GB1492837A - Insulin preparations having antidiabetic activity and process for their manufacture - Google Patents

Insulin preparations having antidiabetic activity and process for their manufacture

Info

Publication number
GB1492837A
GB1492837A GB14079/75A GB1407975A GB1492837A GB 1492837 A GB1492837 A GB 1492837A GB 14079/75 A GB14079/75 A GB 14079/75A GB 1407975 A GB1407975 A GB 1407975A GB 1492837 A GB1492837 A GB 1492837A
Authority
GB
United Kingdom
Prior art keywords
insulin
manufacture
insulin preparations
zinc ion
phenylalanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14079/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2418218A external-priority patent/DE2418218A1/en
Priority claimed from DE19742459515 external-priority patent/DE2459515C3/en
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of GB1492837A publication Critical patent/GB1492837A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Abstract

1492837 Sustained release insulin preparations HOECHST AG 7 April 1975 [13 April 1974 17 Dec 1974] 14079/75 Heading A5B Sustained release insulin preparations comprise (1) an aqueous medium, (2) a crystalline insulin, (3) dissolved des-phenylalanine <SP>B1</SP>-insulin of the same species and (4) 25 to 80 meg of zinc ion per 100 I.U. of insulin. The insulin and insulin derivative may be bovine or porcine. The zinc ion may be present as zinc chloride. The preparation may be made by mixing a suspension of insulin crystals containing zinc ion with a solution of des-phenylalanine-insulin also containing zinc ions and adjusting the pH to the required range.
GB14079/75A 1974-04-13 1975-04-07 Insulin preparations having antidiabetic activity and process for their manufacture Expired GB1492837A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2418218A DE2418218A1 (en) 1974-04-13 1974-04-13 Long acting insulin compstns - contg. a crystalline insulin suspension and des phenyl alanine insulin soln.
DE19742459515 DE2459515C3 (en) 1974-12-17 1974-12-17 Medicinal preparations with an antidiabetic effect

Publications (1)

Publication Number Publication Date
GB1492837A true GB1492837A (en) 1977-11-23

Family

ID=25766977

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14079/75A Expired GB1492837A (en) 1974-04-13 1975-04-07 Insulin preparations having antidiabetic activity and process for their manufacture

Country Status (11)

Country Link
AU (1) AU500430B2 (en)
CA (1) CA1047919A (en)
EG (1) EG12098A (en)
ES (1) ES436398A1 (en)
FI (1) FI751084A (en)
FR (1) FR2267116B1 (en)
GB (1) GB1492837A (en)
IE (1) IE40985B1 (en)
IL (1) IL47043A (en)
LU (1) LU72269A1 (en)
NL (1) NL7504165A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028587A (en) * 1987-05-22 1991-07-02 Hoechst Aktiengesellschaft Mixed crystals of insulin and insulin derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1560232A (en) * 1977-02-01 1980-01-30 Novo Industri As Biphasic insulin preparations comprising crystalline insulin and monodesamido insulin
AU6700696A (en) 1995-07-25 1997-02-26 Novartis Ag Transforming growth factor beta crystals

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028587A (en) * 1987-05-22 1991-07-02 Hoechst Aktiengesellschaft Mixed crystals of insulin and insulin derivatives

Also Published As

Publication number Publication date
IE40985B1 (en) 1979-09-26
IL47043A (en) 1978-06-15
IL47043A0 (en) 1975-06-25
AU500430B2 (en) 1979-05-24
FR2267116A1 (en) 1975-11-07
IE40985L (en) 1975-10-13
NL7504165A (en) 1975-10-15
EG12098A (en) 1980-12-31
FI751084A (en) 1975-10-14
LU72269A1 (en) 1977-02-03
ES436398A1 (en) 1977-05-01
CA1047919A (en) 1979-02-06
FR2267116B1 (en) 1978-10-06
AU8007375A (en) 1976-10-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee