GB2349817A - uSE OF MASKING AGENTS WITH CAPSULES - Google Patents

uSE OF MASKING AGENTS WITH CAPSULES Download PDF

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Publication number
GB2349817A
GB2349817A GB9905576A GB9905576A GB2349817A GB 2349817 A GB2349817 A GB 2349817A GB 9905576 A GB9905576 A GB 9905576A GB 9905576 A GB9905576 A GB 9905576A GB 2349817 A GB2349817 A GB 2349817A
Authority
GB
United Kingdom
Prior art keywords
capsule
delivery system
masking agent
active ingredients
shell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9905576A
Other versions
GB9905576D0 (en
Inventor
K T Lalvani
Robert Taylor
T E J Lalvani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB9905576A priority Critical patent/GB2349817A/en
Publication of GB9905576D0 publication Critical patent/GB9905576D0/en
Publication of GB2349817A publication Critical patent/GB2349817A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)

Abstract

A masking agent is incorporated into both the active ingredients contained in the capsule, and into the gel matrix of the capsule shell, which is typically composed of gelatin, glycerine, or glycerol mono-stearate. The masking agent is orange oil. This 'dual masking' technique improves taste and acceptability during and after swallowing, when a rebound aftertaste may normally occur. It is applicable a wide range of preparations which contain strong tasting ingredients, such as fish oil, or garlic oil/powder, thereby eliminating the need for a deodorising process.

Description

2349817 (Novel Procedure To Mask The Characteristic Aftertaste Of
Ingredients In Soft Or Hard Gel Capsule Form) The invention relates to a novel method of preventing or - minimising the aftertaste associated with certain nutritional supplements, such as cod liver oil and omega-3 fish oil preparations. Such ingredients are well known for their unpleasant odour and often presented in gelatin capsule form for patient convenience.
The product uses a novel procedure to incorporate a masking agent into both the oily (or non-oily) contents of the capsule, and critically into the actual gel matrix of the soft or hard shell delivery system. This dual masking process improves taste and acceptability during swallowing, reducesrebound aftertaste and prevents perceptible odour when opening the bottle or storage container.
The shell to which the agent may be added is typically composed of gelatin and in the case of soft gel shells, glycerine and glycerol mono- stearate. The agent ma'Y,,consist of a synthetic composition flavour, or a concentrated natural extract, for example that of orange oil. The form added to the contents of the capsule may be identical or similar to the masking agent in the gel matrix, depending on the nature of the active ingredients.
The dual technique is applicable to a wide range of ingredients and supplements, including garlic oil or powder. Existing production of odourless forms of garlic may have the -negative effect of removing some of the beneficial active agent. Rather than a deodorising process, the product invention allows for the whole active material to be included, without the usual disadvantage of undesirable aftertaste.
23 February 1999 gned:
Dr K.T.LALVANI (For Vitabiotics Ltd.) 2.

Claims (10)

1. A soft gelatin capsule for oral use, in which a specific masking agent is incorporated into the active pharmaceutical ingredients contained within the capsule and a specific masking agent is incorporated into the gel matrix that forms the capsule shell delivery system.
2. A capsule delivery system as in Claim 1, in which the shell is composed of gelatin, glycerine, or glycerol mono-stearate.
3. A capsule delivery system as in Claim 1, in which the capsule format consists of a two-piece hard gelatin capsule shell.
4. A capsule delivery system as in Claim 1, where the odour-masking agent added to the capsule shell matrix consists of a synthetic flavour.
5. A capsule delivery system as in Claim 1, where the odour-masking agent added to the capsule shell matrix consists of a concentrated natural extract or botanical product.
6. A capsule delivery system as in Claim 4, where the active ingredients include fish oil.
7. A capsule delivery system as in Claim 4, where the active ingredients include garlic.
8. A capsule delivery system as in Claim 4, where the active ingredients include one or more B group vitamins.
9. A capsule delivery system as in Claim 4, where the active ingredients include 1200mg iron.
10. A capsule with a double odour masking system substantially as herein described.
GB9905576A 1999-03-12 1999-03-12 uSE OF MASKING AGENTS WITH CAPSULES Withdrawn GB2349817A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9905576A GB2349817A (en) 1999-03-12 1999-03-12 uSE OF MASKING AGENTS WITH CAPSULES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9905576A GB2349817A (en) 1999-03-12 1999-03-12 uSE OF MASKING AGENTS WITH CAPSULES

Publications (2)

Publication Number Publication Date
GB9905576D0 GB9905576D0 (en) 1999-05-05
GB2349817A true GB2349817A (en) 2000-11-15

Family

ID=10849402

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9905576A Withdrawn GB2349817A (en) 1999-03-12 1999-03-12 uSE OF MASKING AGENTS WITH CAPSULES

Country Status (1)

Country Link
GB (1) GB2349817A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002056709A1 (en) * 2001-01-17 2002-07-25 R.P. Scherer Technologies, Inc. Ingestible compositions containing an odoriferous oil

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2035084A (en) * 1978-11-01 1980-06-18 Unilever Ltd Flavouring oral products
EP0371584A2 (en) * 1988-10-28 1990-06-06 McNEIL-PPC, INC. Unpleasant taste masking compositions and methods for preparing same
GB2283899A (en) * 1993-11-23 1995-05-24 Hitchcock Esmond Antony Coated gelatin capsules
WO1998042316A1 (en) * 1997-03-25 1998-10-01 R.P. Scherer Corporation Comestible capsules having flavoured coatings

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2035084A (en) * 1978-11-01 1980-06-18 Unilever Ltd Flavouring oral products
EP0371584A2 (en) * 1988-10-28 1990-06-06 McNEIL-PPC, INC. Unpleasant taste masking compositions and methods for preparing same
GB2283899A (en) * 1993-11-23 1995-05-24 Hitchcock Esmond Antony Coated gelatin capsules
WO1998042316A1 (en) * 1997-03-25 1998-10-01 R.P. Scherer Corporation Comestible capsules having flavoured coatings

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Abstracts of JP 1O0251143 A [JP 10251143 A (Sansho Iyaku KK)] *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002056709A1 (en) * 2001-01-17 2002-07-25 R.P. Scherer Technologies, Inc. Ingestible compositions containing an odoriferous oil
US20040121000A1 (en) * 2001-01-17 2004-06-24 Dennis Bowe Ingestible compositions containing an odoriferous oil
JP2004520355A (en) * 2001-01-17 2004-07-08 アール．ピー． シェーラー テクノロジーズ インコーポレイテッド Ingestible composition containing odorous oil
US9532585B2 (en) 2001-01-17 2017-01-03 R.P. Scherer Technologies, Llc Ingestible compositions containing an odoriferous oil

Also Published As

Publication number Publication date
GB9905576D0 (en) 1999-05-05

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Legal Events

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)