Uk No 5 Ltd Polipéptidos dirigidos a la fusión de vih
US20180126021A1 (en) * 2016-11-04 2018-05-10 Covidien Lp Sterilization system and method
GB202017681D0 (en) 2020-11-09 2020-12-23 T Balance Therapeutics Gmbh Anti-CD4 antibody or fragment thereof for medical use
AU2022492449A1 (en) * 2022-12-29 2025-07-10 Chang Gung Memorial Hospital, Linkou Antibodies specific to transmembrane and coiled-coil domain family 3 and uses thereof
GB202401501D0 (en) 2024-02-05 2024-03-20 T Balance Therapeutics Gmbh Medical use of regulatory t cell activator

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WO2009112502A1 (en) * 2008-03-13 2009-09-17 Biotest Ag Agent for treating disease
WO2009124815A1 (en) * 2008-03-13 2009-10-15 Biotest Ag Agent for treating disease

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Patent Citations (4)

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Also Published As

Publication number Publication date
BR112012012911A8 (pt) 2018-02-27
EP2470902B1 (en) 2017-07-19
IL219956B (en) 2019-07-31
RU2598719C2 (ru) 2016-09-27
KR20120102733A (ko) 2012-09-18
KR101872746B1 (ko) 2018-06-29
SG181117A1 (en) 2012-07-30
ZA201204845B (en) 2016-06-29
NZ600889A (en) 2015-09-25
GB0920944D0 (en) 2010-01-13
EP2470902A1 (en) 2012-07-04
RU2012127378A (ru) 2014-01-10
MX2012006199A (es) 2012-06-19
JP5959438B2 (ja) 2016-08-02
SG10201407938TA (en) 2015-01-29
US20130004513A1 (en) 2013-01-03
AU2010323045A1 (en) 2012-07-19
AU2010323045B2 (en) 2015-09-24
CN102687010A (zh) 2012-09-19
IL219956A0 (en) 2012-07-31
CA2781836A1 (en) 2011-06-03
US9995733B2 (en) 2018-06-12
JP2013511996A (ja) 2013-04-11
BR112012012911A2 (pt) 2016-10-25
WO2011064407A1 (en) 2011-06-03
ES2643640T3 (es) 2017-11-23
MX347247B (es) 2017-04-17

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