GB748857A - Process for the making of adrenocorticotrophin (acth) preparations having a prolonged action from acth with high specific activity - Google Patents
Process for the making of adrenocorticotrophin (acth) preparations having a prolonged action from acth with high specific activityInfo
- Publication number
- GB748857A GB748857A GB35033/53A GB3503353A GB748857A GB 748857 A GB748857 A GB 748857A GB 35033/53 A GB35033/53 A GB 35033/53A GB 3503353 A GB3503353 A GB 3503353A GB 748857 A GB748857 A GB 748857A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- acth
- specific activity
- adrenocorticotrophin
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Adrenocorticotrophin preparations having a prolonged action are prepared, in the form of a stable suspension suitable for implantation or injection intramuscularly or subcutaneously, by adding a protamine sulphate and a water-soluble zinc salt to an aqueous solution of adrenocorticophin and adjusting the pH of the solution to between 6 and 8 by means of a buffer, e.g. trisodium phosphate. The protamine sulphate addition may take the form of an aqueous solution of concentration greater than one per cent and preferably greater than two per cent. The specific activity of the hormone is greater than 2 I.U. per mg. and the concentration of the hormone solution is such that the concentration in I.U. pre ml. exceeds the amount corresponding to five times the specific activity in I.U. per mg. The suspension may also be formed by dissolving the hormone in a portion of the protamine sulphate solution and adding a corresponding quantity of the zinc salt e.g. zinc sulphate, and buffer solution to attain a pH between 6 and 8. The remainder of the protamine sulphate solution is then added, followed by the remainder of the zinc and buffer solution. Glucose and tricresol may also be present.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO748857X | 1952-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB748857A true GB748857A (en) | 1956-05-09 |
Family
ID=19906898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35033/53A Expired GB748857A (en) | 1952-12-16 | 1953-12-16 | Process for the making of adrenocorticotrophin (acth) preparations having a prolonged action from acth with high specific activity |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB748857A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1236725B (en) * | 1958-08-15 | 1967-03-16 | Armour Pharma | Process for the production of a corticotropin preparation with a long-lasting effect |
| US7314859B2 (en) | 2002-12-27 | 2008-01-01 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
| US7655618B2 (en) | 2002-12-27 | 2010-02-02 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
-
1953
- 1953-12-16 GB GB35033/53A patent/GB748857A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1236725B (en) * | 1958-08-15 | 1967-03-16 | Armour Pharma | Process for the production of a corticotropin preparation with a long-lasting effect |
| US7314859B2 (en) | 2002-12-27 | 2008-01-01 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
| US7642232B2 (en) | 2002-12-27 | 2010-01-05 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
| US7655618B2 (en) | 2002-12-27 | 2010-02-02 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
| US7678762B2 (en) | 2002-12-27 | 2010-03-16 | Diobex, Inc. | Methods for reducing the risk of hypoglycemia |
| US7678763B2 (en) | 2002-12-27 | 2010-03-16 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
| US7683027B2 (en) | 2002-12-27 | 2010-03-23 | Diobex, Inc. | Methods relating to hypoglycemic unawareness |
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