ES2626248T3 - Proceso para la purificación de glucoproteínas - Google Patents
Proceso para la purificación de glucoproteínas Download PDFInfo
- Publication number
- ES2626248T3 ES2626248T3 ES10788242.5T ES10788242T ES2626248T3 ES 2626248 T3 ES2626248 T3 ES 2626248T3 ES 10788242 T ES10788242 T ES 10788242T ES 2626248 T3 ES2626248 T3 ES 2626248T3
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- Prior art keywords
- chromatography
- glycoprotem
- regulator
- fsh
- size exclusion
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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| WO2012016576A1 (en) | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
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| AR100131A1 (es) * | 2014-04-18 | 2016-09-14 | Cadila Healthcare Ltd | Proceso de purificación de gonadotropina |
| EP3145950B1 (en) * | 2014-05-23 | 2019-01-09 | Instituto Massone S.A. | A process for obtaining hmg-up (human menopausal gonadotropin with ultra-purity grade) and a composition free of contaminants |
| CN108348465B (zh) | 2015-09-17 | 2020-11-10 | 葛莱高托普有限公司 | 具有提高的稳定性的哺乳动物促卵泡激素组合物 |
| PH12018502104B1 (en) * | 2016-03-31 | 2024-03-27 | Spark Therapeutics Inc | Column-based fully scalable raav manufacturing process |
| CN106008662A (zh) * | 2016-05-16 | 2016-10-12 | 南京农业大学 | 一种以枸杞蜂花粉为原料制备富锌中性糖蛋白的方法 |
| CN105968185A (zh) * | 2016-07-20 | 2016-09-28 | 宁波人健药业集团股份有限公司 | 一种绒促性素纯化方法 |
| CN106732464B (zh) * | 2017-02-02 | 2020-11-20 | 复旦大学 | 一种亲水树枝和c18修饰的磁性石墨烯材料及其制备方法和应用 |
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| EP4073083A1 (en) * | 2019-12-12 | 2022-10-19 | EMD Millipore Corporation | Intensified virus filtration using diafiltration buffer |
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| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| HK1000547A1 (en) | 1989-12-22 | 1998-04-03 | Merck Serono Sa | Endogenous gene expression modification with regulatory element by way of homologous recombination |
| DE69131978T2 (de) | 1990-05-08 | 2000-10-05 | University Of Medicine And Dentistry Of New Jersey, Newark | Glykoproteinhormon-analoga mit veränderten immunologischen merkmalen, veränderter wirksamkeit und/oder rezeptorspezifität |
| DE69231129D1 (de) | 1991-06-18 | 2000-07-06 | Univ New Jersey Med | Analoga von glykoproteinhormonen mit geänderter rezeptorbindungsspezifität und aktivität und verfahren zur darstellung und verwendung derselben |
| IL117849A (en) | 1995-04-14 | 2002-07-25 | Lepetit Spa | Chromatographic process for clearing glycoproteins |
| UA60311C2 (uk) * | 1996-10-02 | 2003-10-15 | Смітклайн Бічам Корпорейшн | Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція |
| IT1287138B1 (it) | 1996-11-07 | 1998-08-04 | Ibsa Inst Biochimique Sa | Procedimento per la separazione e purificazione di fsh e lh |
| TW518235B (en) | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| PT996629E (pt) | 1997-06-25 | 2006-12-29 | Applied Research Systems | Análogos de hormonas glicoproteicas reticulados com ligações dissulfito, sua preparação e utilização |
| US6414123B1 (en) | 1997-10-21 | 2002-07-02 | Vitro Diagnostics, Inc. | Method for purifying FSH |
| IL139432A0 (en) | 1998-05-07 | 2001-11-25 | Transkaryotic Therapies Inc | Modifying the expression of the fsh beta gene by homologous recombination |
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| EP1169349B1 (en) | 1999-04-16 | 2007-03-28 | Instituto Massone S.A. | Process for preparing gonadotropin compositions |
| WO2001058493A1 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
| SE0001660D0 (sv) | 2000-05-05 | 2000-05-05 | Gramineer Ab | Separation of glyco-containing entities |
| PT1610822E (pt) | 2003-04-02 | 2011-01-05 | Ares Trading Sa | Formulações farmacêuticas líquidas ou liofilizadas de fsh e/ou lh em conjunto com o surfactante não iónico poloxâmero 188 e um agente bacteriostático |
| ES2333128T3 (es) | 2003-12-22 | 2010-02-17 | Ares Trading S.A. | Metodo para purificar fsh. |
| NZ548513A (en) * | 2004-01-14 | 2010-05-28 | Univ Ohio | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
| WO2005110015A2 (en) * | 2004-04-19 | 2005-11-24 | Ohio University | Cross-linkable glycoproteins and methods of making the same |
| SI1809663T1 (sl) * | 2004-11-09 | 2009-02-28 | Ares Trading Sa | Postopek za äśiĺ äśenje fsh |
| US8604175B2 (en) | 2005-12-09 | 2013-12-10 | Ares Trading S.A. | Method for purifying FSH or a FSH mutant |
| JP5364382B2 (ja) | 2006-02-07 | 2013-12-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 遊離チオール部分を有するタンパク質の安定化された組成物 |
| PT2170942E (pt) | 2007-06-28 | 2013-10-22 | Biogenerix Ag | Clone celular produtor de fsh |
| DE102008002209A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur Aufreinigung von Erythropoietin |
-
2009
- 2009-11-24 EP EP09014585A patent/EP2325194A1/en not_active Withdrawn
-
2010
- 2010-11-24 JP JP2012539237A patent/JP5840135B2/ja not_active Expired - Fee Related
- 2010-11-24 ES ES10788242.5T patent/ES2626248T3/es active Active
- 2010-11-24 EP EP10788242.5A patent/EP2504350B1/en not_active Revoked
- 2010-11-24 WO PCT/EP2010/007115 patent/WO2011063943A1/en not_active Ceased
- 2010-11-24 AU AU2010324104A patent/AU2010324104C1/en not_active Ceased
- 2010-11-24 DK DK10788242.5T patent/DK2504350T3/en active
- 2010-11-24 US US13/511,285 patent/US8846344B2/en not_active Expired - Fee Related
- 2010-11-24 CA CA2781132A patent/CA2781132A1/en not_active Abandoned
- 2010-11-24 PL PL10788242T patent/PL2504350T3/pl unknown
- 2010-11-24 LT LTEP10788242.5T patent/LT2504350T/lt unknown
- 2010-11-24 CN CN201080056651.2A patent/CN102656182B/zh active Active
- 2010-11-24 KR KR1020127016158A patent/KR101860830B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102656182A (zh) | 2012-09-05 |
| KR101860830B1 (ko) | 2018-05-24 |
| JP2013511481A (ja) | 2013-04-04 |
| AU2010324104B2 (en) | 2015-02-19 |
| PL2504350T3 (pl) | 2017-08-31 |
| DK2504350T3 (en) | 2017-06-12 |
| CA2781132A1 (en) | 2011-06-03 |
| AU2010324104C1 (en) | 2015-06-11 |
| CN102656182B (zh) | 2015-03-18 |
| EP2504350A1 (en) | 2012-10-03 |
| US8846344B2 (en) | 2014-09-30 |
| JP5840135B2 (ja) | 2016-01-06 |
| EP2504350B1 (en) | 2017-05-10 |
| EP2325194A1 (en) | 2011-05-25 |
| LT2504350T (lt) | 2017-06-12 |
| US20120252069A1 (en) | 2012-10-04 |
| KR20120089755A (ko) | 2012-08-13 |
| AU2010324104A1 (en) | 2012-06-07 |
| WO2011063943A1 (en) | 2011-06-03 |
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