GB839300A - Adrenocorticotropic hormone preparations and process for making same - Google Patents
Adrenocorticotropic hormone preparations and process for making sameInfo
- Publication number
- GB839300A GB839300A GB27188/58A GB2718858A GB839300A GB 839300 A GB839300 A GB 839300A GB 27188/58 A GB27188/58 A GB 27188/58A GB 2718858 A GB2718858 A GB 2718858A GB 839300 A GB839300 A GB 839300A
- Authority
- GB
- United Kingdom
- Prior art keywords
- zinc
- acth
- preparation
- sodium chloride
- hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
An ACTH preparation comprises a substantially water-insoluble complex of ACTH and an electrolytically prepared alpha-zinc hydroxide or basic zinc salt. The preparation is for subcutaneous or intramuscular injection and is characterized by its ease of suspension and resistance to breakdown when subjected to alternate freezing and thawing. The alphazinc hydroxide may be prepared in an electrolytic cell having a zinc anode, a platinum or other inert cathode, e.g. silver, gold or graphite, and an electrolyte which may have an initial pH from 2 to 5, containing aqueous sodium chloride or other pharmaceutically acceptable electrolyte, which may have a normality of 0.01 to 2.0 N. The ACTH may be present in amount of 20 to 80 u.s.p. units for each 0.2 to 3.0 mg. of elemental zinc, and may be added to the zinc compound within a few minutes of the preparation thereof, or may be present in the cell when the zinc compound is formed. Other compatible materials such as preservatives, e.g. phenol or benzyl alcohol, isotomicity producing substances, e.g. sodium chloride, glycerol, buffers or local an thetics, e.g. procaine hydrochloride.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US839300XA | 1957-09-05 | 1957-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB839300A true GB839300A (en) | 1960-06-29 |
Family
ID=22181582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27188/58A Expired GB839300A (en) | 1957-09-05 | 1958-08-25 | Adrenocorticotropic hormone preparations and process for making same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB839300A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0974359B1 (en) * | 1998-07-23 | 2002-12-04 | Eli Lilly And Company | FSH and FSH variant formulations comprising benzyl alcohol as a preservative |
| US7446090B2 (en) | 1998-07-23 | 2008-11-04 | Ares Trading S.A. | FSH formulation |
| US7740884B2 (en) | 2003-06-20 | 2010-06-22 | Ares Trading S.A. | Freeze-dried FSH/LH formulations |
| US7741268B2 (en) | 2003-04-02 | 2010-06-22 | Ares Trading S.A. | Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant |
-
1958
- 1958-08-25 GB GB27188/58A patent/GB839300A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0974359B1 (en) * | 1998-07-23 | 2002-12-04 | Eli Lilly And Company | FSH and FSH variant formulations comprising benzyl alcohol as a preservative |
| US7446090B2 (en) | 1998-07-23 | 2008-11-04 | Ares Trading S.A. | FSH formulation |
| US7563763B2 (en) | 1998-07-23 | 2009-07-21 | Ares Trading S.A. | FSH and FSH variant formulations, products and methods |
| US7741268B2 (en) | 2003-04-02 | 2010-06-22 | Ares Trading S.A. | Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant |
| US7740884B2 (en) | 2003-06-20 | 2010-06-22 | Ares Trading S.A. | Freeze-dried FSH/LH formulations |
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