ES2537296T3 - Composiciones ingeribles que contienen un aceite odorífero - Google Patents

Composiciones ingeribles que contienen un aceite odorífero Download PDF

Info

Publication number
ES2537296T3
ES2537296T3 ES02732094.4T ES02732094T ES2537296T3 ES 2537296 T3 ES2537296 T3 ES 2537296T3 ES 02732094 T ES02732094 T ES 02732094T ES 2537296 T3 ES2537296 T3 ES 2537296T3
Authority
ES
Spain
Prior art keywords
oil
surfactant
compositions containing
capsule
odoriferous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02732094.4T
Other languages
English (en)
Inventor
Dennis Rowe
Kelvin Royce Garnett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RP Scherer Technologies LLC
Original Assignee
RP Scherer Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RP Scherer Technologies LLC filed Critical RP Scherer Technologies LLC
Application granted granted Critical
Publication of ES2537296T3 publication Critical patent/ES2537296T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Edible Oils And Fats (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)

Abstract

Una cápsula de gel blando para la administración de un aceite odorífero y que tiene un olor reducido tras la ingestión, conteniendo dicha cápsula una composición ingerible sustancialmente no acuosa que comprende al menos un aceite odorífero digerible que es un aceite de pescado o una mezcla de diferentes aceites de pescado, al menos un ingrediente comestible enmascarante del olor y al menos una tensioactivo comestible, en donde dicho tensioactivo es una mezcla de al menos un tensioactivo hidrófilo y al menos un tensioactivo lipófilo.

Description

imagen1
imagen2
imagen3
imagen4
E02732094
20-05-2015
Aceite de hígado de bacalao desvitaminado (Seven seas ltd)
285,633 22,80
Aceite de semilla de perejil
1,000 ,08
Monooleato de sorbitán BP
18,000 1,44
Polysorbate 80 BP
9,000 0,72
Suspensión de β-caroteno al 30 %
6,974 0,56
Extracto de ginseng coreano 5:1
2,000 0,16
Extracto de jengibre 3:1
2,000 0,16
Selenita de sodio pentahidratada
0,0832 Traza
Total
1.253,0012
Usando la tecnología convencional de fabricación de cápsulas de gel blando, se introdujo la composición anterior en cápsulas no gelatinosas formadas a partir de los siguientes ingredientes en las proporciones indicadas:
182,6 Glicerina BP/EP/USP 500 Agua purificada BP/EP/USP 234,6 Almidón modificado 75,9 Carragenano
6,9 Difosfato de sodio 1,04 Pasta roja de óxido de hierro E172 4,96 Pasta negra de óxido de hierro E172
Un sujeto de ensayo informó solo de dos pequeños eructos, uno a los 15 minutos de la ingestión de una sola 5 cápsula y un segundo después de aproximadamente 20 minutos.
Ejemplos comparativos 4 a 13
Se formaron composiciones ingeribles mezclando entre sí los ingredientes como se tabulan a continuación. Las
10 composiciones no se formaron en cápsulas. El ensayo se llevó a cabo con un sujeto de ensayo que ingirió una cantidad pesada de la composición (determinada en mg/cápsula equivalente) en la forma como mezclada (es decir, aceite o pasta).
Ejemplo comparativo 4
15
Material
mg/cápsula equivalente %
Carbonato de calcio BP/EP
508 40,97
Aceite de borraja
26,832 2,16
Fumarato ferroso
21,98 1,77
Sulfato de cinc
20,7 1,67
Lecitina
16,508 1,33
Vitamina E
7,6 ,61
Mezcla de grasas
103,584 8,35
Sulfato de glucosamina (sal de K)
67,5 5,44
Sulfato de condriotina
55,552 4,48
Aceite de legumbre (seven Seas Ltd)
100,064 8,07
Aceite de hígado de bacalao desvitaminado (Seven seas ltd)
285,632 23,04
Aceite de semilla de perejil
1 0,081
Monooleato de sorbitán BP
12,52 1,0
Polysorbate 80 BP
12,52 1,0
6
E02732094
20-05-2015
Total
1.239,968
La mezcla producida resultó ser una pasta. El sujeto de ensayo informó que el aceite de pescado era perceptible y que la composición tenía un sabor desagradable.
Ejemplo comparativo 5
Material
mg/cápsula equivalente %
Carbonato de calcio BP/EP
508 40,97
Aceite de borraja
26,832 2,16
Fumarato ferroso
21,98 1,77
Sulfato de cinc
20,7 1,67
Lecitina
16,508 1,33
Vitamina E
7,6 ,61
Mezcla de grasas
103,584 8,35
Sulfato de glucosamina (sal de K)
67,5 5,44
Sulfato de condriotina
55,552 4,48
Aceite de legumbre
100,064 8,07
Aceite de hígado de bacalao desvitaminado (Seven seas ltd)
285,632 23,04
Aceite de semilla de perejil
1 0,081
Polysorbate 80 BP
25,04 2,0
Total
1.239,968
La mezcla producida resultó ser una pasta. Como en el Ejemplo 4, el sujeto de ensayo informó que el aceite de pescado era perceptible y que la composición tenía un sabor desagradable.
Ejemplo comparativo 6
Material
mg/cápsula equivalente %
Carbonato de calcio BP/EP
508 39,70
Aceite de borraja
26,832 2,1
Fumarato ferroso
21,98 1,72
Sulfato de cinc
20,7 1,62
Lecitina
16,508 1,29
Vitamina E
7,6 0,59
Mezcla de grasas
103,584 8,1
Sulfato de glucosamina (sal de K)
67,5 5,28
Sulfato de condriotina
55,552 4,34
Aceite de legumbre (Seven seas ltd)
100,064 7,82
Aceite de hígado de bacalao desvitaminado (Seven seas ltd)
285,632 22,32
Aceite de semilla de perejil
1 0,078
Polysorbate 80 BP
64,52 5,04
Total
1.279,448
7
E02732094
20-05-2015
La mezcla producida resultó ser una pasta. El sujeto de ensayo informó que el aceite de pescado apenas era perceptible, quedando anulado por el sabor más potente del aceite de semilla de perejil.
Ejemplo comparativo 7
Material
mg/cápsula equivalente %
Carbonato de calcio BP/EP
508 37,6
Aceite de borraja
26,832 1,99
Fumarato ferroso
21,98 1,63
Sulfato de cinc
20,7 1,53
Lecitina
16,508 1,22
Vitamina E
7,6 0,56
Mezcla de grasas
103,584 7,67
Sulfato de glucosamina (sal de K)
67,5 5,00
Sulfato de condriotina
55,552 4,11
Aceite de legumbre (Seven seas ltd)
100,064 7,41
Aceite de hígado de bacalao desvitaminado (Seven seas ltd)
285,632 21,14
Aceite de semilla de perejil
1 ,074
Polysorbate 80 BP
136,24 10,08
Total
1.351,168
La mezcla producida resultó ser una pasta. El sujeto de ensayo informó que el aceite de pescado no era perceptible, pero que el sabor a aceite de semilla de perejil era más potente que el indicado para el Ejemplo 6.
10 Ejemplo comparativo 8
Material
mg/cápsula equivalente %
Aceite de pescado 18/12 (EPAX 3000TG, Pronova)
480 94,78
Monooleato de sorbitán BP
16,81 3,32
Polysorbate 80 BP
8,42 1,66
Aceite de semilla de perejil
1,22 0,24
Total
506,45
La mezcla producida resultó ser una sola fase no acuosa continua. El sujeto de ensayo informó que el aceite de pescado estaba a punto de detectarse en la boca.
Ejemplo comparativo 9
Material
mg/cápsula equivalente %
Aceite de pescado 18/12 (EPAX 3000TG, Pronova)
480 96,76
Monooleato de sorbitán BP
9,9 2,00
Polysorbate 80 BP
4,95 1,0
Aceite de semilla de perejil
1,22 0,25
Total
496,07
8
imagen5
imagen6

Claims (1)

  1. imagen1
    imagen2
ES02732094.4T 2001-01-17 2002-01-16 Composiciones ingeribles que contienen un aceite odorífero Expired - Lifetime ES2537296T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0101198.0A GB0101198D0 (en) 2001-01-17 2001-01-17 Ingestible compositions containing an odoriferous oil
GB0101198 2001-01-17
PCT/GB2002/000164 WO2002056709A1 (en) 2001-01-17 2002-01-16 Ingestible compositions containing an odoriferous oil

Publications (1)

Publication Number Publication Date
ES2537296T3 true ES2537296T3 (es) 2015-06-05

Family

ID=9906973

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02732094.4T Expired - Lifetime ES2537296T3 (es) 2001-01-17 2002-01-16 Composiciones ingeribles que contienen un aceite odorífero

Country Status (15)

Country Link
US (1) US9532585B2 (es)
EP (1) EP1351585B1 (es)
JP (1) JP4969763B2 (es)
KR (1) KR100901518B1 (es)
CN (1) CN1241645C (es)
AU (1) AU2002219388B2 (es)
CA (1) CA2434471C (es)
DK (1) DK1351585T3 (es)
ES (1) ES2537296T3 (es)
GB (1) GB0101198D0 (es)
HK (1) HK1055222A1 (es)
MX (1) MXPA03006361A (es)
NO (1) NO20034014D0 (es)
NZ (1) NZ527079A (es)
WO (1) WO2002056709A1 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037065A1 (en) * 1999-05-27 2005-02-17 Drugtech Corporation Nutritional formulations
FR2861261B1 (fr) * 2003-10-22 2007-11-16 Adisseo France Sas Procede zootechnique pour l'administation d'un derive de vitamine e et formulation
GB0601498D0 (en) * 2006-01-25 2006-03-08 Probio Nutraceuticals As Product
JP5183104B2 (ja) * 2006-06-19 2013-04-17 森下仁丹株式会社 口臭除去用多重ソフトカプセル
WO2008101344A1 (en) * 2007-02-22 2008-08-28 Peter Tomlinson Soluble bioactive lipophilic compounds compositions
ES2862336T3 (es) 2008-09-02 2021-10-07 Amarin Pharmaceuticals Ie Ltd Composición farmacéutica que comprende ácido eicosapentaenoico y ácido nicotínico y métodos de uso de la misma
GB0818473D0 (en) 2008-10-08 2008-11-12 Probio Nutraceuticals As Composition
CN102458109B (zh) 2009-04-29 2015-02-11 阿马里纳制药公司 稳定的药物组合物和使用其的方法
CN106822080A (zh) 2009-04-29 2017-06-13 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
SG10201708950XA (en) 2009-06-15 2017-12-28 Ian Osterloh Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
AU2010298222B2 (en) 2009-09-23 2017-01-05 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
ES2661812T3 (es) 2009-10-16 2018-04-04 Mochida Pharmaceutical Co., Ltd. Composiciones
GB201006012D0 (en) * 2010-04-09 2010-05-26 Ayanda As Composition
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
WO2012074930A2 (en) 2010-11-29 2012-06-07 Amarin Pharma, Inc. Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US20130131170A1 (en) 2011-11-07 2013-05-23 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2800469B1 (en) 2012-01-06 2021-08-25 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
JP6042086B2 (ja) * 2012-03-30 2016-12-14 小林製薬株式会社 ゼラチン成形組成物
JP2015522029A (ja) 2012-06-29 2015-08-03 アマリン ファーマシューティカルス アイルランド リミテッド スタチン療法中の患者における心血管系イベントの危険性を減少させる方法
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
JP6444583B2 (ja) * 2013-03-22 2018-12-26 小林製薬株式会社 経口組成物
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
US11096897B2 (en) 2014-12-15 2021-08-24 Societe Des Produits Nestle S.A. Controlled release of caffeine
US11147841B2 (en) 2014-12-19 2021-10-19 Aker Biomarine Antarctic As Enhanced omega-3 formulations
WO2016168837A1 (en) * 2015-04-17 2016-10-20 Stc.Unm A novel non-toxic larvicide
US11337422B2 (en) * 2015-04-17 2022-05-24 Unm Rainforest Innovations Non-toxic larvicide
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
JP6321100B2 (ja) * 2016-09-07 2018-05-09 小林製薬株式会社 ゼラチン成形組成物
WO2018213663A1 (en) 2017-05-19 2018-11-22 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
WO2019093708A1 (ko) * 2017-11-08 2019-05-16 김승수 악취 억제형 불포화오일 및 아르기닌 함유 조성물의 제조 방법
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
CN108208838A (zh) * 2018-03-09 2018-06-29 北京素维生物科技有限公司 一种掩味组合物及其用途
CN112218630A (zh) 2018-09-24 2021-01-12 阿马里纳药物爱尔兰有限公司 降低受试者的心血管事件的风险的方法
WO2022225896A1 (en) 2021-04-21 2022-10-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3721389A (en) * 1971-06-10 1973-03-20 Boeing Co Exit nozzle assemblies for gas turbine power plants
JPS55105623A (en) 1979-02-08 1980-08-13 Grelan Pharmaceut Co Ltd Preparation of filler for hard capsules
JPS5665820A (en) 1979-11-02 1981-06-03 Eisai Co Ltd Hard capsule with high content of tocopherol nicotinate
AU561367B2 (en) 1983-05-02 1987-05-07 Scherer, R.P. Pty. Ltd. Vitamin composition with enhanced bioavailability
JPS6115649A (ja) * 1984-06-30 1986-01-23 Asahi Denka Kogyo Kk 油性食品
JPS6115647A (ja) * 1984-06-30 1986-01-23 Asahi Denka Kogyo Kk 油脂食品
CA1259966A (en) * 1985-02-27 1989-09-26 Taizo Yamamoto Capsule filling apparatus
DE3702031A1 (de) * 1987-01-24 1988-08-04 Basf Ag Verfahren zur herstellung von mikrodispersen fischoelpraeparaten
US4853247A (en) * 1987-06-16 1989-08-01 Warner-Lambert Co. Taste and odor masked edible oil compositions
US4913921A (en) * 1987-09-11 1990-04-03 General Mills, Inc. Food products containing fish oils stabilized with fructose
US4961939A (en) 1989-06-02 1990-10-09 Nabisco Brands, Inc. Deodorized water-in-oil emulsion containing fish oil
DE69013923T2 (de) 1989-08-17 1995-03-16 Cortecs Ltd Arzneiformulierungen.
JPH03130042A (ja) 1989-10-17 1991-06-03 Nippon Oil & Fats Co Ltd 高度不飽和脂肪酸含有油脂の臭気マスキング方法
JPH06505959A (ja) * 1990-05-07 1994-07-07 ボッコー　バリー　アイ 安定な脱臭油及びその医薬組成物の方法及び製剤
JPH0668A (ja) * 1992-06-18 1994-01-11 Sanwa Kagaku Kenkyusho Co Ltd 海産動物性油脂濃縮物含有組成物及び該組成物を含有する食品
JPH06133707A (ja) * 1992-10-23 1994-05-17 Chugai Pharmaceut Co Ltd 多価不飽和脂肪酸含有油脂組成物の香味改善法およびその利用食品
JP3534199B2 (ja) 1993-11-10 2004-06-07 株式会社薬研 界面活性剤組成物
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
US5853761A (en) * 1995-02-13 1998-12-29 Fujisawa Pharmaceutical Co., Ltd. Stabilizing agent for oleaginous, physiologically active substances
JPH09132775A (ja) * 1995-02-13 1997-05-20 Kiteii:Kk 油状生理活性物質の安定化剤
JPH0984557A (ja) * 1995-09-20 1997-03-31 Morimitsu Miyagi 合成肝油の製造物
US5900251A (en) * 1996-06-10 1999-05-04 Breath Asure, Inc. Internal breath freshener and digestive aid
US6056971A (en) 1996-07-24 2000-05-02 Biosytes Usa, Inc. Method for enhancing dissolution properties of relatively insoluble dietary supplements and product incorporating same
US5702231A (en) * 1996-08-09 1997-12-30 The Boeing Company Apparatus and method for reducing noise emissions from a gas turbine engine inlet
JPH10251143A (ja) * 1997-03-10 1998-09-22 Sansei Iyaku Kk ソフトカプセル
GB9705813D0 (en) * 1997-03-20 1997-05-07 Smithkline Beecham Plc Novel compositions
GB2324457B (en) * 1997-04-26 2001-05-30 Cultech Ltd Nutritional supplement
US6112514A (en) * 1997-11-05 2000-09-05 Virginia Tech Intellectual Properties, Inc. Fan noise reduction from turbofan engines using adaptive Herschel-Quincke tubes
KR100587551B1 (ko) * 1997-12-10 2006-06-08 싸이클로스포린 테라퓨틱스 리미티드 오메가-3 지방산 오일을 함유하는 약학 조성물
DE19854987B4 (de) 1998-11-27 2005-12-08 Josef Schwarzkopf Mischung zur Reduzierung von Speisegerüchen
CA2293088A1 (en) * 1998-12-28 2000-06-28 Lionel Leroy Quinlan Method and composition for masking taste and odor from fish oil
GB2349817A (en) * 1999-03-12 2000-11-15 K T Lalvani uSE OF MASKING AGENTS WITH CAPSULES
US6346231B1 (en) * 1999-10-06 2002-02-12 Joar Opheim Flavored gelatin capsule and method of manufacture
JP2001131575A (ja) 1999-11-05 2001-05-15 Nof Corp 臭気がマスクされた水産動物油脂

Also Published As

Publication number Publication date
JP4969763B2 (ja) 2012-07-04
KR20030093198A (ko) 2003-12-06
EP1351585A1 (en) 2003-10-15
US20040121000A1 (en) 2004-06-24
NO20034014L (no) 2003-09-11
US9532585B2 (en) 2017-01-03
MXPA03006361A (es) 2003-10-06
CN1503633A (zh) 2004-06-09
CA2434471A1 (en) 2002-07-25
NO20034014D0 (no) 2003-09-11
HK1055222A1 (en) 2004-01-02
WO2002056709A1 (en) 2002-07-25
EP1351585B1 (en) 2015-04-08
NZ527079A (en) 2005-09-30
CA2434471C (en) 2011-11-22
GB0101198D0 (en) 2001-02-28
AU2002219388B2 (en) 2008-06-05
DK1351585T3 (en) 2015-07-06
JP2004520355A (ja) 2004-07-08
KR100901518B1 (ko) 2009-06-08
CN1241645C (zh) 2006-02-15

Similar Documents

Publication Publication Date Title
ES2537296T3 (es) Composiciones ingeribles que contienen un aceite odorífero
RU2279230C2 (ru) Таблетка, содержащая пищевую композицию, для использования в качестве пищевой добавки
RU2009126740A (ru) Композиция питательной добавки, предназначенная для лечения глазных болезней
JP2013503611A (ja) 食用塩含有マイクロカプセル
CN101478889A (zh) 浓缩型ω-3脂肪酸以及包含它们的混合物
ES2401956T3 (es) Composición lipídica y uso de la misma
AU2004288672B2 (en) Method of utilizing body taste improver comprising long-chain highly unsaturated fatty acid and/or ester thereof
RU2007117803A (ru) Композиция для лечения глаз, содержащая омега-3 жирные кислоты и омега-6 жирные кислоты
TWI659748B (zh) Oral composition
CA2659272C (en) Fat containing composition
JPS61126016A (ja) 不飽和脂肪酸を内相物としたマイクロカプセル
JP2008237058A (ja) 栄養補助食品
JP6450317B2 (ja) Ｄｈａ及びｅｐａを含む軟カプセル
JPS6115647A (ja) 油脂食品
JPH0336493B2 (es)
JP2017002015A (ja) サプリメント及びその製造方法
JP2711064B2 (ja) 健康食品
JPH08140624A (ja) 栄養補助食品
JP3443767B2 (ja) 炊飯用または調理用ｄｈａカプセル
JP5735576B2 (ja) コエンザイムｑ１０を含有する組成物
CN1445349A (zh) 添加共轭亚油酸的油脂及减缓不饱和脂肪酸氧化、促进其吸收的方法
JP5683768B2 (ja) コエンザイムｑ１０を含有する組成物
JP2006262769A (ja) 栄養補助食品
JP3654471B2 (ja) 生鮮魚肉食品
JPS6129695B2 (es)