ES8403723A1 - A process for producing an insulin preparation. - Google Patents

A process for producing an insulin preparation.

Info

Publication number
ES8403723A1
ES8403723A1 ES520249A ES520249A ES8403723A1 ES 8403723 A1 ES8403723 A1 ES 8403723A1 ES 520249 A ES520249 A ES 520249A ES 520249 A ES520249 A ES 520249A ES 8403723 A1 ES8403723 A1 ES 8403723A1
Authority
ES
Spain
Prior art keywords
zinc
insulin
preparation
ions
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520249A
Other languages
Spanish (es)
Other versions
ES520249A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordisk Insulinlaboratorium
Original Assignee
Nordisk Insulinlaboratorium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlaboratorium filed Critical Nordisk Insulinlaboratorium
Publication of ES520249A0 publication Critical patent/ES520249A0/en
Publication of ES8403723A1 publication Critical patent/ES8403723A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A stable, quick-acting insulin preparation is produced by dissolving a zinc-free insulin in an aqueous medium containing monovalent ions, such as sodium ions, but substantially no di- or polyvalent ions, adjusting the pH to the range of 6.9 to 8.0, preferably 7.2 to 7.8, and adding a zinc compound corresponding to 0.5 to 1.0% zinc, preferably 0.7 to 0.9% zinc, based on the weight of insulin. The preparation has a great stability against aggregation at 25 to 37<o>C and therefore lends itself to be used particularly for portable or implantable insulin delivery devices.
ES520249A 1982-03-03 1983-03-02 A process for producing an insulin preparation. Expired ES8403723A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK91882 1982-03-03

Publications (2)

Publication Number Publication Date
ES520249A0 ES520249A0 (en) 1984-04-16
ES8403723A1 true ES8403723A1 (en) 1984-04-16

Family

ID=8099004

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520249A Expired ES8403723A1 (en) 1982-03-03 1983-03-02 A process for producing an insulin preparation.

Country Status (3)

Country Link
EP (1) EP0102976A1 (en)
ES (1) ES8403723A1 (en)
WO (1) WO1983003054A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI78616C (en) * 1982-02-05 1989-09-11 Novo Industri As Process for preparing an infused stabilized insulin solution having an elevated zinc content
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
DE19733651A1 (en) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Aqueous aerosol preparations containing biologically active marrow molecules and processes for producing corresponding aerosols
AU2002300833B2 (en) * 1997-08-04 2007-05-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aqueous aerosol preparations containing biologically active macromolecules and method for producing the corresponding aerosols
RU2251426C1 (en) * 2003-09-18 2005-05-10 Цыганков Владимир Владимирович Method for obtaining insulin out of natural source and insulin
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2414560B1 (en) 2009-03-31 2013-10-23 Boehringer Ingelheim International GmbH Method for coating a surface of a component
JP5763053B2 (en) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Adapter, inhaler and atomizer
JP5658268B2 (en) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064164A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
WO2011160932A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Nebulizer
WO2012130757A1 (en) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medical device comprising a container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
JP6643231B2 (en) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
JP6580070B2 (en) 2014-05-07 2019-09-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Container, nebulizer, and use
PL3139984T3 (en) 2014-05-07 2021-11-08 Boehringer Ingelheim International Gmbh Nebulizer
LT3928818T (en) 2014-05-07 2023-03-27 Boehringer Ingelheim International Gmbh Nebulizer and container

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1212679B (en) * 1957-08-03 1966-03-17 Novo Terapeutisk Labor As Process for the preparation of insulin solutions
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
DK116527B (en) * 1967-03-01 1970-01-19 Nordisk Insulinlab Process for the preparation of a fast-acting, durable, neutral solution of pure crystalline bovine insulin or bovine insulin which is crystallizable in water by the addition of Zn, or mixtures of bovine insulin and insulin of other origin.
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
US3719655A (en) * 1969-12-05 1973-03-06 Lilly Co Eli Process for the crystallization of the ammonium and alkali metal salts in insulin
US3876623A (en) * 1973-05-09 1975-04-08 Lilly Co Eli Process for purifying insulin
US3878186A (en) * 1973-05-09 1975-04-15 Lilly Co Eli Process for purifying insulin
DK80781A (en) * 1980-02-29 1981-08-30 Hospital For Sick Children SOLUTIONS OF POLYPEPTIDES

Also Published As

Publication number Publication date
ES520249A0 (en) 1984-04-16
EP0102976A1 (en) 1984-03-21
WO1983003054A1 (en) 1983-09-15

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