ES2603129T3 - Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2 - Google Patents

Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2 Download PDF

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Publication number
ES2603129T3
ES2603129T3 ES11793928.0T ES11793928T ES2603129T3 ES 2603129 T3 ES2603129 T3 ES 2603129T3 ES 11793928 T ES11793928 T ES 11793928T ES 2603129 T3 ES2603129 T3 ES 2603129T3
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ES
Spain
Prior art keywords
methyl
compound
sulfonyl
benzamide
piperazin
Prior art date
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Active
Application number
ES11793928.0T
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English (en)
Spanish (es)
Inventor
Steven Elmore
Andrew Souers
Li Chun Wang
Tariq Ghayur
Stuart J. Perper
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AbbVie Ireland ULC
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AbbVie Ireland ULC
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Application filed by AbbVie Ireland ULC filed Critical AbbVie Ireland ULC
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES11793928.0T 2010-11-23 2011-11-22 Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2 Active ES2603129T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41668910P 2010-11-23 2010-11-23
US416689P 2010-11-23
PCT/US2011/061769 WO2012071374A1 (en) 2010-11-23 2011-11-22 Methods of treatment using selective bcl-2 inhibitors

Publications (1)

Publication Number Publication Date
ES2603129T3 true ES2603129T3 (es) 2017-02-23

Family

ID=45218888

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11793928.0T Active ES2603129T3 (es) 2010-11-23 2011-11-22 Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2
ES16153335T Active ES2701603T3 (es) 2010-11-23 2011-11-22 Métodos de tratamiento que utilizan inhibidores selectivos de Bcl-2

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES16153335T Active ES2701603T3 (es) 2010-11-23 2011-11-22 Métodos de tratamiento que utilizan inhibidores selectivos de Bcl-2

Country Status (36)

Country Link
US (5) US20120129853A1 (enExample)
EP (2) EP2642999B1 (enExample)
JP (2) JP5876067B2 (enExample)
KR (3) KR101841084B1 (enExample)
CN (2) CN103402521B (enExample)
AR (1) AR083946A1 (enExample)
AU (2) AU2011332000B2 (enExample)
BR (1) BR112013012854B1 (enExample)
CA (1) CA2820618C (enExample)
CL (1) CL2013001458A1 (enExample)
CR (1) CR20130268A (enExample)
CY (1) CY1118442T1 (enExample)
DK (1) DK2642999T3 (enExample)
DO (1) DOP2017000056A (enExample)
EC (1) ECSP13012710A (enExample)
ES (2) ES2603129T3 (enExample)
GT (1) GT201300136A (enExample)
HR (1) HRP20161762T1 (enExample)
HU (1) HUE031267T2 (enExample)
IL (2) IL226490A (enExample)
LT (1) LT2642999T (enExample)
MX (2) MX377232B (enExample)
MY (2) MY165884A (enExample)
NZ (2) NZ708508A (enExample)
PH (2) PH12013501006A1 (enExample)
PL (1) PL2642999T3 (enExample)
PT (1) PT2642999T (enExample)
RS (1) RS55545B1 (enExample)
RU (1) RU2593231C2 (enExample)
SG (2) SG190399A1 (enExample)
SI (1) SI2642999T1 (enExample)
TW (2) TWI535701B (enExample)
UA (2) UA119150C2 (enExample)
UY (1) UY33746A (enExample)
WO (1) WO2012071374A1 (enExample)
ZA (1) ZA201303589B (enExample)

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