ES436398A1 - Insulin preparations having antidiabetic activity and process for their manufacture - Google Patents

Insulin preparations having antidiabetic activity and process for their manufacture

Info

Publication number
ES436398A1
ES436398A1 ES436398A ES436398A ES436398A1 ES 436398 A1 ES436398 A1 ES 436398A1 ES 436398 A ES436398 A ES 436398A ES 436398 A ES436398 A ES 436398A ES 436398 A1 ES436398 A1 ES 436398A1
Authority
ES
Spain
Prior art keywords
insulin
mcg
zinc
isotonia
preservative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436398A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2418218A external-priority patent/DE2418218A1/en
Priority claimed from DE19742459515 external-priority patent/DE2459515C3/en
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES436398A1 publication Critical patent/ES436398A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Procedure for the production of a preparation of insulin based on crystallized insulin and des-phenylalaninB1-insulin dissolved from the same species, characterized in that a sterile aqueous suspension of crystals is adjusted with sodium hydroxide solution to pH 6.8-7.2 Insulin of uniform size 15-35 microns, containing, in addition to a preservative, sodium acetate buffer, common salt to isotonia and 30-8 mcg of zinc ++, and the resulting crystal suspension, containing 40-100 IU insulin per ml, with a sterile aqueous solution of de-phenylalaninB1-insulin of the same species, containing 4O-100 IU/ml and containing, in addition to a preservative, sodium acetate buffer, common salt to isotonia and 10-40 mcg of zinc ++, which had previously been adjusted to pH 6.8-7.2, with the proportion of crystalline insulin to de-phenylalaninB1-insulin dissolved being between 60:40 and 90:10, with the content of zinc at 25-80 mcg/100 IU and eventually adjusting the pH to 6.8-7.2. (Machine-translation by Google Translate, not legally binding)
ES436398A 1974-04-13 1975-04-08 Insulin preparations having antidiabetic activity and process for their manufacture Expired ES436398A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2418218A DE2418218A1 (en) 1974-04-13 1974-04-13 Long acting insulin compstns - contg. a crystalline insulin suspension and des phenyl alanine insulin soln.
DE19742459515 DE2459515C3 (en) 1974-12-17 1974-12-17 Medicinal preparations with an antidiabetic effect

Publications (1)

Publication Number Publication Date
ES436398A1 true ES436398A1 (en) 1977-05-01

Family

ID=25766977

Family Applications (1)

Application Number Title Priority Date Filing Date
ES436398A Expired ES436398A1 (en) 1974-04-13 1975-04-08 Insulin preparations having antidiabetic activity and process for their manufacture

Country Status (11)

Country Link
AU (1) AU500430B2 (en)
CA (1) CA1047919A (en)
EG (1) EG12098A (en)
ES (1) ES436398A1 (en)
FI (1) FI751084A (en)
FR (1) FR2267116B1 (en)
GB (1) GB1492837A (en)
IE (1) IE40985B1 (en)
IL (1) IL47043A (en)
LU (1) LU72269A1 (en)
NL (1) NL7504165A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1560232A (en) * 1977-02-01 1980-01-30 Novo Industri As Biphasic insulin preparations comprising crystalline insulin and monodesamido insulin
DE3717370A1 (en) * 1987-05-22 1988-12-01 Hoechst Ag MIXED CRYSTALS FROM INSULIN AND INSULINE DERIVATIVES, METHOD FOR THE PRODUCTION OF THESE MIXED CRYSTALS, PHARMACEUTICAL AGENTS CONTAINING THESE MIXED CRYSTALS AND THEIR USE FOR TREATING DIABETES MELLITUS
DK0840748T3 (en) 1995-07-25 2003-07-28 Novartis Ag Transforming growth factor beta crystals

Also Published As

Publication number Publication date
IE40985B1 (en) 1979-09-26
FI751084A (en) 1975-10-14
EG12098A (en) 1980-12-31
NL7504165A (en) 1975-10-15
IL47043A0 (en) 1975-06-25
IE40985L (en) 1975-10-13
FR2267116B1 (en) 1978-10-06
CA1047919A (en) 1979-02-06
GB1492837A (en) 1977-11-23
LU72269A1 (en) 1977-02-03
AU500430B2 (en) 1979-05-24
AU8007375A (en) 1976-10-14
IL47043A (en) 1978-06-15
FR2267116A1 (en) 1975-11-07

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