AR100131A1 - Proceso de purificación de gonadotropina - Google Patents
Proceso de purificación de gonadotropinaInfo
- Publication number
- AR100131A1 AR100131A1 ARP150101169A ARP150101169A AR100131A1 AR 100131 A1 AR100131 A1 AR 100131A1 AR P150101169 A ARP150101169 A AR P150101169A AR P150101169 A ARP150101169 A AR P150101169A AR 100131 A1 AR100131 A1 AR 100131A1
- Authority
- AR
- Argentina
- Prior art keywords
- steps
- chromatography
- gonadotropin
- purification process
- column chromatography
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 4
- 102000006771 Gonadotropins Human genes 0.000 abstract 3
- 108010086677 Gonadotropins Proteins 0.000 abstract 3
- 238000001042 affinity chromatography Methods 0.000 abstract 3
- 239000002622 gonadotropin Substances 0.000 abstract 3
- 238000004440 column chromatography Methods 0.000 abstract 2
- 238000011026 diafiltration Methods 0.000 abstract 2
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 238000005349 anion exchange Methods 0.000 abstract 1
- 238000005571 anion exchange chromatography Methods 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 238000011210 chromatographic step Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000001471 micro-filtration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000001728 nano-filtration Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Reivindicación 1: Un proceso de purificación de gonadotropina caracterizado porque comprende los siguientes pasos esenciales: (a) cromatografía de afinidad; (b) cromatografía de intercambio aniónico, seguido de otros pasos de purificación adecuados. Reivindicación 9: El proceso de purificación de gonadotropina de acuerdo con cualquiera de las reivindicaciones anteriores, a partir de una mezcla cruda, caracterizado porque comprende los siguientes pasos: (a) separación de células y reacondicionamiento; (b) cromatografía en columna de afinidad; (c) ultrafiltración-diafiltración y reacondicionamiento; (d) inactivación viral; (e) cromatografía en columna de intercambio aniónico (AEX); (f) reacondicionamiento; (g) cromatografía en columna de interacción hidrofóbica (HIC); (h) ultrafiltración-diafiltración; (i) nanofiltración; (j) microfiltración en donde los pasos de cromatografía de intercambio aniónico e hidrofóbica se pueden llevar a cabo en cualquier orden después del paso de cromatografía de afinidad; y los pasos (c) a (j) se pueden llevar a cabo en cualquier orden. Reivindicación 14: El proceso de acuerdo con cualquier reivindicación anterior, caracterizado porque la gonadotropina se selecciona entre r-hFSH, u-FSH, r-hLH, u-LH, r-hHCG y u-HCG.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1398MU2014 | 2014-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100131A1 true AR100131A1 (es) | 2016-09-14 |
Family
ID=53773477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101169A AR100131A1 (es) | 2014-04-18 | 2015-04-17 | Proceso de purificación de gonadotropina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20170029482A1 (es) |
| EP (1) | EP3131924A1 (es) |
| JP (1) | JP2017514803A (es) |
| KR (1) | KR20160131113A (es) |
| CN (1) | CN106170493A (es) |
| AR (1) | AR100131A1 (es) |
| AU (1) | AU2015248461B2 (es) |
| BR (1) | BR112016023680A2 (es) |
| CA (1) | CA2945591A1 (es) |
| EA (1) | EA201691834A1 (es) |
| IL (1) | IL248293A (es) |
| MX (1) | MX2016013416A (es) |
| MY (1) | MY183011A (es) |
| SG (1) | SG11201608513WA (es) |
| WO (1) | WO2015159309A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108503705A (zh) * | 2018-07-10 | 2018-09-07 | 北京伟杰信生物科技有限公司 | 一种重组绒促性素（rhCG）的纯化方法 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105968185A (zh) * | 2016-07-20 | 2016-09-28 | 宁波人健药业集团股份有限公司 | 一种绒促性素纯化方法 |
| KR20210083174A (ko) * | 2019-12-26 | 2021-07-06 | 주식회사 엘지화학 | 여포 자극 호르몬의 정제 방법 |
| CN111303274B (zh) * | 2020-03-21 | 2024-01-30 | 上海浦东明炎生物技术有限公司 | 一种人绒毛膜促性腺激素纯化方法 |
| CN114591414A (zh) * | 2022-03-24 | 2022-06-07 | 江西浩然生物制药有限公司 | 一种人绒毛膜促性腺激素的制备方法 |
| CN116143901A (zh) * | 2022-11-28 | 2023-05-23 | 景泽生物医药(合肥)股份有限公司 | 一种促卵泡激素的纯化方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060003086A1 (en) | 2003-07-15 | 2006-01-05 | Matsushita Electric Industrial Co., Ltd. | Method for manufacturing plasma display panel |
| CN100554277C (zh) * | 2003-12-22 | 2009-10-28 | 阿雷斯贸易股份有限公司 | Fsh的纯化方法 |
| EP1809663B1 (en) | 2004-11-09 | 2008-09-17 | Ares Trading S.A. | Method for purifying fsh |
| US8604175B2 (en) * | 2005-12-09 | 2013-12-10 | Ares Trading S.A. | Method for purifying FSH or a FSH mutant |
| UA106369C2 (ru) * | 2009-04-01 | 2014-08-26 | Рациофарм Гмбх | Способ очистки рекомбинантного фсг |
| EP2325194A1 (en) * | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Process for the purification of glycoproteins |
| CN102464713A (zh) * | 2010-12-21 | 2012-05-23 | 上海丽珠制药有限公司 | 一种卵泡刺激素的制备方法 |
| CN103059125B (zh) * | 2012-12-27 | 2015-08-12 | 浙江海正药业股份有限公司 | 重组人促卵泡激素的纯化方法 |
-
2015
- 2015-04-17 WO PCT/IN2015/000175 patent/WO2015159309A1/en active Application Filing
- 2015-04-17 CA CA2945591A patent/CA2945591A1/en not_active Abandoned
- 2015-04-17 MY MYPI2016001842A patent/MY183011A/en unknown
- 2015-04-17 EA EA201691834A patent/EA201691834A1/ru unknown
- 2015-04-17 CN CN201580019503.6A patent/CN106170493A/zh active Pending
- 2015-04-17 AU AU2015248461A patent/AU2015248461B2/en not_active Ceased
- 2015-04-17 KR KR1020167028363A patent/KR20160131113A/ko active Search and Examination
- 2015-04-17 MX MX2016013416A patent/MX2016013416A/es unknown
- 2015-04-17 SG SG11201608513WA patent/SG11201608513WA/en unknown
- 2015-04-17 US US15/303,888 patent/US20170029482A1/en not_active Abandoned
- 2015-04-17 AR ARP150101169A patent/AR100131A1/es unknown
- 2015-04-17 BR BR112016023680A patent/BR112016023680A2/pt not_active Application Discontinuation
- 2015-04-17 JP JP2016562233A patent/JP2017514803A/ja active Pending
- 2015-04-17 EP EP15745250.9A patent/EP3131924A1/en not_active Withdrawn
-
2016
- 2016-10-10 IL IL248293A patent/IL248293A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108503705A (zh) * | 2018-07-10 | 2018-09-07 | 北京伟杰信生物科技有限公司 | 一种重组绒促性素（rhCG）的纯化方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015248461B2 (en) | 2017-05-04 |
| CN106170493A (zh) | 2016-11-30 |
| SG11201608513WA (en) | 2016-11-29 |
| EP3131924A1 (en) | 2017-02-22 |
| WO2015159309A1 (en) | 2015-10-22 |
| KR20160131113A (ko) | 2016-11-15 |
| BR112016023680A2 (pt) | 2017-08-15 |
| US20170029482A1 (en) | 2017-02-02 |
| EA201691834A1 (ru) | 2017-02-28 |
| IL248293A (en) | 2017-04-30 |
| CA2945591A1 (en) | 2015-10-22 |
| AU2015248461A1 (en) | 2016-11-03 |
| MX2016013416A (es) | 2017-01-18 |
| JP2017514803A (ja) | 2017-06-08 |
| MY183011A (en) | 2021-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |