KR101860830B1 - 당단백질 정제 방법 - Google Patents

당단백질 정제 방법 Download PDF

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Publication number
KR101860830B1
KR101860830B1 KR1020127016158A KR20127016158A KR101860830B1 KR 101860830 B1 KR101860830 B1 KR 101860830B1 KR 1020127016158 A KR1020127016158 A KR 1020127016158A KR 20127016158 A KR20127016158 A KR 20127016158A KR 101860830 B1 KR101860830 B1 KR 101860830B1
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KR
South Korea
Prior art keywords
chromatography
glycoprotein
size exclusion
buffer
fsh
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020127016158A
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English (en)
Korean (ko)
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KR20120089755A (ko
Inventor
슈테펜 고레츠
라르스 슈퇴클
Original Assignee
글리코토페 게엠베하
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Application filed by 글리코토페 게엠베하 filed Critical 글리코토페 게엠베하
Publication of KR20120089755A publication Critical patent/KR20120089755A/ko
Application granted granted Critical
Publication of KR101860830B1 publication Critical patent/KR101860830B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020127016158A 2009-11-24 2010-11-24 당단백질 정제 방법 Expired - Fee Related KR101860830B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26393109P 2009-11-24 2009-11-24
US61/263,931 2009-11-24
EP09014585A EP2325194A1 (en) 2009-11-24 2009-11-24 Process for the purification of glycoproteins
EP09014585.5 2009-11-24
PCT/EP2010/007115 WO2011063943A1 (en) 2009-11-24 2010-11-24 Process for the purification of glycoproteins

Publications (2)

Publication Number Publication Date
KR20120089755A KR20120089755A (ko) 2012-08-13
KR101860830B1 true KR101860830B1 (ko) 2018-05-24

Family

ID=42173838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127016158A Expired - Fee Related KR101860830B1 (ko) 2009-11-24 2010-11-24 당단백질 정제 방법

Country Status (12)

Country Link
US (1) US8846344B2 (enExample)
EP (2) EP2325194A1 (enExample)
JP (1) JP5840135B2 (enExample)
KR (1) KR101860830B1 (enExample)
CN (1) CN102656182B (enExample)
AU (1) AU2010324104C1 (enExample)
CA (1) CA2781132A1 (enExample)
DK (1) DK2504350T3 (enExample)
ES (1) ES2626248T3 (enExample)
LT (1) LT2504350T (enExample)
PL (1) PL2504350T3 (enExample)
WO (1) WO2011063943A1 (enExample)

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US7470672B2 (en) 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN104101656A (zh) * 2013-04-01 2014-10-15 上海天伟生物制药有限公司 一种促性腺激素的纯度测定方法
EP3131571A1 (en) 2014-04-18 2017-02-22 Glycotope GmbH Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone
AR100131A1 (es) * 2014-04-18 2016-09-14 Cadila Healthcare Ltd Proceso de purificación de gonadotropina
EP3145950B1 (en) * 2014-05-23 2019-01-09 Instituto Massone S.A. A process for obtaining hmg-up (human menopausal gonadotropin with ultra-purity grade) and a composition free of contaminants
CN108348465B (zh) 2015-09-17 2020-11-10 葛莱高托普有限公司 具有提高的稳定性的哺乳动物促卵泡激素组合物
PH12018502104B1 (en) * 2016-03-31 2024-03-27 Spark Therapeutics Inc Column-based fully scalable raav manufacturing process
CN106008662A (zh) * 2016-05-16 2016-10-12 南京农业大学 一种以枸杞蜂花粉为原料制备富锌中性糖蛋白的方法
CN105968185A (zh) * 2016-07-20 2016-09-28 宁波人健药业集团股份有限公司 一种绒促性素纯化方法
CN106732464B (zh) * 2017-02-02 2020-11-20 复旦大学 一种亲水树枝和c18修饰的磁性石墨烯材料及其制备方法和应用
US11385238B2 (en) * 2017-06-30 2022-07-12 Amgen Inc. Methods of protein clips recovery
CN110563832B (zh) * 2019-07-31 2025-11-14 江苏璟泽生物医药有限公司 一种高纯度重组促卵泡刺激素纯化方法
EP4073083A1 (en) * 2019-12-12 2022-10-19 EMD Millipore Corporation Intensified virus filtration using diafiltration buffer
EP3964523A1 (en) * 2020-09-04 2022-03-09 PreviPharma Consulting GmbH Preparation of fetuin a by hydrophobic interaction chromatography
CN114835796A (zh) * 2022-05-05 2022-08-02 江苏尤里卡生物科技有限公司 一种促性腺激素纯化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110015A2 (en) * 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same

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US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4840896A (en) 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
AU606099B2 (en) * 1986-12-07 1991-01-31 Japan Science And Technology Corporation Colony-stimulating factor and method for preparation thereof
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
HK1000547A1 (en) 1989-12-22 1998-04-03 Merck Serono Sa Endogenous gene expression modification with regulatory element by way of homologous recombination
DE69131978T2 (de) 1990-05-08 2000-10-05 University Of Medicine And Dentistry Of New Jersey, Newark Glykoproteinhormon-analoga mit veränderten immunologischen merkmalen, veränderter wirksamkeit und/oder rezeptorspezifität
DE69231129D1 (de) 1991-06-18 2000-07-06 Univ New Jersey Med Analoga von glykoproteinhormonen mit geänderter rezeptorbindungsspezifität und aktivität und verfahren zur darstellung und verwendung derselben
IL117849A (en) 1995-04-14 2002-07-25 Lepetit Spa Chromatographic process for clearing glycoproteins
UA60311C2 (uk) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
TW518235B (en) 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
PT996629E (pt) 1997-06-25 2006-12-29 Applied Research Systems Análogos de hormonas glicoproteicas reticulados com ligações dissulfito, sua preparação e utilização
US6414123B1 (en) 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
IL139432A0 (en) 1998-05-07 2001-11-25 Transkaryotic Therapies Inc Modifying the expression of the fsh beta gene by homologous recombination
PL346127A1 (en) 1998-07-23 2002-01-28 Lilly Co Eli Fsh and fsh variant formulations, products and methods
EP1169349B1 (en) 1999-04-16 2007-03-28 Instituto Massone S.A. Process for preparing gonadotropin compositions
WO2001058493A1 (en) 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
SE0001660D0 (sv) 2000-05-05 2000-05-05 Gramineer Ab Separation of glyco-containing entities
PT1610822E (pt) 2003-04-02 2011-01-05 Ares Trading Sa Formulações farmacêuticas líquidas ou liofilizadas de fsh e/ou lh em conjunto com o surfactante não iónico poloxâmero 188 e um agente bacteriostático
ES2333128T3 (es) 2003-12-22 2010-02-17 Ares Trading S.A. Metodo para purificar fsh.
NZ548513A (en) * 2004-01-14 2010-05-28 Univ Ohio Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
SI1809663T1 (sl) * 2004-11-09 2009-02-28 Ares Trading Sa Postopek za äśiĺ äśenje fsh
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
JP5364382B2 (ja) 2006-02-07 2013-12-11 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 遊離チオール部分を有するタンパク質の安定化された組成物
PT2170942E (pt) 2007-06-28 2013-10-22 Biogenerix Ag Clone celular produtor de fsh
DE102008002209A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110015A2 (en) * 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same

Also Published As

Publication number Publication date
CN102656182A (zh) 2012-09-05
JP2013511481A (ja) 2013-04-04
AU2010324104B2 (en) 2015-02-19
PL2504350T3 (pl) 2017-08-31
ES2626248T3 (es) 2017-07-24
DK2504350T3 (en) 2017-06-12
CA2781132A1 (en) 2011-06-03
AU2010324104C1 (en) 2015-06-11
CN102656182B (zh) 2015-03-18
EP2504350A1 (en) 2012-10-03
US8846344B2 (en) 2014-09-30
JP5840135B2 (ja) 2016-01-06
EP2504350B1 (en) 2017-05-10
EP2325194A1 (en) 2011-05-25
LT2504350T (lt) 2017-06-12
US20120252069A1 (en) 2012-10-04
KR20120089755A (ko) 2012-08-13
AU2010324104A1 (en) 2012-06-07
WO2011063943A1 (en) 2011-06-03

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US20120329092A1 (en) Process for the purification of glycoproteins
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