DE602004030673D1 - Flüssige oder gefriergetrocknete pharmazeutische zusammensetzung enthaltend fsh und/oder lh, das nichtionische tensid poloxamer 188 und ein antibakterielles mittel - Google Patents
Flüssige oder gefriergetrocknete pharmazeutische zusammensetzung enthaltend fsh und/oder lh, das nichtionische tensid poloxamer 188 und ein antibakterielles mittelInfo
- Publication number
- DE602004030673D1 DE602004030673D1 DE602004030673T DE602004030673T DE602004030673D1 DE 602004030673 D1 DE602004030673 D1 DE 602004030673D1 DE 602004030673 T DE602004030673 T DE 602004030673T DE 602004030673 T DE602004030673 T DE 602004030673T DE 602004030673 D1 DE602004030673 D1 DE 602004030673D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical
- poloxamer
- freeze
- liquid
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 239000007788 liquid Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000005498 polishing Methods 0.000 title 1
- 229920001993 poloxamer 188 Polymers 0.000 title 1
- 229940044519 poloxamer 188 Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03100882 | 2003-04-02 | ||
EP03101543 | 2003-05-27 | ||
EP03101828 | 2003-06-20 | ||
PCT/EP2004/050432 WO2004087213A1 (en) | 2003-04-02 | 2004-04-02 | Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004030673D1 true DE602004030673D1 (de) | 2011-02-03 |
Family
ID=33135521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004030673T Expired - Lifetime DE602004030673D1 (de) | 2003-04-02 | 2004-04-02 | Flüssige oder gefriergetrocknete pharmazeutische zusammensetzung enthaltend fsh und/oder lh, das nichtionische tensid poloxamer 188 und ein antibakterielles mittel |
Country Status (25)
Country | Link |
---|---|
US (1) | US7741268B2 (de) |
EP (1) | EP1610822B2 (de) |
JP (1) | JP4699991B2 (de) |
KR (1) | KR101105486B1 (de) |
AR (1) | AR043972A1 (de) |
AT (1) | ATE492292T2 (de) |
AU (1) | AU2004226666B9 (de) |
BR (1) | BRPI0409532B8 (de) |
CA (1) | CA2518903C (de) |
CY (1) | CY1111291T1 (de) |
DE (1) | DE602004030673D1 (de) |
DK (1) | DK1610822T4 (de) |
EA (1) | EA012565B1 (de) |
HK (1) | HK1086503A1 (de) |
HR (1) | HRP20100727T4 (de) |
IL (1) | IL171151A (de) |
ME (1) | ME00217B (de) |
MX (1) | MXPA05010635A (de) |
NO (1) | NO330214B1 (de) |
NZ (1) | NZ542247A (de) |
PL (1) | PL1610822T5 (de) |
PT (1) | PT1610822E (de) |
RS (2) | RS57872B1 (de) |
SI (1) | SI1610822T2 (de) |
WO (1) | WO2004087213A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200640492A (en) * | 2005-02-21 | 2006-12-01 | Lg Life Sciences Ltd | Sustained release composition of protein drug |
TWI369401B (en) * | 2005-07-05 | 2012-08-01 | Ares Trading Sa | Serum-free culture medium for the production of recombinant gonadotropins |
US7866203B2 (en) | 2005-09-14 | 2011-01-11 | Ares Trading S.A. | Method for the quantitative determination of poloxamers |
KR101105871B1 (ko) * | 2005-09-27 | 2012-01-16 | 주식회사 엘지생명과학 | 인 난포자극호르몬의 안정한 용액 제형 |
AU2008320844B2 (en) * | 2007-11-01 | 2013-08-29 | Merck Serono S.A. | LH liquid formulations |
PL2249869T3 (pl) * | 2008-02-08 | 2012-02-29 | Theramex Hq Uk Ltd | Ciekły preparat FSH |
CN101269215B (zh) * | 2008-05-15 | 2011-03-23 | 上海天伟生物制药有限公司 | 一种糖蛋白激素组合物 |
CN102309747B (zh) * | 2008-09-17 | 2013-04-17 | 上海天伟生物制药有限公司 | 高纯度绝经期促性腺素冻干针剂 |
AU2009312235B2 (en) * | 2008-11-04 | 2014-01-16 | Aska Pharmaceutical Co., Ltd. | Aqueous composition containing follicle-stimulating hormone |
ME02277B (me) | 2009-04-01 | 2016-02-20 | Ratiopharm Gmbh | Postupak za prečišćavanje rekombinantnog fsh |
EP2325194A1 (de) | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Verfahren zur Reinigung von Glykoproteinen |
WO2011076117A1 (zh) * | 2009-12-22 | 2011-06-30 | 上海天伟生物制药有限公司 | 绝经期促性腺素组合物 |
WO2012127500A2 (en) * | 2011-03-11 | 2012-09-27 | Sanzyme Limited | Composition for spermatogenesis |
WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
JP6166470B2 (ja) * | 2013-11-12 | 2017-07-19 | カディラ ヘルスケア リミティド | ゴナドトロピンのための新規製剤 |
JP6647220B2 (ja) * | 2014-05-23 | 2020-02-14 | インスティトゥート・マッソーネ・エセ・ア | Hmg−up(超高純度グレードのヒト閉経期ゴナドトロピン)を得るための方法及び夾雑物を含まない組成物 |
US11376220B2 (en) | 2017-06-30 | 2022-07-05 | Therio, LLC | Single-injection methods and formulations to induce and control multiple ovarian follicles in bovine, caprine, ovine, camelid and other female animals |
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GB839300A (en) | 1957-09-05 | 1960-06-29 | Organon Labor Ltd | Adrenocorticotropic hormone preparations and process for making same |
FR3819M (fr) * | 1963-03-11 | 1966-01-10 | Serono Ist Farm | Nouvelle hormone hypophysaire a activité différenciée. |
EP0082481B2 (de) | 1981-12-23 | 1990-09-12 | Schering Corporation | Stabilisierte alpha-Interferon-Zusammensetzungen und ihre Herstellung |
JPS5921613A (ja) | 1982-07-28 | 1984-02-03 | Takeda Chem Ind Ltd | 直腸投与製剤 |
US4659696A (en) | 1982-04-30 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition and its nasal or vaginal use |
US4746508A (en) | 1983-06-06 | 1988-05-24 | Beth Israel Hospital Assn. | Drug administration |
US5639639A (en) | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
US4839341A (en) | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
US4589402A (en) | 1984-07-26 | 1986-05-20 | Serono Laboratories, Inc. | Method of in vitro fertilization |
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US5162306A (en) | 1987-01-23 | 1992-11-10 | Donaldson Lloyd E | Composition and method for producing superovulation in mammals |
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IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
DE3863908D1 (de) | 1987-11-27 | 1991-08-29 | Akzo Nv | Stabilisierung von antikoerpern. |
US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
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IE64738B1 (en) * | 1990-03-20 | 1995-09-06 | Akzo Nv | Stabilized gonadotropin containing preparations |
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MY120063A (en) | 1997-12-09 | 2005-08-30 | Lilly Co Eli | Stabilized teriparatide solutions |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
WO2000004913A1 (en) * | 1998-07-23 | 2000-02-03 | Eli Lilly And Company | Fsh and fsh variant formulations, products and methods |
US20020165146A1 (en) * | 1998-07-23 | 2002-11-07 | Hoffman James Arthur | FSH article of manufacture |
FR2782455B3 (fr) * | 1998-08-20 | 2000-09-15 | Sanofi Sa | Composition pharmaceutique injectable a base d'un sel pharmaceutiquement acceptable du clopidogrel ou de ticlopidine |
WO2000015224A1 (en) | 1998-09-17 | 2000-03-23 | Eli Lilly And Company | Protein formulations |
DE60043106D1 (de) | 1999-06-30 | 2009-11-19 | Takeda Pharmaceutical | Polypeptide und deren dna |
US6573237B2 (en) | 2001-03-16 | 2003-06-03 | Eli Lilly And Company | Protein formulations |
JP2005517012A (ja) | 2002-02-08 | 2005-06-09 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | 持続放出のためのポリマーベース組成物 |
-
2004
- 2004-04-02 KR KR1020057018794A patent/KR101105486B1/ko active IP Right Grant
- 2004-04-02 AT AT04725385T patent/ATE492292T2/de active
- 2004-04-02 AU AU2004226666A patent/AU2004226666B9/en not_active Expired
- 2004-04-02 US US10/551,840 patent/US7741268B2/en not_active Expired - Lifetime
- 2004-04-02 NZ NZ542247A patent/NZ542247A/en unknown
- 2004-04-02 DE DE602004030673T patent/DE602004030673D1/de not_active Expired - Lifetime
- 2004-04-02 AR ARP040101138A patent/AR043972A1/es not_active Application Discontinuation
- 2004-04-02 MX MXPA05010635A patent/MXPA05010635A/es active IP Right Grant
- 2004-04-02 PT PT04725385T patent/PT1610822E/pt unknown
- 2004-04-02 CA CA2518903A patent/CA2518903C/en not_active Expired - Fee Related
- 2004-04-02 ME MEP-2008-317A patent/ME00217B/me unknown
- 2004-04-02 JP JP2006505517A patent/JP4699991B2/ja not_active Expired - Lifetime
- 2004-04-02 RS RS20050737A patent/RS57872B1/sr unknown
- 2004-04-02 SI SI200431587T patent/SI1610822T2/sl unknown
- 2004-04-02 BR BRPI0409532A patent/BRPI0409532B8/pt active IP Right Grant
- 2004-04-02 DK DK04725385.1T patent/DK1610822T4/en active
- 2004-04-02 PL PL04725385T patent/PL1610822T5/pl unknown
- 2004-04-02 RS YUP-2005/0737A patent/RS20050737A/sr unknown
- 2004-04-02 EP EP04725385.1A patent/EP1610822B2/de not_active Expired - Lifetime
- 2004-04-02 WO PCT/EP2004/050432 patent/WO2004087213A1/en active Application Filing
- 2004-04-02 EA EA200501531A patent/EA012565B1/ru unknown
-
2005
- 2005-09-28 IL IL171151A patent/IL171151A/en active IP Right Grant
- 2005-10-26 NO NO20054982A patent/NO330214B1/no unknown
-
2006
- 2006-08-08 HK HK06108755.2A patent/HK1086503A1/xx not_active IP Right Cessation
-
2010
- 2010-12-27 HR HRP20100727TT patent/HRP20100727T4/hr unknown
-
2011
- 2011-01-12 CY CY20111100039T patent/CY1111291T1/el unknown
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