CN102656182B - 纯化糖蛋白的方法 - Google Patents

纯化糖蛋白的方法 Download PDF

Info

Publication number
CN102656182B
CN102656182B CN201080056651.2A CN201080056651A CN102656182B CN 102656182 B CN102656182 B CN 102656182B CN 201080056651 A CN201080056651 A CN 201080056651A CN 102656182 B CN102656182 B CN 102656182B
Authority
CN
China
Prior art keywords
chromatography
steps
fsh
gonad
stimulating hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080056651.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN102656182A (zh
Inventor
S·戈勒兹
L·施特克尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cantonbio Co ltd
Original Assignee
Glycotope GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42173838&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102656182(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glycotope GmbH filed Critical Glycotope GmbH
Publication of CN102656182A publication Critical patent/CN102656182A/zh
Application granted granted Critical
Publication of CN102656182B publication Critical patent/CN102656182B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201080056651.2A 2009-11-24 2010-11-24 纯化糖蛋白的方法 Active CN102656182B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26393109P 2009-11-24 2009-11-24
EP09014585.5 2009-11-24
EP09014585A EP2325194A1 (en) 2009-11-24 2009-11-24 Process for the purification of glycoproteins
US61/263,931 2009-11-24
PCT/EP2010/007115 WO2011063943A1 (en) 2009-11-24 2010-11-24 Process for the purification of glycoproteins

Publications (2)

Publication Number Publication Date
CN102656182A CN102656182A (zh) 2012-09-05
CN102656182B true CN102656182B (zh) 2015-03-18

Family

ID=42173838

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080056651.2A Active CN102656182B (zh) 2009-11-24 2010-11-24 纯化糖蛋白的方法

Country Status (12)

Country Link
US (1) US8846344B2 (enExample)
EP (2) EP2325194A1 (enExample)
JP (1) JP5840135B2 (enExample)
KR (1) KR101860830B1 (enExample)
CN (1) CN102656182B (enExample)
AU (1) AU2010324104C1 (enExample)
CA (1) CA2781132A1 (enExample)
DK (1) DK2504350T3 (enExample)
ES (1) ES2626248T3 (enExample)
LT (1) LT2504350T (enExample)
PL (1) PL2504350T3 (enExample)
WO (1) WO2011063943A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470672B2 (en) 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN104101656A (zh) * 2013-04-01 2014-10-15 上海天伟生物制药有限公司 一种促性腺激素的纯度测定方法
SG11201608132UA (en) 2014-04-18 2016-11-29 Glycotope Gmbh Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone
BR112016023680A2 (pt) * 2014-04-18 2017-08-15 Cadila Healthcare Ltd ?processo de purificação de gonadotropina?
ES2719748T3 (es) * 2014-05-23 2019-07-12 Inst Massone S A Proceso para obtener HMG-UP (gonadotropina menopáusica humana con grado de ultrapureza) y una composición libre de contaminantes
US20180264086A1 (en) 2015-09-17 2018-09-20 Glycotope Gmbh Mammalian follicle-stimulating hormone composition with increased stability
HUE056854T2 (hu) * 2016-03-31 2022-03-28 Spark Therapeutics Inc Oszlop alapú, teljes mértékben méretezhetõ rAAV elõállítási eljárás
CN106008662A (zh) * 2016-05-16 2016-10-12 南京农业大学 一种以枸杞蜂花粉为原料制备富锌中性糖蛋白的方法
CN105968185A (zh) * 2016-07-20 2016-09-28 宁波人健药业集团股份有限公司 一种绒促性素纯化方法
CN106732464B (zh) * 2017-02-02 2020-11-20 复旦大学 一种亲水树枝和c18修饰的磁性石墨烯材料及其制备方法和应用
US11385238B2 (en) * 2017-06-30 2022-07-12 Amgen Inc. Methods of protein clips recovery
CN110563832B (zh) * 2019-07-31 2025-11-14 江苏璟泽生物医药有限公司 一种高纯度重组促卵泡刺激素纯化方法
CN114829371A (zh) * 2019-12-12 2022-07-29 Emd密理博公司 使用透析过滤缓冲液强化的病毒过滤
EP3964523A1 (en) * 2020-09-04 2022-03-09 PreviPharma Consulting GmbH Preparation of fetuin a by hydrophobic interaction chromatography
CN114835796A (zh) * 2022-05-05 2022-08-02 江苏尤里卡生物科技有限公司 一种促性腺激素纯化方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276551A1 (en) * 1986-12-07 1988-08-03 Morinaga Milk Industry Co., Ltd. Colony-stimulating factor and method for preparation thereof
CN1890265A (zh) * 2003-12-22 2007-01-03 阿雷斯贸易股份有限公司 Fsh的纯化方法
CN101087805A (zh) * 2004-11-09 2007-12-12 阿雷斯贸易股份有限公司 Fsh的纯化方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4840896A (en) 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
RU2128227C1 (ru) 1989-12-22 1999-03-27 Апплайд Резеч Системз АРС Холдинг Н.В. (NL) (Антильские острова) Способ активации транскрипционно-молчащего гена
EP0531407B1 (en) 1990-05-08 2000-02-09 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity
EP0673383B1 (en) 1991-06-18 2000-05-31 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
IL117849A (en) 1995-04-14 2002-07-25 Lepetit Spa Chromatographic process for clearing glycoproteins
UA60311C2 (uk) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
TW518235B (en) 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US8530190B1 (en) 1997-06-25 2013-09-10 Merck Serono Sa Disulfide crosslinked glycoprotein hormone analogs, and their preparation and use
US6414123B1 (en) 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
RU2229309C2 (ru) 1998-05-07 2004-05-27 Транскариотик Терапиз, Инк. МОДИФИЦИРОВАНИЕ ЭКСПРЕССИИ ГЕНА FSHβ С ПОМОЩЬЮ ГОМОЛОГИЧНОЙ РЕКОМБИНАЦИИ
BR9912243A (pt) 1998-07-23 2001-10-16 Lilly Co Eli Formulações de fsh e variantes de fsh, produtos e processos
ES2284494T3 (es) 1999-04-16 2007-11-16 Instituto Massone S.A. Procedimiento para preparar composiciones de gonadotropina.
AU2001231531A1 (en) 2000-02-11 2001-08-20 Maxygen Aps Follicle stimulating hormones
SE0001660D0 (sv) 2000-05-05 2000-05-05 Gramineer Ab Separation of glyco-containing entities
ME00217B (me) 2003-04-02 2011-02-10 Ares Trading Sa TEČNE FARMACEUTSKE FORMULACIJE FSH i LH ZAJEDNO SA NEJONSKIM SURFAKTANTOM
WO2005069845A2 (en) * 2004-01-14 2005-08-04 Ohio University Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
CA2573918A1 (en) * 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
SI1986612T1 (sl) 2006-02-07 2013-01-31 Shire Human Genetic Therapies, Inc. Stabilizirana spojina glukocerebrosidaze
SI2170942T1 (sl) 2007-06-28 2013-12-31 Biogenerix Ag Produkcija celičnega klona folikle stimulirajočega hormona FSH
DE102008002209A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276551A1 (en) * 1986-12-07 1988-08-03 Morinaga Milk Industry Co., Ltd. Colony-stimulating factor and method for preparation thereof
CN1890265A (zh) * 2003-12-22 2007-01-03 阿雷斯贸易股份有限公司 Fsh的纯化方法
CN101087805A (zh) * 2004-11-09 2007-12-12 阿雷斯贸易股份有限公司 Fsh的纯化方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
糖蛋白激素的不均一性及其色谱分离纯化研究的进展;阎哲等;《化学进展》;19991231;第19卷(第2期);第7页第2段、最后一段、图2，第8页第2-4段， *

Also Published As

Publication number Publication date
KR101860830B1 (ko) 2018-05-24
LT2504350T (lt) 2017-06-12
DK2504350T3 (en) 2017-06-12
AU2010324104C1 (en) 2015-06-11
EP2504350B1 (en) 2017-05-10
EP2504350A1 (en) 2012-10-03
ES2626248T3 (es) 2017-07-24
WO2011063943A1 (en) 2011-06-03
AU2010324104B2 (en) 2015-02-19
JP2013511481A (ja) 2013-04-04
CN102656182A (zh) 2012-09-05
AU2010324104A1 (en) 2012-06-07
PL2504350T3 (pl) 2017-08-31
JP5840135B2 (ja) 2016-01-06
US8846344B2 (en) 2014-09-30
CA2781132A1 (en) 2011-06-03
KR20120089755A (ko) 2012-08-13
US20120252069A1 (en) 2012-10-04
EP2325194A1 (en) 2011-05-25

Similar Documents

Publication Publication Date Title
CN102656182B (zh) 纯化糖蛋白的方法
CN101087805B (zh) Fsh的纯化方法
CN102448979B (zh) 纯化重组促卵泡激素的方法
EP1960419B1 (en) Method for purifying fsh or a fsh mutant
US20120329092A1 (en) Process for the purification of glycoproteins
CN110563832B (zh) 一种高纯度重组促卵泡刺激素纯化方法
JP4933439B2 (ja) Ｆｓｈの精製方法
HK1108704B (en) Method for purifying fsh

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20221216

Address after: Room 301, Building B, No. 19, Nanxiang Third Road, Huangpu District, Guangzhou, Guangdong

Patentee after: CANTONBIO Co.,Ltd.

Address before: Berlin, Germany

Patentee before: GLYCOTOPE GmbH

TR01 Transfer of patent right