ES2556353T3 - Compuestos que son inhibidores de las ERK - Google Patents

Compuestos que son inhibidores de las ERK Download PDF

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Publication number
ES2556353T3
ES2556353T3 ES09712601.5T ES09712601T ES2556353T3 ES 2556353 T3 ES2556353 T3 ES 2556353T3 ES 09712601 T ES09712601 T ES 09712601T ES 2556353 T3 ES2556353 T3 ES 2556353T3
Authority
ES
Spain
Prior art keywords
group
substituted
alkyl
heteroaryl
triazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09712601.5T
Other languages
English (en)
Spanish (es)
Other versions
ES2556353T8 (es
Inventor
Alan B. Cooper
Yang Nan
Yongqi Deng
Gerald W. Shipps, Jr.
Neng-Yang Shih
Hugh Y. Zhu
Joseph M. Kelly
Subrahmanyam Gudipati
Ronald J. Doll
Mehul F. Patel
Jagdish A. Desai
James J-S Wang
Sunil Paliwal
Hon-Chung Tsui
Sobhana Babu Boga
Abdul-Basit Alhassan
Xiaolei Gao
Liang Zhu
Xin Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40601237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2556353(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2556353T3 publication Critical patent/ES2556353T3/es
Publication of ES2556353T8 publication Critical patent/ES2556353T8/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES09712601.5T 2008-02-21 2009-02-19 Compuestos que son inhibidores de las ERK Active ES2556353T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3040708P 2008-02-21 2008-02-21
US30407P 2008-02-21
PCT/US2009/034447 WO2009105500A1 (en) 2008-02-21 2009-02-19 Compounds that are erk inhibitors

Publications (2)

Publication Number Publication Date
ES2556353T3 true ES2556353T3 (es) 2016-01-15
ES2556353T8 ES2556353T8 (es) 2017-10-13

Family

ID=40601237

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09712601.5T Active ES2556353T3 (es) 2008-02-21 2009-02-19 Compuestos que son inhibidores de las ERK

Country Status (23)

Country Link
US (1) US8716483B2 (en:Method)
EP (1) EP2260031B1 (en:Method)
JP (1) JP5276676B2 (en:Method)
KR (1) KR20100117123A (en:Method)
CN (1) CN102015693B (en:Method)
AR (1) AR070460A1 (en:Method)
AU (1) AU2009215534B8 (en:Method)
BR (1) BRPI0908120A8 (en:Method)
CA (1) CA2714479A1 (en:Method)
CL (1) CL2009000394A1 (en:Method)
CO (1) CO6300939A2 (en:Method)
EC (1) ECSP10010415A (en:Method)
ES (1) ES2556353T3 (en:Method)
IL (1) IL207530A (en:Method)
MX (1) MX2010009268A (en:Method)
MY (1) MY152271A (en:Method)
NZ (1) NZ587504A (en:Method)
PE (1) PE20091491A1 (en:Method)
RU (1) RU2525389C2 (en:Method)
SG (1) SG188179A1 (en:Method)
TW (1) TWI398441B (en:Method)
WO (1) WO2009105500A1 (en:Method)
ZA (2) ZA201005909B (en:Method)

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US9229008B2 (en) 2008-08-19 2016-01-05 Merck Sharp & Dohme Corp. IL-8 level as a determinant of responsivity of a cancer to treatment
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WO2011041152A1 (en) 2009-09-30 2011-04-07 Schering Corporation Novel compounds that are erk inhibitors
US8999957B2 (en) * 2010-06-24 2015-04-07 Merck Sharp & Dohme Corp. Heterocyclic compounds as ERK inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
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KR102057877B1 (ko) * 2012-07-18 2019-12-20 노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드 질소함유 헤테로고리 유도체 및 그의 약물에서의 용도
BR112015006990A2 (pt) * 2012-09-28 2017-07-04 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de pelo menos um composto
US9226922B2 (en) 2012-09-28 2016-01-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
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US8871966B2 (en) 2013-03-15 2014-10-28 Iowa State University Research Foundation, Inc. Regiospecific synthesis of terephthalates
JP6427197B2 (ja) 2013-10-03 2018-11-21 クラ オンコロジー， インコーポレイテッド Ｅｒｋの阻害剤および使用方法
US10428387B2 (en) 2014-05-16 2019-10-01 University Of Massachusetts Treating chronic myelogenous leukemia (CML)
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AU2015362844B2 (en) * 2014-12-18 2019-10-24 Merck Sharp & Dohme Corp. (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations
MX2017008078A (es) * 2014-12-19 2017-09-28 Merck Sharp & Dohme Composiciones de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h-indazol-5- il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il)fenil)-3,6-dihidrop iridin-1(2h)-il)-2-oxoetil)-3-(metiltio)pirrolidin-3-carboxamida para preparaciones farmaceuticas.
JP6737533B2 (ja) * 2015-04-03 2020-08-12 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー スピロ環式化合物
WO2017040362A1 (en) * 2015-09-03 2017-03-09 Merck Sharp & Dohme Corp. Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations
CN106432182B (zh) * 2016-09-06 2019-04-30 铜仁学院 特地唑胺中间体的合成方法
CN109020789B (zh) * 2017-06-12 2021-08-13 浙江医药股份有限公司新昌制药厂 一种制备2-甲氧基丙烯的方法
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Also Published As

Publication number Publication date
BRPI0908120A8 (pt) 2017-10-24
NZ587504A (en) 2012-09-28
RU2010138635A (ru) 2012-03-27
JP5276676B2 (ja) 2013-08-28
MX2010009268A (es) 2010-09-14
TWI398441B (zh) 2013-06-11
CO6300939A2 (es) 2011-07-21
US8716483B2 (en) 2014-05-06
CA2714479A1 (en) 2009-08-27
IL207530A0 (en) 2010-12-30
AR070460A1 (es) 2010-04-07
CL2009000394A1 (es) 2011-02-11
AU2009215534B2 (en) 2014-06-26
JP2011513225A (ja) 2011-04-28
BRPI0908120A2 (en:Method) 2017-08-22
ZA201005909B (en) 2014-03-26
CN102015693A (zh) 2011-04-13
MY152271A (en) 2014-09-15
CN102015693B (zh) 2014-10-29
EP2260031B1 (en) 2015-10-07
TW200948799A (en) 2009-12-01
IL207530A (en) 2014-08-31
AU2009215534B8 (en) 2014-07-10
RU2525389C2 (ru) 2014-08-10
ZA201400396B (en) 2014-12-23
WO2009105500A1 (en) 2009-08-27
AU2009215534A1 (en) 2009-08-27
ES2556353T8 (es) 2017-10-13
US20110189192A1 (en) 2011-08-04
ECSP10010415A (es) 2010-09-30
PE20091491A1 (es) 2009-09-25
AU2009215534A2 (en) 2010-12-23
SG188179A1 (en) 2013-03-28
EP2260031A1 (en) 2010-12-15
AU2009215534A8 (en) 2014-07-10
KR20100117123A (ko) 2010-11-02

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