ES2614912T3 - Combinaciones antineoplásicas de 4-anilino-3-cianoquinolinas y capecitabina - Google Patents

Combinaciones antineoplásicas de 4-anilino-3-cianoquinolinas y capecitabina Download PDF

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Publication number
ES2614912T3
ES2614912T3 ES09791127.5T ES09791127T ES2614912T3 ES 2614912 T3 ES2614912 T3 ES 2614912T3 ES 09791127 T ES09791127 T ES 09791127T ES 2614912 T3 ES2614912 T3 ES 2614912T3
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ES
Spain
Prior art keywords
capecitabine
compound
administered
hki
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09791127.5T
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English (en)
Spanish (es)
Inventor
Kenneth Wang
Charles Zacharchuk
Florence Binlich
Susan Quinn
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Wyeth LLC
Original Assignee
Wyeth LLC
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Filing date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41226678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2614912(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth LLC filed Critical Wyeth LLC
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Publication of ES2614912T3 publication Critical patent/ES2614912T3/es
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES09791127.5T 2008-08-04 2009-08-04 Combinaciones antineoplásicas de 4-anilino-3-cianoquinolinas y capecitabina Active ES2614912T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8591308P 2008-08-04 2008-08-04
US85913P 2008-08-04
US17246609P 2009-04-24 2009-04-24
US172466P 2009-04-24
PCT/US2009/052644 WO2010017163A1 (en) 2008-08-04 2009-08-04 Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine

Publications (1)

Publication Number Publication Date
ES2614912T3 true ES2614912T3 (es) 2017-06-02

Family

ID=41226678

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09791127.5T Active ES2614912T3 (es) 2008-08-04 2009-08-04 Combinaciones antineoplásicas de 4-anilino-3-cianoquinolinas y capecitabina
ES16203986T Active ES2968373T3 (es) 2008-08-04 2009-08-04 Combinaciones antineoplásicas de neratinib y capecitabina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES16203986T Active ES2968373T3 (es) 2008-08-04 2009-08-04 Combinaciones antineoplásicas de neratinib y capecitabina

Country Status (26)

Country Link
US (2) US8669273B2 (enExample)
EP (3) EP2326329B1 (enExample)
JP (1) JP5681108B2 (enExample)
KR (2) KR20140069340A (enExample)
CN (6) CN102202667A (enExample)
AU (1) AU2009279771B2 (enExample)
BR (1) BRPI0916694B1 (enExample)
CA (1) CA2730715C (enExample)
CY (1) CY1118602T1 (enExample)
DK (1) DK2326329T3 (enExample)
ES (2) ES2614912T3 (enExample)
HK (1) HK1218262A1 (enExample)
HR (1) HRP20170074T1 (enExample)
HU (1) HUE032958T2 (enExample)
IL (1) IL210616A (enExample)
LT (1) LT2326329T (enExample)
MX (1) MX2011001318A (enExample)
NZ (1) NZ590464A (enExample)
PL (2) PL3175853T3 (enExample)
PT (1) PT2326329T (enExample)
RU (1) RU2498804C2 (enExample)
SG (2) SG10201702382RA (enExample)
SI (1) SI2326329T1 (enExample)
SM (2) SMT201700084T1 (enExample)
WO (1) WO2010017163A1 (enExample)
ZA (1) ZA201101662B (enExample)

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US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
CN102641270A (zh) 2008-06-17 2012-08-22 惠氏有限责任公司 含有hki-272和长春瑞滨的抗肿瘤组合
HUE032958T2 (hu) 2008-08-04 2017-11-28 Wyeth Llc 4-Anilino-3-ciano-kinolinok és capecitabin antineoplasztikus kombinációi
LT3000467T (lt) 2009-04-06 2023-04-11 Wyeth Llc Krūties vėžio gydymo schema naudojant neratinibą
EP2498751B1 (en) 2009-11-09 2019-04-03 Wyeth LLC Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
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WO2021104319A1 (zh) * 2019-11-25 2021-06-03 正大天晴药业集团股份有限公司 喹唑啉衍生物或其盐的联用药物组合物及其用途

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