ES2641528T3 - Masa celular capaz de servir como estructura de tipo órgano primitivo compuesta por una diversidad de tipos de células de origen somático - Google Patents
Masa celular capaz de servir como estructura de tipo órgano primitivo compuesta por una diversidad de tipos de células de origen somático Download PDFInfo
- Publication number
- ES2641528T3 ES2641528T3 ES12155498.4T ES12155498T ES2641528T3 ES 2641528 T3 ES2641528 T3 ES 2641528T3 ES 12155498 T ES12155498 T ES 12155498T ES 2641528 T3 ES2641528 T3 ES 2641528T3
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- 239000002609 medium Substances 0.000 description 12
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- 108090000623 proteins and genes Proteins 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- 229930105110 Cyclosporin A Natural products 0.000 description 7
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 7
- 108010036949 Cyclosporine Proteins 0.000 description 7
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- 229960001265 ciclosporin Drugs 0.000 description 6
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- 238000003757 reverse transcription PCR Methods 0.000 description 6
- 102000044880 Wnt3A Human genes 0.000 description 5
- 108700013515 Wnt3A Proteins 0.000 description 5
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- 230000004069 differentiation Effects 0.000 description 4
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- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 description 3
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- 102000004142 Trypsin Human genes 0.000 description 3
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- 238000012258 culturing Methods 0.000 description 3
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- 238000010839 reverse transcription Methods 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
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- 230000003247 decreasing effect Effects 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000000185 follicular epithelial cell Anatomy 0.000 description 2
- 230000023643 hair follicle morphogenesis Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 210000004918 root sheath Anatomy 0.000 description 2
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- 102000004190 Enzymes Human genes 0.000 description 1
- 206010020864 Hypertrichosis Diseases 0.000 description 1
- 239000008049 TAE buffer Substances 0.000 description 1
- HGEVZDLYZYVYHD-UHFFFAOYSA-N acetic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound CC(O)=O.OCC(N)(CO)CO.OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O HGEVZDLYZYVYHD-UHFFFAOYSA-N 0.000 description 1
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- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 239000003324 growth hormone secretagogue Substances 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
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- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
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- 210000002107 sheath cell Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0666—Mesenchymal stem cells from hair follicles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Developmental Biology & Embryology (AREA)
- Rheumatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006176763 | 2006-06-27 | ||
| JP2006176763 | 2006-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2641528T3 true ES2641528T3 (es) | 2017-11-10 |
Family
ID=38845692
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12155498.4T Active ES2641528T3 (es) | 2006-06-27 | 2007-06-27 | Masa celular capaz de servir como estructura de tipo órgano primitivo compuesta por una diversidad de tipos de células de origen somático |
| ES07768103T Active ES2419232T3 (es) | 2006-06-27 | 2007-06-27 | Agregado de células que comprende diversas clases de células derivadas del soma con capacidad para formar una estructura de tipo órgano primitivo |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07768103T Active ES2419232T3 (es) | 2006-06-27 | 2007-06-27 | Agregado de células que comprende diversas clases de células derivadas del soma con capacidad para formar una estructura de tipo órgano primitivo |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8563309B2 (enExample) |
| EP (2) | EP2034011B1 (enExample) |
| JP (3) | JP2013059337A (enExample) |
| KR (1) | KR101472594B1 (enExample) |
| CN (1) | CN101479376A (enExample) |
| ES (2) | ES2641528T3 (enExample) |
| WO (1) | WO2008001938A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100291580A1 (en) * | 2007-12-19 | 2010-11-18 | Aderans Research Institute, Inc | Biomarkers for trichogenicity |
| CN101658518B (zh) * | 2009-08-19 | 2011-06-08 | 新疆奥斯曼生物化妆品有限公司 | 靛玉红用作制备育毛发的药物中的用途 |
| GB201112922D0 (en) * | 2011-07-27 | 2011-09-14 | Univ Durham | Micro-organ |
| US10478526B2 (en) * | 2013-05-03 | 2019-11-19 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Skin substitutes and methods for hair follicle neogenesis |
| WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| JP6218238B2 (ja) * | 2014-07-10 | 2017-10-25 | 国立大学法人大阪大学 | 人工皮膚及びその製造方法 |
| US20170296595A1 (en) | 2014-09-18 | 2017-10-19 | North Carolina State University | Mammalian Lung Spheroids and Lung Spheroid Cells and Uses Thereof |
| JP6425319B2 (ja) | 2015-10-30 | 2018-11-28 | 国立大学法人横浜国立大学 | 複数の再生毛包原基の製造方法、毛包組織含有シートの製造方法、毛包組織含有シート及び培養基板の使用 |
| AU2017212629A1 (en) * | 2016-01-28 | 2018-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods for serum-free synthesis |
| FR3061207B1 (fr) * | 2016-12-23 | 2023-03-10 | Oreal | Utilisation des cellules germinales pour la preparation d’un microfollicule pileux |
| KR101948396B1 (ko) * | 2016-12-26 | 2019-02-14 | 동국대학교 산학협력단 | 특정 전자기파 처리를 통한 효율적 3d 중뇌 유사 오가노이드 제조 방법 |
| AU2017386417B2 (en) | 2016-12-30 | 2022-07-14 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
| AU2018250591A1 (en) * | 2017-04-11 | 2019-10-10 | Frequency Therapeutics, Inc. | Methods for hair follicle stem cell proliferation |
| WO2019092667A1 (en) * | 2017-11-10 | 2019-05-16 | Vitroscreen S.R.L. | Method for preparing three-dimensional scaffold-free microtissues for use in the preclinical screening of active substances |
| CN108486035B (zh) * | 2018-03-26 | 2021-11-26 | 西北大学 | 一种三维类器官的液滴培养方法 |
| JP7142840B2 (ja) | 2018-05-16 | 2022-09-28 | 国立大学法人横浜国立大学 | 細胞含有ハイドロゲル体及びその製造方法 |
| JP7246595B2 (ja) * | 2018-11-08 | 2023-03-28 | 国立大学法人横浜国立大学 | 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法 |
| JP7702229B2 (ja) * | 2018-11-19 | 2025-07-03 | 株式会社 資生堂 | 毛包を有するヒト皮膚組織を再構成するための組成物、ヒト皮膚組織モデル動物およびその製造方法 |
| KR102636511B1 (ko) * | 2020-03-20 | 2024-02-14 | 주식회사 에이엔케이 | 기판 상에 형성된 모낭 세포 스페로이드 및 이의 제조방법 |
| KR102636512B1 (ko) * | 2020-03-20 | 2024-02-14 | 주식회사 에이엔케이 | 모유두 세포의 반복 시딩 및 배양을 통한 모유두 스페로이드의 제조방법 |
| CN116368218A (zh) | 2020-08-18 | 2023-06-30 | 东曹株式会社 | 分化诱导为多能干细胞的外胚层、中胚层和内胚层系细胞的方法 |
| JP7635920B2 (ja) | 2020-09-07 | 2025-02-26 | Ｔｏｐｐａｎホールディングス株式会社 | 細胞移植キット、および、細胞移植装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60129799T2 (de) * | 2000-03-31 | 2008-04-30 | The General Hospital Corp., Boston | Verfahren zur steigerung des haarwuchses durch wnt polypeptid |
| WO2003082234A1 (fr) * | 2002-03-28 | 2003-10-09 | Shiseido Co., Ltd. | Derives de phenylacetonitrile, tonique capillaire et preparations externes pour la peau contenant ces derives |
| JP2004248632A (ja) * | 2003-02-21 | 2004-09-09 | Osaka Industrial Promotion Organization | 男性型脱毛症治療薬のスクリーニング方法、男性型脱毛症治療薬の製造方法および男性型脱毛症治療薬。 |
| JP2005237273A (ja) * | 2004-02-26 | 2005-09-08 | Shiseido Co Ltd | 育毛剤の評価方法 |
| BRPI0418641C1 (pt) * | 2004-03-31 | 2009-11-24 | Reliance Life Sciences Pvt Ltd | equivalente tecidual tridimensional usando cultura de macromassa |
| JP4565112B2 (ja) * | 2004-09-15 | 2010-10-20 | 独立行政法人産業技術総合研究所 | 毛髪成長促進剤、発毛促進剤及び脱毛症治療剤 |
| JP2005021171A (ja) * | 2004-10-04 | 2005-01-27 | Shiseido Co Ltd | ヒト毛芽の活性化作用の検出方法 |
-
2007
- 2007-06-27 ES ES12155498.4T patent/ES2641528T3/es active Active
- 2007-06-27 US US12/306,649 patent/US8563309B2/en not_active Expired - Fee Related
- 2007-06-27 EP EP07768103.9A patent/EP2034011B1/en not_active Not-in-force
- 2007-06-27 WO PCT/JP2007/063333 patent/WO2008001938A1/ja not_active Ceased
- 2007-06-27 KR KR1020087028837A patent/KR101472594B1/ko active Active
- 2007-06-27 ES ES07768103T patent/ES2419232T3/es active Active
- 2007-06-27 EP EP12155498.4A patent/EP2455111B1/en not_active Not-in-force
- 2007-06-27 CN CNA2007800242047A patent/CN101479376A/zh active Pending
-
2012
- 2012-11-12 JP JP2012248660A patent/JP2013059337A/ja active Pending
-
2013
- 2013-02-04 JP JP2013019652A patent/JP2013078344A/ja active Pending
- 2013-09-18 US US14/030,449 patent/US20140106432A1/en not_active Abandoned
-
2015
- 2015-06-30 JP JP2015131234A patent/JP5976172B2/ja active Active
- 2015-07-01 US US14/788,925 patent/US10344266B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10344266B2 (en) | 2019-07-09 |
| US20090280469A1 (en) | 2009-11-12 |
| JP2013078344A (ja) | 2013-05-02 |
| JP2013059337A (ja) | 2013-04-04 |
| JP5976172B2 (ja) | 2016-08-23 |
| EP2034011A4 (en) | 2009-11-25 |
| US20140106432A1 (en) | 2014-04-17 |
| ES2419232T3 (es) | 2013-08-20 |
| EP2034011B1 (en) | 2013-05-22 |
| CN101479376A (zh) | 2009-07-08 |
| WO2008001938A1 (en) | 2008-01-03 |
| KR20090021340A (ko) | 2009-03-03 |
| JP2015165823A (ja) | 2015-09-24 |
| EP2455111B1 (en) | 2017-08-16 |
| EP2455111A2 (en) | 2012-05-23 |
| US8563309B2 (en) | 2013-10-22 |
| KR101472594B1 (ko) | 2014-12-15 |
| US20160160185A1 (en) | 2016-06-09 |
| EP2455111A3 (en) | 2012-06-13 |
| EP2034011A1 (en) | 2009-03-11 |
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