ZA201005909B - Compounds that are erk inhibitors - Google Patents

Compounds that are erk inhibitors

Info

Publication number
ZA201005909B
ZA201005909B ZA2010/05909A ZA201005909A ZA201005909B ZA 201005909 B ZA201005909 B ZA 201005909B ZA 2010/05909 A ZA2010/05909 A ZA 2010/05909A ZA 201005909 A ZA201005909 A ZA 201005909A ZA 201005909 B ZA201005909 B ZA 201005909B
Authority
ZA
South Africa
Prior art keywords
compounds
erk inhibitors
erk
inhibitors
Prior art date
Application number
ZA2010/05909A
Other languages
English (en)
Inventor
Alan B Cooper
Yang Nan
Yongqi Deng
Jr Gerald W Shipps
Neng-Yang Shih
Hugh Y Zhu
Joseph M Kelly
Subrahmanyam Gudipati
Ronald J Doll
Mehul F Patel
Jagdish A Desai
James J-S Wang
Sunil Paliwal
Hon-Chung Tsui
Sobhana Babu Boga
Abdul-Basit Alhassan
Xiaolei Gao
Liang Zhu
Xin Yao
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40601237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201005909(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ZA201005909B publication Critical patent/ZA201005909B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA2010/05909A 2008-02-21 2010-08-18 Compounds that are erk inhibitors ZA201005909B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3040708P 2008-02-21 2008-02-21
PCT/US2009/034447 WO2009105500A1 (en) 2008-02-21 2009-02-19 Compounds that are erk inhibitors

Publications (1)

Publication Number Publication Date
ZA201005909B true ZA201005909B (en) 2014-03-26

Family

ID=40601237

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA2010/05909A ZA201005909B (en) 2008-02-21 2010-08-18 Compounds that are erk inhibitors
ZA2014/00396A ZA201400396B (en) 2008-02-21 2014-01-17 Compounds that are erk inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA2014/00396A ZA201400396B (en) 2008-02-21 2014-01-17 Compounds that are erk inhibitors

Country Status (23)

Country Link
US (1) US8716483B2 (en:Method)
EP (1) EP2260031B1 (en:Method)
JP (1) JP5276676B2 (en:Method)
KR (1) KR20100117123A (en:Method)
CN (1) CN102015693B (en:Method)
AR (1) AR070460A1 (en:Method)
AU (1) AU2009215534B8 (en:Method)
BR (1) BRPI0908120A8 (en:Method)
CA (1) CA2714479A1 (en:Method)
CL (1) CL2009000394A1 (en:Method)
CO (1) CO6300939A2 (en:Method)
EC (1) ECSP10010415A (en:Method)
ES (1) ES2556353T3 (en:Method)
IL (1) IL207530A (en:Method)
MX (1) MX2010009268A (en:Method)
MY (1) MY152271A (en:Method)
NZ (1) NZ587504A (en:Method)
PE (1) PE20091491A1 (en:Method)
RU (1) RU2525389C2 (en:Method)
SG (1) SG188179A1 (en:Method)
TW (1) TWI398441B (en:Method)
WO (1) WO2009105500A1 (en:Method)
ZA (2) ZA201005909B (en:Method)

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US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
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MX2017008078A (es) * 2014-12-19 2017-09-28 Merck Sharp & Dohme Composiciones de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h-indazol-5- il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il)fenil)-3,6-dihidrop iridin-1(2h)-il)-2-oxoetil)-3-(metiltio)pirrolidin-3-carboxamida para preparaciones farmaceuticas.
JP6737533B2 (ja) * 2015-04-03 2020-08-12 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー スピロ環式化合物
WO2017040362A1 (en) * 2015-09-03 2017-03-09 Merck Sharp & Dohme Corp. Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations
CN106432182B (zh) * 2016-09-06 2019-04-30 铜仁学院 特地唑胺中间体的合成方法
CN109020789B (zh) * 2017-06-12 2021-08-13 浙江医药股份有限公司新昌制药厂 一种制备2-甲氧基丙烯的方法
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Also Published As

Publication number Publication date
BRPI0908120A8 (pt) 2017-10-24
NZ587504A (en) 2012-09-28
RU2010138635A (ru) 2012-03-27
JP5276676B2 (ja) 2013-08-28
MX2010009268A (es) 2010-09-14
TWI398441B (zh) 2013-06-11
CO6300939A2 (es) 2011-07-21
US8716483B2 (en) 2014-05-06
CA2714479A1 (en) 2009-08-27
IL207530A0 (en) 2010-12-30
AR070460A1 (es) 2010-04-07
CL2009000394A1 (es) 2011-02-11
AU2009215534B2 (en) 2014-06-26
JP2011513225A (ja) 2011-04-28
BRPI0908120A2 (en:Method) 2017-08-22
CN102015693A (zh) 2011-04-13
MY152271A (en) 2014-09-15
CN102015693B (zh) 2014-10-29
EP2260031B1 (en) 2015-10-07
TW200948799A (en) 2009-12-01
ES2556353T3 (es) 2016-01-15
IL207530A (en) 2014-08-31
AU2009215534B8 (en) 2014-07-10
RU2525389C2 (ru) 2014-08-10
ZA201400396B (en) 2014-12-23
WO2009105500A1 (en) 2009-08-27
AU2009215534A1 (en) 2009-08-27
ES2556353T8 (es) 2017-10-13
US20110189192A1 (en) 2011-08-04
ECSP10010415A (es) 2010-09-30
PE20091491A1 (es) 2009-09-25
AU2009215534A2 (en) 2010-12-23
SG188179A1 (en) 2013-03-28
EP2260031A1 (en) 2010-12-15
AU2009215534A8 (en) 2014-07-10
KR20100117123A (ko) 2010-11-02

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